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Shaping the Future

Amander Clark, Ph.D.

Contact Information:

Work Phone Number:

794 4201

Office Address:

615 Charles E Young Drive South
Box 951606
Los Angeles, CA 90095


Email Address:



Home Page:

     Clark Lab

Member, Cell & Developmental Biology GPB Home Area

Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research

Genetics & Genomics GPB Home Area

JCCC Cancer and Stem Cell Biology Program Area

Detailed Biography:

Amander T Clark is a cell biologist and geneticist who was recruited to UCLA Department of Molecular Cell and Developmental Biology and Institute for Stem Cell Biology and Medicine to establish a new and exciting research program in stem cell biology. Prior to joining the faculty at UCLA, Amander was on faculty at the University of California, San Francisco where she worked under the mentorship of Dr. Renee Reijo Pera to build a cell based model to study human embryo development using human embryonic stem cells. This pioneering work was the first to demonstrate that human embryonic stem cells could be used to differentiate the human germ cell lineage in vitro. Amander has been the recipient of a number of awards for her research including a Young Investigator Award from the International Society for Stem Cell Research (2003), a Lalor Foundation Research Award (1999-2000), An Australian Postgraduate Award (1995-1998) and a Deans Prize for academic excellence (1994). Amander's work has published in significant high impact Journals including Nature, Human Molecular Genetics, Stem Cells and Cancer, and is a sought after speaker on the topic of human embryonic stem cell biology.


