Peter Tontonoz, M.D., Ph.D.

A Short Biography:

Dr. Tontonoz is Professor of Pathology and Laboratory Medicine, David Geffen School of Medicine Dean's Scholar, and an Investigator of the Howard Hughes Medical Institute. He received his B.A. from Wesleyan University and his M.D. and Ph.D. from Harvard Medical School. His Ph.D. thesis was carried out at the Dana-Farber Cancer Institute and his postdoctoral training at the Salk Institute for Biological Studies. He completed his residency training in Pathology at the University of California, San Diego. The focus of his laboratory is the control of gene expression by lipids and the role of nuclear receptors in lipid metabolism. His major research contributions include the delineation of role of PPAR and LXR in adipogenesis and atherosclerosis, and elucidation of mechanisms of crosstalk between metabolism, inflammation and immunity. He has been elected to the American Society of Clinical Investigation and the American Association of Physicians. Dr. Tontonoz is the recipient of the Richard. E. Weitzman and Gerald D. Aurbach Awards from the Endocrine Society, the Jeffrey M. Hoeg Award for Basic Science and Clinical Research from the American Heart Association, and a Bristol Myers-Squibb Freedom to Discover Award in Cardiovascular Disease. He is a past President of American Society for Clinical Investigation. Dr. Tontonoz serves on a number of editorial boards and is a Reviewing Editor for eLife and an Associate Editor of Molecular and Cellular Biology.

Work Titles
UCLA Professor, Pathology and Laboratory Medicine
M.D., Harvard School of Public Health, 1990 - 1996
Ph.D., Harvard University, 1990 - 1996
B.A., Wesleyan University, Middletown, CT, 1985 - 1989
1996 - 1997 UCSD Medical Center
1997 - 1999 UCSD Medical Center

Contact Information:

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Office Phone Number:

(310) 206-4546

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Laboratory Address:

675 Charles E Young Drive South
MRL 6-629
Los Angeles, CA 90095

Work Address:

David Geffen School of Medicine
675 Charles E. Young Dr. South
BOX 951662, 6770 MRL
Los Angeles, CA 90095


