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RESEARCH
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Yibin Wang, Ph.D.
Contact Information:
Work Phone Number:
(310)2065197
Laboratory Address:
Laboratory CHS BH-569 UNITED STATES
Work Address:
Office CHS BH-569 Campus - 711520 CA UNITED STATES
Laboratory CSH Los Angeles, CA 90095 UNITED STATES
Vice-Chair, Research,
and
Professor,
Anesthesiology
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Professor,
Medicine
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Member,
ACCESS Program: Dept. of Molecular, Cell & Integrative Physiology
JCCC Signal Transduction and Therapeutics Program Area
California NanoSystems Institute
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Faculty,
Cardiovascular Research Laboratory
Molecular, Cellular, and Integrative Physiology IDP
Cardiology
Molecular Biology IDP
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Detailed Biography:
Dr. Yibin Wang received his Ph.D. in 1993 from Baylor College of Medicine after completion of his thesis work on liver gene regulation in human genetic disease. In 1998, after post-doctoral training at The Scripps Research Institute and University of California, at San Diego, he joined the faculty of Department of Physiology as an
Assistant Professor at University of Maryland School of Medicine, Baltimore and was promoted to Associated Professor with Tenure in 2003. Dr. Wang became an Associate Professor with tenure in the School of Medicine at UCLA, Los Angeles, California. Currently, he is a Full Professor in the Division of Molecular Medicine at Departments of Anesthesiology, Physiology and Medicine, and also holds joint appointments at Molecular Biology Institute, CNSI and Jonsson Comprehensive Cancer Center at UCLA. The main focus of Dr. Wang’s research is stress induced signaling mechanism in human diseases. Using molecular genetics and physiological tools, Dr. Wang has uncovered a number of novel members of protein kinases and phosphatases as well as the underlying regulatory mechanisms of stress-signalng pathways, and demonstrated their in the pathogenesis of human diseases, including heart failure and metabolic diseases. In addition to his extensive publications in many of the top scientific journals, Dr. Wang also received an Established Investigator Award from American Heart Association, Guident Foundation Visiting Professorship from Case Western University, Ruth L. Kirschstein National Research Service Award from National Institute of Health, and Visiting Scholarship Award from Chinese Natual Science Foundation. He also serves in NIH and AHA review panels and a member of the editorial boards of Circulation Research, and Journal of Molecular and Cellular Cardiology.
Yang SH, Chang SY, Ren S, Wang Y, Andres DA, Spielmann HP, Fong LG, Young SG Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin.
Hum Mol Genet.
2011;
20(3):
436-44.
Sun H, Lu G, Ren S, Chen J, Wang Y Catabolism of branched-chain amino acids in heart failure: insights from genetic models.
Pediatr Cardiol.
2011;
32(3):
305-10.
Deng N, Zhang J, Zong C, Wang Y, Lu H, Yang P, Wang W, Young GW, Wang Y, Korge P, Lotz C, Doran P, Liem DA, Apweiler R, Weiss JN, Duan H, Ping P Phosphoproteome analysis reveals regulatory sites in major pathways of cardiac mitochondria.
Mol Cell Proteomics.
2011;
10(2):
.
Sun H, Wang Y Restriction of big hearts by a small RNA.
Circ Res.
2011;
108(3):
274-6.
Davies BS, Barnes RH 2nd, Tu Y, Ren S, Andres DA, Spielmann HP, Lammerding J, Wang Y, Young SG, Fong LG An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria.
Hum Mol Genet.
2010;
19(13):
2682-94.
Streicher JM, Kamei K, Ishikawa TO, Herschman H, Wang Y Compensatory hypertrophy induced by ventricular cardiomyocyte-specific COX-2 expression in mice.
J Mol Cell Cardiol.
2010;
49(1):
88-94.
Drews O, Tsukamoto O, Liem D, Streicher J, Wang Y, Ping P Differential regulation of proteasome function in isoproterenol-induced cardiac hypertrophy.
Circ Res.
2010;
107(9):
1094-101.
Fung AO, Tsiokos C, Paydar O, Chen LH, Jin S, Wang Y, Judy JW Electrochemical properties and myocyte interaction of carbon nanotube microelectrodes.
Nano Lett.
2010;
10(11):
4321-7.
Streicher JM, Ren S, Herschman H, Wang Y MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart.
Circ Res.
2010;
106(8):
1434-43.
Rose BA, Force T, Wang Y Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale.
Physiol Rev.
2010;
90(4):
1507-46.
Ahuja P, Zhao P, Angelis E, Ruan H, Korge P, Olson A, Wang Y, Jin ES, Jeffrey FM, Portman M, Maclellan WR Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice.
