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RESEARCH
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Siavash Kurdistani, M.D.
Contact Information:
Work Phone Number:
(310) 794-5194
(310) 825-1206
Laboratory Address:
Laboratory 615 Charles Young Dr. UNITED STATES
Mailing Address:
David Geffen School of Medicine at UCLA Department of Biological Chemistry BSRB 377B P.O. Box 951737 Los Angeles, CA 90095 UNITED STATES
Work Address:
Office 615 Charles Young Dr. UNITED STATES
Assistant Professor,
Biological Chemistry
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Member,
ACCESS Program: Dept. of Biological Chemistry
JCCC Gene Regulation Program Area
Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research
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Faculty,
Bioinformatics IDP
Cellular and Molecular Pathology PhD Program
Molecular Biology IDP
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Awards and Honors:
University of California, Los Angeles
Member of the MSTP Admissions Committee
Beckman Young Investigator Award
Howard Hughes Medical Institute Early Career Award
UCLA Chancellor's Award for Postdoctoral Fellows
Howard Hughes Medical Institute Postdoctoral Research Fellowship for Physicians
James Tolbert Shipely Prize, Harvard Medical School
Howard Hughes Medical Institute Continued Fellowship Support
Howard Hughes Medical Institute Research Fellowship
Lucy Wortham James Student Research Award, Harvard Medical School
Harvard National Scholarship
The Arthur Furst Award, UCLA
UCLA College of Letters & Science Scholar Award
UCLA Alumni Association Distinguished Scholars Award
Detailed Biography:
Siavash Kurdistani is an Associate Professor in the Department of Biological Chemistry and an Associate Director of the UCLA-Cal Tech MSTP program. He earned his B.S. in Biochemistry from UCLA and M.D. from Harvard Medical School.
McBrian Matthew A, Behbahan Iman Saramipoor, Ferrari Roberto, Su Trent, Huang Ta-Wei, Li Kunwu, Hong Candice S, Christofk Heather R, Vogelauer Maria, Seligson David B, Kurdistani Siavash K Histone Acetylation Regulates Intracellular pH..
Molecular cell.
2013;
49(2):
310-21.
Li Jing-Yu, Patterson Michaela, Mikkola Hanna K A, Lowry William E, Kurdistani Siavash K Dynamic distribution of linker histone H1.5 in cellular
differentiation..
PLoS genetics.
2012;
8(8):
e1002879.
Kurdistani Siavash K Enhancer dysfunction: how the main regulators of gene expression
contribute to cancer..
Genome biology.
2012;
13(5):
156.
Chen Xiao-Fen, Lehmann Lynn, Lin Justin J, Vashisht Ajay, Schmidt Ryan, Ferrari Roberto, Huang Chengyang, McKee Robin, Mosley Amber, Plath Kathrin, Kurdistani Siavash K, Wohlschlegel James, Carey Michael Mediator and SAGA have distinct roles in Pol II preinitiation complex
assembly and function..
Cell reports.
2012;
2(5):
1061-7.
Lehmann Lynn, Ferrari Roberto, Vashisht Ajay A, Wohlschlegel James A, Kurdistani Siavash K, Carey Michael Polycomb repressive complex 1 (PRC1) disassembles RNA polymerase II
preinitiation complexes..
The Journal of biological chemistry.
2012;
287(43):
35784-94.
Ferrari Roberto, Su Trent, Li Bing, Bonora Giancarlo, Oberai Amit, Chan Yvonne, Sasidharan Rajkumar, Berk Arnold J, Pellegrini Matteo, Kurdistani Siavash K Reorganization of the host epigenome by a viral oncogene..
Genome research.
2012;
22(7):
1212-21.
Van Handel Ben, Montel-Hagen Amélie, Sasidharan Rajkumar, Nakano Haruko, Ferrari Roberto, Boogerd Cornelis J, Schredelseker Johann, Wang Yanling, Hunter Sean, Org Tőnis, Zhou Jian, Li Xinmin, Pellegrini Matteo, Chen Jau-Nian, Orkin Stuart H, Kurdistani Siavash K, Evans Sylvia M, Nakano Atsushi, Mikkola Hanna K A Scl represses cardiomyogenesis in prospective hemogenic endothelium
and endocardium..
Cell.
2012;
150(3):
590-605.
Vogelauer Maria, Krall Abigail S, McBrian Matthew A, Li Jing-Yu, Kurdistani Siavash K Stimulation of histone deacetylase activity by metabolites of
intermediary metabolism..
The Journal of biological chemistry.
2012;
287(38):
32006-16.
Chen Xiao-Fen, Kuryan Benjamin, Kitada Tasuku, Tran Nancy, Li Jing-Yu, Kurdistani Siavash, Grunstein Michael, Li Bing, Carey Michael The Rpd3 core complex is a chromatin stabilization module..