Ito, A., Hong, C., Oka, K., Salazar, J.V., Diehl, C., Witztum, J.L., Diaz, M., Castrillo, A., Bensinger, S.V., Chan, L., and Tontonoz, P.   Cholesterol accumulation in CD11c+ immune cells is a causal and targetable factor in autoimmune disease, Immunity, 2016; 45: 1311-1326.
Sallam, T., Jones, M., Gilliland, T., Zhang, Li., Wu, X., Eskin, A., Sandhu, J., Casero, D., Vallim, T., Hong, C., Katz, M., Lee, R., Whitelegge, J., and Tontonoz, P.   Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis, Nature, 2016; 534: 124-128.
Wang, B., Rong, X., Duerr, MA., Hermanson, D., Hedde, PN., Wong, T., Vallim, T., Cravatt, B., Gratton, E., Ford, D.A., and Tontonoz, P.   Intestinal phospholipid remodeling is required for dietary lipid uptake and survival on a high-fat diet, Cell Metabolism, 2016; 23: 492-504.
Tian, X.Y., Ganeshan, K., Hong, C., Nguyen, K.D., Qiu, Y., Kim, J., Tangirala, R.K., Tontonoz, P. and Chawla, A.   Thermoneutral housing accelerates metabolic inflammation to potentiate atherosclerosis but not insulin resistance, Cell Metabolism, 2016; 23: 165-178.
Parks, B.W., Sallam, T., Mehrabian, M., Psychogios, N., Hui, S.T., Norheim, F., Castellani, L.W., Rau, C.D., Pan, C., Phun, J., Zhou, Z., Yang, W.P., Neuhaus, I., Gargalovic, P.S., Kirchgessner, T.G., Graham, M., Lee, R., Tontonoz, P., Gerszten, R.E., Hevener, A.L. and Lusis, A.J.   Genetic architecture of insulin resistance in the mouse, Cell Metabolism, 2015; 21: 334-346.
Ito, A., Hong, C., Rong, X., Tarling, E.J., Hedde, P.N., Gratton, E., Parks, J., and Tontonoz, P.   LXRs repress inflammation through ABCA1-dependent regulation of membrane composition and TLR signaling , eLife, 2015; 4: e08009.
Rong, X., Wang, B., Dunham, M., Wong, J., Young, S.G., Gratton, E., Ford, D.A., and Tontonoz, P.   Lpcat3-dependent production of arachidonyl phospholipids is a key determinant of triglyceride secretion, eLife, 2015; 4: e06557.
Choi, J., Gao, J., Kim, J., Hong, C., Kim, J., and Tontonoz, P.   The E3 ubiquitin ligase Idol controls brain LDLR levels, ApoE clearance and Aβ amyloidosis, Science Translational Medicine, 2015; 314: ra184.
Tontonoz, P., Cortez-Toledo, O., Wroblewski, K., Hong, C., Lim, L., Carranza, R., Conneely, O., Metzger, D., and Chao, L.C.   The orphan nuclear receptor Nur77 is a determinant of myocyte size and muscle mass in mice, Molecular and Cellular Biology, 2015; 35: 1125-38.
Hong Cynthia, Tontonoz Peter   Liver X receptors in lipid metabolism: opportunities for drug discovery Nature Reviews. Drug discovery, 2014; 13(6): 433-44.
Tessem, J.S., Moss, L.G., Chao, L.C., Lu, D., Tontonoz, P., Hohmeier, H.E., and Newgard, C.B.   Nkx6.1 regulates islet β cell proliferation via Nr4a1 and Nr4a3 nuclear receptors. , Proc. Natl. Acad. Sci. USA. , 2014; 111: 5242-5247.
Goddard, L.M., Murphy, T.J., Org, T., Enciso, J.M., Hashimoto-Partyka, M.K., Warren, C.M., Sanchez, L.A., Allen, N.C., Chao, L.C., Tontonoz, P., Mikkola, H., and Iruela-Arispe, M.L.   Physiological vascular permeability requires induction of NR4A1 by progesterone receptor, Cell, 2014; 156: 549-62.
Goulbourne, C.N., Gin, P., Tatar, A., Nobumori, C., Hoenger, A., Jiang, H., Grovenor, C.R.M., Esko, J.D., Goldberg, I.J., 5, Reue, K., Tontonoz, P., Bensadoun, A., Beigneux, A.P., Young, S.G., and Fong, L.G.   The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries. , Cell Metabolism, 2014; 19: 849-860.
Hong Cynthia, Marshall Stephanie M, McDaniel Allison L, Graham Mark, Layne Joseph D, Cai Lei, Scotti Elena, Boyadjian Rima, Kim Jason, Chamberlain Brian T, Tangirala Rajendra K, Jung Michael E, Fong Loren, Lee Richard, Young Stephen G, Temel Ryan E, Tontonoz Peter   The LXR-Idol Axis Differentially Regulates Plasma LDL Levels in Primates and Mice Cell Metabolism, 2014; 20(5): 910-8.
