Seema Tiwari-Woodruff, Ph.D.

Work Titles
UCLA Member, Brain Research Institute Associate Adjunct Professor, Neurology
Ph.D., Southern Illinois UNiversity

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Laboratory Address:

900 University Avenue
Riverside, CA 92521

Detailed Biography:

Seema K Tiwari-Woodruff is a neurobiologist who has served on the UCLA School of Medicine faculty since she joined the Department of Neurology in 2006. She has recently joined the Division of Biomedical Sciences in the School of Medicine at UC-Riverside as an Associate Professor. Dr. Tiwari-Woodruff earned her M.S. in Chemistry and Biochemistry and Ph.D. in Physiology at the Southern Illinois University, Carbondale. She was a postdoctoral fellow at the UCLA School of Medicine. Her laboratory research is focused on understanding the molecular events involved in neurodegeneration and neuroprotection in demyelinating central nervous system. In addition, her lab is testing various compounds as therapeutic agents in mouse models of multiple sclerosis. Other projects include the role of gender specific hormones and sex chromosomes on oligodendrocyte function during developmental myelination and during remyelination. Her lab uses a combination of transgenic mice and two different mouse models of demyelination. Techniques employed in her lab include various behavioral tests, electrophysiology, immunohistochemistry, quantitative morphometry, protein and gene analysis.


A selected list of publications:

Moore Spencer, Khalaj Anna J, Patel Rhusheet, Yoon JaeHee, Ichwan Daniel, Hayardeny Liat, Tiwari-Woodruff Seema K   Restoration of axon conduction and motor deficits by therapeutic treatment with glatiramer acetate Journal of neuroscience research, 2014; .
Khalaj Anna J, Yoon Jaehee, Nakai Jaspreet, Winchester Zachary, Moore Spencer M, Yoo Timothy, Martinez-Torres Leonardo, Kumar Shalini, Itoh Noriko, Tiwari-Woodruff Seema Kaushalya   Estrogen receptor (ER) B expression in oligodendrocytes is required for attenuation of clinical disease by an ERβ ligand Proceedings of the National Academy of Sciences of the United States of America, 2013; .
Moore Spencer, Khalaj Anna J, Yoon Jaehee, Patel Rhusheet, Hannsun Gemmy, Yoo Timothy, Sasidhar Manda, Martinez-Torres Leonardo, Hayardeny Liat, Tiwari-Woodruff Seema K   Therapeutic laquinimod treatment decreases inflammation, initiates axon remyelination, and improves motor deficit in a mouse model of multiple sclerosis Brain and behavior, 2013; 3(6): 664-82.
Bankston Andrew N, Li Wenqi, Zhang Hui, Ku Li, Liu Guanglu, Papa Filomena, Zhao Lixia, Bibb James A, Cambi Franca, Tiwari-Woodruff Seema K, Feng Yue   P39, the Primary Activator for Cyclin-dependent Kinase 5 (Cdk5) in Oligodendroglia, Is Essential for Oligodendroglia Differentiation and Myelin Repair The Journal of biological chemistry, 2013; .
Kumar Shalini, Patel Rhusheet, Moore Spencer, Crawford Daniel K, Suwanna Nirut, Mangiardi Mario, Tiwari-Woodruff Seema K   Estrogen receptor B ligand therapy activates PI3K/Akt/mTOR signaling in oligodendrocytes and promotes remyelination in a mouse model of multiple sclerosis Neurobiology of disease, 2013; .
Moore S, Patel R, Hannsun G, Yang J, Tiwari-Woodruff S K   Sex chromosome complement influences functional callosal myelination Neuroscience, 2013; .
Patel Rhusheet, Moore Spencer, Crawford Daniel K, Hannsun Gemmy, Sasidhar Manda V, Tan Kevin, Molaie Donna, Tiwari-Woodruff Seema K   Attenuation of Corpus Callosum Axon Myelination and Remyelination in the Absence of Circulating Sex Hormones Brain pathology (Zurich, Switzerland), 2013; .
Mangiardi Mario, Crawford Daniel K, Xia Xiaoyu, Du Sienmi, Simon-Freeman Rebecca, Voskuhl Rhonda R, Tiwari-Woodruff Seema K   An Animal Model of Cortical and Callosal Pathology in Multiple Sclerosis Brain pathology (Zurich, Switzerland), 2010; 21(3): .
Crawford Daniel K, Mangiardi Mario, Song Bingbing, Patel Rhusheet, Du Sienmi, Sofroniew Michael V, Voskuhl Rhonda R, Tiwari-Woodruff Seema K   Oestrogen receptor beta ligand: a novel treatment to enhance endogenous functional remyelination Brain : a journal of neurology, 2010; 133(10): 2999-3016.
Ziehn Marina O, Avedisian Andrea A, Tiwari-Woodruff Seema, Voskuhl Rhonda R   Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE Laboratory investigation; a journal of technical methods and pathology, 2010; 90(5): 774-86.
MacKenzie-Graham Allan, Tiwari-Woodruff Seema K, Sharma Gaurav, Aguilar Cynthia, Vo Kieumai T, Strickland Lauren V, Morales Laurie, Fubara Boma, Martin Melanie, Jacobs Russell E, Johnson G Allan, Toga Arthur W, Voskuhl Rhonda R   Purkinje cell loss in experimental autoimmune encephalomyelitis NeuroImage, 2009; 48(4): 637-51.
Gold Stefan M, Sasidhar Manda V, Morales Laurie B, Du Sienmi, Sicotte Nancy L, Tiwari-Woodruff Seema K, Voskuhl Rhonda R   Estrogen treatment decreases matrix metalloproteinase (MMP)-9 in autoimmune demyelinating disease through estrogen receptor alpha (ERalpha) Laboratory investigation; a journal of technical methods and pathology, 2009; 89(10): 1076-83.
Crawford, Mangiardi, Xia, López-Valdés, Tiwari-Woodruff   Functional recovery of callosal axons following demyelination: a critical window Neuroscience, 2009; .
Voskuhl Rhonda R, Peterson R Scott, Song Bingbing, Ao Yan, Morales Laurie Beth J, Tiwari-Woodruff Seema, Sofroniew Michael V   Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009; 29(37): 11511-22.
Crawford Daniel K, Mangiardi Mario, Tiwari-Woodruff Seema K   Assaying the functional effects of demyelination and remyelination: revisiting field potential recordings Journal of neuroscience methods, 2009; 182(1): 25-33.
Tiwari-Woodruff Seema K, Voskuhl Seema K   Neuroprotective and anti-inflammatory effects of estrogen receptor ligand treatment in mice Journal of the neurological sciences, 2009; 182(1): .
Smith-Bouvier Deborah L, Divekar Anagha A, Sasidhar Manda, Du Sienmi, Tiwari-Woodruff Seema K, King Jennifer K, Arnold Arthur P, Singh Ram Raj, Voskuhl Rhonda R   A role for sex chromosome complement in the female bias in autoimmune disease The Journal of experimental medicine, 2008; 205(5): 1099-108.
Tiwari-Woodruff, S. Morales, L. B. Lee, R. Voskuhl, R. R.   Differential neuroprotective and antiinflammatory effects of estrogen receptor (ER)alpha and ERbeta ligand treatment Proc Natl Acad Sci U S A, 2007; 104(37): 14813-8.
Morales, L. B. Loo, K. K. Liu, H. B. Peterson, C. Tiwari-Woodruff, S. Voskuhl, R. R.   Treatment with an estrogen receptor alpha ligand is neuroprotective in experimental autoimmune encephalomyelitis J Neurosci, 2006; 26(25): 6823-33.
Tiwari-Woodruff, S. Beltran-Parrazal, L. Charles, A. Keck, T. Vu, T. Bronstein, J.   K+ channel KV3.1 associates with OSP/claudin-11 and regulates oligodendrocyte development Am J Physiol Cell Physiol, 2006; 291(4): C687-98.
Tiwari-Woodruff, S. K. Beltran-Parrazal, L. Charles, A. Keck, T. Vu, T. Bronstein, J.   K+ channel Kv3.1 associates with OSP/claudin-11 and regulates oligodendrocyte development Am J Physiol Cell Physiol, 2006; .
Tiwari-Woodruff, S. K. Myers, L. W. Bronstein, J. M.   Cerebrospinal fluid immunoglobulin G promotes oligodendrocyte progenitor cell migration J Neurosci Res, 2004; 77(3): 363-6.
Tiwari-Woodruff, S. K. Kaplan, R. Kornblum, H. I. Bronstein, J. M.   Developmental expression of OAP-1/Tspan-3, a member of the tetraspanin superfamily J Neurosci Res, 2004; 77(2): 166-73.
Papazian, D. M. Silverman, W. R. Lin, M. C. Tiwari-Woodruff, S. K. Tang, C. Y.   Structural organization of the voltage sensor in voltage-dependent potassium channels Novartis Found Symp, 2002; 245: 178-90; discussion 190-2, 261-4.
Tiwari-Woodruff, S. K. Buznikov, A. G. Vu, T. Q. Micevych, P. E. Chen, K. Kornblum, H. I. Bronstein, J. M.   OSP/claudin-11 forms a complex with a novel member of the tetraspanin super family and beta1 integrin and regulates proliferation and migration of oligodendrocytes J Cell Biol, 2001; 153(2): 295-305.
Bronstein, J. M. Chen, K. Tiwari-Woodruff, S. Kornblum, H. I.   Developmental expression of OSP/claudin-11 J Neurosci Res, 2000; 60(3): 284-90.
Bronstein, J. M. Tiwari-Woodruff, S. Buznikov, A. G. Stevens, D. B.   Involvement of OSP/claudin-11 in oligodendrocyte membrane interactions: role in biology and disease J Neurosci Res, 2000; 59(6): 706-11.
Tiwari-Woodruff, S. K. Lin, M. A. Schulteis, C. T. Papazian, D. M.   Voltage-dependent structural interactions in the Shaker K(+) channel J Gen Physiol, 2000; 115(2): 123-38.
Tiwari-Woodruff, S. K. Schulteis, C. T. Mock, A. F. Papazian, D. M.   Electrostatic interactions between transmembrane segments mediate folding of Shaker K+ channel subunits Biophys J, 1997; 72(4): 1489-500.
Tiwari-Woodruff, S. K. Cox, T. C.   Boar sperm plasma membrane Ca(2+)-selective channels in planar lipid bilayers Am J Physiol, 1995; 268(5 Pt 1): C1284-94.

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