Login to edit your profile page

Fax Number:

(310) 206-0865

Office Phone Number:

(310) 825-4934

Department Address:

UCLA Med-Cardio
650 Charles E. Young Drive South
A2-237 CHS Bldg.
Los Angeles, CA 90095
UNITED STATES

Mailing Address:

675 Charles E Young Drive South
MRL Room 4770
Los Angeles, CA 90095
UNITED STATES

Office Address:

GONDA 4506A
695 Charles E. Young Drive South
GONDA 4506A
Los Angeles, CA 90095
UNITED STATES

Work Email Address:

sgyoung@mednet.ucla.edu

Website:

Home Page.
Laboratory.
Home Page.

Awards and Honors:

Ernst Jung Prize in Medicine
University of Gothenburg, Sweden Doctor Honoris Causa (Medicine)
American Heart Association Special Recognition Award in Vascular Biology
Named one of "America's Top Physicians"
American Heart Association Council on Arteriosclerosis Irvine H. Page Research Prize for Young Investigators
Certified, American Board of Clinical Lipidology

Detailed Biography:

Stephen Young grew up in Kansas and obtained an undergraduate degree in history from Princeton University. Following medical school at Washington University-St. Louis, he did internal medicine training at UCSF and cardiology training at UCSD. He then embarked on a career in molecular genetics. He did postdoctoral research training in lipid metabolism at UCSD and then worked at a research institute affiliated with UCSF for 17 years. Along the way, he became an expert in using genetically modified mice to decipher gene function. Currently, his laboratory works on protein posttranslational modifications, diseases of the nuclear lamina, and a new molecule required for the metabolism of triglyceride-rich lipoproteins. His laboratory has a strong track record in developing the careers of young scientists.

Coffinier C, Chang SY, Nobumori C, Farber EA, Toth J, Fong LG, and Young SG. Abnormal Development of the Cerebral Cortex and Cerebellum in the Setting of Lamin B2 Defiency.. Proc.Natl.Acad.Sci 2010; (107:): 5076-5081.

Weinstein MM, Yin L, Beigneux AP, Davies BS, Gin P, Estrada K, Melford K, Bishop JR, Esko JD, Dallinga-Thie GM, Fong LG, Bensadoun A, Young SG. Abnormal patterns of lipoprotein lipase release into the plasma in GPIHPB1-deficient mice . J. Biol. Chem. 2010; 12: 34511?34518.

Davies BS, Barnes RH 2nd, Tu Y, Ren S, Andres DA, Spielmann HP, Lammerding J, Wang Y, Young SG, Fong LG. An Accumulation of Non-Farnesylated Prelamin A Causes Cardiomyopathy but Not Progeria.. Hum Mol Genet. 2010; 19: 2692–2694.

Weinstein MM, Yin L, Tu Y, Wang X, Wu X, Castellani LW, Walzem RL, Lusis AL, Fong LG, Beigneux AP, Young SG. Chylomicronemia Elicits Atherosclerosis in Mice. . Arterioscler Thromb Vasc Biol. 2010; (30): 20-23.

Coffinier C, Jung HJ, Li Z, Nobumori C, Yun UJ, Farber EA, Davies BS, Weinstein MM, Yang SH, Lammerding J, Farahani JN, Bentolila LA, Fong LG, Young SG. Direct Synthesis of Lamin A, Bypassing Prelamin A Processing, Causes Misshapen Nuclei in Fibroblasts but No Detectable Pathology in Mice.. J Biol Chem 2010; 285: 20818–20826.

Brandon S. J. Davies, Anne P. Beigneux, Richard H. Barnes II, Yiping Tu, Peter Gin, Michael M. Weinstein, Chika Nobumori, Rakel Nyrén, Ira Goldberg, Gunilla Olivecrona, André Bensadoun, Stephen G. Young, and Loren G. Fong(2010) GPIHBP1 Is Responsible for the Entry of Lipoprotein Lipase into Capillaries. Cell Metabolism 2010; 12: 42–52.

Coffinier C, Hudon SE, Farber EA, Chang SY, Hrycyna CA, Young SG, Fong LG. HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells. Proc. Natl. Acad. Sci. USA 2010; 104: 13432-13437.

