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RESEARCH

Stephen Young, M.D.

Contact Information:

Fax Number:

(310) 206-0865

Office Phone Number:

(310) 825-4934

Department Address:

UCLA Med-Cardio
650 Charles E. Young Drive South
A2-237 CHS Bldg.
Los Angeles, CA 90095
UNITED STATES

Mailing Address:

675 Charles E Young Drive South
MRL Room 4770
Los Angeles, CA 90095
UNITED STATES

Office Address:

GONDA 4506A
695 Charles E. Young Drive South
GONDA 4506A
Los Angeles, CA 90095
UNITED STATES

Work Email Address:

sgyoung@mednet.ucla.edu

Professor, Department of Medicine

Human Genetics

Administrator, ACCESS Program: Dept. of Human Genetics

Member, Access Biochemistry, Biophysics, Structural Biology Home Area

Access Molecular, Cellular and Integrative Physiology Home Area

Adult Cardiac Catheterization Laboratory

CTSI

Center for Duchenne Muscular Dystrophy

JCCC Signal Transduction and Therapeutics Program Area

Research Education, Training, and Career Development Program (CTSI-ED)

Faculty, Cardiology

Molecular Biology IDP


A Short Biography:

Dr. Stephen Young is a cardiologist and molecular geneticist who works on understanding genes relevant to human disease. He focuses on two areas - plasma triglyceride metabolism and diseases of the nuclear envelope.

Awards and Honors:

Ernst Jung Prize in Medicine
University of Gothenburg, Sweden Doctor Honoris Causa (Medicine)
American Heart Association Special Recognition Award in Vascular Biology
Named one of "America's Top Physicians"
American Heart Association Council on Arteriosclerosis Irvine H. Page Research Prize for Young Investigators
Certified, American Board of Clinical Lipidology

Detailed Biography:

Stephen Young grew up in Kansas and obtained an undergraduate degree in history from Princeton University. Following medical school at Washington University-St. Louis, he did internal medicine training at UCSF and cardiology training at UCSD. He then embarked on a career in molecular genetics. He did postdoctoral research training in lipid metabolism at UCSD and then worked at a research institute affiliated with UCSF for 17 years. Along the way, he became an expert in using genetically modified mice to decipher gene function. Currently, his laboratory works on protein posttranslational modifications, diseases of the nuclear lamina, and a new molecule required for the metabolism of triglyceride-rich lipoproteins. His laboratory has a strong track record in developing the careers of young scientists.

Selected Publications:

Villanueva Claudio J, Vergnes Laurent, Wang Jiexin, Drew Brian G, Hong Cynthia, Tu Yiping, Hu Yan, Peng Xu, Xu Feng, Saez Enrique, Wroblewski Kevin, Hevener Andrea L, Reue Karen, Fong Loren G, Young Stephen G, Tontonoz Peter Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs. Cell metabolism. 2013; 17(3): 423-35.
Young Stephen G, Zechner Rudolf Biochemistry and pathophysiology of intravascular and intracellular lipolysis. Genes & development. 2013; 27(5): 459-84.
Wiley Dorothy Joann, Hsu Hilary, Bolan Robert, Voskanian Alen, Elashoff David, Young Stephen, Dayrit Ruvy, Barman Provaboti, Deazambuja Katherine, Masongsong Emmanuel V, Martínez-Maza Otoniel, Detels Roger Comparison of 2 Anal Cytology Protocols to Predict High-Grade Anal Intraepithelial Neoplasia. Journal of lower genital tract disease. 2013; 5(4): .
Jung Hea-Jin, Nobumori Chika, Goulbourne Chris N, Tu Yiping, Lee John M, Tatar Angelica, Wu Daniel, Yoshinaga Yuko, de Jong Pieter J, Coffinier Catherine, Fong Loren G, Young Stephen G Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration. Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(21): E1923-32.
Scotti Elena, Calamai Martino, Goulbourne Chris N, Zhang Li, Hong Cynthia, Lin Ron R, Choi Jinkuk, Pilch Paul F, Fong Loren G, Zou Peng, Ting Alice Y, Pavone Francesco S, Young Stephen G, Tontonoz Peter IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor. Molecular and cellular biology. 2013; 33(8): 1503-14.
Witt Mallory D, Seaberg Eric C, Darilay Annie, Young Stephen, Badri Sheila, Rinaldo Charles R, Jacobson Lisa P, Detels Roger, Thio Chloe L Incident Hepatitis C Virus Infection in Men Who Have Sex With Men: A Prospective Cohort Analysis, 1984-2011. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2013; 5(4): .
Csaki Lauren S, Dwyer Jennifer R, Fong Loren G, Tontonoz Peter, Young Stephen G, Reue Karen Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling. Progress in lipid research. 2013; 52(3): 305-16.
Jung Hea-Jin, Lee John M, Yang Shao H, Young Stephen G, Fong Loren G Nuclear lamins in the brain - new insights into function and regulation. Molecular neurobiology. 2013; 47(1): 290-301.
Chen Xiao-Wei, Wang He, Bajaj Kanika, Zhang Pengcheng, Meng Zhuo-Xian, Ma Danjun, Bai Yongsheng, Liu Hui-Hui, Adams Elizabeth, Baines Andrea, Yu Genggeng, Sartor Maureen A, Zhang Bin, Yi Zhengping, Lin Jiandie, Young Stephen G, Schekman Randy, Ginsburg David SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion. eLife. 2013; 2(4): e00444.
Khan Omar M, Akula Murali K, Skålen Kristina, Karlsson Christin, Ståhlman Marcus, Young Stephen G, Borén Jan, Bergo Martin O Targeting GGTase-I activates RHOA, increases macrophage reverse cholesterol transport, and reduces atherosclerosis in mice. Circulation. 2013; 127(7): 782-90.
Ibrahim Mohamed X, Sayin Volkan I, Akula Murali K, Liu Meng, Fong Loren G, Young Stephen G, Bergo Martin O Targeting Isoprenylcysteine Methylation Ameliorates Disease in a Mouse Model of Progeria. Science (New York, N.Y.). 2013; 110(21): .
Young Stephen G, Yang Shao H, Davies Brandon S J, Jung Hea-Jin, Fong Loren G Targeting protein prenylation in progeria. Science translational medicine. 2013; 5(171): 171ps3.
Davies Brandon S J, Goulbourne Chris N, Barnes Richard H, Turlo Kirsten A, Gin Peter, Vaughan Sue, Vaux David J, Bensadoun André, Beigneux Anne P, Fong Loren G, Young Stephen G Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells. Journal of lipid research. 2012; 53(12): 2690-7.
Gin Peter, Goulbourne Chris N, Adeyo Oludotun, Beigneux Anne P, Davies Brandon S J, Tat Shelly, Voss Constance V, Bensadoun André, Fong Loren G, Young Stephen G Chylomicronemia mutations yield new insights into interactions between lipoprotein lipase and GPIHBP1. Human molecular genetics. 2012; 21(13): 2961-72.
Smith Stuart, Witkowski Andrzej, Moghul Ayesha, Yoshinaga Yuko, Nefedov Michael, de Jong Pieter, Feng Dejiang, Fong Loren, Tu Yiping, Hu Yan, Young Stephen G, Pham Thomas, Cheung Carling, Katzman Shana M, Brand Martin D, Quinlan Casey L, Fens Marcel, Kuypers Frans, Misquitta Stephanie, Griffey Stephen M, Tran Son, Gharib Afshin, Knudsen Jens, Hannibal-Bach Hans Kristian, Wang Grace, Larkin Sandra, Thweatt Jennifer, Pasta Saloni Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium. PloS one. 2012; 7(10): e47196.
