Publications:
A selected list of publications:
Zhang Y, Murugesan P, Huang K, Cai H
NADPH oxiase-dependent oxidase crosstalks in cardiovascular diseases: Targets of novel therapies,
Nature Reviews Cardiology,
2019; In press:
.
Li Q, Youn JY, Siu KL, Murugesan P, Zhang Y, Cai H.
Knockout of dihydrofolate reductase in mice induces abdominal aortic aneurysm and hypertension via mitochondrial dysfunction,
Redox Biology,
2019; Mar 29;24:
101185.
Li H*, Li Q*, Zhang Y, Liu W, Gu B, Narumi T, Siu KL, Youn JY, Liu P, Yang X, Cai H
Novel treatment of hypertension by specifically targeting E2F for the restoration of dihydrofolate reductase and eNOS function under oxidative stress,
Hypertension,
2019; 73(1):
179-189, “High Impact Paper in Hypertension” collection.
Cheng Y, Yuan Q, Vergnes L, Rong X, Youn JY, Li J, Yu Y, Liu W, Cai H, Lin J, Tontonoz P, Hong C, Reue K, Wang CY
KDM4B protects against obesity and metabolic dysfunction,
Proc. Natl. Acad. Sci. U. S. A. ,
2018; 115(24):
E5566-E5575.
Zhang YX, Liu NM, Wang YC, Youn JY, Cai H
Endothelial cell calpain as a critical modulator of angiogenesis,
Biochim Biophys Acta. Mol. Basis of Dis. ,
2017; 1863(6):
1326-1335.
Cai H, Wang C
Surviving With Smog and Smoke: Precision Interventions?,
Chest,
2017; 152(5):
925-929, "Ahead of the Curve" Collection.
Cai H, Wang C
Graphical review: The redox dark side of e-cigarettes; exposure to oxidants and public health concerns,
Redox Biol,
2017; 13:
402-406.
Sun Haipeng, Olson Kristine C, Gao Chen, Prosdocimo Domenick A, Zhou Meiyi, Wang Zhihua, Jeyaraj Darwin, Youn Ji-Youn, Ren Shuxun, Liu Yunxia, Rau Christoph D, Shah Svati, Ilkayeva Olga, Gui Wen-Jun, William Noelle S, Wynn R Max, Newgard Christopher B, Cai Hua, Xiao Xinshu, Chuang David T, Schulze Paul Christian, Lynch Christopher, Jain Mukesh K, Wang Yibin
Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure
Circulation,
2016; 133(21):
2038-49.
Li Jingyuan, Iorga Andrea, Sharma Salil, Youn Ji-Youn, Partow-Navid Rod, Umar Soban, Cai Hua, Rahman Siamak, Eghbali Mansoureh
Intralipid, a clinically safe compound, protects the heart against
ischemia-reperfusion injury more efficiently than cyclosporine-A
Anesthesiology,
2012; 117(4):
836-46.
Zhang Jun, Youn Ji Youn, Kim Antony Y, Ramirez Rafael J, Gao Ling, Ngo Doan, Chen Peng, Scovotti Jennifer, Mahajan Aman, Cai Hua
NOX4-Dependent Hydrogen Peroxide Overproduction in Human Atrial
Fibrillation and HL-1 Atrial Cells: Relationship to Hypertension
Frontiers in physiology,
2012; 3(4):
140.
Zhang Jun, Lin Amanda, Powers Jared, Lam Maggie P, Lotz Christopher, Liem David, Lau Edward, Wang Ding, Deng Ning, Korge Paavo, Zong Nobel C, Cai Hua, Weiss James, Ping Peipei
Perspectives on: SGP symposium on mitochondrial physiology and
medicine: mitochondrial proteome design: from molecular identity to
pathophysiological regulation
The Journal of general physiology,
2012; 139(6):
395-406.
Lu Gang, Sun Haipeng, She Pengxiang, Youn Ji-Youn, Warburton Sarah, Ping Peipei, Vondriska Thomas M, Cai Hua, Lynch Christopher J, Wang Yibin
Protein phosphatase 2Cm is a critical regulator of branched-chain
amino acid catabolism in mice and cultured cells
The Journal of clinical investigation,
2009; 119(6):
1678-87.
Oak, J. H. Cai, H.
Attenuation of angiotensin II signaling recouples eNOS and inhibits nonendothelial NOX activity in diabetic mice,
Diabetes,
2007; 56(1):
118-26..
Cai, H.
A new mechanism for flow-mediated vasoprotection? Focus on "lung endothelial cell proliferation with decreased shear stress is mediated by reactive oxygen species",
Am J Physiol Cell Physiol,
2006; 290(1):
C35-6.
Nguyen, A. Cai, H.
