Pinchas Cohen, M.D.

A Short Biography:

Dr. Cohen is a physician-scientist who serves as the Chief of the Pediatric Endocrinology Division at UCLA and the Co-Director of the UC Diabetes Center as well as being an international expert on growth disorders. He is also an experienced growth-factor biologist and a leader in the emerging field of mitochondrial peptides

Work Titles and Affiliation
UCLA Professor, Pediatrics
Education:
Degrees:
M.D., Israel Institute of Technology Faculty of Medicine, 1978 - 1986
Fellowship:
1986 - 1992 Stanford University, Pediatrics & Endocrine
Fellowship:
1989 - 1992 Stanford University Medical Center
Internship:
1986 - 1987 Stanford University Medical Center
Residency:
1987 - 1989 Stanford University Medical Center
Certifications:
Certifications:
1995 American Board of Pediatrics
1990 American Board of Pediatrics

Contact Information:

Work Phone Number:

(310) 206-5844

(310) 825-6244

Office Address:

10833 Le Conte Ave.
CHS 22-315
Campus - 175217
Los Angeles, CA 90095

Detailed Biography:

Dr. Cohen graduated with highest honors in 1986 from the Technion Medical School in Israel, and trained in Pediatrics and Endocrinology at Stanford University until 1992. He was until 1998 an Associate Professor and Pediatric Endocrinology Program Director at the University of Pennsylvania & Children?s Hospital of Philadelphia. He is currently a Professor and Chief of Pediatric Endocrinology at UCLA and the associate director of the UCSD/UCLA Diabetes/Endocrinology Research Center. He was inducted into both the Society of Pediatric Research and the American Pediatric Society (APS). He is the recipient of the American Diabetes Association, Pediatric Endocrine Society, Eli-Lilly & Ross awards, and most recently, the APS Best Science Award. Dr. Cohen published over 250 papers focusing on cancer, aging, growth disorders, diabetes, GH/IGF biology and the emerging science of mitochondrial-derived peptides. He received grants from the National Institutes of Health (NIH), FDA, and various foundations including the Prostate cancer Foundation. He recently received a EUREKA-Award and the NIH-Director-Transformative RO1-Grant. He serves on several NIH study sections and his editorial services include being an associate editor of Pediatric Research and a member of the editorial boards of Journal of Clinical Endocrinology and Metabolism, Endocrinology, and the Journal of GH and IGF Research as well as being an executive officer of the GH Research society, the IGF society and the Endocrine Society Steering Committee.

Publications:

Cohen Pinchas, Rogol Alan D, Weng Wayne, Kappelgaard Anne-Marie, Rosenfeld Ron G, Germak John, Germak John   Efficacy of IGF-based growth hormone (GH) dosing in nonGH-deficient (nonGHD) short stature children with low IGF-I is not related to basal IGF-I levels Clinical endocrinology, 2013; 78(3): 405-14.
Wan JunXiang, Atzmon Gil, Hwang David, Barzlai Nir, Kratzsch Jurgen, Cohen Pinchas   Growth hormone receptor (GHR) exon 3 polymorphism status detection by dual-enzyme-linked immunosorbent assay (ELISA) The Journal of clinical endocrinology and metabolism, 2013; 98(1): E77-81.
Lee Changhan, Yen Kelvin, Cohen Pinchas   Humanin: a harbinger of mitochondrial-derived peptides? Trends in endocrinology and metabolism: TEM, 2013; 24(5): 222-8.
Seligson David B, Yu Hong, Tze Sheila, Said Jonathan, Pantuck Allan J, Cohen Pinchas, Lee Kuk-Wha   IGFBP-3 nuclear localization predicts human prostate cancer recurrence Hormones & cancer, 2013; 4(1): 12-23.
Parrella Edoardo, Maxim Tom, Maialetti Francesca, Zhang Lu, Wan Junxiang, Wei Min, Cohen Pinchas, Fontana Luigi, Longo Valter D   Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model Aging cell, 2013; 12(2): 257-68.
Dean James P, Sprenger Cynthia C, Wan Junxiang, Haugk Kathleen, Ellis William J, Lin Daniel W, Corman John M, Dalkin Bruce L, Mostaghel Elahe, Nelson Peter S, Cohen Pinchas, Montgomery Bruce, Plymate Stephen R   Response of the Insulin-Like Growth Factor (IGF) System to IGF-IR Inhibition and Androgen Deprivation in a Neoadjuvant Prostate Cancer Trial: Effects of Obesity and Androgen Deprivation The Journal of clinical endocrinology and metabolism, 2013; 98(5): E820-8.
Klink Joseph C, Tewari Alok K, Masko Elizabeth M, Antonelli Jodi, Febbo Phillip G, Cohen Pinchas, Dewhirst Mark W, Pizzo Salvatore V, Freedland Stephen J   Resveratrol worsens survival in SCID mice with prostate cancer xenografts in a cell-line specific manner, through paradoxical effects on oncogenic pathways The Prostate, 2013; 73(7): 754-62.
Yen Kelvin, Lee Changhan, Mehta Hemal, Cohen Pinchas   The emerging role of the mitochondrial-derived peptide humanin in stress resistance Journal of molecular endocrinology, 2013; 50(1): R11-9.
Konijeti Ramdev, Koyama Satomi, Gray Ashley, Barnard R James, Said Jonathan W, Castor Brandon, Elashoff David, Wan Junxiang, Beltran Pedro J, Calzone Frank J, Cohen Pinchas, Galet Colette, Aronson William J   Effect of a low-fat diet combined with IGF-1 receptor blockade on 22Rv1 prostate cancer xenografts Molecular cancer therapeutics, 2012; 11(7): 1539-46.
Pawlikowska-Haddal Anna, Cohen Pinchas, Cook David M   How useful are serum IGF-I measurements for managing GH replacement therapy in adults and children? Pituitary, 2012; 15(2): 126-34.
Zhang Xin, Urbieta-Caceres Victor H, Eirin Alfonso, Bell Caitlin C, Crane John A, Tang Hui, Jordan Kyra L, Oh Yun-Kyu, Zhu Xiang-Yang, Korsmo Michael J, Bachar Adi R, Cohen Pinchas, Lerman Amir, Lerman Lilach O   Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice Life sciences, 2012; 91(5-6): 199-206.
Zacharias David G, Kim Sung Gyun, Massat Alfonso Eirin, Bachar Adi R, Oh Yun K, Herrmann Joerg, Rodriguez-Porcel Martin, Cohen Pinchas, Lerman Lilach O, Lerman Amir   Humanin, a cytoprotective peptide, is expressed in carotid atherosclerotic [corrected] plaques in humans PloS one, 2012; 7(2): e31065.
Rosenfeld Ron G, Cohen Pinchas, Robison Leslie L, Bercu Barry B, Clayton Peter, Hoffman Andrew R, Radovick Sally, Saenger Paul, Savage Martin O, Wit Jan M   Long-term surveillance of growth hormone therapy The Journal of clinical endocrinology and metabolism, 2012; 97(1): 68-72.
Williams Nolann G, Interlichia Jillian P, Jackson Melissa F, Hwang David, Cohen Pinchas, Rodgers Buel D   Endocrine actions of myostatin: systemic regulation of the IGF and IGF binding protein axis Endocrinology, 2011; 152(1): 172-80.
Gray Ashley, Aronson William J, Barnard R James, Mehta Hemal, Wan Junxiang, Said Jonathan, Cohen Pinchas, Galet Colette   Global Igfbp1 deletion does not affect prostate cancer development in a c-Myc transgenic mouse model The Journal of endocrinology, 2011; 211(3): 297-304.
Guevara-Aguirre Jaime, Balasubramanian Priya, Guevara-Aguirre Marco, Wei Min, Madia Federica, Cheng Chia-Wei, Hwang David, Martin-Montalvo Alejandro, Saavedra Jannette, Ingles Sue, de Cabo Rafael, Cohen Pinchas, Longo Valter D   Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans Science translational medicine, 2011; 3(70): 70ra13.
Oh Yun K, Bachar Adi R, Zacharias David G, Kim Sung Gyun, Wan Junxiang, Cobb Laura J, Lerman Lilach O, Cohen Pinchas, Lerman Amir   Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice Atherosclerosis, 2011; 219(1): 65-73.
Mehta Hemal H, Gao Qinglei, Galet Colette, Paharkova Vladislava, Wan Junxiang, Said Jonathan, Sohn Joanne J, Lawson Gregory, Cohen Pinchas, Cobb Laura J, Lee Kuk-Wha   IGFBP-3 is a metastasis suppression gene in prostate cancer Cancer research, 2011; 71(15): 5154-63.
Mason Emily J, Grell Jacquelyn A, Wan Junxiang, Cohen Pinchas, Conover Cheryl A   Insulin-like growth factor (IGF)-I and IGF-II contribute differentially to the phenotype of pregnancy associated plasma protein-A knock-out mice Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2011; 21(5): 243-7.
