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RESEARCH
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Steve Horvath, Ph.D., Sc.D.
Contact Information:
Work Phone Number:
(310) 825-9299
Laboratory Address:
Gonda 4545 UNITED STATES
Mailing Address:
Department of Human Genetics Gonda Research Center David Geffen School of Medicine 695 Charles E. Young Drive South Box 708822 Los Angeles, CA 90095 UNITED STATES
Work Address:
Gonda 4357A Campus - 708822 CA UNITED STATES
Office Gonda Los Angeles, CA 90095 UNITED STATES
Laboratory Gonda Los Angeles, CA 90095 UNITED STATES
Associate Professor,
Biostatistics
UCLA Program on Genomics and Nutrition
Human Genetics
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Member,
ACCESS Affinity - Bioinformatics
ACCESS Program: Dept. of Human Genetics
JCCC Genitourinary Oncology Program Area
JCCC Molecular Epidemiology Program Area
ACCESS Program
CTSI
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Faculty,
Bioinformatics IDP
BWF-IT-MD
Center for Metabolic Disease Prevention
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Investigator,
Biostatistics, Study Design, and Clinical Data Management Program (BSD-CDM)
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Detailed Biography:
Steve Horvath is a Professor in Human Genetics and Biostatistics at UCLA. He develops statistical and bioinformatics methods. Research interests include a) gene networks, systems biology, b) allelic association tests, and c) data mining methods. A major focus of his lab is the development of statistical methods for gene co-expression network analysis.
Langfelder Peter, Castellani Lawrence W, Zhou Zhiqiang, Paul Eric, Davis Richard, Schadt Eric E, Lusis Aldons J, Horvath Steve, Mehrabian Margarete A systems genetic analysis of high density lipoprotein metabolism and
network preservation across mouse models..
Biochimica et biophysica acta.
2011;
76(9):
.
Presson Angela P, Yoon Nam K, Bagryanova Lora, Mah Vei, Alavi Mohammad, Maresh Erin L, Rajasekaran Ayyappan K, Goodglick Lee, Chia David, Horvath Steve Protein expression based multimarker analysis of breast cancer
samples..
BMC cancer.
2011;
11(9):
230.
Voineagu Irina, Wang Xinchen, Johnston Patrick, Lowe Jennifer K, Tian Yuan, Horvath Steve, Mill Jonathan, Cantor Rita M, Blencowe Benjamin J, Geschwind Daniel H Transcriptomic analysis of autistic brain reveals convergent molecular
pathology..
Nature.
2011;
474(7351):
380-4.
Mah Vei, Marquez Diana, Alavi Mohammad, Maresh Erin L, Zhang Li, Yoon Nam, Horvath Steve, Bagryanova Lora, Fishbein Michael C, Chia David, Pietras Richard, Goodglick Lee Expression levels of estrogen receptor beta in conjunction with
aromatase predict survival in non-small cell lung cancer..
Lung cancer (Amsterdam, Netherlands).
2011;
474(7351):
.
Park Christopher C, Gale Greg D, de Jong Simone, Ghazalpour Anatole, Bennett Brian J, Farber Charles R, Langfelder Peter, Lin Andy, Khan Arshad H, Eskin Eleazar, Horvath Steve, Lusis Aldons J, Ophoff Roel A, Smith Desmond J Gene networks associated with conditional fear in mice identified
using a systems genetics approach..
BMC systems biology.
2011;
5(7351):
43.
Yoon Nam K, Maresh Erin L, Shen Dejun, Elshimali Yahya, Apple Sophia, Horvath Steve, Mah Vei, Bose Shikha, Chia David, Chang Helena R, Goodglick Lee Higher levels of GATA3 predict better survival in women with breast
cancer..
Human pathology.
2010;
41(12):
1794-801.
Cai Chaochao, Langfelder Peter, Fuller Tova F, Oldham Michael C, Luo Rui, van den Berg Leonard H, Ophoff Roel A, Horvath Steve Is human blood a good surrogate for brain tissue in transcriptional
studies?.
BMC genomics.
2010;
11(12):
589.
Mumford Jeanette A, Horvath Steve, Oldham Michael C, Langfelder Peter, Geschwind Daniel H, Poldrack Russell A Detecting network modules in fMRI time series: a weighted network
analysis approach..
NeuroImage.
2010;
52(4):
1465-76.
