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Shaping the Future
RESEARCH

Alan Grinnell, Ph.D.

Contact Information:

Lab Number:

(310) 825-7870

Office Phone Number:

310-825-4468

Work Address:

Laboratory
CHS
Los Angeles, CA 90095
UNITED STATES
Office
Dept. of Physiology,
David Geffen School of Medicine at UCLA
Los Angeles, CA 90095
UNITED STATES

Email Address:

adg@ucla.edu

Distinguished Professor, Integrative Biology and Physiology

Professor, Physiology

Associate Dean, Life Sciences

Member, Brain Research Institute

Cell & Developmental Biology GPB Home Area

Center for Duchenne Muscular Dystrophy

Molecular, Cellular & Integrative Physiology GPB Home Area

Neuroscience GPB Home Area

Faculty, Molecular, Cellular, and Integrative Physiology IDP


Detailed Biography:

Dr. Grinnell received his B.A. in 1958 and his PhD in 1962, both from Harvard. He did postdoctoral training in the laboratory of Prof. Bernard Katz, University College London (1962-64) and with Prof. T. H. Bullock, UCLA, (1964-65). He was appointed an Assitant Prof. of Biology at UCLA in 1964, Assoc. Prof. in 1966, and Full Prof. in 1971. Since 1972 he has been a Prof. in the Dept. of Physiology. In 1977 he was named Head of the Ahmanson Laboratory of Neurobiology in the BRI, and from 1978-2002 was Director of the Jerry Lewis Neuromuscular Research Center. IN 1997 he joined the Dept. of Physiological Science and chaired that department until 2001. Since 1990, he has been a Researtch Associate of the Fowler Museum of Cultural History.

Selected Publications:

Yazejian Bruce, Yazejian Rita M, Einarsson Rachel, Grinnell Alan D Simultaneous pre- and post-synaptic electrophysiological recording from Xenopus nerve-muscle co-cultures. Journal of visualized experiments : JoVE. 2013; (73): e50253.
Kim Michelle H, Kay Danielle I, Rudra Renuka T, Chen Bo Ming, Hsu Nigel, Izumiya Yasuhiro, Martinez Leonel, Spencer Melissa J, Walsh Kenneth, Grinnell Alan D, Crosbie Rachelle H Myogenic Akt signaling attenuates muscular degeneration, promotes myofiber regeneration and improves muscle function in dystrophin-deficient mdx mice. Human molecular genetics. 2011; 20(7): 1324-38.
Sun Xiao-Ping, Chen Bo-Ming, Sand Olav, Kidokoro Yoshi, Grinnell Alan D Depolarization-induced Ca2+ entry preferentially evokes release of large quanta in the developing Xenopus neuromuscular junction. Journal of neurophysiology. 2010; 104(5): 2730-40.
Grinnell, A.D. Echolocation I: Behavior. New Encyclopedia of Neuroscience, ed. L. R. Squire, in press, 2007; .
Grinnell, A.D. How Muscle Stretch In fluences Neuromuscular Transmission, ed. L. R. Squire, in press. New Encyclopedia of Neuroscience 2007; .
Sun, X-P, Yazejian, B. and Grinnell, A.D. Electrophysiological properties of BK channels in Xenopus motor nerve terminals. J. Physiol 2004; 557: 207-228.
Sun, XP Yazejian, B Grinnell, AD Electrophysiological properties of BK channels in Xenopus motor nerve terminals. The Journal of physiology. . 2004; 557(Pt 1): 207-28.
Sun Xiao-Ping, Yazejian Bruce, Grinnell Alan D Electrophysiological properties of BK channels in Xenopus motor nerve terminals. The Journal of physiology. 2004; 557(Pt 1): 207-28.
Grinnell Alan D, Chen Bo-Ming, Kashani Amir, Lin Jennifer, Suzuki Kazuhiro, Kidokoro Yoshiaki The role of integrins in the modulation of neurotransmitter release from motor nerve terminals by stretch and hypertonicity. Journal of neurocytology. 2004; 32(5-8): 489-503.
Grinnell, A.D., Chen, B.-M., Kashani, A., Lin, J., Suzuki, K., and Kidokoro, Y. The role of integrins in the modulation of neurotransmitter release from motor nerve terminals by stretch and hypertonicity. J. Neurocytol 2003; 32: 489-503.
Suzuki, K Grinnell, AD Kidokoro, Y Hypertonicity-induced transmitter release at Drosophila neuromuscular junctions is partly mediated by integrins and cAMP/protein kinase A. The Journal of physiology. . 2002; 538(Pt 1): 103-19.
Sand, O Chen, BM Grinnell, AD Contribution of L-type Ca(2+) channels to evoked transmitter release in cultured Xenopus nerve-muscle synapses. The Journal of physiology. . 2001; 536(Pt 1): 21-33.
Kashani, A., Chen, B.-M., and Grinnell Osmotic modulation of transmitter release from frog motor nerve terminals: Ca++-independence and role of integrins. J. Physiol 2001; 530: 243-252.
Yazejian, B, Sun, X.-P, and Grinnell, A.D. Tracking presynaptic Ca++ dynamics during neurotransmitter release with Ca-activated K+ channels. Nature Neuroscience 2000; 3: 566-571.
Kalko, E.K.V., Schnitzler, H.-U., Kaipf, I & Grinnell, A.D. Hunting and echolocation behavior in Noctilio albiventris: the evolution of piscivory. Behavioral Ecology and Sociobiology 1998; 45: 305-319.
Chen, B.M and Grinnell, A.D. Kinetics, Ca++ dependence, and biophysical properties of integrin-mediated mechanical modulation of transmitter release from frog motor nerve terminals. J. Neuroscience 1997; 17: 904-916.
Yazejian, B DiGregorio, DA Vergara, JL Poage, RE Meriney, SD Grinnell, AD Direct measurements of presynaptic calcium and calcium-activated potassium currents regulating neurotransmitter release at cultured Xenopus nerve-muscle synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1997; 17(9): 2990-3001.
Harada, Y Grinnell, AD Regeneration of specific innervation in Xenopus pectoralis muscle. Journal of neurobiology. . 1996; 31(4): 433-48.
Grinnell, AD Harada, Y Specificity and development of innervation pattern of Xenopus pectoralis muscle. Journal of neurobiology. . 1996; 31(4): 415-32.
Grinnell, AD Dynamics of nerve-muscle interaction in developing and mature neuromuscular junctions. Physiological reviews. . 1995; 75(4): 789-834.
Chen, B.M. and Grinnell, A.D. Integrins help mediate the stretch-induced modulation of transmitter release from frog motor nerve terminals. Science 1995; 269: 1578-1580.
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