Olafsen T, Young SG, Davies BSJ, Kenanova VE, Voss C, Young G, Wong K-P, Barnes RH, Tu Y, Weinstein MM, Nobumori C, Huang S-C, Goldberg IJ, Bensadoun A, Wu AM, and Fong LG. Unexpected expression pattern for glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) in mouse tissues revealed by positron emission tomography scanning. J. Biol. Chem. 2010; 285: 39239–39248.

Lee R, Chang SY, Trinh H, White AC, Bergo MO, Fong LG, Lowry WE, and Young SG. Genetic Analysis of the Importance of the Protein Prenyltransferases in Skin Keratinocytes.. Human Molecular Gen. 2009; (19): 1603-1617.

Beigneux AP, Franssen R, Bensadoun A, Gin P, Melford K, Peter J, Walzem RL, Weinstein MM, Davies BS, Kuivenhoven JA, Kastelein JJ, Fong LG, Dallinga-Thie GM, Young SG. Chylomicronemia with a Mutant GPIHBP1 (Q115P) that Cannot Bind Lipoprotein Lipase. . Arterioscler Thromb Vasc Biol. 2009; (29): 956-962.

Beigneux AP, Gin P, Davies BS, Weinstein MM, Bensadoun A, Fong LG, Young SG. Highly Conserved Cysteines within the Ly6 domain of GPIHBP1 are Crucial for the Binding of Lipoprotein Lipase. . J. Biol. Chem. 2009; (284): 30240 - 30247.

Yang SH, Andres DA, Spielmann HP, Young SG, and Fong LG. Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated.. J. Clin. Invest. 2008; 118: 3291-3300.

Gin P, Yin L, Davies BSJ, Weinstein MM, Ryan RO, Bensadoun A, Fong LG, Young SG, and Beigneux AP The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons. J Biol. Chem 2008; 283: 29554-29562.

Beigneux AP, Davies BS, Gin P, Weinstein MM, Farber E, Qiao X, Peale F, Bunting S, Walzem RL, Wong JS, Blaner WS, Ding ZM, Melford K, Wongsiriroj N, Shu X, de Sauvage F, Ryan RO, Fong LG, Bensadoun A, Young SG. Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons.. Cell Metabolism 2007; 5: 279?291.

Gin Peter, Goulbourne Chris N, Adeyo Oludotun, Beigneux Anne P, Davies Brandon S J, Tat Shelly, Voss Constance V, Bensadoun André, Fong Loren G, Young Stephen G Chylomicronemia mutations yield new insights into interactions between lipoprotein lipase and GPIHBP1.. Human molecular genetics. 2012; 21(13): 2961-72.

Young Stephen G, Fong Loren G Lowering plasma cholesterol by raising LDL receptors--revisited.. The New England journal of medicine. 2012; 366(12): 1154-5.

Weinstein Michael M, Goulbourne Christopher N, Davies Brandon S J, Tu Yiping, Barnes Richard H, Watkins Steven M, Davis Ryan, Reue Karen, Tontonoz Peter, Beigneux Anne P, Fong Loren G, Young Stephen G Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice.. Arteriosclerosis, thrombosis, and vascular biology. 2012; 32(2): 230-5.

Jung Hea-Jin, Coffinier Catherine, Choe Youngshik, Beigneux Anne P, Davies Brandon S J, Yang Shao H, Barnes Richard H, Hong Janet, Sun Tao, Pleasure Samuel J, Young Stephen G, Fong Loren G Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA.. Proceedings of the National Academy of Sciences of the United States of America. 2012; 109(7): E423-31.

Coffinier Catherine, Jung Hea-Jin, Nobumori Chika, Chang Sandy, Tu Yiping, Barnes Richard H, Yoshinaga Yuko, de Jong Pieter J, Vergnes Laurent, Reue Karen, Fong Loren G, Young Stephen G Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons.. Molecular biology of the cell. 2011; 22(23): 4683-93.

Patwari Parth, Emilsson Valur, Schadt Eric E, Chutkow William A, Lee Samuel, Marsili Alessandro, Zhang Yongzhao, Dobrin Radu, Cohen David E, Larsen P Reed, Zavacki Ann Marie, Fong Loren G, Young Stephen G, Lee Richard T The arrestin domain-containing 3 protein regulates body mass and energy expenditure.. Cell metabolism. 2011; 14(5): 671-83.

