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RESEARCH
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Eddy De Robertis, M.D., Ph.D.
Contact Information:
Work Phone Number:
(310) 206-1463
Work Address:
Office 5-612A MRL Los Angeles, CA 90095 UNITED STATES
Campus 166222 CA UNITED STATES
Laboratory 5-619 MRL Los Angeles, CA 90095 UNITED STATES
Distinguished Professor,
Biological Chemistry
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Member,
ACCESS Program: Dept. of Biological Chemistry
JCCC Cancer and Stem Cell Biology Program Area
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Investigator,
Howard Hughes Medical Institute
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Awards and Honors:
Pontifical Academy of Sciences
Member
American Academy of Arts and Sciences
Fellow
College de France, Paris
Public Lecture Series and Medal
National Institutes of Health
MERIT Award
Geffen School of Medicine at UCLA
Norman Sprague Endowed Chair for Molecular Biology
School of Medicine, Uruguay
Gold Medal to the top student
International Society of Developmental Biologists (ISDB)
President
Latin American Academy of Sciences
Corresponding Member
Societe de Biologie, Paris, France
Foreign Corresponding Member
European Molecular Biology Organization
Member
Detailed Biography:
Dr. De Robertis is also Norman Sprague Professor of Biological Chemistry at the University of California, Los Angeles, School of Medicine. He received an M.D. from the University of Uruguay and a Ph.D. in Chemistry from the University of Buenos Aires. His postdoctoral training was with Sir John Gurdon at the Medical Research Council Laboratory of Molecular Biology, Cambridge, U.K. Before moving to UCLA, he was professor at the University of Basel. Dr. De Robertis is a member of the Pontifical Academy of Sciences, the European Molecular Biology Organization and the Latin American Academy of Sciences, and a Fellow of the American Academy of Arts and Sciences. He served as President of the International Society of Developmental Biologists until 2006.
Dobrowolski, R. and De Robertis, E.M. Endocytic control of growth factor signaling: multivesicular bodies as signaling organelles.
Nat. Rev. Mol. Cell Biol..
2012;
13:
53-60.
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Eivers, E., Demagny, H., Choi, R.H. and De Robertis, E.M. Phosphorylation of Mad controls competition between Wingless and BMP signaling.
Science Signaling.
2011;
4:
ra68.
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Plouhinec, J.L., Zakin, L. and De Robertis, E.M. Systems control of BMP morphogen flow in vertebrate embryos.
Curr. Opin. Genet Dev..
2011;
21:
1-8.
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Lee, H.X., Mendes, F.A., Plouhinec, J.L. and De Robertis, E.M. Enzymatic regulation of pattern: BMP4 binds CUB domains of Tolloids and inhibits proteinase activity.
Genes Dev.
2009;
23:
2551-2562.
Eivers, E., Demagny, H. and De Robertis, E.M. Integration of BMP and Wnt signaling via vertebrate Smad1/5/8 and Drosophila Mad.
Cytokine Growth F. R..
2009;
20:
357-365.
Fuentealba, L.C., Eivers, E., Geissert, D., Taelman, V. and De Robertis, E.M. Asymmetric mitosis: Unequal segregation of proteins destined for degradation.
PNAS.
2008;
105:
7732-7737.
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Ambrosio, A.L., Taelman, V.F., Lee, H.X., Metzinger, C.A., Coffinier, C. and De Robertis, E.M. Crossveinless-2 is a BMP feedback inhibitor that binds Chordin/BMP to regulate Xenopus embryonic patterning.
Dev. Cell.
2008;
15:
248-260.
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Zakin, L., Metzinger, C.A., Chang, E.Y., Coffinier, C. and De Robertis, E.M. Development of the vertebral morphogenetic field in the mouse: interactions between Crossveinless-2 and Twisted gastrulation.
Dev. Biol..
2008;
323:
6-18.
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De Robertis, E.M. Evo-Devo: Variations on Ancestral themes.
Cell.
2008;
132:
185-195.
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Ishibashi, H., Matsumura, N., Hanafusa, H., Matsumoto, K., De Robertis, E.M. and Kuroda, H. Expression of Siamois and Twin in the blastula Chordin/Noggin signaling center is required for brain formation in Xenopus laevis embryos.
Mech. Dev.
2008;
125:
58-66.
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Eivers, E., Fuentealba, L.C. and De Robertis, E.M. Integrating positional information at the level of Smad1/5/8.
Curr. Opin. Genet. Dev. .
2008;
18:
304-310.
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Yasuda, S., Tanaka, H., Sugiura, H., Okamura, K., Sakaguchi, T., Tran, U., Takemiya, T., Mizoguchi, A., Yagita, Y., Sakurai, T., De Robertis, E.M. and Yamagata, K. Activity-induced protocadherin Arcadlin regulates dendritic spine number by triggering N-Cadherin endocytosis via TAO2? and p38 MAP kinases.
