Amander Clark, Ph.D.

Member, Cell & Developmental Biology GPB Home Area, Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research, Genetics & Genomics GPB Home Area, JCCC Cancer and Stem Cell Biology Program Area

A Short Biography:

Dr Clark’s work is focused on the use of pluripotent stem cells to understand the cell and molecular basis of human fertility and embryo development with a special focus on germline epigenetic reprogramming.

Contact Information:

Email Address:

clarka@ucla.edu

Website:

Home Page

Work Phone Number:

794 4201

Office Address:

615 Charles E Young Drive South
Box 951606
Los Angeles, CA 90095
BSRB II 451C


Detailed Biography:

Amander Clark PhD is Professor and Vice Chair of the Department of Molecular Cell and Developmental Biology at the University of California Los Angeles. She is a key member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and Co-Director of the Embryonic Stem Cell Derivation laboratory. She is also a member of the Jonsson Comprehensive Cancer Center and the Molecular Biology Institute. Dr Clark’s laboratory is funded by the National Institute of Child Health and Human Development, Dr Clark is a recipient of Young Investigator Award from the Lance Armstrong, a Research and Career Development award from STOP Cancer, a Research award from the Concern Foundation and a Young Investigator Award from the International Society for Stem Cell Research. Dr Clark is a member of the Hinxton Group, an International consortium of scientists, ethicists and policy makers for the use of pluripotent stem cell derived gametes.

Publications:

Clark Amander T   DNA methylation remodeling in vitro and in vivo Current opinion in genetics & development, 2015; 34(34): 82-7.
Gkountela Sofia, Zhang Kelvin X, Shafiq Tiasha A, Liao Wen-Wei, Hargan-Calvopiña Joseph, Chen Pao-Yang, Clark Amander T   DNA Demethylation Dynamics in the Human Prenatal Germline Cell, 2015; 161(6): 1425-36.
Chen Di, Clark Amander T   Human germline differentiation charts a new course The EMBO journal, 2015; 34(8): 975-7.
Li Ziwei, Yu Juehua, Hosohama Linzi, Nee Kevin, Gkountela Sofia, Chaudhari Sonal, Cass Ashley A, Xiao Xinshu, Clark Amander T   The Sm protein methyltransferase PRMT5 is not required for primordial germ cell specification in mice The EMBO journal, 2015; 34(6): 748-58.
Gkountela Sofia, Clark Amander T   A big surprise in the little zygote: the curious business of losing methylated cytosines Cell stem cell, 2014; 15(4): 393-4.
Pastor William A, Stroud Hume, Nee Kevin, Liu Wanlu, Pezic Dubravka, Manakov Sergei, Lee Serena A, Moissiard Guillaume, Zamudio Natasha, Bourc'his Déborah, Aravin Alexei A, Clark Amander T, Jacobsen Steven E   MORC1 represses transposable elements in the mouse male germline Nature communications, 2014; 5(6): 5795.
Vincent John J, Huang Yun, Chen Pao-Yang, Feng Suhua, Calvopiña Joseph H, Nee Kevin, Lee Serena A, Le Thuc, Yoon Alexander J, Faull Kym, Fan Guoping, Rao Anjana, Jacobsen Steven E, Pellegrini Matteo, Clark Amander T   Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells Cell stem cell, 2013; 12(4): 470-8.
Gkountela Sofia, Li Ziwei, Vincent John J, Zhang Kelvin X, Chen Angela, Pellegrini Matteo, Clark Amander T   The ontogeny of cKIT+ human primordial germ cells proves to be a resource for human germ line reprogramming, imprint erasure and in vitro differentiation Nature cell biology, 2013; 15(1): 113-22.
Clark Amander T, Phillips Bart T, Orwig Kyle E   Fruitful progress to fertility: male fertility in the test tube Nature medicine, 2011; 17(12): 1564-5.
Tchieu Jason, Kuoy Edward, Chin Mark H, Trinh Hung, Patterson Michaela, Sherman Sean P, Aimiuwu Otaren, Lindgren Anne, Hakimian Shahrad, Zack Jerome A, Clark Amander T, Pyle April D, Lowry William E, Plath Kathrin   Female human iPSCs retain an inactive X chromosome Cell stem cell, 2010; 7(3): 329-42.
Chodavarapu Ramakrishna K, Feng Suhua, Bernatavichute Yana V, Chen Pao-Yang, Stroud Hume, Yu Yanchun, Hetzel Jonathan A, Kuo Frank, Kim Jin, Cokus Shawn J, Casero David, Bernal Maria, Huijser Peter, Clark Amander T, Krämer Ute, Merchant Sabeeha S, Zhang Xiaoyu, Jacobsen Steven E, Pellegrini Matteo   Relationship between nucleosome positioning and DNA methylation Nature, 2010; 466(7304): 388-92.
Lowry, WE., Richter, L,. Yachechko, R., Pyle, AD., Tshieu, J., Sridharan, R., Clark, AT., Plath, K   Generation of human induced pluripotent stem cells from dermal fibroblasts, Proceedings of the National Academy of Sciences, 2008; 105(8): 2883-2888.
Bostick Magnolia, Kim Jong Kyong, Estève Pierre-Olivier, Clark Amander, Pradhan Sriharsa, Jacobsen Steven E   UHRF1 plays a role in maintaining DNA methylation in mammalian cells Science (New York, N.Y.), 2007; 317(5845): 1760-4.
Kile Benjamin T, Hentges Kathryn E, Clark Amander T, Nakamura Hisashi, Salinger Andrew P, Liu Bin, Box Neil, Stockton David W, Johnson Randy L, Behringer Richard R, Bradley Allan, Justice Monica J   Functional genetic analysis of mouse chromosome 11 Nature, 2003; 425(6953): 81-6.

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