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RESEARCH

Jorge N. Artaza, Ph.D.

Contact Information:

Fax Number:

1-323-563-9352

Work Phone Number:

1-323-563-4915

Mailing Address:

Division of Endocrinology
Department of Medicine
Cardio-metabolic Cluster
Lab 3084
1731 E. 120th Street
Los Angeles, CA 90059
UNITED STATES

Email Address:

joartaza@ucla.edu

Website:

Home Page.

Associate Professor, Department of Medicine

Member, CTSI


Awards and Honors:

Endocrine Society (ES) Glenn Foundation Endocrinology and Aging Grant Award
American Federation for Medical Research (AFMR) Glaxo Smith-Kline Endocrinology Scholar Award
Methodist Center for Reproduction and Transplantation Immunology Histocompatibility and Immunology
School of Medicine, University of Buenos Aires (UBA), Argentina Hematology
UCLA Ambulatory Internal Medicine Program (AM019)

Detailed Biography:

Jorge N. Artaza, MS, Ph.D. Associate Professor, Department of Medicine, David Geffen School of Medicine at UCLA. Dr. Artaza received his MS degree in Biochemistry and his Ph.D. in Cell and Molecular Biology, both from the University of Buenos Aires (UBA), Argentina. He was a Fellow at the Methodist Center for Reproduction and Transplantation Immunology at Dr John McIntyre?s laboratory, Methodist Hospital of Indiana (IN) where he was trained in Histocompatibility and Immunology of pregnancy. He was a visiting scientist at UCLA in a training program in Histocompatibility, Molecular biology, DNA oligotyping, and PCR technology at the UCLA/Tissue Typing Laboratory, directed by Dr. Paul I. Terasaki. From 1994 to 1999, Dr. Artaza worked independently as a hematologist / immunologist at various prestigious institutions in Buenos Aires, Argentina, such as the Israeli Hospital "Ezra", the Italian Hospital, and the Otamendi & Miroli hospital. At that time, he was also teaching Hematology at the School of Medicine & Biochemistry within the University of Buenos Aires (UBA). In 1999, Dr. Artaza was awarded the "Rene Thalman" Fellowship that was supported by the University of Buenos Aires (UBA) and the Department of Endocrinology at Charles Drew University, School of Medicine & Science, Los Angeles, CA (CDU). From 2003-2006 Dr. Artaza was a postdoctoral fellow at the division of Endocrinology,directed by Dr. Shalender Bhasin. He is the recipient of numerous awards such as the Glenn Foundation Endocrinology and Aging Grant Award (Endocrine Society), the Glaxo Smith-Kline Endocrinology Scholar Award (AFMR), Endocrinology Scholar Award (AFMR) and the Travel Grant Award (Endocrine Society, RCMI and NIH Summit), Dr. Artaza also holds professional memberships in the Endocrine Society and FASEB since 2003 and the American Federation for Medical Research (AFMR) since 2004.

Selected Publications:

