Login to edit your profile page

Fax Number:

(310) 825-1447

Office Phone Number:

(310) 206-6003
(310) 825-8735
(310) 825-8745

Office Address:

Office
341 Boyer Hall (MBI), 611 Charles E. Young Drive East
Los Angeles, CA 90095
UNITED STATES

Work Email Address:

hherschman@mednet.ucla.edu

Awards and Honors:

Chair, Internal Advisory Board for UCLA-NCI Prostate SPORE program
Pfizer Visiting Professor, Yale University Medical School
Executive Advisory Board for UCLA-NCI Scholars in Oncologic Molecular Imaging Program
Israeli Cancer Research Foundation Award for Excellence in Scientific Research
Merck Visiting Professor, University of Connecticut Health Sciences
Member, ACCESS admissions committee
UCLA Faculty Research Lecture
UCLA Medical School Alumnae Award for Excellence in Scientific Research

Research Interest:

The role of prostaglandins and cycloxygenases in nomal physiology and disease; applications of molecular imaging

<p>Dr. Herschman's laboratory studies how extracellular stimuli elicit changes in cell growth and differentiation, as a result of induced transcription of "primary response" genes. One gene discovered by Dr. Herschman and his colleagues encodes a second form of cyclooxygenase (COX-2), the rate limiting enzyme in prostaglandin production and the target of a new generation of anti-inflammatory, anti-pyretic and analgesic pharmaceutical agents. The laboratory also identified synaptotagmin 4 as a depolarization-induced neuronal gene; a candidate for a mediator of depolarization-induced synaptic plasticity. Lastly, the laboratory has merged principles of cell biology, molecular biology and molecular imaging technologies to develop procedures that repetitively, non-invasively and quantitatively image reporter gene expression in intact, living animals. Current research interests center on improved therapies for colorectal cancer, and on the role of the COX-2 gene in the progression of a variety of epithelial cancers. </p> <p> Dr. Herschman is Distinguished Professor in both the Department of Biological Chemistry and the Department of Molecular and Medical pharmacology. He holds the Ralph and Marjorie Crump Endowed Chair in Molecular Imaging. Dr. Herschman is the Director for Basic Research for the UCLA Jonsson Comprehensive Cancer Center, and the Principal Investigator for the UCLA in vivo Cellular and Molecular Imaging Center, a National Cancer Institute supported center for non-invasive imaging studies of cancer. He is a member of the Molecular Biology Institute, the CNSI and the Jonsson Comprehensive Cancer Center at UCLA.</p>

Detailed Biography:

Dr. Harvey Herschman received a B.A. from Rice University and a Ph.D. from the University of California at San Diego. After two years as a post doctoral fellow at Brandeis University, he joined the UCLA faculty as an Assistant Professor in the Department of Biological Chemistry in 1969 . He is currently Distinguished Professor in both the Department of Biological Chemistry and the Department of Molecular and Medical pharmacology. Dr. Herschman's laboratory discovered the COX-2 gene, and has been involved in studies on COX-2 induction, and in investigations of the role of COX-2 in normal biology and in the pathophysiologies of inflammation, neurodegeneration and cancer. He has also pioneered in the development and application of non-invasive, repeated and quantitative methods for molecular imaging of gene expression in living animals, and is the Director of UCLA's In Vivo Cellular and Molecular Imaging Center, funded by the National Cancer Institute.

Gil Jose S, Machado Hidevaldo B, Herschman Harvey R A Method to Rapidly and Accurately Compare the Relative Efficacies of Non-invasive Imaging Reporter Genes in a Mouse Model and its Application to Luciferase Reporters.. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2011; .

Zaiss Anne K, Lawrence Roger, Elashoff David, Esko Jeffrey D, Herschman Harvey R Differential effects of murine and human factor X on adenovirus transduction via cell-surface heparan sulfate.. The Journal of biological chemistry. 2011; 286(28): 24535-43.

Ishikawa Tomo-o, Jain Naveen K, Herschman Harvey R Cox-2 gene expression in chemically induced skin papillomas cannot predict subsequent tumor fate.. Molecular oncology. 2010; 4(4): 347-56.