Habeeb Omar, Goodglick Lee, Soslow Robert A, Rao Rajiv G, Gordon Lynn K, Schirripa Osvaldo, Horvath Steve, Braun Jonathan, Seligson David B, Wadehra Madhuri Epithelial membrane protein-2 expression is an early predictor of
endometrial cancer development..
Cancer.
2010;
116(20):
4718-26.
Ooi Aik T, Mah Vei, Nickerson Derek W, Gilbert Jennifer L, Ha Vi Luan, Hegab Ahmed E, Horvath Steve, Alavi Mohammad, Maresh Erin L, Chia David, Gower Adam C, Lenburg Marc E, Spira Avrum, Solis Luisa M, Wistuba Ignacio I, Walser Tonya C, Wallace William D, Dubinett Steven M, Goodglick Lee, Gomperts Brigitte N Presence of a putative tumor-initiating progenitor cell population
predicts poor prognosis in smokers with non-small cell lung cancer..
Cancer research.
2010;
70(16):
6639-48.
Yoon Nam K, Maresh Erin L, Elshimali Yahya, Li Ai, Horvath Steve, Seligson David B, Chia David, Goodglick Lee Elevated MED28 expression predicts poor outcome in women with breast
cancer..
BMC cancer.
2010;
10(28):
335.
Le Brandon H, Cheng Chen, Bui Anhthu Q, Wagmaister Javier A, Henry Kelli F, Pelletier Julie, Kwong Linda, Belmonte Mark, Kirkbride Ryan, Horvath Steve, Drews Gary N, Fischer Robert L, Okamuro Jack K, Harada John J, Goldberg Robert B Global analysis of gene activity during Arabidopsis seed development
and identification of seed-specific transcription factors..
Proceedings of the National Academy of Sciences of the United States of America.
2010;
107(18):
8063-70.
Manuyakorn Ananya, Paulus Rebecca, Farrell James, Dawson Nicole A, Tze Sheila, Cheung-Lau Gardenia, Hines Oscar Joe, Reber Howard, Seligson David B, Horvath Steve, Kurdistani Siavash K, Guha Chandhan, Dawson David W Cellular histone modification patterns predict prognosis and treatment
response in resectable pancreatic adenocarcinoma: results from RTOG
9704..
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2010;
28(8):
1358-65.
de Jong Simone, Fuller Tova F, Janson Esther, Strengman Eric, Horvath Steve, Kas Martien J H, Ophoff Roel A Gene expression profiling in C57BL/6J and A/J mouse inbred strains
reveals gene networks specific for brain regions independent of
genetic background..
BMC genomics.
2010;
11(8):
20.
Maresh Erin L, Mah Vei, Alavi Mohammad, Horvath Steve, Bagryanova Lora, Liebeskind Emily S, Knutzen Laura A, Zhou Yong, Chia David, Liu Alvin Y, Goodglick Lee Differential expression of anterior gradient gene AGR2 in prostate
cancer..
BMC cancer.
2010;
10(6):
680.
Plaisier Christopher L, Horvath Steve, Huertas-Vazquez Adriana, Cruz-Bautista Ivette, Herrera Miguel F, Tusie-Luna Teresa, Aguilar-Salinas Carlos, Pajukanta Päivi A systems genetics approach implicates USF1, FADS3, and other causal
candidate genes for familial combined hyperlipidemia..
PLoS genetics.
2009;
5(9):
e1000642.
Kurian Sunil M, Heilman Raymond, Mondala Tony S, Nakorchevsky Aleksey, Hewel Johannes A, Campbell Daniel, Robison Elizabeth H, Wang Lin, Lin Wen, Gaber Lillian, Solez Kim, Shidban Hamid, Mendez Robert, Schaffer Randolph L, Fisher Jonathan S, Flechner Stuart M, Head Steve R, Horvath Steve, Yates John R, Marsh Christopher L, Salomon Daniel R Biomarkers for early and late stage chronic allograft nephropathy by
proteogenomic profiling of peripheral blood..
PloS one.
2009;
4(7):
e6212.
Kleefuss-Lie Ailing, Friedl Waltraut, Cichon Sven, Haug Karsten, Warnstedt Maike, Alekov Alexi, Sander Thomas, Ramirez Alfredo, Poser Barbara, Maljevic Snezana, Hebeisen Simon, Kubisch Christian, Rebstock Johannes, Horvath Steve, Hallmann Kerstin, Dullinger Jörn S, Rau Birgit, Haverkamp Fritz, Beyenburg Stefan, Schulz Herbert, Janz Dieter, Giese Bernd, Müller-Newen Gerhard, Propping Peter, Elger Christian E, Fahlke Christoph, Lerche Holger CLCN2 variants in idiopathic generalized epilepsy..