Garcia Leah A, Ferrini Monica G, Norris Keith C, Artaza Jorge N 1,25(OH)(2)vitamin D(3) Enhances Myogenic Differentiation by Modulating the Expression of Key Angiogenic Growth factors and Angiogenic Inhibitors in C(2)C(12) Skeletal Muscle Cells. J Steroid Biochem Mol Biol. 2013; 133: 1-11.
Hlaing Su M, Garcia Leah A, Kovanecz Istvan, Martinez Ramon A, Shah Sanjana, Artaza Jorge N, Ferrini Monica G Sildenafil promotes neuroprotection of the pelvic ganglia neurones after bilateral cavernosal nerve resection in the rat. BJU Int. 2013; 111(1): 159-70.
Garcia Leah A, King Keisha K, Ferrini Monica G, Norris Keith C, Artaza Jorge N 1,25(OH)2vitamin D3 stimulates myogenic differentiation by inhibiting cell proliferation and modulating the expression of promyogenic growth factors and myostatin in C2C12 skeletal muscle cells. Endocrinology. 2011; 152(8): 2976-86.
Artaza Jorge N, Contreras Sandra, Garcia Leah A, Mehrotra Rajnish, Gibbons Gary, Shohet Ralph, Martins David, Norris Keith C Vitamin D and cardiovascular disease: potential role in health disparities. Journal of health care for the poor and underserved. 2011; 22(4 Suppl): 23-38.
Sirad F., Hlaing S., Kovanecz I., Artaza J. N., Garcia L. A., Rajfer J., Ferrini M. G. Sildenafil Promotes Smooth Muscle Preservation and Ameliorates Fibrosis Through Modulation of Extracellular Matrix and Tissue Growth Factor Gene Expression After Bilateral Cavernosal Nerve Resection in the Rat. J. Sex. Med. 2011; 8(4): 1048-1060.
Artaza J N, Sirad F, Ferrini M G, Norris K C 1,25(OH)(2)vitamin D(3) inhibits cell proliferation by promoting cell cycle arrest without inducing apoptosis and modifies cell morphology of mesenchymal multipotent cells. J Steroid Biochem Mol Biol. 2010; 119(1-2): 73-83.
Artaza Jorge N, Mehrotra Rajnish, Norris Keith C Vitamin D and the cardiovascular system. Clinical journal of the American Society of Nephrology : CJASN. 2009; 4(9): 1515-22.
Singh Rajan, Bhasin Shalender, Braga Melissa, Artaza Jorge N, Pervin Shehla, Taylor Wayne E, Krishnan Venkatesh, Sinha Satyesh K, Rajavashisth Tripathi B, Jasuja Ravi Regulation of myogenic differentiation by androgens: cross talk between androgen receptor/ beta-catenin and follistatin/transforming growth factor-beta signaling pathways. Endocrinology. 2009; 150(3): 1259-68.
Artaza Jorge N, Norris Keith C Vitamin D reduces the expression of collagen and key profibrotic factors by inducing an antifibrotic phenotype in mesenchymal multipotent cells. The Journal of endocrinology. 2009; 200(2): 207-21.
Artaza Jorge N, Singh Rajan, Ferrini Monica G, Braga Melissa, Tsao James, Gonzalez-Cadavid Nestor F Myostatin promotes a fibrotic phenotypic switch in multipotent C3H 10T1/2 cells without affecting their differentiation into myofibroblasts. The Journal of endocrinology. 2008; 196(2): 235-49.
Artaza Jorge N, Reisz-Porszasz Suzanne, Dow Joan S, Kloner Robert A, Tsao James, Bhasin Shalender, Gonzalez-Cadavid Nestor F Alterations in myostatin expression are associated with changes in cardiac left ventricular mass but not ejection fraction in the mouse. The Journal of endocrinology. 2007; 194(1): 63-76.
Magee Thomas R, Artaza Jorge N, Ferrini Monica G, Vernet Dolores, Zuniga Freddi I, Cantini Liliana, Reisz-Porszasz Suzanne, Rajfer Jacob, Gonzalez-Cadavid Nestor F Myostatin short interfering hairpin RNA gene transfer increases skeletal muscle mass. The journal of gene medicine. 2006; 8(9): 1171-81.
Singh Rajan, Artaza Jorge N, Taylor Wayne E, Braga Melissa, Yuan Xin, Gonzalez-Cadavid Nestor F, Bhasin Shalender Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors. Endocrinology. 2006; 147(1): 141-54.
Artaza Jorge N, Bhasin Shalender, Magee Thomas R, Reisz-Porszasz Suzanne, Shen Ruoquin, Groome Nigel P, Meerasahib Mohamed Fareez, Fareez Meerasaluh M, Gonzalez-Cadavid Nestor F Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells. Endocrinology. 2005; 146(8): 3547-57.