J Clin Invest.
2010;
120(5):
1494-505.
Zhang M, Takimoto E, Hsu S, Lee DI, Nagayama T, Danner T, Koitabashi N, Barth AS, Bedja D, Gabrielson KL, Wang Y, Kass DA Myocardial remodeling is controlled by myocyte-targeted gene regulation of phosphodiesterase type 5.
J Am Coll Cardiol.
2010;
56(24):
2021-30.
Paulsson AK, Franklin S, Mitchell-Jordan SA, Ren S, Wang Y, Vondriska TM Post-translational regulation of calsarcin-1 during pressure overload-induced cardiac hypertrophy.
J Mol Cell Cardiol.
2010;
48(6):
1206-14.
Papanicolaou KN, Streicher JM, Ishikawa TO, Herschman H, Wang Y, Walsh K Preserved heart function and maintained response to cardiac stresses in a genetic model of cardiomyocyte-targeted deficiency of cyclooxygenase-2.
J Mol Cell Cardiol.
2010;
49(2):
196-209.
Ota A, Zhang J, Ping P, Han J, Wang Y Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte.
Circ Res.
2010;
106(8):
1401-12.
Liu Z, Fan HY, Wang Y, Richards JS Targeted disruption of Mapk14 (p38MAPKalpha) in granulosa cells and cumulus cells causes cell-specific changes in gene expression profiles that rescue COC expansion and maintain fertility.
Mol Endocrinol.
2010;
24(9):
1794-804.
Marber MS, Rose B, Wang Y The p38 mitogen-activated protein kinase pathway-A potential target for intervention in infarction, hypertrophy, and heart failure.
J Mol Cell Cardiol.
2010;
Epub ahead of print:
.
Sun Y, Ishibashi M, Seimon T, Lee M, Sharma SM, Fitzgerald KA, Samokhin AO, Wang Y, Sayers S, Aikawa M, Jerome WG, Ostrowski MC, Bromme D, Libby P, Tabas IA, Welch CL, Tall AR Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.
Circ Res..
2009;
104(4):
455-65.
Lu G, Sun H, Korge P, Koehler CM, Weiss JN, Wang Y Functional characterization of a mitochondrial Ser/Thr protein phosphatase in cell death regulation.
Methods Enzymol.
2009;
457:
255-73.
Ruan H, Li J, Ren S, Gao J, Li G, Kim R, Wu H, Wang Y. Inducible and cardiac specific PTEN inactivation protects ischemia/reperfusion injury.
Mol Cell Cardiol..
2009;
46(2):
193-200.
Seimon TA, Wang Y, Han S, Senokuchi T, Schrijvers DM, Kuriakose G, Tall AR, Tabas IA Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice.
J Clin Invest..
2009;
119(4):
886-898.
Andersson KB, Finsen AV, Sjåland C, Winer LH, Sjaastad I, Odegaard A, Louch WE, Wang Y, Chen J, Chien KR, Sejersted OM, Christensen G Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models.
Cell Calcium.
2009;
46(3):
219-25.
Andersson KB, Birkeland JA, Finsen AV, Louch WE, Sjaastad I, Wang Y, Chen J, Molkentin JD, Chien KR, Sejersted OM, Christensen G Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene.
J Mol Cell Cardiol.
2009;
47(21):
180-7.
Lu G, Sun H, She P, Youn JY, Warburton S, Ping P, Vondriska TM, Cai H, Lynch CJ, Wang Y Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells.
J Clin Invest.
2009;
119(6):
1678-87.
Vondriska TM, Wang Y. A new (heat) shocking player in cardiac hypertrophy.
Circ Res..
2008;
103(11):
1194-6.
Lu G, Wang Y. Functional diversity of mammalian type 2C protein phosphatase isoforms: new tales from an old family.
Clin Exp Pharmacol Physiol..
2008;
35(2):
107-12.
Mitchell-Jordan SA, Holopainen T, Ren S, Wang S, Warburton S, Zhang MJ, Alitalo K, Wang Y, Vondriska TM. Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy.
Circ Res..
2008;
103(12):
1359-62.
Maclellan WR, Wang Y, Vondriska TM, Weiss JN, Ping P Proteomic insights into cardiac cell death and survival.
Proteomics Clin Appl.
2008;
2(6):
837-44.
Lu G, Ren S, Korge P, Choi J, Dong Y, Weiss J, Koehler C, Chen JN, Wang Y A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development.
Genes Dev. .
2007;
21(7):
784-796.