Nature genetics.
2009;
41(9):
954-5.
Li Ai, Horvath Steve Network module detection: Affinity search technique with the
multi-node topological overlap measure..
BMC research notes.
2009;
2(9):
142.
Haug Karsten, Warnstedt Maike, Alekov Alexi K, Sander Thomas, Ramírez Alfredo, Poser Barbara, Maljevic Snezana, Hebeisen Simon, Kubisch Christian, Rebstock Johannes, Horvath Steve, Hallmann Kerstin, Dullinger Joern S, Rau Birgit, Haverkamp Fritz, Beyenburg Stefan, Schulz Herbert, Janz Dieter, Giese Bernd, Müller-Newen Gerhard, Propping Peter, Elger Christian E, Fahlke Christoph, Lerche Holger Retraction: Mutations in CLCN2 encoding a voltage-gated chloride
channel are associated with idiopathic generalized epilepsies..
Nature genetics.
2009;
41(9):
1043.
Mason Mike J, Fan Guoping, Plath Kathrin, Zhou Qing, Horvath Steve Signed weighted gene co-expression network analysis of transcriptional
regulation in murine embryonic stem cells..
BMC genomics.
2009;
10(9):
327.
Saris Christiaan G J, Horvath Steve, van Vught Paul W J, van Es Michael A, Blauw Hylke M, Fuller Tova F, Langfelder Peter, DeYoung Joseph, Wokke John H J, Veldink Jan H, van den Berg Leonard H, Ophoff Roel A Weighted gene co-expression network analysis of the peripheral blood
from Amyotrophic Lateral Sclerosis patients..
BMC genomics.
2009;
10(9):
405.
Farber Charles R, Aten Jason E, Farber Emily A, de Vera Vincent, Gularte Rodrigo, Islas-Trejo Alma, Wen Pengzi, Horvath Steve, Lucero Michael, Lusis Aldons J, Medrano Juan F Genetic dissection of a major mouse obesity QTL (Carfhg2): integration
of gene expression and causality modeling..
Physiological genomics.
2009;
37(3):
294-302.
Seligson David B, Horvath Steve, McBrian Matthew A, Mah Vei, Yu Hong, Tze Sheila, Wang Qun, Chia David, Goodglick Lee, Kurdistani Siavash K Global levels of histone modifications predict prognosis in different
cancers..
The American journal of pathology.
2009;
174(5):
1619-28.
Laks Dan R, Masterman-Smith Michael, Visnyei Koppany, Angenieux Brigitte, Orozco Nicholas M, Foran Ian, Yong William H, Vinters Harry V, Liau Linda M, Lazareff Jorge A, Mischel Paul S, Cloughesy Timothy F, Horvath Steve, Kornblum Harley I Neurosphere formation is an independent predictor of clinical outcome
in malignant glioma..
Stem cells (Dayton, Ohio).
2009;
27(4):
980-7.
Guo Deliang, Prins Robert M, Dang Julie, Kuga Daisuke, Iwanami Akio, Soto Horacio, Lin Kelly Y, Huang Tiffany T, Akhavan David, Hock M Benjamin, Zhu Shaojun, Kofman Ava A, Bensinger Steve J, Yong William H, Vinters Harry V, Horvath Steve, Watson Andrew D, Kuhn John G, Robins H Ian, Mehta Minesh P, Wen Patrick Y, DeAngelis Lisa M, Prados Michael D, Mellinghoff Ingo K, Cloughesy Timothy F, Mischel Paul S EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant
pathway sensitizes glioblastomas to antilipogenic therapy..
Science signaling.
2009;
2(101):
ra82.
van Nas Atila, Guhathakurta Debraj, Wang Susanna S, Yehya Nadir, Horvath Steve, Zhang Bin, Ingram-Drake Leslie, Chaudhuri Gautam, Schadt Eric E, Drake Thomas A, Arnold Arthur P, Lusis Aldons J Elucidating the role of gonadal hormones in sexually dimorphic gene
coexpression networks..
Endocrinology.
2009;
150(3):
1235-49.
MacLennan Nicole K, Dong Jun, Aten Jason E, Horvath Steve, Rahib Lola, Ornelas Loren, Dipple Katrina M, McCabe Edward R B Weighted gene co-expression network analysis identifies biomarkers in
glycerol kinase deficient mice..
