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RESEARCH
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Guoping Fan, Ph.D.
Contact Information:
Work Phone Number:
(310) 267-0438 Lab
(310) 267-0439 Office
Work Address:
Office 695 Charles Young Drive South UCLA Los Angeles, CA 90095 UNITED STATES
Room 6357C, Gonda Building Campus - 708822 CA UNITED STATES
Laboratory 695 Charles Young Drive South UCLA Los Angeles, CA 90095 UNITED STATES
Professor,
Human Genetics
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Member,
ACCESS Program: Dept. of Human Genetics
JCCC Gene Regulation Program Area
Neuroscience IDP
Brain Research Institute
Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research
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Faculty,
Molecular Biology IDP
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Detailed Biography:
Guoping Fan is a Professor in the Department of Human Genetics, David Geffen School of Medicine at UCLA. He has been a faculty member at UCLA since 2001. Pior to that, he was a postdoctoral fellow at the Whitehead Institute for Biomedical Institute/MIT, where he studies the role of DNA methylation and neurotrophins in neural development. Dr. Fan earned his B.S. in Biochemistry at Nanjing University, China and Ph.D. in Neuroscience at Case Western Reserve University. His current research focuses on the actions of DNA methylation and chromatin-remodeling in regulating neural gene expression, neuronal function, and stem cell differentiation and reprogramming.
Shen, Y., Matsuno, Y., Fouse, S., Rao, N., Root, S., Xu, R.H., Pellegrini, Riggs, A., Fan, G. X-inactivation in female human embryonic stem cells is in a non-random pattern and prone to epigenetic alterations. .
Proc. Natl. Acad. Sci. USA
2008;
105(12):
4709-4714.
Golshani, P., Hutnick, L., Schweizer, F., Fan, G. Conditional Dnmt1 deletion in dorsal forebrain disrupts development of somatosensory barrel cortex and thalamocortical long-term potentiation.
Thalamus and Related System .
2007;
Published online in March 2007:
.
Feng, J., Fouse, S., Fan, G. Epigenetic regulation of neural gene expression and neuronal function.
Pediatric Research.
2007;
61 (5 Pt 2):
58R-63R.
He F, Ge W, Zhu W, Becker-Catania S, Martinowich K, Wu H, Coskun V, Fan G, deVellis J, Sun Y A positive autoregulation loop of JAK-STAT signaling is part of the clock mechanism regulating astrogliogenesis..
Nature Neuroscience
2005;
8:
616-625.
Lyckman AW, Fan G, Rios M, Jaenisch R, Sur M Normal eye-specific patterning of retinal inputs to murine subcortical visual nuclei in the absence of brain-derived neurotrophic factor..
Visual neuroscience. .
2005;
22(1):
27-36.
Fan G, Copray S, Wong E, Yan Q, Jones K, Walro J, Jaenisch R, Kucera J Formation of the cranial proprioceptive system requires multiple neurotrophins..
Developmental Dynamics
2000;
218:
359-370.
Endres M, Fan G (equal contribution), Hirt L, Fujji M, Liu X, Jaenisch R, Moskowitz MA Ischemic brain damage after selectively modifying BDNF or NT-4 expression in vivo..
J. Cereb.Blood Flow. Metab.
2000;
20:
139-144.
Fan G, Jaenisch R, Kucera J A role for p75 receptor in NT3 functioning during the development of limb proprioception..
Neuroscience
1999;
90:
259-268.
Fan Guoping, Tran Jamie X chromosome inactivation in human and mouse pluripotent stem cells..
Human genetics.
2011;
130(2):
217-22.
Huang Kevin, Fan Guoping Epigenetic modifications in distinction: histone versus DNA
methylation in ESCs..
Cell stem cell.
2011;
8(6):
604-5.
Wang Anyou, Huang Kevin, Shen Yin, Xue Zhigang, Cai Chaochao, Horvath Steve, Fan Guoping Functional Modules Distinguish Human Induced Pluripotent Stem Cells
from Embryonic Stem Cells..
Stem cells and development.
2011;
130(2):
.
Le Thuc, Kim Kee-Pyo, Fan Guoping, Faull Kym F A sensitive mass spectrometry method for simultaneous quantification
of DNA methylation and hydroxymethylation levels in biological
samples..
Analytical biochemistry.
2011;
412(2):
203-9.
Dhawan Sangeeta, Georgia Senta, Tschen Shuen-Ing, Fan Guoping, Bhushan Anil Pancreatic β cell identity is maintained by DNA methylation-mediated
repression of Arx..
Developmental cell.
2011;
20(4):
419-29.
Biswas Anuradha, Joo Kye-Il, Liu Jing, Zhao Muxun, Fan Guoping, Wang Pin, Gu Zhen, Tang Yi Endoprotease-mediated intracellular protein delivery using
nanocapsules..
ACS nano.
2011;
5(2):
1385-94.
Liu Bin, Tahk Samuel, Yee Kathleen M, Fan Guoping, Shuai Ke The ligase PIAS1 restricts natural regulatory T cell differentiation
by epigenetic repression..
Science (New York, N.Y.).