Ruan H, Mitchell S, Vainoriene M, Lou Q, Xie LH, Ren S, Goldhaber JI, Wang Y Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy.
Circulation.
2007;
116(6):
596-605.
Peter PS, Brady JE, Yan L, Chen W, Engelhardt S, Wang Y, Sadoshima J, Vatner SF, Vatner DE Inhibition of p38alpha MAPK rescues cardiomyopathy induced by overexpressed beta(2)-adrenergic receptor, but not beta(1)-adrenergic receptor.
J Clin Invest..
2007;
117(5):
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Wang Y. Mitogen-activated protein kinases in heart development and diseases.
Circulation.
2007;
116(12):
1413-23.
Ursitti JA, Petrich BG, Lee PC, Resneck WG, Ye X, Yang J, Randall WR, Bloch RJ, Wang Y Role of an alternatively spliced form of alphaII-spectrin in localization of connexin 43 in cardiomyocytes and regulation by stress-activated protein kinase.
J Mol Cell Cardiol..
2007;
42(3):
572-581.
Vahebi S, Ota A, Li M, Warren CM, de Tombe PP, Wang Y, Solaro RJ p38-MAPK Induced Dephosphorylation of {alpha}-Tropomyosin is Associated With Depression of Myocardial Sarcomeric Tension and ATPase Activity.
Circ Res..
2007;
100(3):
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Mitchell, S., Ota, A., Foster, W., Zhang, B., Fang, Z., Patel, S., Nelson, S. F., Horvath, S., and Wang, Y. Distinct gene expression profiles in adult mouse heart following targeted MAP kinase activation.
Physiol Genomics.
2006;
25(1):
50-59.
Eghbali M, Wang Y, Toro L, Stefani E. Heart hypertrophy during pregnancy: a better functioning heart?.
Trends Cardiovasc Med..
2006;
16(8):
285-291.
Glaser ND, Lukyanenko YO, Wang Y, Wilson GM, Rogers TB. JNK activation decreases PP2A regulatory subunit B56alpha expression and mRNA stability and increases AUF1 expression in cardiomyocytes.
Am J Physiol Heart Circ Physiol..
2006;
291(3):
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Xing, W., Zhang, T.C., Cao, D., Wang, Z., Antos, C.L., Li, S., Wang, Y., Olson, E.N., and Wang, D.Z. Myocardin induces cardiomyocyte hypertrophy.
Circ Res.
2006;
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Chen, H., Yong, W., Ren, S., Shen, W., He, Y., Cox, K.A., Zhu, W., Li, W., Soonpaa, M., Payne, R.M., Franco, D., Field, L.J., Rosen, V., Wang, Y., and Shou W. Overexpression of bone morphogenetic protein 10 in myocardium disrupts cardiac postnatal hypertrophic growth.
J Biol Chem..
2006;
281:
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Liu J, Sadoshima J, Zhai P, Hong C, Yang G, Chen W, Yan L, Wang Y, Vatner SF, Vatner DE. Pressure overload induces greater hypertrophy and mortality in female mice with p38alpha MAPK inhibition.
J Mol Cell Cardiol..
2006;
41(4):
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Ruan, H. Mitchell, S. Goldhaber, J. I. Wang, Y. Ras induced G alpha i signaling in cardiac dysfunction and arrhythmias.
Circulation.
2006;
114:
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Lu, G., Kang, Y. J., Han, J., Herschman, H. R., Stefani, E., and Wang, Y. TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling.
J Biol Chem.
2006;
281:
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Devries-Seimon, T., Li, Y., Yao, P. M., Stone, E., Wang, Y., Davis, R. J., Flavell, R., and Tabas, I. Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor.
J Cell Biol..
2005;
171(1):
61-73.
Takimoto E., Champion H.C., Li M., Belardi D., Ren S., Rodriguez E.R., Bedja D., Gabrielson K.L., Wang Y., Kass D.A. Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy.
Nature Medicine.
2005;
11(2):
214-222.
Mansoureh Eghbali, Rupal Deva, Abderrahmane Alioua, Tamara Y. Minosyan, Hongmei Ruan, Wang Y, Ligia Toro and Enrico Stefani Molecular and Functional Signature of Heart Hypertrophy During Pregnancy.
Circulation Research.
2005;
96(11):
1208-1216.
Wang, G., Liem, D. A., Vondriska, T. M., Honda, H. M., Korge, P., Pantaleon, D. M., Qiao, X., Wang, Y., Weiss, J. N., and Ping, P. Nitric oxide donors protect murine myocardium against infarction via modulation of mitochondrial permeability transition .