Neuron
2007;
56:
456-471.
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Fuentealba, L.C., Eivers, E., Ikeda, A., Hurtado, C., Kuroda, H., Pera, E.M. and De Robertis, E.M. Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal.
Cell.
2007;
131:
980-993.
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Hurtado, C. and De Robertis, E. M. Neural induction in the absence of organizer in salamanders is mediated by MAPK..
Dev. Biol..
2007;
307:
282-289.
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Plouhinec, J.-L. and De Robertis, E.M. Systems biology of embryonic morphogens..
Mol. Biosyst..
2007;
3:
454-457.
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Sander, V., Reversade, B. and De Robertis E.M. The opposing homeobox genes Goosecoid and Vent1/2 self-regulate Xenopus patterning.
EMBO J..
2007;
26:
2955-2965.
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Lee HX, Ambrosio AL, Reversade B, De Robertis EM Embyonic dorsal-ventral signaling: secreted Frizzled-related proteins as inhibitors of Tolloid proteases.
Cell.
2006;
124:
147-159.
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Reversade B, Kuroda H, Lee H, Mays A, De Robertis EM Depletion of BMP2, 4, 7 and Spemann organizer signals induces massive brain formation in Xenopus embryo.
Development.
2005;
132:
3381-3392.
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Pera EM, Hou S, Strate I, Wessely O, De Robertis EM Exploration of the extracellular space by a large-scale secretion screen in the early Xenopus embryo.
Int. J. Dev. Biol.
2005;
49:
781-796.
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Reversade B, De Robertis EM Formation of a self-differentiating morphogenetic field via reciprocal regulation of Admp and Bmp2/4/7 at opposite poles of the Xenopus embryo.
Cell.
2005;
123:
1147-1160.
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Zakin L, Reversade B, Kuroda H, Lyons KM, De Robertis EM Sirenomelia in Bmp7 and Twisted gastrulation composed mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm.
Development.
2005;
132:
2489-2499.
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Oelgeschlager M, Tran U, Grubisic K, De Robertis EM Identification of a second Xenopus twisted gastrulation gene.
Int J Dev Biol.
2004;
48(1):
57-61.
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Oelgeschlager M, Kuroda H, Reversade B, De Robertis EM Chordin is required for the Spemann organizer transplantation phenomenon in Xenopus embryos.
Dev Cell.
2003;
4(2):
219-30.
Larrain J, Brown C, De Robertis EM Integrin-alpha3 mediates binding of Chordin to the cell surface and promotes its endocytosis.
EMBO Rep.
2003;
4(8):
813-8.
Oelgeschlager M, Reversade B, Larrain J, Little S, Mullins MC, De Robertis EM The pro-BMP activity of Twisted gastrulation is independent of BMP binding.
Development.
2003;
130(17):
4047-56.
Garcia Abreu J, Coffinier C, Larrain J, Oelgeschlager M, De Robertis EM Chordin-like CR domains and the regulation of evolutionarily conserved extracellular signaling systems.
Gene.
2002;
287(1-2):
39-47.
Abreu JG, Ketpura NI, Reversade B, De Robertis EM Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta.
Nat Cell Biol.
2002;
4(8):
599-604.
De Robertis EM, Wessely O, Oelgeschlager M, Brizuela B, Pera E, Larrain J, Abreu J, Bachiller D Molecular mechanisms of cell-cell signaling by the Spemann-Mangold organizer.
Int J Dev Biol.
2001;
45(1):
189-97.
Wessely O, Agius E, Oelgeschlager M, Pera EM, De Robertis EM Neural induction in the absence of mesoderm: beta-catenin-dependent expression of secreted BMP antagonists at the blastula stage in Xenopus.
Dev Biol.
2001;
234(1):
161-73.
Coffinier C, Tran U, Larrain J, De Robertis EM Neuralin-1 is a novel Chordin-related molecule expressed in the mouse neural plate.
Mech Dev.
2001;
100(1):
119-22.
Larrain J, Oelgeschlager M, Ketpura NI, Reversade B, Zakin L, De Robertis EM Proteolytic cleavage of Chordin as a switch for the dual activities of Twisted gastrulation in BMP signaling.
Development.
2001;
128(22):
4439-47.
Larrain J, Bachiller D, Lu B, Agius E, Piccolo S, De Robertis EM BMP-binding modules in chordin: a model for signalling regulation in the extracellular space.
Development.
2000;
127(4):
821-30.
Belo JA, Bachiller D, Agius E, Kemp C, Borges AC, Marques S, Piccolo S, De Robertis EM Cerberus-like is a secreted BMP and nodal antagonist not essential for mouse development.
Genesis.
2000;
26(4):
265-70.
