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Shaping the Future
RESEARCH

Louis Ignarro, Ph.D.

Contact Information:

Lab Number:

310-825-5159

Office Phone Number:

310-825-5159

Laboratory Address:

Laboratory
23-305 CHS
Los Angeles, CA 90095
UNITED STATES

Office Address:

Office
23-305 CHS
Los Angeles, CA 90095
UNITED STATES

Work Email Address:

lignarro@mednet.ucla.edu

Professor, Molecular & Medical Pharmacology

Member, Brain Research Institute

Faculty, Molecular Toxicology IDP


Selected Publications:

Napoli Claudio, Paolisso Giuseppe, Casamassimi Amelia, Al-Omran Mohammed, Barbieri Michelangela, Sommese Linda, Infante Teresa, Ignarro Louis J Effects of nitric oxide on cell proliferation: novel insights. Journal of the American College of Cardiology. 2013; 62(2): 89-95.
Kwon Kyoung Ja, Kim Jung Nam, Kim Min Kyeong, Kim Su Young, Cho Kyu Suk, Jeon Se Jin, Kim Hahn Young, Ryu Jong Hoon, Han Sun-Young, Cheong Jae Hoon, Ignarro Louis J, Han Seol-Heui, Shin Chan Young Neuroprotective effects of valproic acid against hemin toxicity: possible involvement of the down-regulation of heme oxygenase-1 by regulating ubiquitin-proteasomal pathway. Neurochemistry international. 2013; 62(3): 240-50.
de Nigris Filomena, Rienzo Monica, Sessa Marcella, Infante Teresa, Cesario Elena, Ignarro Louis J, Al-Omran Mohammed, Giordano Antonio, Palinski Wulf, Napoli Claudio Glycoxydation promotes vascular damage via MAPK-ERK/JNK pathways. Journal of cellular physiology. 2012; 227(11): 3639-47.
Zheng Min, Kim Seul-Ki, Joe Yeonsoo, Back Sung Hoon, Cho Hong R, Kim Hong Pyo, Ignarro Louis J, Chung Hun-Taeg Sensing endoplasmic reticulum stress by protein kinase RNA-like endoplasmic reticulum kinase promotes adaptive mitochondrial DNA biogenesis and cell survival via heme oxygenase-1/carbon monoxide activity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012; 26(6): 2558-68.
Fukuto Jon M, Carrington Samantha J, Tantillo Dean J, Harrison Jason G, Ignarro Louis J, Freeman Bruce A, Chen Andrew, Wink David A Small molecule signaling agents: the integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived species. Chemical research in toxicology. 2012; 25(4): 769-93.
Zhang Rong, Jack Gregory S, Rao Nagesh, Zuk Patricia, Ignarro Louis J, Wu Benjamin, Rodríguez Larissa V Nuclear fusion-independent smooth muscle differentiation of human adipose-derived stem cells induced by a smooth muscle environment. Stem cells (Dayton, Ohio). 2012; 30(3): 481-90.
Ma Limin, Yang Yijun, Sikka Suresh C, Kadowitz Philip J, Ignarro Louis J, Abdel-Mageed Asim B, Hellstrom Wayne J G Adipose tissue-derived stem cell-seeded small intestinal submucosa for tunica albuginea grafting and reconstruction. Proceedings of the National Academy of Sciences of the United States of America. 2012; 109(6): 2090-5.
Meldrum David R, Gambone Joseph C, Morris Marge A, Meldrum Donald A N, Esposito Katherine, Ignarro Louis J The link between erectile and cardiovascular health: the canary in the coal mine. The American journal of cardiology. 2011; 108(4): 599-606.
Kwon Kyoung Ja, Cho Kyu Suk, Lee Sung Hoon, Kim Jung Nam, Joo So Hyun, Ryu Jong Hoon, Ignarro Louis J, Han Seol-Heui, Shin Chan Young Regulation of tissue plasminogen activator/plasminogen activator inhibitor-1 by hydrocortisone in rat primary astrocytes. Journal of neuroscience research. 2011; 89(7): 1059-69.
Matsui-Hirai Hisako, Hayashi Toshio, Yamamoto Seiji, Ina Koichiro, Maeda Morihiko, Kotani Hitoshi, Iguchi Akihisa, Ignarro Louis J, Hattori Yuichi Dose-dependent modulatory effects of insulin on glucose-induced endothelial senescence in vitro and in vivo: a relationship between telomeres and nitric oxide. The Journal of pharmacology and experimental therapeutics. 2011; 337(3): 591-9.