Aronson William J, Kobayashi Naoko, Barnard R James, Henning Susanne, Huang Min, Jardack Patricia M, Liu Bingrong, Gray Ashley, Wan Junxiang, Konijeti Ramdev, Freedland Stephen J, Castor Brandon, Heber David, Elashoff David, Said Jonathan, Cohen Pinchas, Galet Colette   Phase II prospective randomized trial of a low-fat diet with fish oil supplementation in men undergoing radical prostatectomy Cancer prevention research (Philadelphia, Pa.), 2011; 4(12): 2062-71.
Konijeti Ramdev, Henning Susanne, Moro Aune, Sheikh Ahmed, Elashoff David, Shapiro Ari, Ku Melvin, Said Jonathan W, Heber David, Cohen Pinchas, Aronson William J   Chemoprevention of prostate cancer with lycopene in the TRAMP model The Prostate, 2010; 70(14): 1547-54.
Buschemeyer W Cooper, Klink Joseph C, Mavropoulos John C, Poulton Susan H, Demark-Wahnefried Wendy, Hursting Stephen D, Cohen Pinchas, Hwang David, Johnson Tracy L, Freedland Stephen J   Effect of intermittent fasting with or without caloric restriction on prostate cancer growth and survival in SCID mice The Prostate, 2010; 70(10): 1037-43.
Aronson William J, Barnard R James, Freedland Stephen J, Henning Susanne, Elashoff David, Jardack Patricia M, Cohen Pinchas, Heber David, Kobayashi Naoko   Growth inhibitory effect of low fat diet on prostate cancer cells: results of a prospective, randomized dietary intervention trial in men with prostate cancer The Journal of urology, 2010; 183(1): 345-50.
Bachar Adi R, Scheffer Lea, Schroeder Andreas S, Nakamura Hiromi K, Cobb Laura J, Oh Yun K, Lerman Lilach O, Pagano Richard E, Cohen Pinchas, Lerman Amir   Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress Cardiovascular research, 2010; 88(2): 360-6.
Jia Yue, Lee Kuk-Wha, Swerdloff Ronald, Hwang David, Cobb Laura J, Sinha Hikim Amiya, Lue Yan He, Cohen Pinchas, Wang Christina   Interaction of insulin-like growth factor-binding protein-3 and BAX in mitochondria promotes male germ cell apoptosis The Journal of biological chemistry, 2010; 285(3): 1726-32.
Lue YanHe, Swerdloff Ronald, Liu QingHai, Mehta Hemal, Hikim Amiya Sinha, Lee Kuk-Wha, Jia Yue, Hwang David, Cobb Laura J, Cohen Pinchas, Wang Christina   Opposing roles of insulin-like growth factor binding protein 3 and humanin in the regulation of testicular germ cell apoptosis Endocrinology, 2010; 151(1): 350-7.
Koyama Satomi, Cobb Laura J, Mehta Hemal H, Seeram Navindra P, Heber David, Pantuck Allan J, Cohen Pinchas   Pomegranate extract induces apoptosis in human prostate cancer cells by modulation of the IGF-IGFBP axis Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2010; 20(1): 55-62.
Lee Changhan, Safdie Fernando M, Raffaghello Lizzia, Wei Min, Madia Federica, Parrella Edoardo, Hwang David, Cohen Pinchas, Bianchi Giovanna, Longo Valter D   Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index Cancer research, 2010; 70(4): 1564-72.
Hoang Phuong T, Park Patricia, Cobb Laura J, Paharkova-Vatchkova Valdislava, Hakimi Michael, Cohen Pinchas, Lee Kuk-Wha   The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice Metabolism: clinical and experimental, 2010; 59(3): 343-9.
Cohen Pinchas, Germak John, Rogol Alan D, Weng Wayne, Kappelgaard Anne-Marie, Rosenfeld Ron G, Rosenfeld Ron G   Variable degree of growth hormone (GH) and insulin-like growth factor (IGF) sensitivity in children with idiopathic short stature compared with GH-deficient patients: evidence from an IGF-based dosing study of short children The Journal of clinical endocrinology and metabolism, 2010; 95(5): 2089-98.
Cohen Pinchas   Clinical management of growth hormone therapy for children Managed care (Langhorne, Pa.), 2009; 18(8 Suppl 6): 4-9.
Cobb Laura J, Mehta Hemal, Cohen Pinchas   Enhancing the apoptotic potential of insulin-like growth factor-binding protein-3 in prostate cancer by modulation of CK2 phosphorylation Molecular endocrinology (Baltimore, Md.), 2009; 23(10): 1624-33.
Safdie Fernando M, Dorff Tanya, Quinn David, Fontana Luigi, Wei Min, Lee Changhan, Cohen Pinchas, Longo Valter D   Fasting and cancer treatment in humans: A case series report Aging, 2009; 1(12): 988-1007.
Cohen Pinchas   Growth hormone treatment: evidence, practice, and emerging issues Managed care (Langhorne, Pa.), 2009; 18(8 Suppl 6): 2-3.
Muzumdar Radhika H, Huffman Derek M, Atzmon Gil, Buettner Christoph, Cobb Laura J, Fishman Sigal, Budagov Temuri, Cui Lingguang, Einstein Francine H, Poduval Aruna, Hwang David, Barzilai Nir, Cohen Pinchas   Humanin: a novel central regulator of peripheral insulin action PloS one, 2009; 4(7): e6334.
Fan Yong, Menon Ram K, Cohen Pinchas, Hwang David, Clemens Thomas, DiGirolamo Douglas J, Kopchick John J, Le Roith Derek, Trucco Massimo, Sperling Mark A   Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism The Journal of biological chemistry, 2009; 284(30): 19937-44.
Keni Jyotsna, Cohen Pinchas   Optimizing growth hormone dosing in children with idiopathic short stature Hormone research, 2009; 71 Suppl 1(3): 70-4.
Miyako Kenichi, Cobb Laura J, Francis Malik, Huang Alden, Peng Bonnie, Pintar John E, Ariga Hiroyoshi, Cohen Pinchas   PAPA-1 Is a nuclear binding partner of IGFBP-2 and modulates its growth-promoting actions Molecular endocrinology (Baltimore, Md.), 2009; 23(2): 169-75.