Netrin-1 induces angiogenesis via a DCC-dependent ERK1/2-eNOS feed-forward mechanism,
Proc Natl Acad Sci U S A,
2006; 103(17):
6530-5. Epub 2006 Apr 12..
Cai, H.
Hydrogen peroxide regulation of endothelial function: origins, mechanisms, and consequences,
Cardiovasc Res,
2005; 68(1):
26-36.
Chalupsky, K. Cai, H.
Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase,
Proc Natl Acad Sci U S A,
2005; 102(25):
9056-61. Epub 2005 Jun 7..
Laude, K. Cai, H. Fink, B. Hoch, N. Weber, D. S. McCann, L. Kojda, G. Fukai, T. Schmidt, H. H. Dikalov, S. Ramasamy, S. Gamez, G. Griendling, K. K. Harrison, D. G.
Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice,
Am J Physiol Heart Circ Physiol,
2005; 288(1):
H7-H12. Epub 2004 Oct 07..
McNally, J. S. Saxena, A. Cai, H. Dikalov, S. Harrison, D. G.
Regulation of xanthine oxidoreductase protein expression by hydrogen peroxide and calcium,
Arterioscler Thromb Vasc Biol,
2005; 25(8):
1623-8. Epub 2005 May 19..
Cai, H.
NAD(P)H oxidase-dependent self-propagation of hydrogen peroxide and vascular disease,
Circ Res,
2005; 96(8):
818-22..
Nguyen, A. Chen, P. Cai, H.
Role of CaMKII in hydrogen peroxide activation of ERK1/2, p38 MAPK, HSP27 and actin reorganization in endothelial cells,
FEBS Lett,
2004; 572(1-3):
307-13..
Lade, K. Cai, H. Fink, B. Hoch, N. Weber, D. S. McCann, L. Kojda, G. Fukai, T. Dikalov, S. Ramasamy, S. Gamez, G. Griendling, K. Harrison, D.
Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice,
Am J Physiol,
2004; In-press:
.
Cai, H. McNally, J. S. Weber, M. Harrison, D.G.
Oscillatory shear stress upregulation of endothelial nitric oxide synthase requires intracellular hydrogen peroxide and CaMKII,
J Mol Cell Cardiol,
2004; 37(1):
121-5.
Cai, H. Li, Z. Davis, M. E. Kanner, W. Harrison, D. G. Dudley, S. C., Jr.
Akt-dependent phosphorylation of serine 1179 and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide,
Mol Pharmacol,
2003; 63(2):
325-31..
Davis, M. E. Cai, H. McCann, L. Fukai, T. Harrison, D. G.
Role of c-Src in regulation of endothelial nitric oxide synthase expression during exercise training,
Am J Physiol Heart Circ Physiol,
2003; 284(4):
H1449-53..
Alp, N. J. Mussa, S. Khoo, J. Cai, S. Guzik, T. Jefferson, A. Goh, N. Rockett, K. A. Channon, K. M.
Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression,
J Clin Invest,
2003; 112(5):
725-35..
Cai, H. Griendling, K. K. Harrison, D. G.
The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases,
Trends Pharmacol Sci,
2003; 24(9):
471-8..
Cai, H. Li, Z. Goette, A. Mera, F. Honeycutt, C. Feterik, K. Wilcox, J. N. Dudley, S. C., Jr. Harrison, D. G. Langberg, J. J.
Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis and stroke,
Circulation,
2002; 106(22):
2854-8..
Cai, H. Li, Z. Dikalov, S. Holland, S. M. Hwang, J. Jo, H. Dudley, S. C., Jr. Harrison, D. G.
NAD(P)H oxidase-derived hydrogen peroxide mediates endothelial nitric oxide production in response to angiotensin II,
J Biol Chem,
2002; 277(50):
48311-7..
Landmesser, U. Cai, H. Dikalov, S. McCann, L. Hwang, J. Jo, H. Holland, S. M. Harrison, D. G.
Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II,
Hypertension,
2002; 40(4):
511-5..
Cai, H. Davis, M. E. Drummond, G. R. Harrison, D. G.
Induction of endothelial NO synthase by hydrogen peroxide via a Ca(2+)/calmodulin-dependent protein kinase II/janus kinase 2-dependent pathway,
Arterioscler Thromb Vasc Biol,
2001; 21(10):
1571-6..
Davis, M. E. Cai, H. Drummond, G. R. Harrison, D. G.
Shear stress regulates endothelial nitric oxide synthase expression through c-Src by divergent signaling pathways,
Circ Res,
2001; 89(11):
1073-80..
Cai, H. Harrison, D. G.
Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress,
Circ Res,
2000; 87(10):
840-4..
Drummond, G. R. Cai, H. Davis, M. E. Ramasamy, S. Harrison, D. G.
Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide,
Circ Res,
2000; 86(3):
347-54.