Molecular genetics and metabolism.
2009;
98(1-2):
203-14.
Farber Charles R, van Nas Atila, Ghazalpour Anatole, Aten Jason E, Doss Sudheer, Sos Brandon, Schadt Eric E, Ingram-Drake Leslie, Davis Richard C, Horvath Steve, Smith Desmond J, Drake Thomas A, Lusis Aldons J An integrative genetics approach to identify candidate genes
regulating BMD: combining linkage, gene expression, and association..
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2009;
24(1):
105-16.
Yoon Nam K, Seligson David B, Chia David, Elshimali Yahya, Sulur Giri, Li Ai, Horvath Steve, Maresh Erin, Mah Vei, Bose Shikha, Bonavida Benjamin, Goodglick Lee Higher expression levels of 14-3-3sigma in ductal carcinoma in situ of
the breast predict poorer outcome..
Cancer biomarkers : section A of Disease markers.
2009;
5(4):
215-24.
Sridharan Rupa, Tchieu Jason, Mason Mike J, Yachechko Robin, Kuoy Edward, Horvath Steve, Zhou Qing, Plath Kathrin Role of the murine reprogramming factors in the induction of
pluripotency..
Cell.
2009;
136(2):
364-77.
Hu Shen, Zhou Michael, Jiang Jiang, Wang Jianghua, Elashoff David, Gorr Sven, Michie Sara A, Spijkervet Fred K L, Bootsma Hendrika, Kallenberg Cees G M, Vissink Arjan, Horvath Steve, Wong David T Systems biology analysis of Sjögren's syndrome and mucosa-associated
lymphoid tissue lymphoma in parotid glands..
Arthritis and rheumatism.
2009;
60(1):
81-92.
Winden Kellen D, Oldham Michael C, Mirnics Karoly, Ebert Philip J, Swan Christo H, Levitt Pat, Rubenstein John L, Horvath Steve, Geschwind Daniel H The organization of the transcriptional network in specific neuronal
classes..
Molecular systems biology.
2009;
5(1):
291.
Oldham Michael C, Konopka Genevieve, Iwamoto Kazuya, Langfelder Peter, Kato Tadafumi, Horvath Steve, Geschwind Daniel H Functional organization of the transcriptome in human brain..
Nature neuroscience.
2008;
11(11):
1271-82.
Lee Yohan, Scheck Adrienne C, Cloughesy Timothy F, Lai Albert, Dong Jun, Farooqi Haumith K, Liau Linda M, Horvath Steve, Mischel Paul S, Nelson Stanley F Gene expression analysis of glioblastomas identifies the major
molecular basis for the prognostic benefit of younger age..
BMC medical genomics.
2008;
1(11):
52.
Horvath Steve, Dong Jun Geometric interpretation of gene coexpression network analysis..
PLoS computational biology.
2008;
4(8):
e1000117.
Aten Jason E, Fuller Tova F, Lusis Aldons J, Horvath Steve Using genetic markers to orient the edges in quantitative trait
networks: the NEO software..
BMC systems biology.
2008;
2(8):
34.
Langfelder Peter, Zhang Bin, Horvath Steve Defining clusters from a hierarchical cluster tree: the Dynamic Tree
Cut package for R..
Bioinformatics (Oxford, England).
2008;
24(5):
719-20.
Chen Yanqing, Zhu Jun, Lum Pek Yee, Yang Xia, Pinto Shirly, MacNeil Douglas J, Zhang Chunsheng, Lamb John, Edwards Stephen, Sieberts Solveig K, Leonardson Amy, Castellini Lawrence W, Wang Susanna, Champy Marie-France, Zhang Bin, Emilsson Valur, Doss Sudheer, Ghazalpour Anatole, Horvath Steve, Drake Thomas A, Lusis Aldons J, Schadt Eric E Variations in DNA elucidate molecular networks that cause disease..
Nature.
2008;
452(7186):
429-35.
Cloughesy Tim F, Yoshimoto Koji, Nghiemphu Phioanh, Brown Kevin, Dang Julie, Zhu Shaojun, Hsueh Teli, Chen Yinan, Wang Wei, Youngkin David, Liau Linda, Martin Neil, Becker Don, Bergsneider Marvin, Lai Albert, Green Richard, Oglesby Tom, Koleto Michael, Trent Jeff, Horvath Steve, Mischel Paul S, Mellinghoff Ingo K, Sawyers Charles L Antitumor activity of rapamycin in a Phase I trial for patients with
recurrent PTEN-deficient glioblastoma..