Yakar Shoshana, Rosen Clifford J, Bouxsein Mary L, Sun Hui, Mejia Wilson, Kawashima Yuki, Wu Yingjie, Emerton Kelly, Williams Valerie, Jepsen Karl, Schaffler Mitchell B, Majeska Robert J, Gavrilova Oksana, Gutierrez Mariana, Hwang David, Pennisi Patricia, Frystyk Jan, Boisclair Yves, Pintar John, Jasper Héctor, Domene Horacio, Cohen Pinchas, Clemmons David, LeRoith Derek   Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2009; 23(3): 709-19.
Mavropoulos John C, Buschemeyer W Cooper, Tewari Alok K, Rokhfeld Dmitriy, Pollak Michael, Zhao Yunhua, Febbo Phillip G, Cohen Pinchas, Hwang David, Devi Gayathri, Demark-Wahnefried Wendy, Westman Eric C, Peterson Bercedis L, Pizzo Salvatore V, Freedland Stephen J   The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model Cancer prevention research (Philadelphia, Pa.), 2009; 2(6): 557-65.
Freedland Stephen J, Mavropoulos John, Wang Amy, Darshan Medha, Demark-Wahnefried Wendy, Aronson William J, Cohen Pinchas, Hwang David, Peterson Bercedis, Fields Timothy, Pizzo Salvatore V, Isaacs William B   Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis The Prostate, 2008; 68(1): 11-9.
Kobayashi Naoko, Barnard R James, Said Jonathan, Hong-Gonzalez Jenny, Corman Dan M, Ku Melvin, Doan Ngan Bao, Gui Dorina, Elashoff David, Cohen Pinchas, Aronson William J   Effect of low-fat diet on development of prostate cancer and Akt phosphorylation in the Hi-Myc transgenic mouse model Cancer research, 2008; 68(8): 3066-73.
Suh Yousin, Atzmon Gil, Cho Mi-Ook, Hwang David, Liu Bingrong, Leahy Daniel J, Barzilai Nir, Cohen Pinchas   Functionally significant insulin-like growth factor I receptor mutations in centenarians Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(9): 3438-42.
Park Jung Yoon, Cho Mi-Ook, Leonard Shanique, Calder Brent, Mian I Saira, Kim Woo Ho, Wijnhoven Susan, van Steeg Harry, Mitchell James, van der Horst Gijsbertus T J, Hoeijmakers Jan, Cohen Pinchas, Vijg Jan, Suh Yousin   Homeostatic imbalance between apoptosis and cell renewal in the liver of premature aging Xpd mice PloS one, 2008; 3(6): e2346.
Salusky Isidro B, Cohen Pinchas   Lost in translation? Pediatric research, 2008; 64(3): 225.
Hwang David L, Lee Phillip D K, Cohen Pinchas   Quantitative ontogeny of murine insulin-like growth factor (IGF)-I, IGF-binding protein-3 and the IGF-related acid-labile subunit Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2008; 18(1): 65-74.
Ding Feng, Li Hong Hua, Zhang Shengwen, Solomon Nicola M, Camper Sally A, Cohen Pinchas, Francke Uta   SnoRNA Snord116 (Pwcr1/MBII-85) deletion causes growth deficiency and hyperphagia in mice PloS one, 2008; 3(3): e1709.
Cohen Pinchas   Statement 1: a serum insulin-like growth factor I (IGF-I) level should be part of the evaluation of children with short stature Pediatric endocrinology reviews : PER, 2008; 5 Suppl 3(8): 834-6.
Hernández Maria Isabel, Cohen Pinchas   Surprising new height regulating genes: beyond growth hormone and IGF-I Pediatric research, 2008; 64(5): 461.
Anzo Makoto, Cobb Laura J, Hwang David L, Mehta Hemal, Said Jonathan W, Yakar Shoshana, LeRoith Derek, Cohen Pinchas   Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression Cancer research, 2008; 68(9): 3342-9.
Barnard R James, Leung Pak Shan, Aronson William J, Cohen Pinchas, Golding Lawrence A   A mechanism to explain how regular exercise might reduce the risk for clinical prostate cancer European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2007; 16(5): 415-21.
Lee Kuk-Wha, Cobb Laura J, Paharkova-Vatchkova Vladislava, Liu Bingrong, Milbrandt Jeffrey, Cohen Pinchas   Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3 Carcinogenesis, 2007; 28(8): 1653-8.
Raina Komal, Blouin Marie-José, Singh Rana P, Majeed Noreen, Deep Gagan, Varghese Leyon, Glodé L Michael, Greenberg Norman M, Hwang David, Cohen Pinchas, Pollak Michael N, Agarwal Rajesh   Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model Cancer research, 2007; 67(22): 11083-91.
Ali Omar, Shim Melanie, Fowler Eileen, Greenberg Marcia, Perkins Donna, Oppenheim William, Cohen Pinchas   Growth hormone therapy improves bone mineral density in children with cerebral palsy: a preliminary pilot study The Journal of clinical endocrinology and metabolism, 2007; 92(3): 932-7.
Degraff David J, Malik Manisha, Chen Qian, Miyako Kenichi, Rejto Lidia, Aguiar Adam A, Bancroft Diccon R E, Cohen Pinchas, Sikes Robert A   Hormonal regulation of IGFBP-2 proteolysis is attenuated with progression to androgen insensitivity in the LNCaP progression model Journal of cellular physiology, 2007; 213(1): 261-8.
Cohen Pinchas, Rogol Alan D, Howard Campbell P, Bright George M, Kappelgaard Anne-Marie, Rosenfeld Ron G, Rosenfeld Ron G   Insulin growth factor-based dosing of growth hormone therapy in children: a randomized, controlled study The Journal of clinical endocrinology and metabolism, 2007; 92(7): 2480-6.
Kim Hae Soon, Ali Omar, Shim Melanie, Lee Kuk-Wha, Vuguin Patricia, Muzumdar Radhika, Barzilai Nir, Cohen Pinchas   Insulin-like growth factor binding protein-3 induces insulin resistance in adipocytes in vitro and in rats in vivo Pediatric research, 2007; 61(2): 159-64.
Ali Omar, Shim Melanie, Fowler Eileen, Cohen Pinchas, Oppenheim William   Spinal bone mineral density, IGF-1 and IGFBP-3 in children with cerebral palsy Hormone research, 2007; 68(6): 316-20.
Kaplan Solomon A, Cohen Pinchas   The somatomedin hypothesis 2007: 50 years later The Journal of clinical endocrinology and metabolism, 2007; 92(12): 4529-35.
