Brent Fogel, M.D., Ph.D.

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A Short Biography:

Dr. Brent Fogel obtained a Ph.D. in Microbiology and Molecular Genetics from the Medical College of Wisconsin as well as an M.D. degree. He completed his residency training in Neurology at UCLA as well as a research fellowship in Neurogenetics. He is currently an Associate Professor in the Departments of Neurology and Human Genetics at the David Geffen School of Medicine at UCLA. Dr. Fogel’s research studies basic molecular mechanisms of neuronal function to understand how impairment can lead to neurodegenerative disorders such as cerebellar ataxia or neurodevelopmental conditions such as autism spectrum disorder. Clinically, Dr. Fogel directs the UCLA Neurogenetics Clinic where he is using genome-wide methods to identify rare and novel causes of neurodegenerative disease, particularly cerebellar ataxia, as well as other disorders including various forms of leukodystrophy and spastic paraparesis. Dr. Fogel is  a member of the UCLA Ataxia Center and directs the Ataxia and Neurogenetics Biobank Program. Dr. Fogel also directs the Clinical Neurogenomics Research Center (CNRC) with the UCLA Department of Neurology. The CNRC facilitates incorporation of genomic data into clinical care and links patient populations with precision health-based research studies into the genetic and molecular basis of disease to improve diagnosis and treatment. He has authored many research and clinical articles, reviews, and book chapters on spinocerebellar ataxia, clinical neurogenetics, and neurodevelopmental disease. Dr. Fogel’s work has been funded by the American Academy of Neurology, the American Brain Foundation, the National Institutes of Health, and the National Ataxia Foundation.

Work Titles
CTSI Member, CTSI
UCLA Associate Professor, Neurology Associate Professor, Brain Research Institute Associate Professor, Human Genetics Member, Bioinformatics GPB Home Area Member, Genetics & Genomics GPB Home Area Member, Neuroscience GPB Home Area
Education:
Degrees:
M.D., Medical College of Wisconsin
Ph.D., Medical College of Wisconsin
Fellowship:
UCLA
Certifications:
Certifications:
ABPN

Contact Information:

Email Address:

bfogel@ucla.edu


Website:

Laboratory
Clinic

Work Address:

695 Charles E. Young Drive South, Gonda Room 1206
Los Angeles, CA 90095


Publications:

A selected list of publications:

Fogel Brent L   Autosomal-recessive cerebellar ataxias Handbook of clinical neurology, 2018; 147(3): 187-209.
Fogel Brent L   Collaborative Science Unites Researchers and a Novel Spastic Ataxia Gene Annals of neurology, 2018; .
Ngo Kathie, Aker Mamdouh, Petty Lauren E, Chen Jason, Cavalcanti Francesca, Nelson Alexandra B, Hassin-Baer Sharon, Geschwind Michael D, Perlman Susan, Italiano Domenico, Laganà Angelina, Cavallaro Sebastiano, Coppola Giovanni, Below Jennifer E, Fogel Brent L   Expanding the global prevalence of spinocerebellar ataxia type 42 Neurology. Genetics, 2018; 4(3): e232.
Fogel Brent L   Genetic and genomic testing for neurologic disease in clinical practice Handbook of clinical neurology, 2018; 147(3): 11-22.
Valera Juliana M, Diaz Tatyana, Petty Lauren E, Quintáns Beatriz, Yáñez Zuleima, Boerwinkle Eric, Muzny Donna, Akhmedov Dmitry, Berdeaux Rebecca, Sobrido Maria J, Gibbs Richard, Lupski James R, Geschwind Daniel H, Perlman Susan, Below Jennifer E, Fogel Brent L   Prevalence of spinocerebellar ataxia 36 in a US population Neurology. Genetics, 2017; 3(4): e174.
Zambonin Jessica L, Bellomo Allison, Ben-Pazi Hilla, Everman David B, Frazer Lee M, Geraghty Michael T, Harper Amy D, Jones Julie R, Kamien Benjamin, Kernohan Kristin, Koenig Mary Kay, Lines Matthew, Palmer Elizabeth Emma, Richardson Randal, Segel Reeval, Tarnopolsky Mark, Vanstone Jason R, Gibbons Melissa, Collins Abigail, Fogel Brent L, Fogel Brent L, Dudding-Byth Tracy, Boycott Kym M   Spinocerebellar ataxia type 29 due to mutations in ITPR1: a case series and review of this emerging congenital ataxia Orphanet journal of rare diseases, 2017; 12(1): 121.
Wolf Susan M, Thyagarajan Bharat, Fogel Brent L   The need to develop a patient-centered precision medicine model for adults with chronic disability Expert review of molecular diagnostics, 2017; 17(5): 415-418.
Berto Stefano, Usui Noriyoshi, Konopka Genevieve, Fogel Brent L   ELAVL2-regulated transcriptional and splicing networks in human neurons link neurodevelopment and autism Human molecular genetics, 2016; 25(12): 2451-2464.
Vanderver Adeline, Simons Cas, Helman Guy, Crawford Joanna, Wolf Nicole I, Bernard Geneviève, Pizzino Amy, Schmidt Johanna L, Takanohashi Asako, Miller David, Khouzam Amirah, Rajan Vani, Ramos Erica, Chowdhury Shimul, Hambuch Tina, Ru Kelin, Baillie Gregory J, Grimmond Sean M, Caldovic Ljubica, Devaney Joseph, Bloom Miriam, Evans Sarah H, Murphy Jennifer L P, McNeill Nathan, Fogel Brent L, Fogel Brent L, Schiffmann Raphael, van der Knaap Marjo S, Taft Ryan J   Whole exome sequencing in patients with white matter abnormalities Annals of neurology, 2016; .
Fogel Brent L, Satya-Murti Saty, Cohen Bruce H   Clinical exome sequencing in neurologic disease Neurology. Clinical practice, 2016; 6(2): 164-176.
Aranca Tanya V, Jones Tracy M, Shaw Jessica D, Staffetti Joseph S, Ashizawa Tetsuo, Kuo Sheng-Han, Fogel Brent L, Wilmot George R, Perlman Susan L, Onyike Chiadi U, Ying Sarah H, Zesiewicz Theresa A   Emerging therapies in Friedreich's ataxia Neurodegenerative disease management, 2016; 6(1): 49-65.
Becherel Olivier J, Sun Jane, Yeo Abrey J, Nayler Sam, Fogel Brent L, Gao Fuying, Coppola Giovanni, Criscuolo Chiara, De Michele Giuseppe, Wolvetang Ernst, Lavin Martin F   A new model to study neurodegeneration in ataxia oculomotor apraxia type 2 Human molecular genetics, 2015; 24(20): 5759-74.
Fogel Brent L, Lee Hane, Strom Samuel P, Deignan Joshua L, Nelson Stanley F   Clinical exome sequencing in neurogenetic and neuropsychiatric disorders Annals of the New York Academy of Sciences, 2015; 24(20): .
Legati Andrea, Giovannini Donatella, Nicolas Gaël, López-Sánchez Uriel, Quintáns Beatriz, Oliveira João R M, Sears Renee L, Ramos Eliana Marisa, Spiteri Elizabeth, Sobrido María-Jesús, Carracedo Ángel, Castro-Fernández Cristina, Cubizolle Stéphanie, Fogel Brent L, Goizet Cyril, Jen Joanna C, Kirdlarp Suppachok, Lang Anthony E, Miedzybrodzka Zosia, Mitarnun Witoon, Paucar Martin, Paulson Henry, Pariente Jérémie, Richard Anne-Claire, Salins Naomi S, Simpson Sheila A, Striano Pasquale, Svenningsson Per, Tison François, Unni Vivek K, Vanakker Olivier, Wessels Marja W, Wetchaphanphesat Suppachok, Yang Michele, Boller Francois, Campion Dominique, Hannequin Didier, Sitbon Marc, Geschwind Daniel H, Battini Jean-Luc, Coppola Giovanni   Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export Nature genetics, 2015; 47(6): 579-81.
