Fabrizio Billi, Ph.D.

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A Short Biography:

Fabrizio Billi earned his Ph.D. in Biomaterials and Biomechanics in 2000 from the Università La Sapienza, Roma, Italy. He has been a researcher at the Joint Research Centre of the European Commission from 1995 to 2001 and post-doctoral fellow at UCLA from 2002 to 2006. He is currently Associate Professor in the Department of Orthopaedic Surgery.

Work Titles
CTSI Member, CTSI
UCLA Adjunct Professor, Orthopaedic Surgery
Education:
Degrees:
Ph.D., Universita' di Roma "La Sapienza", Italy, 2000
Honors and Awards:
2012 UCLA, Stein Oppenheimer Award
2011 The Hip Society, The John Charnley Award
2008 G. June Marshall Award, Exemplary Achievement in Orthopaedic Research

Contact Information:

Email Address:

F.Billi@ucla.edu

Work Email Address:

fabriziobilli@mednet.ucla.edu


Website:

Our Research

Fax Number:

310-825-5409

Lab Number:

310-983-1035

Work Phone Number:

424-442-0364

Office Address:

UCLA Campus
615 Charles E. Young Dr. South
Los Angeles, CA 90095


Research Interest:

Billi's Lab

Dr. Billi's current research interests concern bone biology; materials and medical devices biocompatibility and immunology; anti-infective strategies; tribology; biomaterials and smart materials; and wearable orthopaedic devices and technologies. The research in the lab is supported by a number of NIH/NIAMS and industry grants.

Billi's Lab

Dr. Billi's current research interest concerns bone biology, and specifically the development more specifically a novel 3D bone model for osteoclastogenesis; materials biocompatibility and immunology, and more specifically the effect of corrosion and metal bio-products on cell viability; anti-infective strategies such as smart coatings for the release of antibacterial drugs; tribology and biomaterials, to develop new smart implants; wearable orthopaedic devices and technologies to improve patient screening, outcome and monitoring before, after surgery, and during rehabilitation. The application of these wearable devices extends to sport medicine and military personnel.

Detailed Biography:

Fabrizio Billi is a biomaterials and biomechanics engineer who joined the Department of Orthopaedic Surgery in 2002. He became Associate Professor in 2011. Dr. Billi earned his B.S./M.S. in Chemical/Materials Engineering and Ph.D. in Biomaterials and Biomechanics at the University of Rome, "La Sapienza", Italy. He was a postdoctoral fellow at the JVL Orthopaedic Research Center at Orthoapedic Hospital/UCLA, where he worked on developing a new fretting and a new artificial intervertebral disc wear simulators. Dr. Billi research is currently focused on wearable technologies, bone biology, smart materials, and biomechanics.

Publications:

A selected list of publications:

Tellisi Nazzar, Ashammakhi Nureddin A, Billi Fabrizio, Kaarela Outi   Three Dimensional Printed Bone Implants in the Clinic The Journal of craniofacial surgery, 2018; 29(8): 2363-2367.
Perez-Maceda Blanca Teresa, López-Fernández María Encarnación, Díaz Iván, Kavanaugh Aaron, Billi Fabrizio, Escudero María Lorenza, García-Alonso María Cristina, Lozano Rosa María   Macrophage Biocompatibility of CoCr Wear Particles Produced under Polarization in Hyaluronic Acid Aqueous Solution Materials (Basel, Switzerland), 2018; 11(5): 2363-2367.
Stavrakis Alexandra I, Niska Jared A, Shahbazian Jonathan H, Loftin Amanda H, Ramos Romela Irene, Billi Fabrizio, Francis Kevin P, Otto Michael, Bernthal Nicholas M, Uslan Daniel Z, Miller Lloyd S   Combination prophylactic therapy with rifampin increases efficacy against an experimental Staphylococcus epidermidis subcutaneous implant-related infection Antimicrobial agents and chemotherapy, 2014; 58(4): 2377-86.
Pedowitz Robert A, Billi Fabrizio, Kavanaugh Aaron, Colbert Andrew, Liu Sen, Savoie Felix H, You Zongbing   Arthroscopic surgical tools: a source of metal particles and possible joint damage Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 2013; 29(9): 1559-65.
Stavrakis Alexandra I, Niska Jared A, Loftin Amanda H, Billi Fabrizio, Bernthal Nicholas M   Understanding infection: a primer on animal models of periprosthetic joint infection TheScientificWorldJournal, 2013; 2013(4): 925906.
Zhang Dongning, Page Janet R, Kavanaugh Aaron E, Billi Fabrizio   A new method for shape and texture classification of orthopedic wear nanoparticles Journal of applied biomaterials & functional materials, 2012; 10(2): 141-8.
Niska Jared A, Shahbazian Jonathan H, Ramos Romela Irene, Pribaz Jonathan R, Billi Fabrizio, Francis Kevin P, Miller Lloyd S   Daptomycin and Tigecycline Have Broader Effective Dose Ranges than Vancomycin as Prophylaxis against a Staphylococcus aureus Surgical Implant Infection in Mice Antimicrobial agents and chemotherapy, 2012; 56(5): 2590-7.
Pribaz Jonathan R, Bernthal Nicholas M, Billi Fabrizio, Cho John S, Ramos Romela Irene, Guo Yi, Cheung Ambrose L, Francis Kevin P, Miller Lloyd S   Mouse model of chronic post-arthroplasty infection: Noninvasive in vivo bioluminescence imaging to monitor bacterial burden for long-term study Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2012; 30(3): 335-40.
Billi Fabrizio, Benya Paul, Kavanaugh Aaron, Adams John, McKellop Harry, Ebramzadeh Edward   The john charnley award: an accurate and extremely sensitive method to separate, display, and characterize wear debris part 2: metal and ceramic particles Clinical orthopaedics and related research, 2012; 470(2): 339-50.
Billi Fabrizio, Benya Paul, Kavanaugh Aaron, Adams John, Ebramzadeh Edward, McKellop Harry   The john charnley award: an accurate and sensitive method to separate, display, and characterize wear debris: part 1: polyethylene particles Clinical orthopaedics and related research, 2012; 470(2): 329-38.
Ascenzi Maria-Grazia, Liao Vivian P, Lee Brittany M, Billi Fabrizio, Zhou Hua, Lindsay Robert, Cosman Felicia, Nieves Jeri, Bilezikian John P, Dempster David W   Parathyroid hormone treatment improves the cortical bone micro-structure by improving the distribution of type I collagen in postmenopausal women with osteoporosis Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011; 470(2): .
Bernthal Nicholas M, Pribaz Jonathan R, Stavrakis Alexandra I, Billi Fabrizio, Cho John S, Ramos Romela Irene, Francis Kevin P, Iwakura Yoichiro, Miller Lloyd S   Protective role of IL-1β against post-arthroplasty Staphylococcus aureus infection Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2011; 29(10): 1621-6.
Bernthal Nicholas M, Stavrakis Alexandra I, Billi Fabrizio, Cho John S, Kremen Thomas J, Simon Scott I, Cheung Ambrose L, Finerman Gerald A, Lieberman Jay R, Adams John S, Miller Lloyd S   A mouse model of post-arthroplasty Staphylococcus aureus joint infection to evaluate in vivo the efficacy of antimicrobial implant coatings PloS one, 2010; 5(9): e12580.
Blumenfeld Thomas J, McKellop Harry A, Schmalzried Thomas P, Billi Fabrizio   Fracture of a Cross-Linked Polyethylene Liner A Multifactorial Issue The Journal of arthroplasty, 2010; .
Billi Fabrizio, Sangiorgio Sophia N, Aust Sarah, Ebramzadeh Edward   Material and surface factors influencing backside fretting wear in total knee replacement tibial components Journal of biomechanics, 2010; 43(7): 1310-5.
Billi Fabrizio, Campbell Pat   Nanotoxicology of metal wear particles in total joint arthroplasty: a review of current concepts Journal of applied biomaterials & biomechanics : JABB, 2010; 8(1): 1-6.
Billi Fabrizio, Benya Paul, Ebramzadeh Edward, Campbell Pat, Chan Frank, McKellop Harry A   Metal wear particles: What we know, what we do not know, and why SAS journal, 2009; 3(4): 133-42.
Lee Jessica L, Billi Fabrizio, Sangiorgio Sophia N, McGarry William, Krueger David J, Miller Peter T, McKellop Harry, Ebramzadeh Edward   Wear of an experimental metal-on-metal artificial disc for the lumbar spine Spine, 2008; 33(6): 597-606.
Ebramzadeh Edward, Billi Fabrizio, Sangiorgio Sophia N, Mattes Sarah, Schmoelz Werner, Dorr Lawrence   Simulation of fretting wear at orthopaedic implant interfaces Journal of biomechanical engineering, 2005; 127(3): 357-63.

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