Zhang Li, Reue Karen, Fong Loren G, Young Stephen G, Tontonoz Peter Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis. Arteriosclerosis, thrombosis, and vascular biology. 2012; 32(11): 2541-6.
Chang Sandy Y, Hudon-Miller Sarah E, Yang Shao H, Jung Hea-Jin, Lee John M, Farber Emily, Subramanian Thangaiah, Andres Douglas A, Spielmann H Peter, Hrycyna Christine A, Young Stephen G, Fong Loren G Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24. Journal of lipid research. 2012; 53(6): 1176-82.
Nyrén Rakel, Chang Chuchun L, Lindström Per, Barmina Anastasia, Vorrsjö Evelina, Ali Yusuf, Juntti-Berggren Lisa, Bensadoun André, Young Stephen G, Olivecrona Thomas, Olivecrona Gunilla Localization of lipoprotein lipase and GPIHBP1 in mouse pancreas: effects of diet and leptin deficiency. BMC physiology. 2012; 12(12): 14.
Young Stephen G, Fong Loren G Lowering plasma cholesterol by raising LDL receptors--revisited. The New England journal of medicine. 2012; 366(12): 1154-5.
Dwyer Jennifer R, Donkor Jimmy, Zhang Peixiang, Csaki Lauren S, Vergnes Laurent, Lee Jessica M, Dewald Jay, Brindley David N, Atti Elisa, Tetradis Sotirios, Yoshinaga Yuko, De Jong Pieter J, Fong Loren G, Young Stephen G, Reue Karen Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum. Proceedings of the National Academy of Sciences of the United States of America. 2012; 109(37): E2486-95.
Davies Brandon S J, Beigneux Anne P, Fong Loren G, Young Stephen G New wrinkles in lipoprotein lipase biology. Current opinion in lipidology. 2012; 23(1): 35-42.
Weinstein Michael M, Goulbourne Christopher N, Davies Brandon S J, Tu Yiping, Barnes Richard H, Watkins Steven M, Davis Ryan, Reue Karen, Tontonoz Peter, Beigneux Anne P, Fong Loren G, Young Stephen G Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice. Arteriosclerosis, thrombosis, and vascular biology. 2012; 32(2): 230-5.
Jung Hea-Jin, Coffinier Catherine, Choe Youngshik, Beigneux Anne P, Davies Brandon S J, Yang Shao H, Barnes Richard H, Hong Janet, Sun Tao, Pleasure Samuel J, Young Stephen G, Fong Loren G Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA. Proceedings of the National Academy of Sciences of the United States of America. 2012; 109(7): E423-31.
Yang Shao H, Chang Sandy Y, Tu Yiping, Lawson Gregory W, Bergo Martin O, Fong Loren G, Young Stephen G Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases. Journal of lipid research. 2012; 53(1): 77-86.
Borowsky Alexander D, Bandhuvula Padmavathi, Kumar Ashok, Yoshinaga Yuko, Nefedov Mikhail, Fong Loren G, Zhang Meng, Baridon Brian, Dillard Lisa, de Jong Pieter, Young Stephen G, West David B, Saba Julie D Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues. Journal of lipid research. 2012; 53(9): 1920-31.
Young Stephen G, Jung Hea-Jin, Coffinier Catherine, Fong Loren G Understanding the roles of nuclear A- and B-type lamins in brain development. The Journal of biological chemistry. 2012; 287(20): 16103-10.
Yang Shao H, Chang Sandy Y, Ren Shuxun, Wang Yibin, Andres Douglas A, Spielmann H Peter, Fong Loren G, Young Stephen G Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin. Human molecular genetics. 2011; 20(3): 436-44.
Yang Shao H, Chang Sandy Y, Yin Liya, Tu Yiping, Hu Yan, Yoshinaga Yuko, de Jong Pieter J, Fong Loren G, Young Stephen G An absence of both lamin B1 and lamin B2 in keratinocytes has no effect on cell proliferation or the development of skin and hair. Human molecular genetics. 2011; 20(18): 3537-44.
Yang Shao H, Jung Hea-Jin, Coffinier Catherine, Fong Loren G, Young Stephen G Are B-type lamins essential in all mammalian cells?. Nucleus (Austin, Tex.). 2011; 2(6): 562-9.
Beigneux Anne P, Davies Brandon S J, Tat Shelly, Chen Jenny, Gin Peter, Voss Constance V, Weinstein Michael M, Bensadoun André, Pullinger Clive R, Fong Loren G, Young Stephen G Assessing the role of the glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) three-finger domain in binding lipoprotein lipase. The Journal of biological chemistry. 2011; 286(22): 19735-43.