Napoli Claudio, Giordano Antonio, Casamassimi Amelia, Pentimalli Francesca, Ignarro Louis J, De Nigris Filomena Directed in vivo angiogenesis assay and the study of systemic neoangiogenesis in cancer. International journal of cancer. Journal international du cancer. 2011; 128(7): 1505-8.
Napoli Claudio, Hayashi Toshio, Cacciatore Francesco, Casamassimi Amelia, Casini Costanza, Al-Omran Mohammed, Ignarro Louis J Endothelial progenitor cells as therapeutic agents in the microcirculation: an update. Atherosclerosis. 2011; 215(1): 9-22.
Kwon Kyoung Ja, Kim Jung Nam, Kim Min Kyeong, Lee Jongmin, Ignarro Louis J, Kim Hee-Jin, Shin Chan Young, Han Seol-Heui Melatonin synergistically increases resveratrol-induced heme oxygenase-1 expression through the inhibition of ubiquitin-dependent proteasome pathway: a possible role in neuroprotection. Journal of pineal research. 2011; 50(2): 110-23.
Kim Ji Woon, Lee Sung Hoon, Ko Hyun Myung, Kwon Kyoung Ja, Cho Kyu Suk, Choi Chang Soon, Park Jin-Hee, Kim Hahn Young, Lee Jongmin, Han Seol-Heui, Ignarro Louis J, Cheong Jae Hoon, Kim Won-Ki, Shin Chan Young Biphasic regulation of tissue plasminogen activator activity in ischemic rat brain and in cultured neural cells: essential role of astrocyte-derived plasminogen activator inhibitor-1. Neurochemistry international. 2011; 58(3): 423-33.
Meldrum David R, Gambone Joseph C, Morris Marge A, Ignarro Louis J A multifaceted approach to maximize erectile function and vascular health. Fertility and sterility. 2010; 94(7): 2514-20.
de Nigris Filomena, Crudele Valeria, Giovane Alfonso, Casamassimi Amelia, Giordano Antonio, Garban Hermes J, Cacciatore Francesco, Pentimalli Francesca, Marquez-Garban Diana C, Petrillo Antonella, Cito Letizia, Sommese Linda, Fiore Andrea, Petrillo Mario, Siani Alfredo, Barbieri Antonio, Arra Claudio, Rengo Franco, Hayashi Toshio, Al-Omran Mohammed, Ignarro Louis J, Napoli Claudio CXCR4/YY1 inhibition impairs VEGF network and angiogenesis during malignancy. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(32): 14484-9.
Napoli Claudio, Ignarro Louis J Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases. Archives of pharmacal research. 2009; 32(8): 1103-8.
Ignarro Louis J Preface to this special journal issue on nitric oxide chemistry and biology. Archives of pharmacal research. 2009; 32(8): 1099-101.
Crimi Ettore, Ignarro Louis J, Cacciatore Francesco, Napoli Claudio Mechanisms by which exercise training benefits patients with heart failure. Nature reviews. Cardiology. 2009; 6(4): 292-300.
Strauch Berish, Herman Charles, Dabb Richard, Ignarro Louis J, Pilla Arthur A Evidence-based use of pulsed electromagnetic field therapy in clinical plastic surgery. Aesthetic surgery journal / the American Society for Aesthetic Plastic surgery. 2009; 29(2): 135-43.
d'Emmanuele di Villa Bianca Roberta, Sorrentino Raffaella, Maffia Pasquale, Mirone Vincenzo, Imbimbo Ciro, Fusco Ferdinando, De Palma Raffaele, Ignarro Louis J, Cirino Giuseppe Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106(11): 4513-8.
Griscavage, JM Fukuto, JM Komori, Y Ignarro, LJ Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide. The Journal of biological chemistry. . 1994; 269(34): 21644-9.
Rajfer, J., Aronson, W.J., Bush, P.A., Dorey, F.J. and Ignarro, L.J. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N. Engl. J. Med 1992; 326: 90-94.
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