PLoS medicine.
2008;
5(1):
e8.
Yoshimoto Koji, Dang Julie, Zhu Shaojun, Nathanson David, Huang Tiffany, Dumont Rebecca, Seligson David B, Yong William H, Xiong Zhenggang, Rao Nagesh, Winther Henrik, Chakravarti Arnab, Bigner Darell D, Mellinghoff Ingo K, Horvath Steve, Cavenee Webster K, Cloughesy Timothy F, Mischel Paul S Development of a real-time RT-PCR assay for detecting EGFRvIII in
glioblastoma samples..
Clinical cancer research : an official journal of the American Association for Cancer Research.
2008;
14(2):
488-93.
Presson Angela P, Sobel Eric M, Papp Jeanette C, Suarez Charlyn J, Whistler Toni, Rajeevan Mangalathu S, Vernon Suzanne D, Horvath Steve Integrated weighted gene co-expression network analysis with an
application to chronic fatigue syndrome..
BMC systems biology.
2008;
2(1):
95.
Nakano Ichiro, Masterman-Smith Michael, Saigusa Kuniyasu, Paucar Andres A, Horvath Steve, Shoemaker Lorelei, Watanabe Momoko, Negro Alejandra, Bajpai Ruchi, Howes Amy, Lelievre Vincent, Waschek James A, Lazareff Jorge A, Freije William A, Liau Linda M, Gilbertson Richard J, Cloughesy Timothy F, Geschwind Daniel H, Nelson Stanley F, Mischel Paul S, Terskikh Alexey V, Kornblum Harley I Maternal embryonic leucine zipper kinase is a key regulator of the
proliferation of malignant brain tumors, including brain tumor stem
cells..
Journal of neuroscience research.
2008;
86(1):
48-60.
Seligson David B, Rajasekaran Sigrid A, Yu Hong, Liu Xueli, Eeva Mervi, Tze Sheila, Ball William, Horvath Steve, deKernion Jean B, Rajasekaran Ayyappan K Na,K-adenosine triphosphatase alpha1-subunit predicts survival of
renal clear cell carcinoma..
The Journal of urology.
2008;
179(1):
338-45.
Langfelder Peter, Horvath Steve WGCNA: an R package for weighted correlation network analysis..
BMC bioinformatics.
2008;
9(1):
559.
Abba Martín C, Sun Hongxia, Hawkins Kathleen A, Drake Jeffrey A, Hu Yuhui, Nunez Maria I, Gaddis Sally, Shi Tao, Horvath Steve, Sahin Aysegul, Aldaz C Marcelo Breast cancer molecular signatures as determined by SAGE: correlation
with lymph node status..
Molecular cancer research : MCR.
2007;
5(9):
881-90.
Dong Jun, Horvath Steve Understanding network concepts in modules..
BMC systems biology.
2007;
1(6-7):
24.
Rahib Lola, MacLennan Nicole K, Horvath Steve, Liao James C, Dipple Katrina M Glycerol kinase deficiency alters expression of genes involved in
lipid metabolism, carbohydrate metabolism, and insulin signaling..
European journal of human genetics : EJHG.
2007;
15(6):
646-57.
Carlson Marc R J, Pope Whitney B, Horvath Steve, Braunstein Jerome G, Nghiemphu Phioanh, Tso Cho-Lea, Mellinghoff Ingo, Lai Albert, Liau Linda M, Mischel Paul S, Dong Jun, Nelson Stanley F, Cloughesy Timothy F Relationship between survival and edema in malignant gliomas: role of
vascular endothelial growth factor and neuronal pentraxin 2..
Clinical cancer research : an official journal of the American Association for Cancer Research.
2007;
13(9):
2592-8.
Yip Andy M, Horvath Steve Gene network interconnectedness and the generalized topological
overlap measure..
BMC bioinformatics.
2007;
8(1-2):
22.
Eller C Daniel, Regelson Moira, Merriman Barry, Nelson Stan, Horvath Steve, Marahrens York Repetitive sequence environment distinguishes housekeeping genes..
Gene.
2007;
390(1-2):
153-65.
Gong Ke Wei, Zhao Wei, Li Ning, Barajas Berenice, Kleinman Michael, Sioutas Constantinos, Horvath Steve, Lusis Aldons J, Nel Andre, Araujo Jesus A Air-pollutant chemicals and oxidized lipids exhibit genome-wide
synergistic effects on endothelial cells..