Jasuja R, Catlin DH, Miller A, Chang YC, Herbst KL, Starcevic B, Artaza JN, Singh R, Datta G, Sarkissian A, Chandsawangbhuwana C, Baker M, Bhasin S Tetrahydrogestrinone is an androgenic steroid that stimulates androgen receptor-mediated, myogenic differentiation in C3H10T1/2 multipotent mesenchymal cells and promotes muscle accretion in orchidectomized male rats. Endocrinology 2005; 146(10): 4472-8.
Jasuja Ravi, Ramaraj Pandurangan, Mac Ricky Phong, Singh Atam B, Storer Thomas W, Artaza Jorge, Miller Aria, Singh Rajan, Taylor Wayne E, Lee Martin L, Davidson Tina, Sinha-Hikim Indrani, Gonzalez-Cadavid Nestor, Bhasin Shalender Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men. The Journal of clinical endocrinology and metabolism. 2005; 90(2): 855-63.
Bhasin Shalender, Taylor Wayne E, Singh Rajan, Artaza Jorge, Sinha-Hikim Indrani, Jasuja Ravi, Choi Helen, Gonzalez-Cadavid Nestor F The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen action. The journals of gerontology. Series A, Biological sciences and medical sciences. 2003; 58(12): M1103-10.
Singh Rajan, Artaza Jorge N, Taylor Wayne E, Gonzalez-Cadavid Nestor F, Bhasin Shalender Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway. Endocrinology. 2003; 144(11): 5081-8.
Reisz-Porszasz Suzanne, Bhasin Shalender, Artaza Jorge N, Shen Ruoqing, Sinha-Hikim Indrani, Hogue Aimee, Fielder Thomas J, Gonzalez-Cadavid Nestor F Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatin. American journal of physiology. Endocrinology and metabolism. 2003; 285(4): E876-88.
Ma Kun, Mallidis Con, Bhasin Shalender, Mahabadi Vahid, Artaza Jorge, Gonzalez-Cadavid Nestor, Arias Jose, Salehian Behrouz Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression. American journal of physiology. Endocrinology and metabolism. 2003; 285(2): E363-71.
Sinha-Hikim Indrani, Artaza Jorge, Woodhouse Linda, Gonzalez-Cadavid Nestor, Singh Atam B, Lee Martin I, Storer Thomas W, Casaburi Richard, Shen Ruoquing, Bhasin Shalender Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy. American journal of physiology. Endocrinology and metabolism. 2002; 283(1): E154-64.
Artaza Jorge N, Bhasin Shalender, Mallidis Con, Taylor Wayne, Ma Kun, Gonzalez-Cadavid Nestor F Endogenous expression and localization of myostatin and its relation to myosin heavy chain distribution in C2C12 skeletal muscle cells. Journal of cellular physiology. 2002; 190(2): 170-9.
Sinha-Hikim I, Artaza J, Woodhouse L, Gonzalez-Cadavid N, Singh AB, Lee MI, Storer TW, Casaburi R, Shen R, Bhasin S. Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy. Am J Physiol Endocrinol Metab 2002; 283(1): E154-64.
Taylor WE, Bhasin S, Artaza J, Byhower F, Azam M, Willard DH Jr, Kull FC Jr, Gonzalez-Cadavid N. Myostatin inhibits cell proliferation and protein synthesis in C2C12 muscle cells. Am J Physiol Endocrinol Metab 2001; 280(2): E221-8.
Ma K, Mallidis C, Artaza J, Taylor W, Gonzalez-Cadavid N, Bhasin S. Characterization of 5'-regulatory region of human myostatin gene: regulation by dexamethasone in vitro. Am J Physiol Endocrinol Metab 2001; 281(6): E1128-36.
Diaz de Domingo NB, Lardo MM, Artaza J, Merelli A, Carbia CD, Sánchez Avalos JC. Immunocytochemistry techniques for the diagnosis of hematologic neoplasms. Medicina (B Aires) 1999; 59(1): 11-6.
Artaza J, Carbia CD, Ceballo MF, Díaz NB. Red cell distribution width (RDW): its use in the characterization of microcytic and hypochromic anemias. Medicina (B Aires) 1999; 59(1): 17-22.
De Domingo NBD, Carbia C, Artaza J, Lardo M, Ceballo MF. Red cell ferritin - measurement and diagnostic applications. Acta Bioquímica Clínica Latinoamericana 1997; 31(4): 415-419 .
Lardo MM, Díaz NB, Artaza JR, Carbia CD, Nazer R, Valdez R. Vitamin E as protective agent against hemolysis in leprosy patients under dapsone treatment. Medicina (B Aires) 1997; 57(2): 150-4.
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