Publications:
A selected list of publications:
Magnusson Mattias, Sierra Maria I, Sasidharan Rajkumar, Prashad Sacha L, Romero Melissa, Saarikoski Pamela, Van Handel Ben, Huang Andy, Li Xinmin, Mikkola Hanna K A
Expansion on stromal cells preserves the undifferentiated state of
human hematopoietic stem cells despite compromised reconstitution
ability
PloS one,
2013; 8(1):
e53912.
Nakano Haruko, Liu Xiaoqian, Arshi Armin, Nakashima Yasuhiro, van Handel Ben, Sasidharan Rajkumar, Harmon Andrew W, Shin Jae-Ho, Schwartz Robert J, Conway Simon J, Harvey Richard P, Pashmforoush Mohammad, Mikkola Hanna K A, Nakano Atsushi
Haemogenic endocardium contributes to transient definitive
haematopoiesis
Nature communications,
2013; 4(4):
1564.
Oh Philmo, Lobry Camille, Gao Jie, Tikhonova Anastasia, Loizou Evangelia, Manent Jan, van Handel Ben, Ibrahim Sherif, Greve Jeffrey, Mikkola Hanna, Artavanis-Tsakonas Spyros, Aifantis Iannis
In Vivo mapping of notch pathway activity in normal and stress
hematopoiesis
Cell stem cell,
2013; 13(2):
190-204.
Palomares Karina, Vigant Frederic, Van Handel Ben, Pernet Olivier, Chikere Kelechi, Hong Patrick, Sherman Sean P, Patterson Michaela, An Dong Sung, Lowry William E, Mikkola Hanna K A, Morizono Kouki, Pyle April D, Lee Benhur
Nipah virus envelope-pseudotyped lentiviruses efficiently target
ephrinB2-positive stem cell populations in vitro and bypass the liver
sink when administered in vivo
Journal of virology,
2013; 87(4):
2094-108.
Hall-Glenn Faith, De Young R Andrea, Huang Bau-Lin, van Handel Ben, Hofmann Jennifer J, Chen Tom T, Choi Aaron, Ong Jessica R, Benya Paul D, Mikkola Hanna, Iruela-Arispe M Luisa, Lyons Karen M
CCN2/connective tissue growth factor is essential for pericyte
adhesion and endothelial basement membrane formation during
angiogenesis
PloS one,
2012; 7(2):
e30562.
Nsair Ali, Schenke-Layland Katja, Van Handel Ben, Evseenko Denis, Kahn Michael, Zhao Peng, Mendelis Joseph, Heydarkhan Sanaz, Awaji Obina, Vottler Miriam, Geist Susanne, Chyu Jennifer, Gago-Lopez Nuria, Crooks Gay M, Plath Kathrin, Goldhaber Josh, Mikkola Hanna K A, MacLellan W Robb
Characterization and therapeutic potential of induced pluripotent stem
cell-derived cardiovascular progenitor cells
PloS one,
2012; 7(10):
e45603.
Xu Jian, Shao Zhen, Glass Kimberly, Bauer Daniel E, Pinello Luca, Van Handel Ben, Hou Serena, Stamatoyannopoulos John A, Mikkola Hanna K A, Yuan Guo-Cheng, Orkin Stuart H
Combinatorial assembly of developmental stage-specific enhancers
controls gene expression programs during human erythropoiesis
Developmental cell,
2012; 23(4):
796-811.
Hong Cynthia, Kidani Yoko, A-Gonzalez Noelia, Phung Tram, Ito Ayaka, Rong Xin, Ericson Katrin, Mikkola Hanna, Beaven Simon W, Miller Lloyd S, Shao Wen-Hai, Cohen Philip L, Castrillo Antonio, Tontonoz Peter, Bensinger Steven J
Coordinate regulation of neutrophil homeostasis by liver X receptors
in mice
The Journal of clinical investigation,
2012; 122(1):
337-47.
Van Handel Ben, Montel-Hagen Amélie, Sasidharan Rajkumar, Nakano Haruko, Ferrari Roberto, Boogerd Cornelis J, Schredelseker Johann, Wang Yanling, Hunter Sean, Org Tõnis, Zhou Jian, Li Xinmin, Pellegrini Matteo, Chen Jau-Nian, Orkin Stuart H, Kurdistani Siavash K, Evans Sylvia M, Nakano Atsushi, Mikkola Hanna K A
Scl represses cardiomyogenesis in prospective hemogenic endothelium
and endocardium
Cell,
2012; 150(3):
590-605.