Rosenthal Stephen, Cohen Pinchas, Clayton Peter, Backeljauw Philippe, Bang Peter, Ten Svetlana   Treatment perspectives in idiopathic short stature with a focus on IGF-I deficiency Pediatric endocrinology reviews : PER, 2007; 4 Suppl 2(1): 252-71.
Pawlikowska-Haddal Anna, Cohen Pinchas   Advances in pediatric growth hormone therapy: IGF-I-based dosing Indian pediatrics, 2006; 43(7): 577-81.
Colón Eugenia, Strand Mona-Lisa, Carlsson-Skwirut Christine, Wahlgren Aida, Svechnikov Konstantin V, Cohen Pinchas, Söder Olle   Anti-apoptotic factor humanin is expressed in the testis and prevents cell-death in leydig cells during the first wave of spermatogenesis Journal of cellular physiology, 2006; 208(2): 373-85.
Muzumdar Radhika H, Ma Xiaohui, Fishman Sigal, Yang Xiaoman, Atzmon Gil, Vuguin Patricia, Einstein Francine H, Hwang David, Cohen Pinchas, Barzilai Nir   Central and opposing effects of IGF-I and IGF-binding protein-3 on systemic insulin action Diabetes, 2006; 55(10): 2788-96.
Cohen Pinchas   Controversy in clinical endocrinology: problems with reclassification of insulin-like growth factor I production and action disorders The Journal of clinical endocrinology and metabolism, 2006; 91(11): 4235-6.
Kobayashi Naoko, Barnard R James, Henning Susanne M, Elashoff David, Reddy Srinivasa T, Cohen Pinchas, Leung Pak, Hong-Gonzalez Jenny, Freedland Stephen J, Said Jonathan, Gui Dorina, Seeram Navindra P, Popoviciu Laura M, Bagga Dilprit, Heber David, Glaspy John A, Aronson William J   Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2 Clinical cancer research : an official journal of the American Association for Cancer Research, 2006; 12(15): 4662-70.
Oh Seung-Hyun, Kim Woo-Young, Kim Jai-Hyun, Younes Maher N, El-Naggar Adel K, Myers Jeffrey N, Kies Merril, Cohen Pinchas, Khuri Fadlo, Hong Waun K, Lee Ho-Young   Identification of insulin-like growth factor binding protein-3 as a farnesyl transferase inhibitor SCH66336-induced negative regulator of angiogenesis in head and neck squamous cell carcinoma Clinical cancer research : an official journal of the American Association for Cancer Research, 2006; 12(2): 653-61.
Benini Stefania, Zuntini Monia, Manara Maria Cristina, Cohen Pinchas, Nicoletti Giordano, Nanni Patrizia, Oh Youngman, Picci Piero, Scotlandi Katia   Insulin-like growth factor binding protein 3 as an anticancer molecule in Ewing's sarcoma International journal of cancer. Journal international du cancer, 2006; 119(5): 1039-46.
Cohen Pinchas   Overview of the IGF-I system Hormone research, 2006; 65 Suppl 1(2): 3-8.
Cobb Laura J, Liu Bingrong, Lee Kuk-Wha, Cohen Pinchas   Phosphorylation by DNA-dependent protein kinase is critical for apoptosis induction by insulin-like growth factor binding protein-3 Cancer research, 2006; 66(22): 10878-84.
Oufattole Mohammed, Lin Sally Wan-Jung, Liu Bingrong, Mascarenhas Desmond, Cohen Pinchas, Rodgers Buel D   Ribonucleic acid polymerase II binding subunit 3 (Rpb3), a potential nuclear target of insulin-like growth factor binding protein-3 Endocrinology, 2006; 147(5): 2138-46.
Yakar Shoshana, Bouxsein Mary L, Canalis Ernesto, Sun Hui, Glatt Vaida, Gundberg Caren, Cohen Pinchas, Hwang David, Boisclair Yves, Leroith Derek, Rosen Clifford J   The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone The Journal of endocrinology, 2006; 189(2): 289-99.
Rosen Clifford J, Ackert-Bicknell Cheryl, Beamer Wesley G, Nelson Tracy, Adamo Martin, Cohen Pinchas, Bouxsein Mary L, Horowitz Mark C   Allelic differences in a quantitative trait locus affecting insulin-like growth factor-I impact skeletal acquisition and body composition Pediatric nephrology (Berlin, Germany), 2005; 20(3): 255-60.
Liu Bingrong, Lee Kuk-Wha, Li Heju, Ma Liqun, Lin George L, Chandraratna Roshantha A S, Cohen Pinchas   Combination therapy of insulin-like growth factor binding protein-3 and retinoid X receptor ligands synergize on prostate cancer cell apoptosis in vitro and in vivo Clinical cancer research : an official journal of the American Association for Cancer Research, 2005; 11(13): 4851-6.
Yang Joshua, Anzo Makoto, Cohen Pinchas   Control of aging and longevity by IGF-I signaling Experimental gerontology, 2005; 40(11): 867-72.
Park Patricia, Cohen Pinchas   Insulin-like growth factor I (IGF-I) measurements in growth hormone (GH) therapy of idiopathic short stature (ISS) Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2005; 15 Suppl A(13): S13-20.
Ferry Robert J, Cohen Pinchas, Levitt Katz Lorraine E   Pharmacodynamic considerations with recombinant human insulin-like growth factor-I in children Hormone research, 2005; 63(5): 220-7.
Freedland Stephen J, Aronson William J, Trock Bruce, Cohen Pinchas, Kane Christopher J, Amling Christopher L, Presti Joseph C, Terris Martha K, Terris Martha K   Racial differences in prognostic value of adult height for biochemical progression following radical prostatectomy Clinical cancer research : an official journal of the American Association for Cancer Research, 2005; 11(21): 7735-42.
Lee Kuk-Wha, Ma Liqun, Yan Xinmin, Liu Bingrong, Zhang Xiao-kun, Cohen Pinchas   Rapid apoptosis induction by IGFBP-3 involves an insulin-like growth factor-independent nucleomitochondrial translocation of RXRalpha/Nur77 The Journal of biological chemistry, 2005; 280(17): 16942-8.
Randhawa Ruvdeep, Cohen Pinchas   The role of the insulin-like growth factor system in prenatal growth Molecular genetics and metabolism, 2005; 86(1-2): 84-90.