Genome biology.
2007;
8(7):
R149.
Langfelder Peter, Horvath Steve Eigengene networks for studying the relationships between
co-expression modules..
BMC systems biology.
2007;
1(1):
54.
Lam John S, Seligson David B, Yu Hong, Li Ai, Eeva Mervi, Pantuck Allan J, Zeng Gang, Horvath Steve, Belldegrun Arie S Flap endonuclease 1 is overexpressed in prostate cancer and is
associated with a high Gleason score..
BJU international.
2006;
98(2):
445-51.
Gargalovic Peter S, Imura Minori, Zhang Bin, Gharavi Nima M, Clark Michael J, Pagnon Joanne, Yang Wen-Pin, He Aiqing, Truong Amy, Patel Shilpa, Nelson Stanley F, Horvath Steve, Berliner Judith A, Kirchgessner Todd G, Lusis Aldons J Identification of inflammatory gene modules based on variations of
human endothelial cell responses to oxidized lipids..
Proceedings of the National Academy of Sciences of the United States of America.
2006;
103(34):
12741-6.
Ghazalpour Anatole, Doss Sudheer, Zhang Bin, Wang Susanna, Plaisier Christopher, Castellanos Ruth, Brozell Alec, Schadt Eric E, Drake Thomas A, Lusis Aldons J, Horvath Steve Integrating genetic and network analysis to characterize genes related
to mouse weight..
PLoS genetics.
2006;
2(8):
e130.
Mitchell Scherise, Ota Asuka, Foster William, Zhang Bin, Fang Zixing, Patel Shilpa, Nelson Stanley F, Horvath Steve, Wang Yibin Distinct gene expression profiles in adult mouse heart following
targeted MAP kinase activation..
Physiological genomics.
2006;
25(1):
50-9.
Carlson Marc R J, Zhang Bin, Fang Zixing, Mischel Paul S, Horvath Steve, Nelson Stanley F Gene connectivity, function, and sequence conservation: predictions
from modular yeast co-expression networks..
BMC genomics.
2006;
7(1):
40.
Bocklandt Sven, Horvath Steve, Vilain Eric, Hamer Dean H Extreme skewing of X chromosome inactivation in mothers of homosexual
men..
Human genetics.
2006;
118(6):
691-4.
MacLennan Nicole K, Rahib Lola, Shin Cynthia, Fang Zixing, Horvath Steve, Dean Jason, Liao James C, McCabe Edward R B, Dipple Katrina M Targeted disruption of glycerol kinase gene in mice: expression
analysis in liver shows alterations in network partners related to
glycerol kinase activity..
Human molecular genetics.
2006;
15(3):
405-15.
Ouyang Yan, Salstrom Jennifer, Diaz-Perez Silvia, Nahas Shareef, Matsuno Youko, Dawson David, Teitell Michael A, Horvath Steve, Riggs Arthur D, Gatti Richard A, Marahrens York Inhibition of Atm and/or Atr disrupts gene silencing on the inactive X
chromosome..
Biochemical and biophysical research communications.
2005;
337(3):
875-80.
Mellinghoff Ingo K, Wang Maria Y, Vivanco Igor, Haas-Kogan Daphne A, Zhu Shaojun, Dia Ederlyn Q, Lu Kan V, Yoshimoto Koji, Huang Julie H Y, Chute Dennis J, Riggs Bridget L, Horvath Steve, Liau Linda M, Cavenee Webster K, Rao P Nagesh, Beroukhim Rameen, Peck Timothy C, Lee Jeffrey C, Sellers William R, Stokoe David, Prados Michael, Cloughesy Timothy F, Sawyers Charles L, Mischel Paul S Molecular determinants of the response of glioblastomas to EGFR kinase
inhibitors..
The New England journal of medicine.
2005;
353(19):
2012-24.
Seligson David, Horvath Steve, Huerta-Yepez Sara, Hanna Stephanie, Garban Hermes, Roberts Alice, Shi Tao, Liu Xueli, Chia David, Goodglick Lee, Bonavida Benjamin Expression of transcription factor Yin Yang 1 in prostate cancer..
International journal of oncology.
2005;
27(1):
131-41.
Lam John S, Shvarts Oleg, Said Jonathan W, Pantuck Allan J, Seligson David B, Aldridge Michael E, Bui Matthew H T, Liu Xueli, Horvath Steve, Figlin Robert A, Belldegrun Arie S Clinicopathologic and molecular correlations of necrosis in the
primary tumor of patients with renal cell carcinoma..