2010;
330(6003):
521-5.
Huang Kevin, Fan Guoping DNA methylation in cell differentiation and reprogramming: an emerging
systematic view..
Regenerative medicine.
2010;
5(4):
531-44.
Hutnick Leah K, Huang Xinhua, Loo Tao-Chuan, Ma Zhicheng, Fan Guoping Repression of retrotransposal elements in mouse embryonic stem cells
is primarily mediated by a DNA methylation-independent mechanism..
The Journal of biological chemistry.
2010;
285(27):
21082-91.
Dvash Tamar, Lavon Neta, Fan Guoping Variations of X chromosome inactivation occur in early passages of
female human embryonic stem cells..
PloS one.
2010;
5(6):
e11330.
Tamar Dvash, Neta Lavon, Guoping Fan Variations of X Chromosome Inactivation Occur in Early Passages of Female Human Embryonic Stem Cells.
PLOS ONE
2010;
5(6):
e11330.
Download
Feng Jian, Zhou Yu, Campbell Susan L, Le Thuc, Li En, Sweatt J David, Silva Alcino J, Fan Guoping Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic
function in adult forebrain neurons..
Nature neuroscience.
2010;
13(4):
423-30.
Zhong Jin, Chan Albert, Morad Leeron, Kornblum Harley I, Fan Guoping, Carmichael S Thomas Hydrogel Matrix to Support Stem Cell Survival After Brain
Transplantation in Stroke..
Neurorehabilitation and neural repair.
2010;
285(27):
.
Fan Zhipeng, Yamaza Takayoshi, Lee Janice S, Yu Jinhua, Wang Songlin, Fan Guoping, Shi Songtao, Wang Cun-Yu BCOR regulates mesenchymal stem cell function by epigenetic
mechanisms..
Nature cell biology.
2009;
11(8):
1002-9.
Hutnick Leah K, Golshani Peyman, Namihira Masakasu, Xue Zhigang, Matynia Anna, Yang X William, Silva Alcino J, Schweizer Felix E, Fan Guoping DNA hypomethylation restricted to the murine forebrain induces
cortical degeneration and impairs postnatal neuronal maturation..
Human molecular genetics.
2009;
18(15):
2875-88.
Mason Mike J, Fan Guoping, Plath Kathrin, Zhou Qing, Horvath Steve Signed weighted gene co-expression network analysis of transcriptional
regulation in murine embryonic stem cells..
BMC genomics.
2009;
10(8):
327.
Fouse, S., Shen, Y., Pellegrini, M., Cole, S., Meissner, A., Van Neste, L., Jaenisch, R., Fan, G. Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation..
Cell Stem Cell
2008;
2(2):
160-169.
Download
Shen Y, Chow J, Wang Z, FanG Abnormal CpG island methylation occurs during in vitro differentiation of human embryonic stem cells. .
Human Molecular Genetics.
2006;
15(17):
2623-2635.
Download
Fan G, Martinowich K, Chin MH, He F, Fouse SD, Hutnick L, Hattori D, Ge W, Shen Y, Wu H, ten Hoeve J, Shuai K, Sun YE DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling..
Development (Cambridge, England) .
2005;
132(15):
3345-56.
Fan G, Hutnick L Methyl-CpG binding proteins in the nervous system..
Cell research. .
2005;
15(4):
255-61.
Feng J, Chang H, Li E, Fan G Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system.
J Neurosci Res.
2005;
79:
734-746 (Cover art).
Martinowich K, Hattori D, Wu H, Fouse S, He F, Hu Y, Fan G, Sun YE DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation..
Science. .
2003;
302(5646):
890-3.
Ge W, Martinowich K, Wu X, He F, Miyamoto A, Fan G, Weinmaster G, Sun YE Notch signaling promotes astrogliogenesis via direct CSL-mediated glial gene activation..
Journal of neuroscience research. .
2002;
69(6):
848-60.
Sun Y, Nadal-Vicens M, Misono S, Lin MZ, Zubiaga A, Hua X, Fan G, Greenberg ME Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms..
Cell. .
2001;
104(3):
365-76.
Fan G, Beard C, Chen RZ, Csankovszki G, Sun Y, Siniaia M, Biniszkiewicz D, Bates B, Lee PP, Kuhn R, Trumpp A, Poon C, Wilson CB, Jaenisch R DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals..
The Journal of neuroscience : the official journal of the Society for Neuroscience. .
2001;
21(3):
788-97.
Fan G, Egles C, Sun Y, Minichiello L, Renger JJ, Klein R, Liu G, Jaenisch R Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activities..
Nature neuroscience. .
2000;
3(4):
350-7.
Fan G, Xiao L, Cheng L, Wang X, Sun B, Hu G Targeted disruption of NDST-1 gene leads to pulmonary hypoplasia and neonatal respiratory distress in mice..
FEBS letters. .
2000;
467(1):
7-11.
Bates B, Rios M, Trumpp A, Chen C, Fan G, Bishop JM, Jaenisch R Neurotrophin-3 is required for proper cerebellar development..
Nature neuroscience. .
1999;
2(2):
115-7.
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