Fogel Brent L, Hanson Sonya M, Becker Esther B E   Do mutations in the murine ataxia gene TRPC3 cause cerebellar ataxia in humans? Movement disorders : official journal of the Movement Disorder Society, 2014; .
Lee Hane, Deignan Joshua L, Dorrani Naghmeh, Strom Samuel P, Kantarci Sibel, Quintero-Rivera Fabiola, Das Kingshuk, Toy Traci, Harry Bret, Yourshaw Michael, Fox Michelle, Fogel Brent L, Martinez-Agosto Julian A, Wong Derek A, Chang Vivian Y, Shieh Perry B, Palmer Christina G S, Dipple Katrina M, Grody Wayne W, Vilain Eric, Nelson Stanley F   Clinical exome sequencing for genetic identification of rare Mendelian disorders JAMA, 2014; 312(18): 1880-7.
Fogel Brent L, Lee Hane, Deignan Joshua L, Strom Samuel P, Kantarci Sibel, Wang Xizhe, Quintero-Rivera Fabiola, Vilain Eric, Grody Wayne W, Perlman Susan, Geschwind Daniel H, Nelson Stanley F   Exome sequencing in the clinical diagnosis of sporadic or familial cerebellar ataxia JAMA neurology, 2014; 71(10): 1237-46.
Fogel Brent L, Cho Ellen, Wahnich Amanda, Gao Fuying, Becherel Olivier J, Wang Xizhe, Fike Francesca, Chen Leslie, Criscuolo Chiara, De Michele Giuseppe, Filla Alessandro, Collins Abigail, Hahn Angelika F, Gatti Richard A, Konopka Genevieve, Perlman Susan, Lavin Martin F, Geschwind Daniel H, Coppola Giovanni   Mutation of senataxin alters disease-specific transcriptional networks in patients with ataxia with oculomotor apraxia type 2 Human molecular genetics, 2014; 23(18): 4758-69.
Fogel Brent L, Clark Mary C, Geschwind Daniel H   The neurogenetics of atypical parkinsonian disorders Seminars in neurology, 2014; 34(2): 217-24.
Shakkottai Vikram G, Fogel Brent L   Clinical neurogenetics: autosomal dominant spinocerebellar ataxia Neurologic clinics, 2013; 31(4): 987-1007.
Bill Brent R, Lowe Jennifer K, Dybuncio Christina T, Fogel Brent L   Orchestration of neurodevelopmental programs by RBFOX1: implications for autism spectrum disorder International review of neurobiology, 2013; 113(4): 251-67.
Fogel Brent L, Vickrey Barbara G, Walton-Wetzel Jenny, Lieber Eli, Browner Carole H   Utilization of Genetic Testing Prior to Subspecialist Referral for Cerebellar Ataxia Genetic testing and molecular biomarkers, 2013; .
Giorgio Elisa, Rolyan Harshvardhan, Kropp Laura, Chakka Anish Baswanth, Yatsenko Svetlana, Gregorio Eleonora Di, Lacerenza Daniela, Vaula Giovanna, Talarico Flavia, Mandich Paola, Toro Camilo, Pierre Eleonore Eymard, Labauge Pierre, Capellari Sabina, Cortelli Pietro, Vairo Filippo Pinto, Miguel Diego, Stubbolo Danielle, Marques Lourenco Charles, Gahl William, Boespflug-Tanguy Odile, Melberg Atle, Hassin-Baer Sharon, Cohen Oren S, Pjontek Rastislav, Grau Armin, Klopstock Thomas, Fogel Brent, Meijer Inge, Rouleau Guy, Bouchard Jean-Pierre L, Ganapathiraju Madhavi, Vanderver Adeline, Dahl Niklas, Hobson Grace, Brusco Alfredo, Brussino Alessandro, Padiath Quasar Saleem   Analysis of LMNB1 Duplications in Autosomal Dominant Leukodystrophy Provides Insights into Duplication Mechanisms and Allele-Specific Expression Human mutation, 2013; .
Hsu Sandy Chan, Sears Renee L, Lemos Roberta R, Quintáns Beatriz, Huang Alden, Spiteri Elizabeth, Nevarez Lisette, Mamah Catherine, Zatz Mayana, Pierce Kerrie D, Fullerton Janice M, Adair John C, Berner Jon E, Bower Matthew, Brodaty Henry, Carmona Olga, Dobrici? Valerija, Fogel Brent L, García-Estevez Daniel, Goldman Jill, Goudreau John L, Hopfer Suellen, Jankovi? Milena, Jaumà Serge, Jen Joanna C, Kirdlarp Suppachok, Klepper Joerg, Kosti? Vladimir, Lang Anthony E, Linglart Agnès, Maisenbacher Melissa K, Manyam Bala V, Mazzoni Pietro, Miedzybrodzka Zofia, Mitarnun Witoon, Mitchell Philip B, Mueller Jennifer, Novakovi? Ivana, Paucar Martin, Paulson Henry, Simpson Sheila A, Svenningsson Per, Tuite Paul, Vitek Jerrold, Wetchaphanphesat Suppachok, Williams Charles, Yang Michele, Schofield Peter R, de Oliveira João R M, Sobrido María-Jesús, Geschwind Daniel H, Coppola Giovanni   Mutations in SLC20A2 are a major cause of familial idiopathic basal ganglia calcification Neurogenetics, 2013; 14(1): 11-22.