Cancer.
2005;
103(12):
2517-25.
Seligson David B, Horvath Steve, Shi Tao, Yu Hong, Tze Sheila, Grunstein Michael, Kurdistani Siavash K Global histone modification patterns predict risk of prostate cancer
recurrence..
Nature.
2005;
435(7046):
1262-6.
Kim Hyung L, Seligson David, Liu Xueli, Janzen Nicolette, Bui Matthew H T, Yu Hong, Shi Tao, Belldegrun Arie S, Horvath Steve, Figlin Robert A Using tumor markers to predict the survival of patients with
metastatic renal cell carcinoma..
The Journal of urology.
2005;
173(5):
1496-501.
Shvarts Oleg, Seligson David, Lam John, Shi Tao, Horvath Steve, Figlin Robert, Belldegrun Arie, Pantuck Allan J p53 is an independent predictor of tumor recurrence and progression
after nephrectomy in patients with localized renal cell carcinoma..
The Journal of urology.
2005;
173(3):
725-8.
Garraway Isla P, Seligson David, Said Jonathan, Horvath Steve, Reiter Robert E Trefoil factor 3 is overexpressed in human prostate cancer..
The Prostate.
2004;
61(3):
209-14.
Freije William A, Castro-Vargas F Edmundo, Fang Zixing, Horvath Steve, Cloughesy Timothy, Liau Linda M, Mischel Paul S, Nelson Stanley F Gene expression profiling of gliomas strongly predicts survival..
Cancer research.
2004;
64(18):
6503-10.
Flechner Stuart M, Kurian Sunil M, Head Steven R, Sharp Starlette M, Whisenant Thomas C, Zhang Jie, Chismar Jeffrey D, Horvath Steve, Mondala Tony, Gilmartin Timothy, Cook Daniel J, Kay Steven A, Walker John R, Salomon Daniel R Kidney transplant rejection and tissue injury by gene profiling of
biopsies and peripheral blood lymphocytes..
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2004;
4(9):
1475-89.
Bui Matthew H T, Visapaa Harri, Seligson David, Kim Hyung, Han Ken-Ryu, Huang Yunda, Horvath Steve, Stanbridge Eric J, Palotie Aarno, Figlin Robert A, Belldegrun Arie S Prognostic value of carbonic anhydrase IX and KI67 as predictors of
survival for renal clear cell carcinoma..
The Journal of urology.
2004;
171(6 Pt 1):
2461-6.
Han Ken-Ryu, Seligson David B, Liu Xueli, Horvath Steve, Shintaku Peter I, Thomas George V, Said Jonathan W, Reiter Robert E Prostate stem cell antigen expression is associated with gleason
score, seminal vesicle invasion and capsular invasion in prostate
cancer..
The Journal of urology.
2004;
171(3):
1117-21.
Horvath Steve, Xu Xin, Lake Stephen L, Silverman Edwin K, Weiss Scott T, Laird Nan M Family-based tests for associating haplotypes with general phenotype
data: application to asthma genetics..
Genetic epidemiology.
2004;
26(1):
61-9.
Dewing Phoebe, Shi Tao, Horvath Steve, Vilain Eric Sexually dimorphic gene expression in mouse brain precedes gonadal
differentiation..
Brain research. Molecular brain research.
2003;
118(1-2):
82-90.
Kraft Peter, Horvath Steve The genetics of gene expression and gene mapping..
Trends in biotechnology.
2003;
21(9):
377-8.
Shai Ruty, Shi Tao, Kremen Thomas J, Horvath Steve, Liau Linda M, Cloughesy Timothy F, Mischel Paul S, Nelson Stanley F Gene expression profiling identifies molecular subtypes of gliomas..
Oncogene.
2003;
22(31):
4918-23.
Choe Gheeyoung, Horvath Steve, Cloughesy Timothy F, Crosby Katherine, Seligson David, Palotie Aarno, Inge Landon, Smith Bradley L, Sawyers Charles L, Mischel Paul S Analysis of the phosphatidylinositol 3'-kinase signaling pathway in
glioblastoma patients in vivo..
Cancer research.
2003;
63(11):
2742-6.
Kraft Peter, Schadt Eric, Aten Jason, Horvath Steve A family-based test for correlation between gene expression and trait
values..
American journal of human genetics.
2003;
72(5):
1323-30.