Gin Peter, Beigneux Anne P, Voss Constance, Davies Brandon S J, Beckstead Jennifer A, Ryan Robert O, Bensadoun André, Fong Loren G, Young Stephen G Binding preferences for GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells. Arteriosclerosis, thrombosis, and vascular biology. 2011; 31(1): 176-82.
Coffinier Catherine, Jung Hea-Jin, Nobumori Chika, Chang Sandy, Tu Yiping, Barnes Richard H, Yoshinaga Yuko, de Jong Pieter J, Vergnes Laurent, Reue Karen, Fong Loren G, Young Stephen G Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons. Molecular biology of the cell. 2011; 22(23): 4683-93.
Huang Danshan, Dhawan Tania, Young Stephen, Yong William H, Boros Laszlo G, Heaney Anthony P Fructose impairs glucose-induced hepatic triglyceride synthesis. Lipids in health and disease. 2011; 10(9): 20.
Young Stephen G, Davies Brandon S J, Voss Constance V, Gin Peter, Weinstein Michael M, Tontonoz Peter, Reue Karen, Bensadoun André, Fong Loren G, Beigneux Anne P GPIHBP1, an endothelial cell transporter for lipoprotein lipase. Journal of lipid research. 2011; 52(11): 1869-84.
Vergnes Laurent, Chin Robert, Young Stephen G, Reue Karen Heart-type fatty acid-binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance. The Journal of biological chemistry. 2011; 286(1): 380-90.
Davies Brandon Sj, Coffinier Catherine, Yang Shao H, Barnes Richard H, Jung Hea-Jin, Young Stephen G, Fong Loren G Investigating the purpose of prelamin A processing. Nucleus (Austin, Tex.). 2011; 2(1): 4-9.
Im Seung-Soon, Yousef Leyla, Blaschitz Christoph, Liu Janet Z, Edwards Robert A, Young Stephen G, Raffatellu Manuela, Osborne Timothy F Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a. Cell metabolism. 2011; 13(5): 540-9.
Voss Constance V, Davies Brandon S J, Tat Shelly, Gin Peter, Fong Loren G, Pelletier Christopher, Mottler Charlene D, Bensadoun André, Beigneux Anne P, Young Stephen G Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(19): 7980-4.
Verstraeten Valerie L R M, Peckham Lana A, Olive Michelle, Capell Brian C, Collins Francis S, Nabel Elizabeth G, Young Stephen G, Fong Loren G, Lammerding Jan Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(12): 4997-5002.
Feig Jonathan E, Parathath Sajesh, Rong James X, Mick Stephanie L, Vengrenyuk Yuliya, Grauer Lisa, Young Stephen G, Fisher Edward A Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques. Circulation. 2011; 123(9): 989-98.
Scotti Elena, Hong Cynthia, Yoshinaga Yuko, Tu Yiping, Hu Yan, Zelcer Noam, Boyadjian Rima, de Jong Pieter J, Young Stephen G, Fong Loren G, Tontonoz Peter Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists. Molecular and cellular biology. 2011; 31(9): 1885-93.
Patwari Parth, Emilsson Valur, Schadt Eric E, Chutkow William A, Lee Samuel, Marsili Alessandro, Zhang Yongzhao, Dobrin Radu, Cohen David E, Larsen P Reed, Zavacki Ann Marie, Fong Loren G, Young Stephen G, Lee Richard T The arrestin domain-containing 3 protein regulates body mass and energy expenditure. Cell metabolism. 2011; 14(5): 671-83.
Coffinier Catherine, Chang Sandy Y, Nobumori Chika, Tu Yiping, Farber Emily A, Toth Julia I, Fong Loren G, Young Stephen G Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(11): 5076-81.
Weinstein MM, Yin L, Beigneux AP, Davies BS, Gin P, Estrada K, Melford K, Bishop JR, Esko JD, Dallinga-Thie GM, Fong LG, Bensadoun A, Young SG. Abnormal patterns of lipoprotein lipase release into the plasma in GPIHPB1-deficient mice . J. Biol. Chem. 2010; 12: 34511?34518.
Davies Brandon S J, Barnes Richard H, Tu Yiping, Ren Shuxun, Andres Douglas A, Spielmann H Peter, Lammerding Jan, Wang Yibin, Young Stephen G, Fong Loren G An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria. Human molecular genetics. 2010; 19(13): 2682-94.
Yang Shao H, Chang Sandy Y, Andres Douglas A, Spielmann H Peter, Young Stephen G, Fong Loren G Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria. Journal of lipid research. 2010; 51(2): 400-5.