Grimberg Adda, Coleman Carrie M, Burns Timothy F, Himelstein Bruce P, Koch Cameron J, Cohen Pinchas, El-Deiry Wafik S   p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia The Journal of clinical endocrinology and metabolism, 2005; 90(6): 3568-74.
Mikheev Andrei M, Mikheeva Svetlana A, Liu Binrong, Cohen Pinchas, Zarbl Helmut   A functional genomics approach for the identification of putative tumor suppressor genes: Dickkopf-1 as suppressor of HeLa cell transformation Carcinogenesis, 2004; 25(1): 47-59.
Lee Kuk-Wha, Liu Bingrong, Ma Liqun, Li Heju, Bang Peter, Koeffler H Phillip, Cohen Pinchas   Cellular internalization of insulin-like growth factor binding protein-3: distinct endocytic pathways facilitate re-uptake and nuclear localization The Journal of biological chemistry, 2004; 279(1): 469-76.
Prieur Alexandre, Tirode Franck, Cohen Pinchas, Delattre Olivier   EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3 Molecular and cellular biology, 2004; 24(16): 7275-83.
Ikezoe Takayuki, Tanosaki Sakae, Krug Utz, Liu Bingrong, Cohen Pinchas, Taguchi Hirokuni, Koeffler H Phillip   Insulin-like growth factor binding protein-3 antagonizes the effects of retinoids in myeloid leukemia cells Blood, 2004; 104(1): 237-42.
Shim Melanie L, Levitt Katz Lorraine E, Davis Jason, Dotzler Whittney C, Cohen Pinchas, Ferry Robert J   Insulin-like growth factor binding protein-3 is a novel mediator of apoptosis in insulin-secreting cells Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2004; 14(3): 216-25.
Shim Melanie L, Moshang Thomas, Oppenheim William L, Cohen Pinchas   Is treatment with growth hormone effective in children with cerebral palsy? Developmental medicine and child neurology, 2004; 46(8): 569-71.
Licinio Julio, Caglayan Sinan, Ozata Metin, Yildiz Bulent O, de Miranda Patricia B, O'Kirwan Fiona, Whitby Robert, Liang Liyin, Cohen Pinchas, Bhasin Shalender, Krauss Ronald M, Veldhuis Johannes D, Wagner Anthony J, DePaoli Alex M, McCann Samuel M, Wong Ma-Li   Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults Proceedings of the National Academy of Sciences of the United States of America, 2004; 101(13): 4531-6.
Park Patricia, Cohen Pinchas   The role of insulin-like growth factor I monitoring in growth hormone-treated children Hormone research, 2004; 62 Suppl 1(1): 59-65.
Ngo Tung H, Barnard R James, Cohen Pinchas, Freedland Stephen, Tran Chris, deGregorio Frank, Elshimali Yahya I, Heber David, Aronson William J   Effect of isocaloric low-fat diet on human LAPC-4 prostate cancer xenografts in severe combined immunodeficient mice and the insulin-like growth factor axis Clinical cancer research : an official journal of the American Association for Cancer Research, 2003; 9(7): 2734-43.
Lee Kuk-Wha, Cohen Pinchas   Individualized growth hormone therapy in children: advances beyond weight-based dosing Journal of pediatric endocrinology & metabolism : JPEM, 2003; 16 Suppl 3(1): 625-30.
Wetterau Lawrence A, Francis Malik J, Ma Liqun, Cohen Pinchas   Insulin-like growth factor I stimulates telomerase activity in prostate cancer cells The Journal of clinical endocrinology and metabolism, 2003; 88(7): 3354-9.
Ikonen Maaria, Liu Bingrong, Hashimoto Yuichi, Ma Liqun, Lee Kuk-Wha, Niikura Takako, Nishimoto Ikuo, Cohen Pinchas   Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis Proceedings of the National Academy of Sciences of the United States of America, 2003; 100(22): 13042-7.
Moore Michael G, Wetterau Lawrence A, Francis Malik J, Peehl Donna M, Cohen Pinchas   Novel stimulatory role for insulin-like growth factor binding protein-2 in prostate cancer cells International journal of cancer. Journal international du cancer, 2003; 105(1): 14-9.
Franklin Sherry Lynn, Ferry Robert J, Cohen Pinchas   Rapid insulin-like growth factor (IGF)-independent effects of IGF binding protein-3 on endothelial cell survival The Journal of clinical endocrinology and metabolism, 2003; 88(2): 900-7.
Liu Bingrong, Weinzimer Stuart A, Gibson Tara Beers, Mascarenhas Desmond, Cohen Pinchas   Type Ialpha collagen is an IGFBP-3 binding protein Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2003; 13(2-3): 89-97.
Wilson Thomas A, Rose Susan R, Cohen Pinchas, Rogol Alan D, Backeljauw Philippe, Brown Rosalind, Hardin Dana S, Kemp Stephen F, Lawson Margaret, Radovick Sally, Rosenthal Stephen M, Silverman Lawrence, Speiser Phyllis, Speiser Phyllis   Update of guidelines for the use of growth hormone in children: the Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee The Journal of pediatrics, 2003; 143(4): 415-21.
Ngo Tung H, Barnard R James, Tymchuk Christopher N, Cohen Pinchas, Aronson William J   Effect of diet and exercise on serum insulin, IGF-I, and IGFBP-1 levels and growth of LNCaP cells in vitro (United States) Cancer causes & control : CCC, 2002; 13(10): 929-35.
Cohen Pinchas, Bright George M, Rogol Alan D, Kappelgaard Anne-Marie, Rosenfeld Ron G, Rosenfeld Ron G   Effects of dose and gender on the growth and growth factor response to GH in GH-deficient children: implications for efficacy and safety The Journal of clinical endocrinology and metabolism, 2002; 87(1): 90-8.
Monzavi Roshanak, Cohen Pinchas   IGFs and IGFBPs: role in health and disease Best practice & research. Clinical endocrinology & metabolism, 2002; 16(3): 433-47.