Tseng Han-Ching, Arasteh Aida, Paranjpe Avina, Teruel Antonia, Yang Wendy, Behel Armin, Alva Jackelyn A, Walter Gina, Head Christian, Ishikawa Tomo-o, Herschman Harvey R, Cacalano Nicholas, Pyle April D, Park No-Hee, Jewett Anahid Increased lysis of stem cells but not their differentiated cells by natural killer cells; de-differentiation or reprogramming activates NK cells.. PloS one. 2010; 5(7): e11590.

Papanicolaou Kyriakos N, Streicher John M, Ishikawa Tomo-O, Herschman Harvey, Wang Yibin, Walsh Kenneth Preserved heart function and maintained response to cardiac stresses in a genetic model of cardiomyocyte-targeted deficiency of cyclooxygenase-2.. Journal of molecular and cellular cardiology. 2010; 49(2): 196-209.

Streicher John M, Kamei Kenichiro, Ishikawa Tomo-o, Herschman Harvey, Wang Yibin Compensatory hypertrophy induced by ventricular cardiomyocyte-specific COX-2 expression in mice.. Journal of molecular and cellular cardiology. 2010; 49(1): 88-94.

Watanabe Junji, Lin James A, Narasimha Ajay J, Shahbazian Ani, Ishikawa Tomo-O, Martin Martin G, Herschman Harvey R, Reddy Srinivasa T Novel anti-inflammatory functions for endothelial and myeloid cyclooxygenase-2 in a new mouse model of Crohn's disease.. American journal of physiology. Gastrointestinal and liver physiology. 2010; 298(6): G842-50.

Ishikawa Tomo-O, Herschman Harvey R Conditional Bicistronic Cre Reporter Line Expressing Both Firefly Luciferase and beta-galactosidase.. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2010; 298(6): .

Streicher John M, Ren Shuxun, Herschman Harvey, Wang Yibin MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart.. Circulation research. 2010; 106(8): 1434-43.

Huang Hechang, Chikazu Daichi, Voznesensky Olga S, Herschman Harvey R, Kream Barbara E, Drissi Hicham, Pilbeam Carol C Parathyroid hormone induction of cyclooxygenase-2 in murine osteoblasts: role of the calcium-calcineurin-NFAT pathway.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2010; 25(4): 819-29.

Ishikawa Tomo-O, Kumar Indracanti Prem, Machado Hidevaldo B, Wong Koon-Pong, Kusewitt Donna, Huang Sung-Cheng, Fischer Susan M, Herschman Harvey R Positron emission tomography imaging of DMBA/TPA mouse skin multi-step tumorigenesis.. Molecular oncology. 2010; 4(2): 119-25.

Ishikawa Tomo-O, Herschman Harvey R Tumor formation in a mouse model of colitis-associated colon cancer does not require COX-1 or COX-2 expression.. Carcinogenesis. 2010; 31(4): 729-36.

Toy Gerald, Austin Wayne R, Liao Hsiang-I, Cheng Donghui, Singh Arun, Campbell Dean O, Ishikawa Tomo-o, Lehmann Lynn W, Satyamurthy Nagichettiar, Phelps Michael E, Herschman Harvey R, Czernin Johannes, Witte Owen N, Radu Caius G Requirement for deoxycytidine kinase in T and B lymphocyte development.. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(12): 5551-6.

Narasimha Ajay J, Watanabe Junji, Ishikawa Tomo-o, Priceman Saul J, Wu Lily, Herschman Harvey R, Reddy Srinivasa T Absence of myeloid COX-2 attenuates acute inflammation but does not influence development of atherosclerosis in apolipoprotein E null mice.. Arteriosclerosis, thrombosis, and vascular biology. 2010; 30(2): 260-8.

Johnson Stuart L, Franz Christoph, Kuhn Stephanie, Furness David N, Rüttiger Lukas, Münkner Stefan, Rivolta Marcelo N, Seward Elizabeth P, Herschman Harvey R, Engel Jutta, Knipper Marlies, Marcotti Walter Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses.. Nature neuroscience. 2010; 13(1): 45-52.