Yang Shao H, Chang Sandy Y, Yin Liya, Tu Yiping, Hu Yan, Yoshinaga Yuko, de Jong Pieter J, Fong Loren G, Young Stephen G An absence of both lamin B1 and lamin B2 in keratinocytes has no effect on cell proliferation or the development of skin and hair.. Human molecular genetics. 2011; 20(18): 3537-44.

Beigneux Anne P, Davies Brandon S J, Tat Shelly, Chen Jenny, Gin Peter, Voss Constance V, Weinstein Michael M, Bensadoun André, Pullinger Clive R, Fong Loren G, Young Stephen G Assessing the role of the glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) three-finger domain in binding lipoprotein lipase.. The Journal of biological chemistry. 2011; 286(22): 19735-43.

Voss Constance V, Davies Brandon S J, Tat Shelly, Gin Peter, Fong Loren G, Pelletier Christopher, Mottler Charlene D, Bensadoun André, Beigneux Anne P, Young Stephen G Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1.. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(19): 7980-4.

Yang Shao H, Chang Sandy Y, Ren Shuxun, Wang Yibin, Andres Douglas A, Spielmann H Peter, Fong Loren G, Young Stephen G Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin.. Human molecular genetics. 2011; 20(3): 436-44.

Shu Xiao, Nelbach Lisa, Weinstein Michael M, Burgess Braydon L, Beckstead Jennifer A, Young Stephen G, Ryan Robert O, Forte Trudy M Intravenous injection of apolipoprotein A-V reconstituted high-density lipoprotein decreases hypertriglyceridemia in apoav-/- mice and requires glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1.. Arteriosclerosis, thrombosis, and vascular biology. 2010; 30(12): 2504-9.

Beigneux Anne P, Gin Peter, Davies Brandon S J, Weinstein Michael M, Bensadoun André, Fong Loren G, Young Stephen G Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein lipase.. The Journal of biological chemistry. 2009; 284(44): 30240-7.

Weinstein Michael M, Yin Liya, Beigneux Anne P, Davies Brandon S J, Gin Peter, Estrada Kristine, Melford Kristan, Bishop Joseph R, Esko Jeffrey D, Dallinga-Thie Geesje M, Fong Loren G, Bensadoun André, Young Stephen G Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice.. The Journal of biological chemistry. 2008; 283(50): 34511-8.

Davies Brandon S J, Waki Hironori, Beigneux Anne P, Farber Emily, Weinstein Michael M, Wilpitz Damien C, Tai Li-Jung, Evans Ronald M, Fong Loren G, Tontonoz Peter, Young Stephen G The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma.. Molecular endocrinology (Baltimore, Md.). 2008; 22(11): 2496-504.

Peterson Andrew S, Fong Loren G, Young Stephen G PCSK9 function and physiology.. Journal of lipid research. 2008; 49(7): 1595-9.

Beigneux Anne P, Gin Peter, Davies Brandon S J, Weinstein Michael M, Bensadoun André, Ryan Robert O, Fong Loren G, Young Stephen G Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase.. Journal of lipid research. 2008; 49(6): 1312-21.

Coffinier Catherine, Hudon Sarah E, Lee Roger, Farber Emily A, Nobumori Chika, Miner Jeffrey H, Andres Douglas A, Spielmann H Peter, Hrycyna Christine A, Fong Loren G, Young Stephen G A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells.. The Journal of biological chemistry. 2008; 283(15): 9797-804.

Véniant Murielle M, Beigneux Anne P, Bensadoun André, Fong Loren G, Young Stephen G Lipoprotein size and susceptibility to atherosclerosis--insights from genetically modified mouse models.. Current drug targets. 2008; 9(3): 174-89.

Gin Peter, Beigneux Anne P, Davies Brandon, Young Madeline F, Ryan Robert O, Bensadoun André, Fong Loren G, Young Stephen G Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to GPIHBP1 containing a G56R amino acid substitution.. Biochimica et biophysica acta. 2007; 1771(12): 1464-8.

Young Stephen G, Davies Brandon S J, Fong Loren G, Gin Peter, Weinstein Michael M, Bensadoun André, Beigneux Anne P GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicrons.. Current opinion in lipidology. 2007; 18(4): 389-96.

Coffinier Catherine, Hudon Sarah E, Farber Emily A, Chang Sandy Y, Hrycyna Christine A, Young Stephen G, Fong Loren G HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells.. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(33): 13432-7.