Espineda Cromwell, Seligson David B, James Ball William, Rao JianYu, Palotie Aarno, Horvath Steve, Huang Yunda, Shi Tao, Rajasekaran Ayyappan K Analysis of the Na,K-ATPase alpha- and beta-subunit expression
profiles of bladder cancer using tissue microarrays..
Cancer.
2003;
97(8):
1859-68.
Visapää Harri, Bui Matthew, Huang Yunda, Seligson David, Tsai Henry, Pantuck Allan, Figlin Robert, Rao Jian Y u, Belldegrun Arie, Horvath Steve, Palotie Aarno Correlation of Ki-67 and gelsolin expression to clinical outcome in
renal clear cell carcinoma..
Urology.
2003;
61(4):
845-50.
Mischel Paul S, Shai Ruty, Shi Tao, Horvath Steve, Lu Kan V, Choe Gheeyoung, Seligson David, Kremen Thomas J, Palotie Aarno, Liau Linda M, Cloughesy Timothy F, Nelson Stanley F Identification of molecular subtypes of glioblastoma by gene
expression profiling..
Oncogene.
2003;
22(15):
2361-73.
Freedland Stephen J, Seligson David B, Liu Alvin Y, Pantuck Allan J, Paik Sun H, Horvath Steve, Wieder Jeffrey A, Zisman Amnon, Nguyen David, Tso Cho-Lea, Palotie Aarno V, Belldegrun Arie S Loss of CD10 (neutral endopeptidase) is a frequent and early event in
human prostate cancer..
The Prostate.
2003;
55(1):
71-80.
Haug Karsten, Warnstedt Maike, Alekov Alexi K, Sander Thomas, Ramírez Alfredo, Poser Barbara, Maljevic Snezana, Hebeisen Simon, Kubisch Christian, Rebstock Johannes, Horvath Steve, Hallmann Kerstin, Dullinger Joern S, Rau Birgit, Haverkamp Fritz, Beyenburg Stefan, Schulz Herbert, Janz Dieter, Giese Bernd, Müller-Newen Gerhard, Propping Peter, Elger Christian E, Fahlke Christoph, Lerche Holger, Heils Armin Mutations in CLCN2 encoding a voltage-gated chloride channel are
associated with idiopathic generalized epilepsies..
Nature genetics.
2003;
33(4):
527-32.
Bui Matthew H T, Seligson David, Han Ken-ryu, Pantuck Allan J, Dorey Frederick J, Huang Yunda, Horvath Steve, Leibovich Bradley C, Chopra Shefali, Liao Shu-Yuan, Stanbridge Eric, Lerman Michael I, Palotie Aarno, Figlin Robert A, Belldegrun Arie S Carbonic anhydrase IX is an independent predictor of survival in
advanced renal clear cell carcinoma: implications for prognosis and
therapy..
Clinical cancer research : an official journal of the American Association for Cancer Research.
2003;
9(2):
802-11.
Visapää Harri, Seligson David, Huang Yunda, Rao Jian Yu, Belldegrun Arie, Horvath Steve, Palotie Aarno Ki67, gelsolin and PTEN expression in sarcomatoid renal tumors..
Urological research.
2003;
30(6):
387-9.
Tilgen Nikola, Rebstock Johannes, Horvath Steve, Propping Peter, Elger Christian Erich, Heils Armin Prodynorphin gene promoter polymorphism and temporal lobe epilepsy..
Annals of neurology.
2003;
53(2):
280-1; author reply 281-2.
Kraft Peter, Bauman Lara, Yuan Jin Ying, Horvath Steve, Horvath Steve Multivariate variance-components analysis of longitudinal blood
pressure measurements from the Framingham Heart Study..
BMC genetics.
2003;
4 Suppl 1(1):
S55.
Tilgen Nikola, Pfeiffer Heike, Cobilanschi Joana, Rau Birgit, Horvath Steve, Elger Christian E, Propping Peter, Heils Armin Association analysis between the human interleukin 1beta (-511) gene
polymorphism and susceptibility to febrile convulsions..
Neuroscience letters.
2002;
334(1):
68-70.
Rao JianYu, Seligson David, Visapaa Harri, Horvath Steve, Eeva Mervi, Michel Kia, Pantuck Allan, Belldegrun Arie, Palotie Aarno Tissue microarray analysis of cytoskeletal actin-associated biomarkers
gelsolin and E-cadherin in urothelial carcinoma..
Cancer.
2002;
95(6):
1247-57.
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