Fogel Brent L, Baker Cameron, Curnow Andrew, Perlman Susan L, Geschwind Daniel H, Coppola Giovanni   Mutations in PDYN are not responsible for multiple system atrophy Journal of neurology, 2013; 14(1): .
Fogel Brent L, Pribadi Mochtar, Pi Sarah, Perlman Susan L, Geschwind Daniel H, Coppola Giovanni   C9ORF72 expansion is not a significant cause of sporadic spinocerebellar ataxia Movement disorders : official journal of the Movement Disorder Society, 2012; .
Mochel Fanny, Schiffmann Raphael, Steenweg Marjan E, Akman Hasan O, Wallace Mary, Sedel Frédéric, Laforêt Pascal, Levy Richard, Powers J Michael, Demeret Sophie, Maisonobe Thierry, Froissart Roseline, Da Nobrega Bruno Barcelos, Fogel Brent L, Natowicz Marvin R, Lubetzki Catherine, Durr Alexandra, Brice Alexis, Rosenmann Hanna, Barash Varda, Kakhlon Or, Gomori J Moshe, van der Knaap Marjo S, Lossos Alexander   Adult polyglucosan body disease: Natural History and Key Magnetic Resonance Imaging Findings Annals of neurology, 2012; 72(3): 433-41.
Cho Ellen, Fogel Brent L   A Family with Spinocerebellar Ataxia Type 5 Found to Have a Novel Missense Mutation within a SPTBN2 Spectrin Repeat Cerebellum (London, England), 2012; 72(3): .
Fogel Brent L   Childhood Cerebellar Ataxia Journal of child neurology, 2012; .
Fogel Brent L, Wexler Eric, Wahnich Amanda, Friedrich Tara, Vijayendran Chandran, Gao Fuying, Parikshak Neelroop, Konopka Genevieve, Geschwind Daniel H   RBFOX1 Regulates Both Splicing and Transcriptional Networks in Human Neuronal Development Human molecular genetics, 2012; .
Fogel Brent L, Lee Ji Yong, Lane Jessica, Wahnich Amanda, Chan Sandy, Huang Alden, Osborn Greg E, Klein Eric, Mamah Catherine, Perlman Susan, Geschwind Daniel H, Coppola Giovanni   Mutations in rare ataxia genes are uncommon causes of sporadic cerebellar ataxia Movement disorders : official journal of the Movement Disorder Society, 2012; 27(3): 442-6.
Wexler Eric, Fogel Brent L   New-onset psychosis in a patient with spinocerebellar ataxia type 10 The American journal of psychiatry, 2011; 168(12): 1339-40.
Becker Esther B E, Fogel Brent L, Rajakulendran Sanjeev, Dulneva Anna, Hanna Michael G, Perlman Susan L, Geschwind Daniel H, Davies Kay E   Candidate screening of the TRPC3 gene in cerebellar ataxia Cerebellum (London, England), 2011; 10(2): 296-9.
Fogel Brent L   Interpretation of genetic testing: variants of unknown significance Continuum (Minneapolis, Minn.), 2011; 17(2 Neurogenetics): 347-52.
Fogel Brent L, Lee Ji Yong, Perlman Susan   Aberrant splicing of the senataxin gene in a patient with ataxia with oculomotor apraxia type 2 Cerebellum (London, England), 2009; 8(4): 448-53.
Fogel Brent L, Young Pari, Thompson Arthur R, Perlman Susan   A family with combined mutations of the hemophilia A and X-linked adrenoleukodystrophy genes Neurogenetics, 2008; 9(3): 215-8.
Fogel Brent L, Perlman Susan   Clinical features and molecular genetics of autosomal recessive cerebellar ataxias Lancet neurology, 2007; 6(3): 245-57.
Fogel Brent L, Perlman Susan   Novel mutations in the senataxin DNA/RNA helicase domain in ataxia with oculomotor apraxia 2 Neurology, 2006; 67(11): 2083-4.
Fogel Brent L, Perlman Susan   An approach to the patient with late-onset cerebellar ataxia Nature clinical practice. Neurology, 2006; 2(11): 629-35; quiz 1 p following 635.
Fogel Brent, Cardenas Doris, Ovbiagele Bruce   Magnetic resonance imaging abnormalities in the corpus callosum of a patient with neuropsychiatric lupus The neurologist, 2006; 12(5): 271-3.
Fogel Brent, Wu Mark, Kremen Sarah, Murthy Kolar, Jackson George, Vanek Zeba   Creutzfeldt-Jakob disease presenting with alien limb sign Movement disorders : official journal of the Movement Disorder Society, 2006; 21(7): 1040-2.
Fogel Brent L, McNally Lisa M, McNally Mark T   Efficient polyadenylation of Rous sarcoma virus RNA requires the negative regulator of splicing element Nucleic acids research, 2002; 30(3): 810-7.
Fogel B L, McNally M T   A cellular protein, hnRNP H, binds to the negative regulator of splicing element from Rous sarcoma virus The Journal of biological chemistry, 2000; 275(41): 32371-8.
Fogel B L, McNally M T   Trace contamination following reuse of anion-exchange DNA purification resins BioTechniques, 2000; 28(2): 299-302.

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