MeSH Terms:

What is MeSH?

Medical Subject Headings

We have integrated Faculty Profiles with the U.S. National Library of Medicine's MeSH terms. For every publication added to a profile, we pull its MeSH terms and display it here. This enhancement allows you to search for research themes of our faculty members.

Click on any of the terms below to see additional researchers with similar keywords.

MeSH is:

  • an acronym for Medical Subject Headings.
  • the U.S. National Library of Medicine's controlled vocabulary (thesaurus).
  • a vocabulary that gives uniformity and consistency to the indexing and cataloging of biomedical literature.
  • a distinctive feature of MEDLINE.
  • arranged in a hierarchical manner called the MeSH Tree Structures.
  • updated annually.

MeSH Vocabulary includes four types of terms:

  • Headings
  • Subheadings
  • Supplementary Concept Records
  • Publication Characteristics (or Types)

Over 26,000 MeSH headings (also called "main headings" or "descriptors" represents concepts found in the biomedical literature

Subheadings - (also called qualifiers) are attached to MeSH headings to describe a specific aspect of a concept.

Supplementary Concept Records are over 200,000 terms in a separate thesaurus from the Medical Subject Headings. These are primarily substance terms, but also include some protocols and rare desease terms. These terms are updated weekly.

Publication Characteristics or (Publication Types) describe the type of publication being indexed; i.e., what the item is, not what the article is about.

Information from U.S. National Library of Medicine.

