Amander Clark, Ph.D.

A Short Biography:

Amander Clark is a stem cell biologist who is developing enabling technology for human in vitro gametogenesis (IVG); a tool for understanding and treating human infertility.  In 2006, Dr. Clark joined the UCLA faculty as an Assistant Professor in the Department of Molecular Cell and Developmental Biology (MCDB) in the Division of Life Sciences, College of Letters and Science.  In 2012 she was awarded Associate Professor with tenure and in 2013 was appointed to the Vice Chair of the MCDB Department.  In 2015, Dr. Clark was promoted to Professor and  since 2017 she has served as Department Chair.  Dr. Clark earned her PhD in Cell and Developmental Biology at the University of Melbourne.  Following this, she trained as a postdoctoral fellow at Baylor College of Medicine, and the University of California, San Francisco where she trained in mouse genetics and stem cell biology respectively. Dr Clark's laboratory studies the origins of the human germline with an emphasis on chromatin, epigenetic reprogramming and inheritance which informs her reserach on IVG. Her lab uses CRISPR/Cas9, next generation sequencing, pluripotent stem cells and mouse models to meet her research goals. The laboratory's long-term research objective is to understand the fundamental principles of human germline cell formation in vivo and in vitro towards the genesis of high quality gametes and the birth of healthy children.


Work Titles
UCLA Member, Cell & Developmental Biology GPB Home Area Member, Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research Member, Genetics & Genomics GPB Home Area Member, JCCC Cancer and Stem Cell Biology Program Area
Education:
Degrees:
Ph.D.

Contact Information:

Work Phone Number:

794 4201

Office Address:

615 Charles E Young Drive South
Box 951606
Los Angeles, CA 90095

BSRB II 451C


Detailed Biography:

Amander Clark Ph.D., is an Australian born American stem cell biologist specializing in stem cell self-renewal pluripotency and differentiation.  Growing up on a sheep farm in rural Australia, she was the first in her family to attend University obtaining her PhD in Cell and Developmental Biology at the University of Melbourne. For her postdoctoral studies in the U.S.A she was mentored by Professor Monica Justice at Baylor College of Medicine in mouse genetics, followed by Professor Renee Reijo-Pera at UCSF in stem cell biology.  Currently Dr. Clark is Professor and Chair of the Department of Molecular Cell and Developmental Biology at UCLA.  She is a key member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA and an elected office holder to the Executive Committee and Board of the International Society for Stem Cell Research.  Dr Clark’s laboratory performs fundamental research that serves as the basis for translational projects related to pluripotent stem cells,  in vitro gametogenesis (IVG), germ cell tumors, environmental effects on the germline and contraception discovery. Dr. Clark is a recipient of a Young Investigator Award from the Lance Armstrong Foundation, a Research and Career Development award from STOP Cancer, a Research Award from the Concern Foundation and a Young Investigator Award from the International Society for Stem Cell Research. Dr. Clark is a member of the Hinxton Group, an International consortium of scientists, ethicists and policy makers responsible for generating position statements that affect policy for the use of pluripotent stem cell derived gametes and germline genome editing in human embryos.

Publications:

A selected list of publications:

Hancock Grace V, Wamaitha Sissy E, Peretz Lior, Clark Amander T   Mammalian primordial germ cell specification Development (Cambridge, England), 2021; 148(6): .
Guo Jingtao, Sosa Enrique, Chitiashvili Tsotne, Nie Xichen, Rojas Ernesto Javier, Oliver Elizabeth, Oliver Elizabeth, Plath Kathrin, Hotaling James M, Stukenborg Jan-Bernd, Clark Amander T, Cairns Bradley R   Single-cell analysis of the developing human testis reveals somatic niche cell specification and fetal germline stem cell establishment Cell stem cell, 2021; 16(1): 1-2.
Pandolfi Erica C, Sosa Enrique, Hunt Timothy J, Goldsmith Sierra, Hurlbut Kellie, Silber Sherman J, Clark Amander T   Generation of six human induced pluripotent stem cell sublines (MZT01E, MZT01F, MZT01N and MZT02D, MZT02G and MZT02H) for reproductive science research Stem cell research, 2021; 51: 102204.
Gell Joanna J, Liu Wanlu, Sosa Enrique, Chialastri Alex, Hancock Grace, Tao Yu, Wamaitha Sissy E, Bower Grace, Dey Siddharth S, Clark Amander T   An Extended Culture System that Supports Human Primordial Germ Cell-like Cell Survival and Initiation of DNA Methylation Erasure Stem cell reports, 2020; 14(3): 433-446.
Chitiashvili Tsotne, Dror Iris, Kim Rachel, Hsu Fei-Man, Chaudhari Rohan, Pandolfi Erica, Chen Di, Liebscher Simone, Schenke-Layland Katja, Plath Kathrin, Clark Amander   Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation Nature cell biology, 2020; 22(12): 1436-1446.
Liu Xiaodong, Ouyang John F, Rossello Fernando J, Tan Jia Ping, Davidson Kathryn C, Valdes Daniela S, Schröder Jan, Sun Yu B Y, Chen Joseph, Knaupp Anja S, Sun Guizhi, Chy Hun S, Huang Ziyi, Pflueger Jahnvi, Firas Jaber, Tano Vincent, Buckberry Sam, Paynter Jacob M, Larcombe Michael R, Poppe Daniel, Choo Xin Yi, O'Brien Carmel M, Pastor William A, Chen Di, Leichter Anna L, Naeem Haroon, Tripathi Pratibha, Das Partha P, Grubman Alexandra, Powell David R, Laslett Andrew L, David Laurent, Nilsson Susan K, Clark Amander T, Lister Ryan, Nefzger Christian M, Martelotto Luciano G, Rackham Owen J L, Polo Jose M   Reprogramming roadmap reveals route to human induced trophoblast stem cells Nature, 2020; 586(7827): 101-107.
Chen Di, Sun Na, Hou Lei, Kim Rachel, Faith Jared, Aslanyan Marianna, Tao Yu, Zheng Yi, Fu Jianping, Liu Wanlu, Kellis Manolis, Clark Amander   Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors Cell reports, 2019; 29(13): 4568-4582.e5.
Clark Amander T   Human embryo implantation modelled in microfluidic channels Nature, 2019; 573(7774): 350-351.
Sosa Enrique, Chen Di, Rojas Ernesto J, Hennebold Jon D, Peters Karen A, Wu Zhuang, Lam Truong N, Mitchell Jennifer M, Sukhwani Meena, Tailor Ramesh C, Meistrich Marvin L, Orwig Kyle E, Shetty Gunapala, Clark Amander T   Differentiation of primate primordial germ cell-like cells following transplantation into the adult gonadal niche Nature communications, 2018; 9(1): 5339.
Chen Di, Clark Amander T   Mitochondrial DNA selection in human germ cells Nature cell biology, 2018; 20(2): 118-120.
Gell Joanna J, Clark Amander T   Restoring Fertility with Human Induced Pluripotent Stem Cells: Are We There Yet? Cell stem cell, 2018; 23(6): 777-779.
Pastor William A, Liu Wanlu, Chen Di, Ho Jamie, Kim Rachel, Hunt Timothy J, Lukianchikov Anastasia, Liu Xiaodong, Polo Jose M, Jacobsen Steven E, Clark Amander T   TFAP2C regulates transcription in human naive pluripotency by opening enhancers Nature cell biology, 2018; 20(5): 553-564.