Agius E, Oelgeschlager M, Wessely O, Kemp C, De Robertis EM Endodermal Nodal-related signals and mesoderm induction in Xenopus.
Development.
2000;
127(6):
1173-83.
Yamamoto A, Kemp C, Bachiller D, Geissert D, De Robertis EM Mouse paraxial protocadherin is expressed in trunk mesoderm and is not essential for mouse development.
Genesis.
2000;
27(2):
49-57.
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O The establishment of Spemann's organizer and patterning of the vertebrate embryo.
Nat Rev Genet.
2000;
1(3):
171-81.
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O The establishment of Spemann?s Organizer and patterning of the vertebrate embryo..
Nature Reviews Genetics
2000;
1, 171-181.
Oelgeschlager M, Larrain J, Geissert D, De Robertis EM The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling.
Nature.
2000;
405(6788):
757-63.
Oelgeschlager M, Larrain J, Geissert D, De Robertis EM The evolutionary conserved BMP-binding protein Twisted Gastrulation promotes BMP signalling..
Nature
2000;
405, 757-763.
Agius PE, Piccolo S, De Robertis EM [The head inducer Cerberus in a multivalent extracellular inhibitor].
J Soc Biol.
1999;
193(4-5):
347-54.
Blumberg B, Kang H, Bolado Jr. J, Chen H, Craig AG, Moreno TA, Umesono K, Perlmann T, De Robertis EM, Evans RM BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites.
Genes Dev.
1998;
12(9):
1269-77.
Sasai Y, De Robertis EM Ectodermal patterning in vertebrate embryos.
Dev Biol.
1997;
182(1):
5-20.
De Robertis EM Evolutionary biology. The ancestry of segmentation.
Nature.
1997;
387(6628):
25-6.
De Robertis EM, Kim S, Leyns L, Piccolo S, Bachiller D, Agius E, Belo JA, Yamamoto A, Hainski-Brousseau A, Brizuela B, Wessely O, Lu B, Bouwmeester T Patterning by genes expressed in Spemann's organizer.
Cold Spring Harb Symp Quant Biol.
1997;
62:
169-75.
Guenet JL, Simon-Chazottes D, de Robertis E, Blum M The mouse goosecoid gene (Gsc) maps to the telomeric part of mouse chromosome 12.
Mamm Genome.
1995;
6(11):
816-7.
Schulte-Merker S, Hammerschmidt M, Beuchle D, Cho KW, De Robertis EM, Nusslein-Volhard C Expression of zebrafish goosecoid and no tail gene products in wild-type and mutant no tail embryos.
Development.
1994;
120(4):
843-52.
Niehrs C, Steinbeisser H, De Robertis EM Mesodermal patterning by a gradient of the vertebrate homeobox gene goosecoid.
Science.
1994;
263(5148):
817-20.
Fainsod A, Steinbeisser H, De Robertis EM On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo.
Embo J.
1994;
13(21):
5015-25.
De Robertis EM, Fainsod A, Gont LK, Steinbeisser H The evolution of vertebrate gastrulation.
Dev Suppl.
1994;
117-24.
Gaunt SJ, Blum M, De Robertis EM Expression of the mouse goosecoid gene during mid-embryogenesis may mark mesenchymal cell lineages in the developing head, limbs and body wall.
Development.
1993;
117(2):
769-78.
Gont LK, Steinbeisser H, Blumberg B, de Robertis EM Tail formation as a continuation of gastrulation: the multiple cell populations of the Xenopus tailbud derive from the late blastopore lip.
Development.
1993;
119(4):
991-1004.
Izpisua-Belmonte JC, De Robertis EM, Storey KG, Stern CD The homeobox gene goosecoid and the origin of organizer cells in the early chick blastoderm.
Cell.
1993;
74(4):
645-59.
Steinbeisser H, De Robertis EM Xenopus goosecoid: a gene expressed in the prechordal plate that has dorsalizing activity.
C R Acad Sci III.
1993;
316(9):
959-71.
De Robertis EM, Oliver G, Wright CV Homeobox genes and the vertebrate body plan.
Sci Am.
1990;
263(1):
46-52.
Wright CV, Schnegelsberg P, De Robertis EM XlHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm.
Development.
1989;
105(4):
787-94.
Oliver G, Wright CV, Hardwicke J, De Robertis EM Differential antero-posterior expression of two proteins encoded by a homeobox gene in Xenopus and mouse embryos.
Embo J.
1988;
7(10):
3199-209.
De Robertis EM, Burglin TR, Fritz A, Oliver G, Cho K, Wright CV Sequence conservations in vertebrate homeo-box mRNAs.
Arch Biol Med Exp (Santiago).
1988;
21(3-4):
443-7.
Mattaj IW, Coppard NJ, Brown RS, Clark BF, De Robertis EM 42S p48--the most abundant protein in previtellogenic Xenopus oocytes--resembles elongation factor 1 alpha structurally and functionally.