Weinstein Michael M, Tu Yiping, Beigneux Anne P, Davies Brandon S J, Gin Peter, Voss Constance, Walzem Rosemary L, Reue Karen, Tontonoz Peter, Bensadoun André, Fong Loren G, Young Stephen G Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice. Arteriosclerosis, thrombosis, and vascular biology. 2010; 30(11): 2106-13.
Weinstein Michael M, Yin Liya, Tu Yiping, Wang Xuping, Wu Xiaohui, Castellani Lawrence W, Walzem Rosemary L, Lusis Aldons J, Fong Loren G, Beigneux Anne P, Young Stephen G Chylomicronemia elicits atherosclerosis in mice--brief report. Arteriosclerosis, thrombosis, and vascular biology. 2010; 30(1): 20-3.
Franssen Remco, Young Stephen G, Peelman Frank, Hertecant Jozef, Sierts Jeroen A, Schimmel Alinda W M, Bensadoun André, Kastelein John J P, Fong Loren G, Dallinga-Thie Geesje M, Beigneux Anne P Chylomicronemia with low postheparin lipoprotein lipase levels in the setting of GPIHBP1 defects. Circulation. Cardiovascular genetics. 2010; 3(2): 169-78.
Bishop Joseph R, Passos-Bueno Maria Rita, Fong Loren, Stanford Kristin I, Gonzales Jon C, Yeh Erika, Young Stephen G, Bensadoun Andre, Witztum Joseph L, Esko Jeffrey D, Moulton Karen S Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans. PloS one. 2010; 5(11): e13919.
Coffinier Catherine, Jung Hea-Jin, Li Ziwei, Nobumori Chika, Yun Ui Jeong, Farber Emily A, Davies Brandon S, Weinstein Michael M, Yang Shao H, Lammerding Jan, Farahani Javad N, Bentolila Laurent A, Fong Loren G, Young Stephen G Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice. The Journal of biological chemistry. 2010; 285(27): 20818-26.
Hernandez Lidia, Roux Kyle J, Wong Esther Sook Miin, Mounkes Leslie C, Mutalif Rafidah, Navasankari Raju, Rai Bina, Cool Simon, Jeong Jae-Wook, Wang Honghe, Lee Hyun-Shik, Kozlov Serguei, Grunert Martin, Keeble Thomas, Jones C Michael, Meta Margarita D, Young Stephen G, Daar Ira O, Burke Brian, Perantoni Alan O, Stewart Colin L Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria. Developmental cell. 2010; 19(3): 413-25.
Davies Brandon S J, Beigneux Anne P, Barnes Richard H, Tu Yiping, Gin Peter, Weinstein Michael M, Nobumori Chika, Nyrén Rakel, Goldberg Ira, Olivecrona Gunilla, Bensadoun André, Young Stephen G, Fong Loren G GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries. Cell metabolism. 2010; 12(1): 42-52.
Lee Roger, Chang Sandy Y, Trinh Hung, Tu Yiping, White Andrew C, Davies Brandon S J, Bergo Martin O, Fong Loren G, Lowry William E, Young Stephen G Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes. Human molecular genetics. 2010; 19(8): 1603-17.
Coffinier C, Hudon SE, Farber EA, Chang SY, Hrycyna CA, Young SG, Fong LG. HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells. Proc. Natl. Acad. Sci. USA 2010; 104: 13432-13437.
Shu Xiao, Nelbach Lisa, Weinstein Michael M, Burgess Braydon L, Beckstead Jennifer A, Young Stephen G, Ryan Robert O, Forte Trudy M Intravenous injection of apolipoprotein A-V reconstituted high-density lipoprotein decreases hypertriglyceridemia in apoav-/- mice and requires glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1. Arteriosclerosis, thrombosis, and vascular biology. 2010; 30(12): 2504-9.
Coffinier Catherine, Fong Loren G, Young Stephen G LINCing lamin B2 to neuronal migration: growing evidence for cell-specific roles of B-type lamins. Nucleus (Austin, Tex.). 2010; 1(5): 407-11.
Olivecrona Gunilla, Ehrenborg Ewa, Semb Henrik, Makoveichuk Elena, Lindberg Anna, Hayden Michael R, Gin Peter, Davies Brandon S J, Weinstein Michael M, Fong Loren G, Beigneux Anne P, Young Stephen G, Olivecrona Thomas, Hernell Olle Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia. Journal of lipid research. 2010; 51(6): 1535-45.
Liu Meng, Sjogren Anna-Karin M, Karlsson Christin, Ibrahim Mohamed X, Andersson Karin M E, Olofsson Frida J, Wahlstrom Annika M, Dalin Martin, Yu Huiming, Chen Zhenggang, Yang Shao H, Young Stephen G, Bergo Martin O Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(14): 6471-6.