Tao Yu, Yen Ming-Ren, Chitiashvili Tsotne, Nakano Haruko, Kim Rachel, Hosohama Linzi, Tan Yao Chang, Nakano Atsushi, Chen Pao-Yang, Clark Amander T   TRIM28-Regulated Transposon Repression Is Required for Human Germline Competency and Not Primed or Naive Human Pluripotency Stem cell reports, 2018; 10(1): 243-256.
Chen Di, Liu Wanlu, Zimmerman Jill, Pastor William A, Kim Rachel, Hosohama Linzi, Ho Jamie, Aslanyan Marianna, Gell Joanna J, Jacobsen Steven E, Clark Amander T   The TFAP2C-Regulated OCT4 Naive Enhancer Is Involved in Human Germline Formation Cell reports, 2018; 25(13): 3591-3602.e5.
Chen Di, Liu Wanlu, Lukianchikov Anastasia, Hancock Grace V, Zimmerman Jill, Lowe Matthew G, Kim Rachel, Galic Zoran, Irie Naoko, Surani M Azim, Jacobsen Steven E, Clark Amander T   Germline competency of human embryonic stem cells depends on eomesodermin Biology of reproduction, 2017; 97(6): 850-861.
Chen Di, Gell Joanna J, Tao Yu, Sosa Enrique, Clark Amander T   Modeling human infertility with pluripotent stem cells Stem cell research, 2017; 21(1): 187-192.
Clark Amander T, Gkountela Sofia, Chen Di, Liu Wanlu, Sosa Enrique, Sukhwani Meena, Hennebold Jon D, Orwig Kyle E   Primate Primordial Germ Cells Acquire Transplantation Potential by Carnegie Stage 23 Stem cell reports, 2017; 9(1): 329-341.
Pastor William A, Chen Di, Liu Wanlu, Kim Rachel, Sahakyan Anna, Lukianchikov Anastasia, Plath Kathrin, Jacobsen Steven E, Clark Amander T   Naive Human Pluripotent Cells Feature a Methylation Landscape Devoid of Blastocyst or Germline Memory Cell stem cell, 2016; 18(3): 323-9.
Gkountela Sofia, Zhang Kelvin X, Shafiq Tiasha A, Liao Wen-Wei, Hargan-Calvopiña Joseph, Chen Pao-Yang, Clark Amander T   DNA Demethylation Dynamics in the Human Prenatal Germline Cell, 2015; 161(6): 1425-36.
Hsu Fei-Man, Clark Amander, Chen Pao-Yang   Epigenetic reprogramming in the mammalian germline Oncotarget, 2015; 6(34): 35151-2.
Gkountela Sofia, Li Ziwei, Vincent John J, Zhang Kelvin X, Chen Angela, Pellegrini Matteo, Clark Amander T   The ontogeny of cKIT+ human primordial germ cells proves to be a resource for human germ line reprogramming, imprint erasure and in vitro differentiation Nature cell biology, 2013; 15(1): 113-22.
Clark Amander T, Phillips Bart T, Orwig Kyle E   Fruitful progress to fertility: male fertility in the test tube Nature medicine, 2011; 17(12): 1564-5.
Chodavarapu Ramakrishna K, Feng Suhua, Bernatavichute Yana V, Chen Pao-Yang, Stroud Hume, Yu Yanchun, Hetzel Jonathan A, Kuo Frank, Kim Jin, Cokus Shawn J, Casero David, Bernal Maria, Huijser Peter, Clark Amander T, Krämer Ute, Merchant Sabeeha S, Zhang Xiaoyu, Jacobsen Steven E, Pellegrini Matteo   Relationship between nucleosome positioning and DNA methylation Nature, 2010; 466(7304): 388-92.
Lowry, WE., Richter, L,. Yachechko, R., Pyle, AD., Tshieu, J., Sridharan, R., Clark, AT., Plath, K   Generation of human induced pluripotent stem cells from dermal fibroblasts, Proceedings of the National Academy of Sciences, 2008; 105(8): 2883-2888.
Bostick Magnolia, Kim Jong Kyong, Estève Pierre-Olivier, Clark Amander, Pradhan Sriharsa, Jacobsen Steven E   UHRF1 plays a role in maintaining DNA methylation in mammalian cells Science (New York, N.Y.), 2007; 317(5845): 1760-4.

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