Embo J.
1987;
6(8):
2409-13.
Wright CV, Cho KW, Fritz A, Burglin TR, De Robertis EM A Xenopus laevis gene encodes both homeobox-containing and homeobox-less transcripts.
Embo J.
1987;
6(13):
4083-94.
Burglin TR, De Robertis EM The nuclear migration signal of Xenopus laevis nucleoplasmin.
Embo J.
1987;
6(9):
2617-25.
Burglin TR, Wright CV, De Robertis EM Translational control in homoeobox mRNAs?.
Nature.
1987;
330(6150):
701-2.
Newmeyer DD, Lucocq JM, Burglin TR, De Robertis EM Assembly in vitro of nuclei active in nuclear protein transport: ATP is required for nucleoplasmin accumulation.
Embo J.
1986;
5(3):
501-10.
Mattaj IW, Lienhard S, Jiricny J, De Robertis EM An enhancer-like sequence within the Xenopus U2 gene promoter facilitates the formation of stable transcription complexes..
Nature. .
1985;
316(6024):
163-7.
Carrasco AE, McGinnis W, Gehring WJ, De Robertis EM Cloning of an X. laevis gene expressed during early embryogenesis coding for a peptide region homologous to Drosophila homeotic genes.
Cell.
1984;
37(2):
409-14.
Shepherd JC, McGinnis W, Carrasco AE, De Robertis EM, Gehring WJ Fly and frog homoeo domains show homologies with yeast mating type regulatory proteins..
Nature. .
1984;
310(5972):
70-1.
Nishikura K, Kurjan J, Hall BD, De Robertis EM Genetic analysis of the processing of a spliced tRNA.
Embo J.
1982;
1(2):
263-8.
Melton DA, Cortese R, de Robertis EM, Trendelenburg MF, Gurdon JB Gene injection into amphibian oocytes.
Results Probl Cell Differ.
1980;
11:
8-14.
De Robertis EM, Gurdon JB Gene transplantation and the analysis of development.
Sci Am.
1979;
241(6):
74-82.
Gurdon JB, Melton DA, De Robertis EM Genetics in an oocyte.
Ciba Found Symp.
1979;
(66):
63-80.
De Robertis EM, Gurdon JB, Partington GA, Mertz JE, Laskey RA Injected amphibian oocytes: a living test tube for the study of eukaryotic gene transcription?.
Biochemical Society symposium. .
1977;
(42):
181-91.
De Robertis EM, Jr. Judewicz ND, Torres HN Regulation of uracil uptake in Escherichia coli by adenosine 3',5'-monophosphate.
Biochim Biophys Acta.
1976;
426(3):
451-63.
Judewicz ND, De Robertis EM, Jr. Torres HN Control of uracil transport by cyclic AMP in E. coli.
FEBS Lett.
1974;
45(1):
155-8.
Vorwald-Denholtz, P.P. and De Robertis, E.M. Temporal pattern of the posterior expression of Wingless in Drosophila.
Gene Expr Patterns.
2011;
11:
456-463.
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Ploper Diego, Lee Hojoon X, De Robertis Edward M Dorsal-Ventral patterning: Crescent is a dorsally secreted Frizzled-related protein that competitively inhibits Tolloid proteases..
Developmental Biology.
2011;
352:
317-328.
Taelman Vincent F, Dobrowolski Radoslaw, Plouhinec Jean-Louis, Fuentealba Luis C, Vorwald Peggy P, Gumper Iwona, Sabatini David D, De Robertis Edward M Wnt signaling requires sequestration of glycogen synthase kinase 3
inside multivesicular endosomes..
Cell.
2010;
143(7):
1136-48.
Zakin Lise, Chang Ellen Y, Plouhinec Jean-Louis, De Robertis E M Crossveinless-2 is required for the relocalization of Chordin protein
within the vertebral field in mouse embryos..
Developmental biology.
2010;
347(1):
204-15.
Sander Veronika, Eivers Edward, Choi Renee H, De Robertis Edward M Drosophila Smad2 opposes Mad signaling during wing vein development..
PloS one.
2010;
5(4):
e10383.
De Robertis Edward M Wnt signaling in axial patterning and regeneration: lessons from
planaria..
Science signaling.
2010;
3(127):
pe21.
Tran Uyen, Zakin Lise, Schweickert Axel, Agrawal Raman, Döger Remziye, Blum Martin, De Robertis E M, Wessely Oliver The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity..
Development (Cambridge, England).
2010;
137(7):
1107-16.
Zakin Lise, De Robertis E M Extracellular regulation of BMP signaling..
Current biology : CB.
2010;
20(3):
R89-92.
Wessely O, Kim JI, Tran U, Fuentealba L, De Robertis EM xBtg-x regulates Wnt/beta-Catenin signaling during early Xenopus development..
