Yvonne Bryson, M.D.

A Short Biography:

Yvonne J. Bryson, MD is a Professor of Pediatrics and Chief of Pediatric Infectious Diseases at the David Geffen School of Medicine at UCLA and Mattel Children?s Hospital UCLA and is the Director of the Los Angeles Brazil AIDS Consortium. She is a world-renown leader, researcher, virologist and clinician in the field of HIV pathogenesis, prevention and treatment of maternal-fetal and pediatric HIV-1, and is an active member of the Pediatric AIDS Clinical Trial Group. She is currently the Chair of the NIH Network IMPAACT (International Maternal Pediatric Adolescent AIDS Clinical Trials) PMTCT Committee (Prevention of Mother-to-Child Transmission of HIV). An invited member on the U.S. Public Health Service Task Force on the Use of Zidovudine to Reduce Perinatal Transmission of Human Immunodeficiency Virus, Dr. Bryson was influential in the development of CDC and Public Health guidelines for the diagnosis and treatment of HIV-infected pregnant women and has been involved in the planning and execution of national cooperative studies of maternal-fetal HIV transmission. She has made significant contributions to the development of some of the original studies of the use of Zidovudine for the prevention of perinatal HIV, studies of maternal risk factors for vertical transmission of HIV, as well as advances in the early diagnosis of HIV in newborns. Dr. Bryson has significant experience in leading large multicenter clinical trials and networks and developing clinical sites and laboratories. She is recognized as a national and international expert and leader in the field of HIV and perinatal transmission. She has made important and original scientific contributions to the field and served on many advisory committees and NIH Study Sections, and has been consistently funded by the National Institutes of Health, including numerous RO1 grants. Dr. Bryson has mentored numerous postdoctoral fellows and young faculty for successful careers in academic medicine. She was one of the original members of the Elizabeth Glaser Pediatric AIDS Foundation heath advisory board and helped start the foundation with Elizabeth, Dr. Richard Stiehm, and two co-founders. She has made a strong commitment to international studies and to her collaborators in Brazil to help them develop the necessary infrastructure to design, conduct, and implement new approaches to prevent and treat HIV. Dr. Bryson is a strong advocate for mothers and children

Work Titles
CTSI Member, CTSI Member, Workforce Development
UCLA Distinguished Professor, Pediatrics Chief, Pediatric Infectious Diseases Member, Care 4 Kids, Youth, and Moms
Education:
Degrees:
M.D., University of Texas Southwestern, 1966 - 1970
B.S., University of Texas Southwestern, 1962 - 1966
Internship:
1970 - 1971 University of California, San Diego
Residency:
1971 - 1974 University of California, San Diego

Contact Information:

Email Address:

ybryson@mednet.ucla.edu

Work Email Address:

ybryson@mednet.ucla.edu


Website:

Web Profile 2
Web-Profile

Work Phone Number:

310-825-5235

Mailing Address:

UCLA Ped-Inf Dis
BOX 951752, 22-442 MDCC
Los Angeles, CA 90095

Main Office
10833 Le Conte Ave
CHS 22-442
Los Angeles, CA 90095


Publications:

Farzin Azadeh, Boyer Pamela, Ank Bonnie, Nielsen-Saines Karin, Bryson Yvonne   Amniotic fluid exhibits an innate inhibitory activity against HIV type 1 replication in vitro AIDS research and human retroviruses, 2013; 29(1): 77-83.
Petz Lawrence D, Redei Istvan, Bryson Yvonne, Regan Donna, Kurtzberg Joanne, Shpall Elizabeth, Gutman Jonathan, Querol Sergio, Clark Pamela, Tonai Richard, Santos Sarah, Bravo Aide, Spellman Stephen, Gragert Loren, Rossi John, Li Shirley, Li Haitang, Senitzer David, Zaia John, Rosenthal Joseph, Forman Stephen, Chow Robert   Hematopoietic cell transplantation with cord blood for cure of HIV infections Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2013; 19(3): 393-7.
Vyas Girish N, Stoddart Cheryl A, Killian M Scott, Brennan Todd V, Goldberg Tiffany, Ziman Alyssa, Bryson Yvonne   Derivation of non-infectious envelope proteins from virions isolated from plasma negative for HIV antibodies Biologicals : journal of the International Association of Biological Standardization, 2012; 40(1): 15-20.
Nielsen-Saines Karin, Watts D Heather, Veloso Valdilea G, Bryson Yvonne J, Joao Esau C, Pilotto Jose Henrique, Gray Glenda, Theron Gerhard, Santos Breno, Fonseca Rosana, Kreitchmann Regis, Pinto Jorge, Mussi-Pinhata Marisa M, Ceriotto Mariana, Machado Daisy, Bethel James, Morgado Marisa G, Dickover Ruth, Camarca Margaret, Mirochnick Mark, Siberry George, Grinsztejn Beatriz, Moreira Ronaldo I, Bastos Francisco I, Xu Jiahong, Moye Jack, Mofenson Lynne M, Mofenson Lynne M   Three postpartum antiretroviral regimens to prevent intrapartum HIV infection The New England journal of medicine, 2012; 366(25): 2368-79.
Mirochnick Mark, Nielsen-Saines Karin, Pilotto Jose Henrique, Pinto Jorge, Veloso Valdilea Gonçalves, Rossi Steven, Moye Jack, Bryson Yvonne, Mofenson Lynne, Camarca Margaret, Watts D Heather, Watts D Heather   Nelfinavir and Lamivudine pharmacokinetics during the first two weeks of life The Pediatric infectious disease journal, 2011; 30(9): 769-72.
Ching Natascha, Nielsen-Saines Karin A, Deville Jaime G, Wei Lian S, Garratty Eileen, Bryson Yvonne J   Autologous neutralizing antibody to human immunodeficiency virus-1 and replication-competent virus recovered from CD4+ T-cell reservoirs in pediatric HIV-1-infected patients on HAART AIDS research and human retroviruses, 2010; 26(5): 585-91.
Truong Hong-Ha M, Sim Myung S, Dillon Maryanne, Uittenbogaart Christel H, Dickover Ruth, Plaeger Susan F, Bryson Yvonne J   Correlation of immune activation during late pregnancy and early postpartum with increases in plasma HIV RNA, CD4/CD8 T cells, and serum activation markers Clinical and vaccine immunology : CVI, 2010; 17(12): 2024-8.
Veloso Valdiléa G, Bastos Francisco I, Portela Margareth Crisóstomo, Grinsztejn Beatriz, João Esau Custodio, Pilotto Jose Henrique da Silva, Araújo Ana Beatriz Busch, Santos Breno Riegel, Fonseca Rosana Campos da, Kreitchmann Regis, Derrico Monica, Friedman Ruth Khalili, Cunha Cynthia B, Morgado Mariza Gonçalves, Saines Karin Nielsen, Bryson Yvonne J   HIV rapid testing as a key strategy for prevention of mother-to-child transmission in Brazil Revista de saúde pública, 2010; 44(5): 803-11.
Bennetto-Hood Chantelle, Bryson Yvonne J, Stek Alice, King Jennifer R, Mirochnick Mark, Acosta Edward P   Zidovudine, lamivudine, and nelfinavir concentrations in amniotic fluid and maternal serum HIV clinical trials, 2010; 10(1): 41-7.
Johnston Samantha H, Lobritz Michael A, Nguyen Sandra, Lassen Kara, Delair Shirley, Posta Filippo, Bryson Yvonne J, Arts Eric J, Chou Tom, Lee Benhur   A quantitative affinity-profiling system that reveals distinct CD4/CCR5 usage patterns among human immunodeficiency virus type 1 and simian immunodeficiency virus strains Journal of virology, 2009; 83(21): 11016-26.