Olafsen Tove, Young Stephen G, Davies Brandon S J, Beigneux Anne P, Kenanova Vania E, Voss Constance, Young Glen, Wong Koon-Pong, Barnes Richard H, Tu Yiping, Weinstein Michael M, Nobumori Chika, Huang Sung-Cheng, Goldberg Ira J, Bensadoun André, Wu Anna M, Fong Loren G Unexpected expression pattern for glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) in mouse tissues revealed by positron emission tomography scanning. The Journal of biological chemistry. 2010; 285(50): 39239-48.
Beigneux AP, Franssen R, Bensadoun A, Gin P, Melford K, Peter J, Walzem RL, Weinstein MM, Davies BS, Kuivenhoven JA, Kastelein JJ, Fong LG, Dallinga-Thie GM, Young SG. Chylomicronemia with a Mutant GPIHBP1 (Q115P) that Cannot Bind Lipoprotein Lipase. . Arterioscler Thromb Vasc Biol 2009; (29): 956-962.
Lee R, Chang SY, Trinh H, White AC, Bergo MO, Fong LG, Lowry WE, and Young SG. Genetic Analysis of the Importance of the Protein Prenyltransferases in Skin Keratinocytes. Human Molecular Gen 2009; (19): 1603-1617.
Beigneux Anne P, Gin Peter, Davies Brandon S J, Weinstein Michael M, Bensadoun André, Fong Loren G, Young Stephen G Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein lipase. The Journal of biological chemistry. 2009; 284(44): 30240-7.
Coffinier Catherine, Hudon Sarah E, Lee Roger, Farber Emily A, Nobumori Chika, Miner Jeffrey H, Andres Douglas A, Spielmann H Peter, Hrycyna Christine A, Fong Loren G, Young Stephen G A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells. The Journal of biological chemistry. 2008; 283(15): 9797-804.
Weinstein Michael M, Yin Liya, Beigneux Anne P, Davies Brandon S J, Gin Peter, Estrada Kristine, Melford Kristan, Bishop Joseph R, Esko Jeffrey D, Dallinga-Thie Geesje M, Fong Loren G, Bensadoun André, Young Stephen G Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice. The Journal of biological chemistry. 2008; 283(50): 34511-8.
Beigneux Anne P, Gin Peter, Davies Brandon S J, Weinstein Michael M, Bensadoun André, Ryan Robert O, Fong Loren G, Young Stephen G Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase. Journal of lipid research. 2008; 49(6): 1312-21.
Véniant Murielle M, Beigneux Anne P, Bensadoun André, Fong Loren G, Young Stephen G Lipoprotein size and susceptibility to atherosclerosis--insights from genetically modified mouse models. Current drug targets. 2008; 9(3): 174-89.
Peterson Andrew S, Fong Loren G, Young Stephen G PCSK9 function and physiology. Journal of lipid research. 2008; 49(7): 1595-9.
Yang SH, Andres DA, Spielmann HP, Young SG, and Fong LG. Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated. J. Clin. Invest 2008; 118: 3291-3300.
Gin P, Yin L, Davies BSJ, Weinstein MM, Ryan RO, Bensadoun A, Fong LG, Young SG, and Beigneux AP The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons. J Biol. Chem 2008; 283: 29554-29562.
Davies Brandon S J, Waki Hironori, Beigneux Anne P, Farber Emily, Weinstein Michael M, Wilpitz Damien C, Tai Li-Jung, Evans Ronald M, Fong Loren G, Tontonoz Peter, Young Stephen G The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma. Molecular endocrinology (Baltimore, Md.). 2008; 22(11): 2496-504.
Young Stephen G, Davies Brandon S J, Fong Loren G, Gin Peter, Weinstein Michael M, Bensadoun André, Beigneux Anne P GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicrons. Current opinion in lipidology. 2007; 18(4): 389-96.
Beigneux AP, Davies BS, Gin P, Weinstein MM, Farber E, Qiao X, Peale F, Bunting S, Walzem RL, Wong JS, Blaner WS, Ding ZM, Melford K, Wongsiriroj N, Shu X, de Sauvage F, Ryan RO, Fong LG, Bensadoun A, Young SG. Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons. Cell Metabolism 2007; 5: 279?291.
Coffinier Catherine, Hudon Sarah E, Farber Emily A, Chang Sandy Y, Hrycyna Christine A, Young Stephen G, Fong Loren G HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(33): 13432-7.
Gin Peter, Beigneux Anne P, Davies Brandon, Young Madeline F, Ryan Robert O, Bensadoun André, Fong Loren G, Young Stephen G Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to GPIHBP1 containing a G56R amino acid substitution. Biochimica et biophysica acta. 2007; 1771(12): 1464-8.
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