Lomenick Brett, Hao Rui, Jonai Nao, Chin Randall M, Aghajan Mariam, Warburton Sarah, Wang Jianing, Wu Raymond P, Gomez Fernando, Loo Joseph A, Wohlschlegel James A, Vondriska Thomas M, Pelletier Jerry, Herschman Harvey R, Clardy Jon, Clarke Catherine F, Huang Jing Target identification using drug affinity responsive target stability (DARTS).. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106(51): 21984-9.

Lu Yujie, Douraghy Ali, Machado Hidevaldo B, Stout David, Tian Jie, Herschman Harvey, Chatziioannou Arion F Spectrally resolved bioluminescence tomography with the third-order simplified spherical harmonics approximation.. Physics in medicine and biology. 2009; 54(21): 6477-93.

Zaiss Anne K, Machado Hidevaldo B, Herschman Harvey R The influence of innate and pre-existing immunity on adenovirus therapy.. Journal of cellular biochemistry. 2009; 108(4): 778-90.

Lu Yujie, Machado Hidevaldo B, Douraghy Ali, Stout David, Herschman Harvey, Chatziioannou Arion F Experimental bioluminescence tomography with fully parallel radiative-transfer-based reconstruction framework.. Optics express. 2009; 17(19): 16681-95.

Ohashi Koji, Ouchi Noriyuki, Sato Kaori, Higuchi Akiko, Ishikawa Tomo-o, Herschman Harvey R, Kihara Shinji, Walsh Kenneth Adiponectin promotes revascularization of ischemic muscle through a cyclooxygenase 2-dependent mechanism.. Molecular and cellular biology. 2009; 29(13): 3487-99.

Laing Rachel E, Walter Martin A, Campbell Dean O, Herschman Harvey R, Satyamurthy Nagichettiar, Phelps Michael E, Czernin Johannes, Witte Owen N, Radu Caius G Noninvasive prediction of tumor responses to gemcitabine using positron emission tomography.. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106(8): 2847-52.

Li Hua-Jung, Everts Maaike, Yamamoto Masato, Curiel David T, Herschman Harvey R Combined transductional untargeting/retargeting and transcriptional restriction enhances adenovirus gene targeting and therapy for hepatic colorectal cancer tumors.. Cancer research. 2009; 69(2): 554-64.

Ishikawa Tomo-O, Jain Naveen, Herschman Harvey R Feedback regulation of cyclooxygenase-2 transcription ex vivo and in vivo.. Biochemical and biophysical research communications. 2009; 378(3): 534-8.

Kenanova Vania, Barat Bhaswati, Olafsen Tove, Chatziioannou Arion, Herschman Harvey R, Braun Jonathan, Wu Anna M Recombinant carcinoembryonic antigen as a reporter gene for molecular imaging.. European journal of nuclear medicine and molecular imaging. 2009; 36(1): 104-14.

Machado Hidevaldo B, Vician Linda J, Herschman Harvey R The MAPK pathway is required for depolarization-induced . Journal of neuroscience research. 2008; 86(3): 593-602.

Weber Wolfgang A, Czernin Johannes, Phelps Michael E, Herschman Harvey R Technology Insight: novel imaging of molecular targets is an emerging area crucial to the development of targeted drugs.. Nature clinical practice. Oncology. 2008; 5(1): 44-54.

Ishikawa Tomo-o, Herschman Harvey R Two inducible, functional cyclooxygenase-2 genes are present in the rainbow trout genome.. Journal of cellular biochemistry. 2007; 102(6): 1486-92.

Sui Guodong, Lee Cheng-Chung, Kamei Ken-Ichiro, Li Hua-Jung, Wang Jin-Yi, Wang Jun, Herschman Harvey R, Tseng Hsian-Rong A microfluidic platform for sequential ligand labeling and cell binding analysis.. Biomedical microdevices. 2007; 9(3): 301-5.