Clark Amander T   Pluripotency Takes Off without Blimp1 Cell stem cell, 2012; 11(1): 1-2.
Deshpande Amit M, Khalid Omar, Kim Jeffrey J, Kim Yong, Lindgren Anne, Clark Amander T, Wong David T W   Cdk2ap2 Is a Novel Regulator for Self-Renewal of Murine Embryonic Stem Cells Stem cells and development, 2012; 11(1): .
Gossett Daniel R, Tse Henry T K, Lee Serena A, Ying Yong, Lindgren Anne G, Yang Otto O, Rao Jianyu, Clark Amander T, Di Carlo Dino   Hydrodynamic stretching of single cells for large population mechanical phenotyping Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(20): 7630-5.
Diaz Perez Silvia V, Kim Rachel, Li Ziwei, Marquez Victor E, Patel Sanjeet, Plath Kathrin, Clark Amander T   Derivation of new human embryonic stem cell lines reveals rapid epigenetic progression in vitro that can be prevented by chemical modification of chromatin Human molecular genetics, 2012; 21(4): 751-64.
Clark Amander T, Phillips Bart T, Orwig Kyle E   Fruitful progress to fertility: male fertility in the test tube Nature medicine, 2011; 17(12): 1564-5.
Lindgren Anne G, Natsuhara Kyle, Tian E, Vincent John J, Li Xinmin, Jiao Jing, Wu Hong, Banerjee Utpal, Clark Amander T   Loss of Pten causes tumor initiation following differentiation of murine pluripotent stem cells due to failed repression of Nanog PloS one, 2011; 6(1): e16478.
Vincent John J, Li Ziwei, Lee Serena A, Liu Xian, Etter Marisabel O, Diaz-Perez Silvia V, Taylor Sara K, Gkountela Sofia, Lindgren Anne G, Clark Amander T   Single cell analysis facilitates staging of Blimp1-dependent primordial germ cells derived from mouse embryonic stem cells PloS one, 2011; 6(12): e28960.
Mandal Sudip, Lindgren Anne G, Srivastava Anand S, Clark Amander T, Banerjee Utpal   Mitochondrial Function Controls Proliferation and Early Differentiation Potential of Embryonic Stem Cells Stem cells (Dayton, Ohio), 2010; .
Mayshar Yoav, Ben-David Uri, Lavon Neta, Biancotti Juan-Carlos, Yakir Benjamin, Clark Amander T, Plath Kathrin, Lowry William E, Benvenisty Nissim   Identification and classification of chromosomal aberrations in human induced pluripotent stem cells Cell stem cell, 2010; 7(4): 521-31.
Tchieu Jason, Kuoy Edward, Chin Mark H, Trinh Hung, Patterson Michaela, Sherman Sean P, Aimiuwu Otaren, Lindgren Anne, Hakimian Shahrad, Zack Jerome A, Clark Amander T, Pyle April D, Lowry William E, Plath Kathrin   Female human iPSCs retain an inactive X chromosome Cell stem cell, 2010; 7(3): 329-42.
Ambartsumyan Gayane, Gill Rajbir K, Perez Silvia Diaz, Conway Deirdre, Vincent John, Dalal Yamini, Clark Amander T   Centromere protein A dynamics in human pluripotent stem cell self-renewal, differentiation and DNA damage Human molecular genetics, 2010; 7(3): .
Biancotti Juan-Carlos, Narwani Kavita, Buehler Nicole, Mandefro Berhan, Golan-Lev Tamar, Yanuka Ofra, Clark Amander T, Hill David, Benvenisty Nissim, Lavon Neta   Human Embryonic Stem Cells as Models for Aneuploid Chromosomal Syndromes Stem cells (Dayton, Ohio), 2010; 7(3): .
Chodavarapu Ramakrishna K, Feng Suhua, Bernatavichute Yana V, Chen Pao-Yang, Stroud Hume, Yu Yanchun, Hetzel Jonathan A, Kuo Frank, Kim Jin, Cokus Shawn J, Casero David, Bernal Maria, Huijser Peter, Clark Amander T, Krämer Ute, Merchant Sabeeha S, Zhang Xiaoyu, Jacobsen Steven E, Pellegrini Matteo   Relationship between nucleosome positioning and DNA methylation Nature, 2010; 466(7304): 388-92.
Kamei Ken-ichiro, Ohashi Minori, Gschweng Eric, Ho Quinn, Suh Jane, Tang Jinghua, For Yu Zeta Tak, Clark Amander T, Pyle April D, Teitell Michael A, Lee Ki-Bum, Witte Owen N, Tseng Hsian-Rong   Microfluidic image cytometry for quantitative single-cell profiling of human pluripotent stem cells in chemically defined conditions Lab on a chip, 2010; 10(9): 1113-9.
Clark Amander T   Egg-citing advances in generating primordial germ cells in the laboratory Biology of reproduction, 2010; 82(2): 233-4.
Kim Yong, Deshpande Amit, Dai Yanshan, Kim Jeffrey J, Lindgren Anne, Conway Anne, Clark Amander T, Wong David T   Cyclin-dependent kinase 2-associating protein 1 commits murine embryonic stem cell differentiation through retinoblastoma protein regulation The Journal of biological chemistry, 2009; 284(35): 23405-14.
Chin Mark H, Mason Mike J, Xie Wei, Volinia Stefano, Singer Mike, Peterson Cory, Ambartsumyan Gayane, Aimiuwu Otaren, Richter Laura, Zhang Jin, Khvorostov Ivan, Ott Vanessa, Grunstein Michael, Lavon Neta, Benvenisty Nissim, Croce Carlo M, Clark Amander T, Baxter Tim, Pyle April D, Teitell Mike A, Pelegrini Matteo, Plath Kathrin, Lowry William E   Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures Cell stem cell, 2009; 5(1): 111-23.
Wei Xie, Chunying Song, Nicolas L. Young, Adam S. Sperling, Feng Xu, Rupa Sridharan, Anne E. Conway, Benjamin A. Garcia, Kathrin Plath, Amander T. Clark, Michael Grunstein   Histone H3 Lysine 56 Acetylation Is Linked to the Core Transcriptional Network in Human Embryonic Stem Cells, Molecular Cell, 2009; 33(4): 417.
