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Work Phone Number:

310-206-3121
310-825-8363

Work Address:

Laboratory
Department of Biological Chemistry
PO Box 951737
UCLa School of Medicine
Los Angeles, CA 90095
UNITED STATES Office
Department of Biological Chemistry
PO Box 951737
UCLA School of Medicine
Los Angeles, CA 90095
UNITED STATES

Email Address:

gpayne@mednet.ucla.edu

Awards and Honors:

Lysosomes and Endocytosis Gordon Conference Chair
Lysosomes and Endocytosis Gordon Conference Vice-Chair
Pew Scholars Award

Detailed Biography:

Greg Payne is a cell biologist and geneticist studying mechanisms of intracellular protein transport. He joined the Department of Biological Chemistry in the UCLA School of Medicine in 1987, received tenure in 1994, became full professor in 2000, and was appointed departmental Vice Chair in 2004. Dr. Payne received his B.S. in Cell Biology with Honors in Drama from University of Michigan in 1977 and his Ph.D. in Biochemistry in the lab of Harold Varmus from University of California, San Francisco. He was a postdoctoral with Randy Schekman at University of California, Berkeley. He has served as curriculum coordinator for the joint Ph.D. admissions program, ACCESS, since its inception and became director in 2008. Dr. Payne research involves cell biological, biochemical, molecular and standard genetic and genomic approaches to understand vesicle mediated traffic in yeast.

Costaguta, G., Duncan, M.C., Fernandez, G.E., Huang, G.H. and Payne, G.S. Distinct Roles for TGN/endosome epsin-like adaptors Ent3p and Ent5p. Mol. Biol. Cell 2006; 17: 3907-3920.

Parsons, A.B., Lopez, A., Givoni, I.E., Williams, D.E., Gray, C.A., Porter, J., Chua, G., Sopko, R., Brost, R.L., Ho, C.-H., Wang, J., Ketela, T., Brenner, C., Brill, J.A., Esteban Fernandez , G., Lorenz, T.C., Payne, G.S., Ishihara, S., Ohya, Y., Andrews, B., Hughes, T.R., Frey, B.J., Graham, T.R., Andersen, R.J. and Boone, C. Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast.. Cell 2006; 126 (3): 611-625.

Fernandez, G. Esteban and Payne, G.S. Laa1p, a conserved AP-1 accessory protein important for AP-1 localization in yeast. . Mol. Biol. Cell 2006; 17: 3304-3317.

Duncan, M.C. and Payne, G.S. Protein Choreography. Nature 2005; 438 571-573: 571-573.

Howard, J. P., Hutton, J.L., Olson, J.M. and Payne, G.S. Sla1p serves as the targeting signal recognition factor for NPFX(1,2)D-mediated endocytosis.. J. Cell Biol. 2002; 157: 315-326.

Bensen, E., Costaguta, G. and Payne, G.S. Synthetic interactions with temperature-sensitive clathrin in Saccharomyces cerevisiae: roles for dynamin-related Vps1p and synaptojanin-like Inp53p in clathrin-dependent TGN membrane protein localization.. Genetics 2000; 154: 83-97.

van der Bliek Alexander M, Payne Gregory S Dynamin subunit interactions revealed.. Developmental cell. 2010; 18(5): 687-8.

Di Pietro Santiago M, Cascio Duilio, Feliciano Daniel, Bowie James U, Payne Gregory S Regulation of clathrin adaptor function in endocytosis: novel role for the SAM domain.. The EMBO journal. 2010; 29(6): 1033-44.

Anand Vikram C, Daboussi Lydia, Lorenz Todd C, Payne Gregory S Genome-wide analysis of AP-3-dependent protein transport in yeast.. Molecular biology of the cell. 2009; 20(5): 1592-604.

Lorenz Todd C, Anand Vikram C, Payne Gregory S High-throughput protein extraction and immunoblotting analysis in Saccharomyces cerevisiae.. Methods in molecular biology (Clifton, N.J.). 2008; 457(1): 13-27.

Duncan Mara C, Ho David G, Huang Jing, Jung Michael E, Payne Gregory S Composite synthetic lethal identification of membrane traffic inhibitors.. Proc. Natl. Acad. Sci. U.S.A.. 2007; 104(15): 6235-40.

Mahadev Ravi K, Di Pietro Santiago M, Olson John M, Piao Hai Lan, Payne Gregory S, Overduin Michael Structure of Sla1p homology domain 1 and interaction with the NPFxD endocytic internalization motif.. EMBO J.. 2007; 26(7): 1963-71.

Piao Hai Lan, Machado Iara M P, Payne Gregory S NPFXD-mediated endocytosis is required for polarity and function of a yeast cell wall stress sensor.. Mol. Biol. Cell. 2007; 18(1): 57-65.

Duncan, MC Payne, GS ENTH/ANTH domains expand to the Golgi.. Trends in cell biology. . 2003; 13(5): 211-5.

Duncan, MC Costaguta, G Payne, GS Yeast epsin-related proteins required for Golgi-endosome traffic define a gamma-adaptin ear-binding motif.. Nature cell biology. . 2003; 5(1): 77-81.

Dell'Angelica, EC Payne, GS Intracellular cycling of lysosomal enzyme receptors: cytoplasmic tails' tales.. Cell. . 2001; 106(4): 395-8.

Yeung, BG Payne, GS Clathrin interactions with C-terminal regions of the yeast AP-1 beta and gamma subunits are important for AP-1 association with clathrin coats.. Traffic (Copenhagen, Denmark) . 2001; 2(8): 565-76.

Costaguta, G Stefan, CJ Bensen, ES Emr, SD Payne, GS Yeast Gga coat proteins function with clathrin in Golgi to endosome transport.. Molecular biology of the cell. . 2001; 12(6): 1885-96.

Bensen, ES Yeung, BG Payne, GS Ric1p and the Ypt6p GTPase function in a common pathway required for localization of trans-Golgi network membrane proteins.. Molecular biology of the cell. . 2001; 12(1): 13-26.

Pishvaee, B Costaguta, G Yeung, BG Ryazantsev, S Greener, T Greene, LE Eisenberg, E McCaffery, JM Payne, GS A yeast DNA J protein required for uncoating of clathrin-coated vesicles in vivo.. Nature cell biology. . 2000; 2(12): 958-63.

Chu, DS Pishvaee, B Payne, GS A modulatory role for clathrin light chain phosphorylation in Golgi membrane protein localization during vegetative growth and during the mating response of Saccharomyces cerevisiae.. Molecular biology of the cell. . 1999; 10(3): 713-26.

Vowels, JJ Payne, GS A dileucine-like sorting signal directs transport into an AP-3-dependent, clathrin-independent pathway to the yeast vacuole.. The EMBO journal. . 1998; 17(9): 2482-93.

Pishvaee, B Munn, A Payne, GS A novel structural model for regulation of clathrin function.. The EMBO journal. . 1997; 16(9): 2227-39.

Tan, PK Howard, JP Payne, GS The sequence NPFXD defines a new class of endocytosis signal in Saccharomyces cerevisiae.. The Journal of cell biology. . 1996; 135(6 Pt 2): 1789-800.