Current biology : CB.
2012;
22(1):
56-63.
Marban Céline, Su Trent, Ferrari Roberto, Li Bing, Vatakis Dimitrios, Pellegrini Matteo, Zack Jerome A, Rohr Olivier, Kurdistani Siavash K Genome-wide binding map of the HIV-1 Tat protein to the human genome..
PloS one.
2011;
6(11):
e26894.
Seligson David B, Horvath Steve, McBrian Matthew A, Mah Vei, Yu Hong, Tze Sheila, Wang Qun, Chia David, Goodglick Lee, Kurdistani Siavash K Global levels of histone modifications predict prognosis in different
cancers..
The American journal of pathology.
2009;
174(5):
1619-28.
Gekas Christos, Rhodes Katrin E, Gereige Laurraine M, Helgadottir Hildur, Ferrari Roberto, Kurdistani Siavash K, Montecino-Rodriguez Encarnación, Bassel-Duby Rhonda, Olson Eric, Krivtsov Andrei V, Armstrong Scott, Orkin Stuart H, Pellegrini Matteo, Mikkola Hanna K A Mef2C is a lineage-restricted target of Scl/Tal1 and regulates
megakaryopoiesis and B-cell homeostasis..
Blood.
2009;
113(15):
3461-71.
Ferrari Roberto, Berk Arnold J, Kurdistani Siavash K Viral manipulation of the host epigenome for oncogenic transformation..
Nature reviews. Genetics.
2009;
10(5):
290-4.
Horwitz Gregory A, Zhang Kangling, McBrian Matthew A, Grunstein Michael, Kurdistani Siavash K, Berk Arnold J Adenovirus small e1a alters global patterns of histone modification..
Science (New York, N.Y.).
2008;
321(5892):
1084-5.
Ferrari Roberto, Pellegrini Matteo, Horwitz Gregory A, Xie Wei, Berk Arnold J, Kurdistani Siavash K Epigenetic reprogramming by adenovirus e1a..
Science (New York, N.Y.).
2008;
321(5892):
1086-8.
Peng Weimin, Togawa Cynthia, Zhang Kangling, Kurdistani Siavash K Regulators of cellular levels of histone acetylation in Saccharomyces
cerevisiae..
Genetics.
2008;
179(1):
277-89.
Pham Hung, Ferrari Roberto, Cokus Shawn J, Kurdistani Siavash K, Pellegrini Matteo Modeling the regulatory network of histone acetylation in
Saccharomyces cerevisiae..
Molecular systems biology.
2007;
3(1):
153.
Seligson DB, Horvath S, Shi T, Yu H, Tze S, Grunstein M, Kurdistani SK Global histone modification patterns predict risk of prostate cancer recurrence..
Nature. .
2005;
435(7046):
1262-6.
Robyr D, Kurdistani SK, Grunstein M Analysis of genome-wide histone acetylation state and enzyme binding using DNA microarrays..
Methods in enzymology. .
2004;
376:
289-304.
Kim KT, Ongusaha PP, Hong YK, Kurdistani SK, Nakamura M, Lu KP, Lee SW Function of Drg1/Rit42 in p53-dependent mitotic spindle checkpoint..
The Journal of biological chemistry. .
2004;
279(37):
38597-602.
Kurdistani SK, Tavazoie S, Grunstein M Mapping global histone acetylation patterns to gene expression..
Cell. .
2004;
117(6):
721-33.
Kurdistani SK, Grunstein M Histone acetylation and deacetylation in yeast.
Nat Rev Mol Cell Biol.
2003;
4(4):
276-84.
Kurdistani SK, Grunstein M In vivo protein-protein and protein-DNA crosslinking for genomewide binding microarray..
Methods (San Diego, Calif.) .
2003;
31(1):
90-5.
Kurdistani SK, Robyr D, Tavazoie S, Grunstein M Genome-wide binding map of the histone deacetylase Rpd3 in yeast..
Nature genetics. .
2002;
31(3):
248-54.
Robyr D, Suka Y, Xenarios I, Kurdistani SK, Wang A, Suka N, Grunstein M Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases..
Cell. .
2002;
109(4):
437-46.
Wang A, Kurdistani SK, Grunstein M Requirement of Hos2 histone deacetylase for gene activity in yeast..
Science. .
2002;
298(5597):
1412-4.
Reimer CL, Borras AM, Kurdistani SK, Garreau JR, Chung M, Aaronson SA, Lee SW Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells..
The Journal of biological chemistry. .
1999;
274(16):
11022-9.
Kurdistani SK, Arizti P, Reimer CL, Sugrue MM, Aaronson SA, Lee SW Inhibition of tumor cell growth by RTP/rit42 and its responsiveness to p53 and DNA damage..
Cancer research. .
1998;
58(19):
4439-44.
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