Schenke-Layland Katja, Nsair Ali, Van Handel Ben, Angelis Ekaterini, Gluck Jessica M, Votteler Miriam, Goldhaber Joshua I, Mikkola Hanna K, Kahn Michael, Maclellan William R
Recapitulation of the embryonic cardiovascular progenitor cell niche
Biomaterials,
2011; 32(11):
2748-56.
Park Tae Sub, Galic Zoran, Conway Anne E, Lindgren Anne, van Handel Benjamin J, Magnusson Mattias, Richter Laura, Teitell Michael A, Mikkola Hanna K A, Lowry William E, Plath Kathrin, Clark Amander T
Derivation of primordial germ cells from human embryonic and induced
pluripotent stem cells is significantly improved by coculture with
human fetal gonadal cells
Stem cells (Dayton, Ohio),
2009; 27(4):
783-95.
Gekas Christos, Rhodes Katrin E, Gereige Laurraine M, Helgadottir Hildur, Ferrari Roberto, Kurdistani Siavash K, Montecino-Rodriguez Encarnación, Bassel-Duby Rhonda, Olson Eric, Krivtsov Andrei V, Armstrong Scott, Orkin Stuart H, Pellegrini Matteo, Mikkola Hanna K A
Mef2C is a lineage-restricted target of Scl/Tal1 and regulates
megakaryopoiesis and B-cell homeostasis
Blood,
2009; 113(15):
3461-71.
Sankaran Vijay G, Menne Tobias F, Xu Jian, Akie Thomas E, Lettre Guillaume, Van Handel Ben, Mikkola Hanna K A, Hirschhorn Joel N, Cantor Alan B, Orkin Stuart H
Human fetal hemoglobin expression is regulated by the developmental
stage-specific repressor BCL11A
Science (New York, N.Y.),
2008; 322(5909):
1839-42.
Schenke-Layland Katja, Rhodes Katrin E, Angelis Ekaterini, Butylkova Yekaterina, Heydarkhan-Hagvall Sepideh, Gekas Christos, Zhang Rui, Goldhaber Joshua I, Mikkola Hanna K, Plath Kathrin, MacLellan W Robb
Reprogrammed mouse fibroblasts differentiate into cells of the
cardiovascular and hematopoietic lineages
Stem cells (Dayton, Ohio),
2008; 26(6):
1537-46.
Rhodes Katrin E, Gekas Christos, Wang Yanling, Lux Christopher T, Francis Cameron S, Chan David N, Conway Simon, Orkin Stuart H, Yoder Mervin C, Mikkola Hanna K A
The emergence of hematopoietic stem cells is initiated in the
placental vasculature in the absence of circulation
Cell stem cell,
2008; 2(3):
252-63.
Mikkola HKA, Gekas C, Orkin SH, Dieterlen-Lievre F
Placenta as a site for hematopoietic stem cell development,
Experimental Hematology,
2005; 33:
1048-1054.
Hamaguchi I, Woods NB, Panagopoulos I, Andersson E, Mikkola H, Fahlman C, Zufferey R, Carlsson L, Trono D, Karlsson S
Lentivirus vector gene expression during ES cell-derived hematopoietic development in vitro
Journal of virology. ,
2000; 74(22):
10778-84.
Loewy A, McDonagh J, Mikkola H, Teller DC, Yee VC
Structure and Function of Factor XIII ,
Hemostasis and Thrombosis: Basic Principles and Clinical Practise,
2000;
233-247.
Balogh I, Szoke G, Karpati L, Wartiovaara U, Katona E, Komaromi I, Haramura G, Pfliegler G, Mikkola H, Muszbek L
Val34Leu polymorphism of plasma factor XIII: biochemistry and epidemiology in familial thrombophilia
Blood,
2000; 96(7):
2479-86.
Wartiovaara U, Perola M, Mikkola H, Totterman K, Savolainen V, Penttila A, Grant PJ, Tikkanen MJ, Vartiainen E, Karhunen PJ, Peltonen L, Palotie A
Association of FXIII Val34Leu with decreased risk of myocardial infarction in Finnish males
Atherosclerosis,
1999; 142(2):
295-300.
Wartiovaara U, Salven P, Mikkola H, Lassila R, Kaukonen J, Joukov V, Orpana A, Ristimki A, Heikinheimo M, Joensuu H, Alitalo K, Palotie A
Peripheral blood platelets express VEGF-C and VEGF which are released during platelet activation
Thrombosis and haemostasis. ,
1998; 80(1):
171-5.
Mikkola H, Yee VC, Syrjala M, Seitz R, Egbring R, Petrini P, Ljung R, Ingerslev J, Teller DC, Peltonen L, Palotie A
Four novel mutations in deficiency of coagulation factor XIII: consequences to expression and structure of the A-subunit
Blood,
1996; 87(1):
141-51.