Developmental biology. .
2005;
283(1):
17-28.
Kuroda H, Fuentealba L, Ikeda A, Reversade B, De Robertis EM Default neural induction: neuralization of dissociated Xenopus cells is mediated by Ras/MAPK activation..
Genes & development. .
2005;
19(9):
1022-7.
Unterseher F, Hefele JA, Giehl K, De Robertis EM, Wedlich D, Schambony A Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK.
Embo J.
2004;
23(16):
3259-69.
Wessely O, Kim JI, Geissert D, Tran U, De Robertis EM Analysis of Spemann organizer formation in Xenopus embryos by cDNA macroarrays..
Developmental biology. .
2004;
269(2):
552-66.
Kuroda H, Wessely O, De Robertis EM Neural induction in Xenopus: requirement for ectodermal and endomesodermal signals via Chordin, Noggin, beta-Catenin, and Cerberus..
PLoS biology. .
2004;
2(5):
E92.
Zakin L, De Robertis EM Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development..
Development (Cambridge, England) .
2004;
131(2):
413-24.
Pera EM, Ikeda A, Eivers E, De Robertis EM Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction..
Genes & development. .
2003;
17(24):
3023-8.
Bachiller D, Klingensmith J, Shneyder N, Tran U, Anderson R, Rossant J, De Robertis EM The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome..
Development (Cambridge, England) .
2003;
130(15):
3567-78.
Pera EM, Martinez SL, Flanagan JJ, Brechner M, Wessely O, De Robertis EM Darmin is a novel secreted protein expressed during endoderm development in Xenopus..
Gene expression patterns : GEP. .
2003;
3(2):
147-52.
Coffinier C, Ketpura N, Tran U, Geissert D, De Robertis EM Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling..
Mechanisms of development. .
2002;
119 Suppl 1:
S179-84.
Pera EM, Kim JI, Martinez SL, Brechner M, Li SY, Wessely O, De Robertis EM Isthmin is a novel secreted protein expressed as part of the Fgf-8 synexpression group in the Xenopus midbrain-hindbrain organizer..
Mechanisms of development. .
2002;
116(1-2):
169-72.
Wessely O, De Robertis EM Neural plate patterning by secreted signals..
Neuron. .
2002;
33(4):
489-91.
Pera EM, Wessely O, Li SY, De Robertis EM Neural and head induction by insulin-like growth factor signals..
Developmental cell. .
2001;
1(5):
655-65.
Pera EM, Wessely O, Li SY, De Robertis EM Neural and head induction by insulin-like growth factor signals..
Developmental cell. .
2001;
1(5):
655-65.
De Robertis EM, Bouwmeester T New twists on embryonic patterning. EMBO workshop: embryonic organizer signaling: the next frontiers..
EMBO reports. .
2001;
2(8):
661-5.
Wessely O, Tran U, Zakin L, De Robertis EM Identification and expression of the mammalian homologue of Bicaudal-C..
Mechanisms of development. .
2001;
101(1-2):
267-70.
Brizuela BJ, Wessely O, De Robertis EM Overexpression of the Xenopus tight-junction protein claudin causes randomization of the left-right body axis..
Developmental biology. .
2001;
230(2):
217-29.
Pera EM, De Robertis EM A direct screen for secreted proteins in Xenopus embryos identifies distinct activities for the Wnt antagonists Crescent and Frzb-1..
Mechanisms of development. .
2000;
96(2):
183-95.
Kim SH, Jen WC, De Robertis EM, Kintner C The protocadherin PAPC establishes segmental boundaries during somitogenesis in xenopus embryos..
Current biology : CB. .
2000;
10(14):
821-30.
Wessely O, De Robertis EM The Xenopus homologue of Bicaudal-C is a localized maternal mRNA that can induce endoderm formation..
Development (Cambridge, England) .
2000;
127(10):
2053-62.
Bachiller D, Klingensmith J, Kemp C, Belo JA, Anderson RM, May SR, McMahon JA, McMahon AP, Harland RM, Rossant J, De Robertis EM The organizer factors Chordin and Noggin are required for mouse forebrain development..
Nature. .
2000;
403(6770):
658-61.
Bachiller D, Klingensmith J, Kemp C, Belo JA, Anderson RM, May SR, McMahon JA, McMahon AP, Harland RM, Rossant J, De Robertis EM The organizer factors Chordin and Noggin are required for mouse forebrain development..
Nature. .
2000;
403(6770):
658-61.
Duprez D, Leyns L, Bonnin MA, Lapointe F, Etchevers H, De Robertis EM, Le Douarin N Expression of Frzb-1 during chick development..
Mechanisms of development. .
1999;
89(1-2):
179-83.