Adenocarcinoma Adolescent Adult Affect Age Factors Aged Aged, 80 and over Aging Amino Acid Sequence Amino Acids Animals Animals, Newborn Antibodies Antineoplastic Agents Antineoplastic Combined Chemotherapy Protocols Antioxidants Apolipoproteins E Apoptosis Arm Asthma Atherosclerosis Base Sequence Behavior Therapy Binding Sites Biological Assay Biological Markers Biology Biomarkers, Pharmacological Blood Circulation Blood Glucose Blotting, Western Body Composition Body Fluids Body Height Body Mass Index Body Weight Bone Density Bone Development Bone and Bones Brain Breast Neoplasms, Male Bronchopulmonary Dysplasia CCAAT-Enhancer-Binding Proteins Calcium Calcium-Binding Proteins Calmodulin-Binding Proteins Carbohydrate Metabolism Carcinoma, Non-Small-Cell Lung Carotenoids Carrier Proteins Caspases Catheters Cell Aging Cell Death Cell Differentiation Cell Division Cell Line Cell Line, Tumor Cell Movement Cell Nucleus Cell Proliferation Cell Survival Cells Cells, Cultured Cerebral Palsy Cerebrospinal Fluid Child Child, Preschool Chlorophyll Binding Proteins Chromosomes Chronic Disease Circumcision, Female Circumcision, Male Cohort Studies Collagenases Colon Condoms, Female Contraceptive Agents, Female Contraceptive Agents, Male Contraceptive Devices, Female Contraceptive Devices, Male Cord Blood Stem Cell Transplantation Cricetinae Cytokine Receptor Common beta Subunit Cytokine Receptor gp130 Cytokine-Induced Killer Cells Cytokines Cytokinesis Cytoprotection DNA Damage DNA Methylation DNA Mutational Analysis DNA-Binding Proteins Developed Countries Developing Countries Diabetes Mellitus Diagnosis Diet Therapy Diet, Carbohydrate-Restricted Diet, Fat-Restricted Dietary Carbohydrates Dietary Fats Dietary Supplements Disease Disease Models, Animal Disease Progression Dizocilpine Maleate Dose-Response Relationship, Drug Doxorubicin Drug Design Drug Interactions Drug Monitoring Drug Resistance, Neoplasm Dwarfism, Pituitary Electron Transport Endopeptidases Endothelium, Vascular Energy Metabolism Environmental Exposure Enzyme Activation Enzyme Inhibitors Enzyme-Linked Immunosorbent Assay Ethylmaleimide Evidence-Based Medicine Exercise Family Fasting Fatty Acid-Binding Proteins Fatty Acids, Omega-3 Fatty Acids, Omega-6 Fatty Liver Female Athlete Triad Syndrome Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Femur Fertility Agents, Female Fertility Agents, Male Fetal Development Fetal Growth Retardation Fibroblasts GTP-Binding Proteins Gene Deletion Gene Expression Gene Expression Profiling Gene Expression Regulation, Developmental Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor Genetic Predisposition to Disease Genital Diseases, Female Genital Diseases, Male Genital Neoplasms, Female Genital Neoplasms, Male Genitalia, Female Genitalia, Male Genome Genomics Genotype Gestational Age Glucose Glycoproteins Goals Growth Growth Disorders Growth Hormone Growth Substances Health Health Promotion Heterotrimeric GTP-Binding Proteins Histones Homosexuality, Female Homosexuality, Male Hormone Replacement Therapy Human Growth Hormone Humans Hypercholesterolemia Hyperglycemia Hyperinsulinism Hypoglycemia Immunoenzyme Techniques Immunohistochemistry In Situ Hybridization In Situ Nick-End Labeling Infant Infant, Newborn Infant, Small for Gestational Age Infertility, Female Infertility, Male Injections, Subcutaneous Insulin Insulin Resistance Insulin-Like Growth Factor Binding Protein 1 Insulin-Like Growth Factor Binding Protein 2 Insulin-Like Growth Factor Binding Protein 3 Insulin-Like Growth Factor Binding Protein 4 Insulin-Like Growth Factor Binding Proteins Insulin-Like Growth Factor I Insulin-Like Growth Factor II Intercellular Signaling Peptides and Proteins Intracellular Signaling Peptides and Proteins Iron-Binding Proteins Ketones Knowledge Latent TGF-beta Binding Proteins Lead Life Life Style Ligands Light Liver Longevity Longitudinal Studies Lung Male Urogenital Diseases Maleates Maleic Anhydrides Maleic Hydrazide Maleimides Maltose-Binding Proteins Matrix Attachment Region Binding Proteins Matrix Metalloproteinase 9 Medicine Metabolism Metformin Methods Mice Mice, Inbred C57BL Mice, Knockout Mice, Nude Mice, SCID Mice, Transgenic Microbial Collagenase Microscopy, Fluorescence Middle Aged Mitochondria Mitochondrial Proteins Molecular Sequence Data Monomeric GTP-Binding Proteins Muscle Cells Mutagenesis, Site-Directed Mutation Myoblasts, Smooth Muscle Myocytes, Smooth Muscle N-Ethylmaleimide-Sensitive Proteins Names Nature Nematoda Neoplasms Neoplastic Processes Neovascularization, Pathologic Nerve Degeneration Neurons Nuclear Localization Signals Nuclear Proteins Nurses, Male Obesity Oligonucleotide Array Sequence Analysis Open Reading Frames Organelles Orphan Nuclear Receptors Overweight Oxidative Stress Oxygen Consumption Paper Pathologic Processes Patients Penicillin-Binding Proteins Peptide Fragments Peptides Periplasmic Binding Proteins Phenotype Phosphate-Binding Proteins Phosphatidylinositol 3-Kinases Phosphorylation Physiology Pilot Projects Placebos Plants Plasma Poly(A)-Binding Proteins Polymerase Chain Reaction Population Prader-Willi Syndrome Pregnancy Pregnancy-Associated Plasma Protein-A Prions Prognosis Proportional Hazards Models Prospective Studies Prostate Prostatectomy Prostatic Neoplasms Protein Binding Protein Biosynthesis Protein Transport Protein-Serine-Threonine Kinases Proteins Proteolysis Proteomics Proto-Oncogene Proteins Proto-Oncogene Proteins c-akt Publications RNA Cap-Binding Proteins RNA, Messenger RNA, Ribosomal, 16S RNA-Binding Proteins Random Allocation Rats Rats, Sprague-Dawley Reaction Time Reactive Oxygen Species Receptor, IGF Type 1 Receptors, Cytokine Receptors, Somatotropin Recombinant Proteins Research Research Personnel Respiration Respiratory Muscles Retinoblastoma Binding Proteins Retinol-Binding Proteins Retinol-Binding Proteins, Cellular Retinol-Binding Proteins, Plasma Reverse Transcriptase Polymerase Chain Reaction Risk Risk Factors Role Rotenone Sample Size Sarcoma, Ewing Selenium-Binding Proteins Sequence Homology Serum Sex Factors Signal Transduction Smooth Muscle Myosins Smooth Muscle Tumor Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins Somatomedins Spine Sterol Regulatory Element Binding Proteins Suppressor of Cytokine Signaling Proteins Survival Analysis Syndrome Tacrolimus Binding Proteins Technology Telomerase Telomere-Binding Proteins Testis Thermoplasmales Thyroxine-Binding Proteins Time Time Factors Tissues Transcription Factors Transcription, Genetic Transfection Transferrin-Binding Proteins Transforming Growth Factors Translating Treatment Outcome Tuberculosis, Female Genital Tuberculosis, Male Genital Tumor Cells, Cultured Tumor Suppressor Protein p53 Two-Hybrid System Techniques Umbilical Veins Urologic Surgical Procedures, Male Vascular Endothelial Growth Factor A Work Xenograft Model Antitumor Assays Young Adult rab GTP-Binding Proteins rab1 GTP-Binding Proteins rab3 GTP-Binding Proteins rab4 GTP-Binding Proteins rab5 GTP-Binding Proteins rac GTP-Binding Proteins ral GTP-Binding Proteins rap GTP-Binding Proteins rap1 GTP-Binding Proteins rho GTP-Binding Proteins

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