Am J Physiol Heart Circ Physiol.
2005;
288(3):
1290-1295.
Takimoto E., Champion H.C., Li M., Ren S., Rodriguez E.R., Tavazzi B., Lazzarino G., Paolocci N., Gabrielson K.L., Wang, Y., et al. Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load.
J Clin Invest. .
2005;
115(5):
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Engel, F. B. Schebesta, M. Duong, M. T. Lu, G. Ren, S. X. Madwed, J. B. Jiang, H. P. Wang, Y. Keating, M. T. P38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes.
Genes & Development.
2005;
19(10):
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Ren, J., Zhang, S., Kovacs, A., Wang, Y., Muslin, A. J. Role of p38a MAPK in cardiac apoptosis and remodeling after myocardial infarction.
J Mol Cell Cardiol.
2005;
38(4):
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Li M, Georgakopoulos D, Lu G, Hester L, Kass DA, Hasday J, Wang Y. p38 MAP kinase mediates inflammatory cytokine induction in cardiomyocytes and extracellular-matrix remodeling in heart.
Circulation.
2005;
111(19):
2494-2502.
Minamisawa, S., Oshikawa, J., Takeshima, H., Hoshijima, M., Wang, Y., Chien, K. R., Ishikawa, Y., and Matsuoka, R. Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies.
Biochem Biophys Res Commun.
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325(3):
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Zhang L., Zhu H., Davis J.J., Jacob D., Wu S., Teraishi F., Gutierrez A., Wang Y., Fang B. Lack of p38 MAP Kinase Activation in TRAIL-Resistant Cells is Not Related to the Resistance to TRAIL-Mediated Cell Death.
Cancer Biol Ther.
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3(3):
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Champion HC, Georgakopoulos D, Takimoto E, Isoda T, Wang Y, Kass DA Modulation of In Vivo Cardiac Function by Myocyte-Specific Nitric Oxide Synthase-3.
Circ Res.
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Wang Y., Goldhaber, J. Return of calcium: Manipulating intracellular calcium to prevent cardiac pathologies.
Proc Natl Acad Sci U S A.
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Brian G. Petrich, Benjamin C. Eloff, Deborah L. Lerner , Attila Kovacs, Jeffrey E. Saffitz, David S. Rosenbaum and Yibin Wang Targeted Activation of c-Jun N-terminal Kinase in Vivo Induces Restrictive Cardiomyopathy and Conduction Defects.
J Biol Chem .
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Minamisawa S, Wang Y, Chen J, Ishikawa Y, Chien KR, Matsuoka R. Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling.
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Yang D, Song LS, Zhu WZ, Chakir K, Wang W, Wu C, Wang Y, Xiao RP, Chen SR, Cheng H. Calmodulin Regulation of Excitation-Contraction Coupling in Cardiac Myocytes.
Circ Res..
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Christensen G, Gruber PJ, Wang Y, Chien KR Embryonic and neonatal cardiac gene transfer in vivo.
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Mol Cell Biol..
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Isoda T, Paolocci N, Haghighi K, Wang C, Wang Y, Georgakopoulos D, Servillo G, Della Fazia MA, Kranias EG, Depaoli-Roach AA, Sassone-Corsi P, Kass DA Novel regulation of cardiac force-frequency relation by CREM (cAMP response element modulator).
Faseb J..
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Champion HC, Georgakopoulos D, Haldar S, Wang L, Wang Y, Kass DA Robust Adenoviral and Adeno-Associated Viral Gene Transfer to the In Vivo Murine Heart: Application to Study of Phospholamban Physiology.
Circulation.
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Shaosong Zhang, Jie Ren, Cindy E. Zhang, Ilya Treskov, Yibin Wang, Anthony J. Muslin Role of 14-3-3-Mediated p38 Mitogen-Activated Protein Kinase Inhibition in Cardiac Myocyte Survival.
Circulation Research.
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Mansouri A, Ridgway LD, Korapati AL, Zhang Q, Tian L, Wang Y, Siddik ZH, Mills GB, Claret FX Sustained activation of JNK-p38 MAP kinase pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells.
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Faseb J..
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Nat Med..
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Am J Physiol Heart Circ Physiol.
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Xu L, Zhan Y, Wang Y, Feuerstein GZ, Wang X Recombinant adenoviral expression of dominant negative IkappaBalpha protects brain from cerebral ischemic injury.
Biochem Biophys Res Commun..
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Petrich BG, Liao P, Wang Y Using a gene-switch transgenic approach to dissect distinct roles of MAP kinases in heart failure.
Cold Spring Harb Symp Quant Biol..
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