Zhu L, Belo JA, De Robertis EM, Stern CD Goosecoid regulates the neural inducing strength of the mouse node..
Developmental biology. .
1999;
216(1):
276-81.
Konishi Y, Tominaga M, Watanabe Y, Imamura F, Goldfarb A, Maki R, Blum M, De Robertis EM, Tominaga A GOOSECOID inhibits erythrocyte differentiation by competing with Rb for PU.1 binding in murine cells..
Oncogene. .
1999;
18(48):
6795-805.
Piccolo S, Agius E, Leyns L, Bhattacharyya S, Grunz H, Bouwmeester T, De Robertis EM The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals..
Nature. .
1999;
397(6721):
707-10.
Piccolo S, Agius E, Leyns L, Bhattacharyya S, Grunz H, Bouwmeester T, De Robertis EM The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals..
Nature. .
1999;
397(6721):
707-10.
Yamamoto A, Amacher SL, Kim SH, Geissert D, Kimmel CB, De Robertis EM Zebrafish paraxial protocadherin is a downstream target of spadetail involved in morphogenesis of gastrula mesoderm..
Development (Cambridge, England) .
1998;
125(17):
3389-97.
Belo JA, Leyns L, Yamada G, De Robertis EM The prechordal midline of the chondrocranium is defective in Goosecoid-1 mouse mutants..
Mechanisms of development. .
1998;
72(1-2):
15-25.
Pillemer G, Epstein M, Blumberg B, Yisraeli JK, De Robertis EM, Steinbeisser H, Fainsod A Nested expression and sequential downregulation of the Xenopus caudal genes along the anterior-posterior axis..
Mechanisms of development. .
1998;
71(1-2):
193-6.
Heanue TA, Johnson RL, Izpisua-Belmonte JC, Stern CD, De Robertis EM, Tabin CJ Goosecoid misexpression alters the morphology and Hox gene expression of the developing chick limb bud..
Mechanisms of development. .
1997;
69(1-2):
31-7.
Belo JA, Bouwmeester T, Leyns L, Kertesz N, Gallo M, Follettie M, De Robertis EM Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula..
Mechanisms of development. .
1997;
68(1-2):
45-57.
Piccolo S, Agius E, Lu B, Goodman S, Dale L, De Robertis EM Cleavage of Chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity..
Cell. .
1997;
91(3):
407-16.
Pfeffer PL, De Robertis EM, Izpisua-Belmonte JC Crescent, a novel chick gene encoding a Frizzled-like cysteine-rich domain, is expressed in anterior regions during early embryogenesis..
The International journal of developmental biology. .
1997;
41(3):
449-58.
Leyns L, Bouwmeester T, Kim SH, Piccolo S, De Robertis EM Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer..
Cell. .
1997;
88(6):
747-56.
Sasai Y, Lu B, Piccolo S, De Robertis EM Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps..
The EMBO journal. .
1996;
15(17):
4547-55.
Catala M, Teillet MA, De Robertis EM, Le Douarin ML A spinal cord fate map in the avian embryo: while regressing, Hensen's node lays down the notochord and floor plate thus joining the spinal cord lateral walls..
Development (Cambridge, England) .
1996;
122(9):
2599-610.
Piccolo S, Sasai Y, Lu B, De Robertis EM Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4..
Cell. .
1996;
86(4):
589-98.
Holley SA, Neul JL, Attisano L, Wrana JL, Sasai Y, O'Connor MB, De Robertis EM, Ferguson EL The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor..
Cell. .
1996;
86(4):
607-17.
Bouwmeester T, Kim S, Sasai Y, Lu B, De Robertis EM Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer..
Nature.
1996;
382(6592):
595-601.
De Robertis EM, Sasai Y A common plan for dorsoventral patterning in Bilateria..
Nature. .
1996;
380(6569):
37-40.
Gont LK, Fainsod A, Kim SH, De Robertis EM Overexpression of the homeobox gene Xnot-2 leads to notochord formation in Xenopus..
Developmental biology. .
1996;
174(1):
174-8.
Sasal Y, Lu B, Steinbelsser H, De Robertis EM Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus..
Nature. .
1995;
378(6555):
419.
Steinbeisser H, Fainsod A, Niehrs C, Sasai Y, De Robertis EM The role of gsc and BMP-4 in dorsal-ventral patterning of the marginal zone in Xenopus: a loss-of-function study using antisense RNA..
The EMBO journal. .
1995;
14(21):
5230-43.
Sasai Y, Lu B, Steinbeisser H, De Robertis EM Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus..
Nature. .
1995;
377(6551):
757.
Yamada G, Mansouri A, Torres M, Stuart ET, Blum M, Schultz M, De Robertis EM, Gruss P Targeted mutation of the murine goosecoid gene results in craniofacial defects and neonatal death..
Development (Cambridge, England) .
1995;
121(9):
2917-22.