Park Tae Sub, Galic Zoran, Conway Anne E, Lindgren Anne, van Handel Benjamin J, Magnusson Mattias, Richter Laura, Teitell Michael A, Mikkola Hanna K A, Lowry William E, Plath Kathrin, Clark Amander T   Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cells Stem cells (Dayton, Ohio), 2009; 27(4): 783-95.
Karumbayaram Saravanan, Novitch Bennett G, Patterson Michaela, Umbach Joy A, Richter Laura, Lindgren Anne, Conway Anne E, Clark Amander T, Goldman Steve A, Plath Kathrin, Wiedau-Pazos Martina, Kornblum Harley I, Lowry William E   Directed differentiation of human-induced pluripotent stem cells generates active motor neurons Stem cells (Dayton, Ohio), 2009; 27(4): 806-11.
Xie Wei, Song Chunying, Young Nicolas L, Sperling Adam S, Xu Feng, Sridharan Rupa, Conway Anne E, Garcia Benjamin A, Plath Kathrin, Clark Amander T, Grunstein Michael   Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells Molecular cell, 2009; 33(4): 417-27.
Conway Anne E, Lindgren Anne, Galic Zoran, Pyle April D, Wu Hong, Zack Jerome A, Pelligrini Matteo, Teitell Michael A, Clark Amander T   A self-renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cell-derived tumors Stem cells (Dayton, Ohio), 2009; 27(1): 18-28.
Lowry, WE., Richter, L,. Yachechko, R., Pyle, AD., Tshieu, J., Sridharan, R., Clark, AT., Plath, K   Generation of human induced pluripotent stem cells from dermal fibroblasts, Proceedings of the National Academy of Sciences, 2008; 105(8): 2883-2888.
Wu Hao, Kim Kevin J, Mehta Kshama, Paxia Salvatore, Sundstrom Andrew, Anantharaman Thomas, Kuraishy Ali I, Doan Tri, Ghosh Jayati, Pyle April D, Clark Amander, Lowry William, Fan Guoping, Baxter Tim, Mishra Bud, Sun Yi, Teitell Michael A   Copy number variant analysis of human embryonic stem cells Stem cells (Dayton, Ohio), 2008; 26(6): 1484-9.
Ambartsumyan Gayane, Clark Amander T   Aneuploidy and early human embryo development Human molecular genetics, 2008; 17(R1): R10-5.
Bostick Magnolia, Kim Jong Kyong, Estève Pierre-Olivier, Clark Amander, Pradhan Sriharsa, Jacobsen Steven E   UHRF1 plays a role in maintaining DNA methylation in mammalian cells Science (New York, N.Y.), 2007; 317(5845): 1760-4.
Clark Amander T   Establishment and differentiation of human embryonic stem cell derived germ cells Society of Reproduction and Fertility supplement, 2007; 63(2): 77-86.
Fox Mark S, Clark Amander T, El Majdoubi Mohammed, Vigne Jean-Louis, Urano Jun, Hostetler Chris E, Griswold Michael D, Weiner Richard I, Reijo Pera Renee A   Intermolecular interactions of homologs of germ plasm components in mammalian germ cells Developmental biology, 2007; 301(2): 417-31.
Clark Amander T   The stem cell identity of testicular cancer Stem cell reviews, 2007; 3(1): 49-59.
Kee Kehkooi, Gonsalves Joanna M, Clark Amander T, Pera Renee A Reijo   Bone morphogenetic proteins induce germ cell differentiation from human embryonic stem cells Stem cells and development, 2006; 15(6): 831-7.
Clark Amander T, Reijo Pera Renee A   Modeling human germ cell development with embryonic stem cells Regenerative medicine, 2006; 1(1): 85-93.
Ezeh Uche I, Turek Paul J, Reijo Renee A, Clark Amander T   Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma Cancer, 2005; 104(10): 2255-65.
Clark Amander T, Goldowitz Daniel, Takahashi Joseph S, Vitaterna Martha Hotz, Siepka Sandra M, Peters Luanne L, Frankel Wayne N, Carlson George A, Rossant Janet, Nadeau Joseph H, Justice Monica J   Implementing large-scale ENU mutagenesis screens in North America Genetica, 2004; 122(1): 51-64.
Clark Amander T, Bodnar Megan S, Fox Mark, Rodriquez Ryan T, Abeyta Michael J, Firpo Meri T, Pera Renee A Reijo   Spontaneous differentiation of germ cells from human embryonic stem cells in vitro Human molecular genetics, 2004; 13(7): 727-39.
Clark Amander T, Rodriguez Ryan T, Bodnar Megan S, Abeyta Michael J, Cedars Marcelle I, Turek Paul J, Firpo Meri T, Reijo Pera Renee A   Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma Stem cells (Dayton, Ohio), 2004; 22(2): 169-79.
Abeyta Michael J, Clark Amander T, Rodriguez Ryan T, Bodnar Megan S, Pera Renee A Reijo, Firpo Meri T   Unique gene expression signatures of independently-derived human embryonic stem cell lines Human molecular genetics, 2004; 13(6): 601-8.
Kile Benjamin T, Hentges Kathryn E, Clark Amander T, Nakamura Hisashi, Salinger Andrew P, Liu Bin, Box Neil, Stockton David W, Johnson Randy L, Behringer Richard R, Bradley Allan, Justice Monica J   Functional genetic analysis of mouse chromosome 11 Nature, 2003; 425(6953): 81-6.
Joyce, I. M. Clark, A. T. Pendola, F. L. Eppig, J. J.   Comparison of recombinant growth differentiation factor-9 and oocyte regulation of KIT ligand messenger ribonucleic acid expression in mouse ovarian follicles, Biol Reprod, 2000; 63(6): 1669-75.
Elvin, J. A. Clark, A. T. Wang, P. Wolfman, N. M. Matzuk, M. M.   Paracrine actions of growth differentiation factor-9 in the mammalian ovary Mol Endocrinol, 1999; 13(6): 1035-48.
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