Sim Myung Shin K, Cumberland William G, Duan Naihua, Bryson Yvonne J   Modeling vertical transmission of HIV: imperfect vaccines can be of benefit Vaccine, 2009; 27(50): 7003-10.
Mirochnick Mark, Nielsen-Saines Karin, Pilotto Jose Henrique, Pinto Jorge, Jiménez Eleanor, Veloso Valdilea G, Parsons Teresa, Watts D Heather, Moye Jack, Mofenson Lynne M, Camarca Margaret, Bryson Yvonne, Bryson Yvonne   Nevirapine concentrations in newborns receiving an extended prophylactic regimen Journal of acquired immune deficiency syndromes (1999), 2008; 47(3): 334-7.
Ching Natascha, Deville Jaime G, Nielsen Karin A, Ank Bonnie, Wei Lian S, Sim Myung Shin, Wolinsky Steven M, Bryson Yvonne J   Cellular and humoral immune responses to a tetanus toxoid booster in perinatally HIV-1-infected children and adolescents receiving highly active antiretroviral therapy (HAART) European journal of pediatrics, 2007; 166(1): 51-6.
Ching Natascha, Yang Otto O, Deville Jaime G, Nielsen-Saines Karin, Ank Bonnie J, Sim Myung-Shin, Bryson Yvonne J   Pediatric HIV-1-specific cytotoxic T-lymphocyte responses suggesting ongoing viral replication despite combination antiretroviral therapy Pediatric research, 2007; 61(6): 692-7.
Tremoulet Adriana H, Capparelli Edmund V, Patel Parul, Acosta Edward P, Luzuriaga Katherine, Bryson Yvonne, Wara Diane, Zorrilla Carmen, Holland Diane, Mirochnick Mark, Mirochnick Mark   Population pharmacokinetics of lamivudine in human immunodeficiency virus-exposed and -infected infants Antimicrobial agents and chemotherapy, 2007; 51(12): 4297-302.
Pedroza-Martins Livia, Boscardin W John, Anisman-Posner Deborah J, Redsar Beverly N, Bryson Yvonne J, Yang Otto O, Uittenbogaart Christel H   Interferon-gamma decreases replication of primary R5 HIV-1 isolates in thymocytes AIDS (London, England), 2006; 20(6): 939-42.
Dickover Ruth, Garratty Eileen, Yusim Karina, Miller Catherine, Korber Bette, Bryson Yvonne   Role of maternal autologous neutralizing antibody in selective perinatal transmission of human immunodeficiency virus type 1 escape variants Journal of virology, 2006; 80(13): 6525-33.
Yang Otto O, Church Joseph, Kitchen Christina M R, Kilpatrick Ryan, Ali Ayub, Geng Yongzhi, Killian M Scott, Sabado Rachel Lubong, Ng Hwee, Suen Jeffrey, Bryson Yvonne, Jamieson Beth D, Krogstad Paul   Genetic and stochastic influences on the interaction of human immunodeficiency virus type 1 and cytotoxic T lymphocytes in identical twins Journal of virology, 2005; 79(24): 15368-75.
Mirochnick Mark, Stek Alice, Acevedo Midnela, Keller Margaret, Holland Diane, Capparelli Edmund, Connor James, Huang Sharon, Hughes Michael, Watts Heather, Mofenson Lynne, Bryson Yvonne   Safety and pharmacokinetics of nelfinavir coadministered with zidovudine and lamivudine in infants during the first 6 weeks of life Journal of acquired immune deficiency syndromes (1999), 2005; 39(2): 189-94.
Tuomala Ruth E, Shapiro David E, Mofenson Lynne M, Bryson Yvonne, Culnane Mary, Hughes Michael D, O'Sullivan M J, Scott Gwendolyn, Stek Alice M, Wara Diane, Bulterys Marc   Antiretroviral therapy during pregnancy and the risk of an adverse outcome The New England journal of medicine, 2002; 346(24): 1863-70.
Pedroza-Martins Livia, Boscardin W John, Anisman-Posner Deborah J, Schols Dominique, Bryson Yvonne J, Uittenbogaart Christel H   Impact of cytokines on replication in the thymus of primary human immunodeficiency virus type 1 isolates from infants Journal of virology, 2002; 76(14): 6929-43.
Deville Jaime, Bryson Yvonne   Perinatal Transmission of HIV: Recognition and Treatment Interventions Current infectious disease reports, 2001; 3(4): 388-396.

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