Holley SA, Jackson PD, Sasai Y, Lu B, De Robertis EM, Hoffmann FM, Ferguson EL A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin..
Nature. .
1995;
376(6537):
249-53.
De Robertis EM Developmental biology. Dismantling the organizer..
Nature. .
1995;
374(6521):
407-8.
Sasai Y, Lu B, Steinbeisser H, Geissert D, Gont LK, De Robertis EM Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes..
Cell. .
1994;
79(5):
779-90.
Blum M, De Robertis EM, Kojis T, Heinzmann C, Klisak I, Geissert D, Sparkes RS Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32.1..
Genomics. .
1994;
21(2):
388-93.
Pfeffer PL, De Robertis EM Regional specificity of RAR gamma isoforms in Xenopus development..
Mechanisms of development. .
1994;
45(2):
147-53.
Steinbeisser H, De Robertis EM, Ku M, Kessler DS, Melton DA Xenopus axis formation: induction of goosecoid by injected Xwnt-8 and activin mRNAs..
Development (Cambridge, England) .
1993;
118(2):
499-507.
Niehrs C, Keller R, Cho KW, De Robertis EM The homeobox gene goosecoid controls cell migration in Xenopus embryos..
Cell. .
1993;
72(4):
491-503.
Jegalian BG, De Robertis EM Homeotic transformations in the mouse induced by overexpression of a human Hox3.3 transgene..
Cell. .
1992;
71(6):
901-10.
Jegalian BG, Miller RW, Wright CV, Blum M, De Robertis EM A Hox 3.3-lacZ transgene expressed in developing limbs..
Mechanisms of development. .
1992;
39(3):
171-80.
Blum M, Gaunt SJ, Cho KW, Steinbeisser H, Blumberg B, Bittner D, De Robertis EM Gastrulation in the mouse: the role of the homeobox gene goosecoid..
Cell. .
1992;
69(7):
1097-106.
Storey KG, Crossley JM, De Robertis EM, Norris WE, Stern CD Neural induction and regionalisation in the chick embryo..
Development (Cambridge, England) .
1992;
114(3):
729-41.
Cho KW, Blumberg B, Steinbeisser H, De Robertis EM Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid..
Cell. .
1991;
67(6):
1111-20.
Niehrs C, De Robertis EM Ectopic expression of a homeobox gene changes cell fate in Xenopus embryos in a position-specific manner..
The EMBO journal. .
1991;
10(12):
3621-9.
Blumberg B, Wright CV, De Robertis EM, Cho KW Organizer-specific homeobox genes in Xenopus laevis embryos..
Science. .
1991;
253(5016):
194-6.
Cho KW, Morita EA, Wright CV, De Robertis EM Overexpression of a homeodomain protein confers axis-forming activity to uncommitted Xenopus embryonic cells..
Cell. .
1991;
65(1):
55-64.
Chuong CM, Oliver G, Ting SA, Jegalian BG, Chen HM, De Robertis EM Gradients of homeoproteins in developing feather buds..
Development (Cambridge, England) .
1990;
110(4):
1021-30.
Cho KW, De Robertis EM Differential activation of Xenopus homeo box genes by mesoderm-inducing growth factors and retinoic acid..
Genes & development. .
1990;
4(11):
1910-6.
Oliver G, De Robertis EM, Wolpert L, Tickle C Expression of a homeobox gene in the chick wing bud following application of retinoic acid and grafts of polarizing region tissue..
The EMBO journal. .
1990;
9(10):
3093-9.
Livingston BD, De Robertis EM, Paulson JC Expression of beta-galactoside alpha 2,6 sialyltransferase blocks synthesis of polysialic acid in Xenopus embryos..
Glycobiology. .
1990;
1(1):
39-44.
Molven A, Wright CV, Bremiller R, De Robertis EM, Kimmel CB Expression of a homeobox gene product in normal and mutant zebrafish embryos: evolution of the tetrapod body plan..
Development (Cambridge, England) .
1990;
109(2):
279-88.
Wright CV, Morita EA, Wilkin DJ, De Robertis EM The Xenopus XIHbox 6 homeo protein, a marker of posterior neural induction, is expressed in proliferating neurons..
Development (Cambridge, England) .
1990;
109(1):
225-34.
Wright CV, Cho KW, Hardwicke J, Collins RH, De Robertis EM Interference with function of a homeobox gene in Xenopus embryos produces malformations of the anterior spinal cord..
Cell. .
1989;
59(1):
81-93.
Oliver G, Sidell N, Fiske W, Heinzmann C, Mohandas T, Sparkes RS, De Robertis EM Complementary homeo protein gradients in developing limb buds..
Genes & development. .
1989;
3(5):
641-50.
De Robertis EM, Oliver G, Wright CV Determination of axial polarity in the vertebrate embryo: homeodomain proteins and homeogenetic induction..