Li Hua-Jung, Everts Maaike, Pereboeva Larisa, Komarova Svetlana, Idan Anat, Curiel David T, Herschman Harvey R Adenovirus tumor targeting and hepatic untargeting by a coxsackie/adenovirus receptor ectodomain anti-carcinoembryonic antigen bispecific adapter.. Cancer research. 2007; 67(11): 5354-61.

Koya Richard C, Kimura Takahiro, Ribas Antoni, Rozengurt Nora, Lawson Gregory W, Faure-Kumar Emmanuelle, Wang He-jing, Herschman Harvey, Kasahara Noriyuki, Stripecke Renata Lentiviral vector-mediated autonomous differentiation of mouse bone marrow cells into immunologically potent dendritic cell vaccines.. Molecular therapy : the journal of the American Society of Gene Therapy. 2007; 15(5): 971-80.

Ishikawa Tomo-O, Griffin Kevin J P, Banerjee Utpal, Herschman Harvey R The zebrafish genome contains two inducible, functional cyclooxygenase-2 genes.. Biochemical and biophysical research communications. 2007; 352(1): 181-7.

Su Helen, Bodenstein Claudia, Dumont Rebecca A, Seimbille Yann, Dubinett Steven, Phelps Michael E, Herschman Harvey, Czernin Johannes, Weber Wolfgang Monitoring tumor glucose utilization by positron emission tomography for the prediction of treatment response to epidermal growth factor receptor kinase inhibitors.. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006; 12(19): 5659-67.

Ishikawa Tomo-O, Jain Naveen K, Taketo Makoto M, Herschman Harvey R Imaging cyclooxygenase-2 (Cox-2) gene expression in living animals with a luciferase knock-in reporter gene.. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2006; 8(3): 171-87.

Xu Zheng, Choudhary Shilpa, Voznesensky Olga, Mehrotra Meenal, Woodard Monica, Hansen Marc, Herschman Harvey, Pilbeam Carol Overexpression of COX-2 in human osteosarcoma cells decreases proliferation and increases apoptosis.. Cancer research. 2006; 66(13): 6657-64.

Kamei Ken-ichiro, Ishikawa Tomo-o, Herschman Harvey R Transgenic mouse for conditional, tissue-specific Cox-2 overexpression.. Genesis (New York, N.Y. : 2000). 2006; 44(4): 177-82.

Ishikawa Tomo-O, Herschman Harvey R Conditional knockout mouse for tissue-specific disruption of the cyclooxygenase-2 (Cox-2) gene.. Genesis (New York, N.Y. : 2000). 2006; 44(3): 143-9.

Czernin Johannes, Weber Wolfgang A, Herschman Harvey R Molecular imaging in the development of cancer therapeutics.. Annual review of medicine. 2006; 57(3): 99-118.

Lu Gang, Kang Young Jun, Han Jiahuai, Herschman Harvey R, Stefani Enrico, Wang Yibin TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling.. The Journal of biological chemistry. 2006; 281(9): 6087-95.

Chikazu Daichi, Li Xiaodong, Kawaguchi Hiroshi, Sakuma Yoko, Voznesensky Olga S, Adams Douglas J, Xu Manshan, Hoshi Kazuto, Katavic Vedran, Herschman Harvey R, Raisz Lawrence G, Pilbeam Carol C Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfa1 binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo. 2002.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2005; 20(10): 1888-98.

Yaghoubi Shahriar S, Barrio Jorge R, Namavari Mohammad, Satyamurthy Nagichettiar, Phelps Michael E, Herschman Harvey R, Gambhir Sanjiv S Imaging progress of herpes simplex virus type 1 thymidine kinase suicide gene therapy in living subjects with positron emission tomography.. Cancer gene therapy. 2005; 12(3): 329-39.

Vician Linda J, Xu Guoping, Liu Wei, Feldman Jonathan D, Machado Hidevaldo B, Herschman Harvey R MAPKAP kinase-2 is a primary response gene induced by depolarization in PC12 cells and in brain.. Journal of neuroscience research. 2004; 78(3): 315-28.