Cell. .
1989;
57(2):
189-91.
Fritz AF, Cho KW, Wright CV, Jegalian BG, De Robertis EM Duplicated homeobox genes in Xenopus..
Developmental biology. .
1989;
131(2):
584-8.
Wright CV, Cho KW, Oliver G, De Robertis EM Vertebrate homeodomain proteins: families of region-specific transcription factors..
Trends in biochemical sciences. .
1989;
14(2):
52-6.
Oliver G, Wright CV, Hardwicke J, De Robertis EM A gradient of homeodomain protein in developing forelimbs of Xenopus and mouse embryos..
Cell. .
1988;
55(6):
1017-24.
Fritz AF, Martin G, Wright CV, De Robertis EM Site-specific inversions in repeated Xenopus laevis homeobox gene 2 sequences..
Nucleic acids research. .
1988;
16(18):
9058.
Cho KW, Goetz J, Wright CV, Fritz A, Hardwicke J, De Robertis EM Differential utilization of the same reading frame in a Xenopus homeobox gene encodes two related proteins sharing the same DNA-binding specificity..
The EMBO journal. .
1988;
7(7):
2139-49.
Fritz A, De Robertis EM Xenopus homeobox-containing cDNAs expressed in early development..
Nucleic acids research. .
1988;
16(4):
1453-69.
Sharpe CR, Fritz A, De Robertis EM, Gurdon JB A homeobox-containing marker of posterior neural differentiation shows the importance of predetermination in neural induction..
Cell. .
1987;
50(5):
749-58.
Mattaj IW, De Robertis EM Nuclear segregation of U2 snRNA requires binding of specific snRNP proteins..
Cell. .
1985;
40(1):
111-8.
Fritz A, Parisot R, Newmeyer D, De Robertis EM Small nuclear U-ribonucleoproteins in Xenopus laevis development. Uncoupled accumulation of the protein and RNA components..
Journal of molecular biology. .
1984;
178(2):
273-85.
Zeller R, Carri MT, Mattaj IW, De Robertis EM Xenopus laevis U1 snRNA genes: characterisation of transcriptionally active genes reveals major and minor repeated gene families..
The EMBO journal. .
1984;
3(5):
1075-81.
Zeller R, Nyffenegger T, De Robertis EM Nucleocytoplasmic distribution of snRNPs and stockpiled snRNA-binding proteins during oogenesis and early development in Xenopus laevis..
Cell. .
1983;
32(2):
425-34.
Matter L, Schopfer K, Wilhelm JA, Nyffenegger T, Parisot RF, De Robertis EM Molecular characterization of ribonucleoprotein antigens bound by antinuclear antibodies. A diagnostic evaluation..
Arthritis and rheumatism. .
1982;
25(11):
1278-83.
De Robertis EM, Lienhard S, Parisot RF Intracellular transport of microinjected 5S and small nuclear RNAs..
Nature. .
1982;
295(5850):
572-7.
Nishikura K, De Robertis EM RNA processing in microinjected Xenopus oocytes. Sequential addition of base modifications in the spliced transfer RNA..
Journal of molecular biology. .
1981;
145(2):
405-20.
De Robertis EM, Black P, Nishikura K Intranuclear location of the tRNA splicing enzymes..
Cell. .
1981;
23(1):
89-93.
Mills AD, Laskey RA, Black P, De Robertis EM An acidic protein which assembles nucleosomes in vitro is the most abundant protein in Xenopus oocyte nuclei..
Journal of molecular biology. .
1980;
139(3):
561-8.
Melton DA, De Robertis EM, Cortese R Order and intracellular location of the events involved in the maturation of a spliced tRNA..
Nature. .
1980;
284(5752):
143-8.
De Robertis EM, Olson MV Transcription and processing of cloned yeast tyrosine tRNA genes microinjected into frog oocytes..
Nature. .
1979;
278(5700):
137-43.
de Robertis EM, Black P Hybrids of Xenopus laevis and Xenopus borealis express proteins from both parents..
Developmental biology. .
1979;
68(1):
334-9.
De Robertis EM, Longthorne RF, Gurdon JB Intracellular migration of nuclear proteins in Xenopus oocytes..
Nature. .
1978;
272(5650):
254-6.
De Robertis EM, Mertz JE Coupled transcription-translation of DNA injected into Xenopus oocytes..
Cell. .
1977;
12(1):
175-82.
Gurdon JB, De Robertis EM, Partington G Injected nuclei in frog oocytes provide a living cell system for the study of transcriptional control.
Nature.
1976;
260(5547):
116-20.
De Robertis EM, Ezcurra PM, Judewicz ND, Pucci PR, Torres HN Inhibition of E. coli RNA polymerase by polyadenylic acid..
FEBS Lett.
1972;
25(1):
175-178.
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