Liang Qianwa, Yamamoto Masato, Curiel David T, Herschman Harvey R Noninvasive imaging of transcriptionally restricted transgene expression following intratumoral injection of an adenovirus in which the COX-2 promoter drives a reporter gene.. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2004; 6(6): 395-404.

Liang Qianwa, Dmitriev Igor, Kashentseva Elena, Curiel David T, Herschman Harvey R Noninvasive of adenovirus tumor retargeting in living subjects by a soluble adenovirus receptor-epidermal growth factor (sCAR-EGF) fusion protein.. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2004; 6(6): 385-94.

Singh Vinita, Miranda Tina Branscombe, Jiang Wei, Frankel Adam, Roemer Martha E, Robb Victoria A, Gutmann David H, Herschman Harvey R, Clarke Steven, Newsham Irene F DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo.. Oncogene. 2004; 23(47): 7761-71.

Herschman Harvey R PET reporter genes for noninvasive imaging of gene therapy, cell tracking and transgenic analysis.. Critical reviews in oncology/hematology. 2004; 51(3): 191-204.

Ferguson Gregory D, Herschman Harvey R, Storm Daniel R Reduced anxiety and depression-like behavior in synaptotagmin IV (-/-) mice.. Neuropharmacology. 2004; 47(4): 604-11.

Machado Hidevaldo B, Liu Wei, Vician Linda J, Herschman Harvey R Synaptotagmin IV overexpression inhibits depolarization-induced exocytosis in PC12 cells.. Journal of neuroscience research. 2004; 76(3): 334-41.

Ferguson Gregory D, Wang Hongbing, Herschman Harvey R, Storm Daniel R Altered hippocampal short-term plasticity and associative memory in synaptotagmin IV (-/-) mice.. Hippocampus. 2004; 14(8): 964-74.

Chen Ian Y, Wu Joseph C, Min Jung-Jun, Sundaresan Gobalakrishnan, Lewis Xiaoman, Liang Qianwa, Herschman Harvey R, Gambhir Sanjiv S Micro-positron emission tomography imaging of cardiac gene expression in rats using bicistronic adenoviral vector-mediated gene delivery.. Circulation. 2004; 109(11): 1415-20.

Herschman Harvey R Molecular imaging: a view from the inside.. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 2004; 11(2): 210-4.

Herschman Harvey R Noninvasive imaging of reporter gene expression in living subjects.. Advances in cancer research. 2004; 92(2): 29-80.

Smith Jeffrey B, Herschman Harvey R Targeted identification of glucocorticoid-attenuated response genes: in vitro and in vivo models.. Proceedings of the American Thoracic Society. 2004; 1(3): 275-81.

Symensma Tonia L, Martinez-Guzman DeeAnn, Jia Qingmei, Bortz Eric, Wu Ting-Ting, Rudra-Ganguly Nandini, Cole Steve, Herschman Harvey, Sun Ren COX-2 induction during murine gammaherpesvirus 68 infection leads to enhancement of viral gene expression.. Journal of virology. 2003; 77(23): 12753-63.

Herschman Harvey R, Talley John J, DuBois Raymond Cyclooxygenase 2 (COX-2) as a target for therapy and noninvasive imaging.. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2003; 5(5): 286-303.

Herschman Harvey R Molecular imaging: looking at problems, seeing solutions.. Science (New York, N.Y.). 2003; 302(5645): 605-8.

Herschman Harvey R Micro-PET imaging and small animal models of disease.. Current opinion in immunology. 2003; 15(4): 378-84.

Nguyen Julie T, Machado Hidevaldo, Herschman Harvey R Repetitive, noninvasive imaging of cyclooxygenase-2 gene expression in living mice.. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2003; 5(4): 248-56.

Liu Wei, Feldman Jonathan D, Machado Hidevaldo B, Vician Linda J, Herschman Harvey R Expression of depolarization-induced immediate early gene proteins in PC12 cells.. Journal of neuroscience research. 2003; 72(6): 670-8.