Calkin Anna C, Lee Stephen D, Kim Jason, Van Stijn Caroline M W, Wu Xiao-Hui, Lusis Aldons J, Hong Cynthia, Tangirala Rajendra I, Tontonoz Peter   Transgenic expression of dominant-active IDOL in liver causes diet-induced hypercholesterolemia and atherosclerosis in mice Circulation Research, 2014; 115(4): 442-9.
Villanueva Claudio J, Vergnes Laurent, Wang Jiexin, Drew Brian G, Hong Cynthia, Tu Yiping, Hu Yan, Peng Xu, Xu Feng, Saez Enrique, Wroblewski Kevin, Hevener Andrea L, Reue Karen, Fong Loren G, Young Stephen G, Tontonoz Peter   Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs Cell Metabolism, 2013; 17(3): 423-35.
Chao Lily C, Soto Erin, Hong Cynthia, Ito Ayaka, Pei Liming, Chawla Ajay, Conneely Orla M, Tangirala Rajendra K, Evans Ronald M, Tontonoz Peter   Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice Journal of Lipid Research, 2013; 54(3): 806-15.
Zhang Li, Xu Ming, Scotti Elena, Chen Zhijian J, Tontonoz Peter   Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor Journal of Lipid Research, 2013; 54(5): 1410-20.
Scotti Elena, Calamai Martino, Goulbourne Chris N, Zhang Li, Hong Cynthia, Lin Ron R, Choi Jinkuk, Pilch Paul F, Fong Loren G, Zou Peng, Ting Alice Y, Pavone Francesco S, Young Stephen G, Tontonoz Peter   IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor Molecular and Cellular Biology, 2013; 33(8): 1503-14.
Rong, X., Albert, C.J., Hong, C., Chamberlain, B., Tarling, E.J., Ito, A., Gao, J., Edwards, P.A., Jung, M., Ford, D.A., and Tontonoz, P.   LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition, Cell Metabolism, 2013; 18: 685-697.
Beaven, S.W., Matveyenko, A., Wroblewski, K., Chao, L.C, Wilpitz, D., Hsu, T.W., Lentz, J., Drew, B., Hevener, A., and Tontonoz, P.   Reciprocal regulation of hepatic and adipose lipogenesis by LXRs in obesity and insulin resistance, Cell Metabolism, 2013; 18: 106-117.
Halperin Daniel S, Pan Calvin, Lusis Aldons J, Tontonoz Peter   Vestigial-like 3 is an inhibitor of adipocyte differentiation Journal of Lipid Research, 2013; 54(2): 473-81.
Hong, C., Kitani, Y., A-Gonzalez, N., Castrillo, A., Tontonoz, P., and Bensinger, S.J.   An LXR-dependent pathway modulates neutrophil homeostasis in mice. , J. Clin. Invest, 2012; 122: 337-47.
Hong Cynthia, Kidani Yoko, A-Gonzalez Noelia, Phung Tram, Ito Ayaka, Rong Xin, Ericson Katrin, Mikkola Hanna, Beaven Simon W, Miller Lloyd S, Shao Wen-Hai, Cohen Philip L, Castrillo Antonio, Tontonoz Peter, Bensinger Steven J   Coordinate regulation of neutrophil homeostasis by liver X receptors in mice The Journal of Clinical Investigation, 2012; 122(1): 337-47.
Zhang Li, Reue Karen, Fong Loren G, Young Stephen G, Tontonoz Peter   Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis Arteriosclerosis, Thrombosis, and Vascular Biology, 2012; 32(11): 2541-6.
Hong Cynthia, Bradley Michele N, Rong Xin, Wang Xuping, Wagner Alan, Grijalva Victor, Castellani Lawrence W, Salazar Jon, Realegeno Susan, Boyadjian Rima, Fogelman Alan M, Van Lenten Brian J, Reddy Srinivasa T, Lusis Aldons J, Tangirala Rajendra K, Tontonoz Peter   LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice Journal of Lipid Research, 2012; 53(6): 1126-33.
Chao Lily C, Wroblewski Kevin, Ilkayeva Olga R, Stevens Robert D, Bain James, Meyer Gretchen A, Schenk Simon, Martinez Leonel, Vergnes Laurent, Narkar Vihang A, Drew Brian G, Hong Cynthia, Boyadjian Rima, Hevener Andrea L, Evans Ronald M, Reue Karen, Spencer Melissa J, Newgard Christopher B, Tontonoz Peter   Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization Journal of Lipid Research, 2012; 53(12): 2610-9.
Chen Xuqi, McClusky Rebecca, Chen Jenny, Beaven Simon W, Tontonoz Peter, Arnold Arthur P, Reue Karen   The number of x chromosomes causes sex differences in adiposity in mice PLoS genetics, 2012; 8(5): e1002709.
Calkin Anna C, Tontonoz Peter   Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR Nature Reviews. Molecular Cell Biology, 2012; 13(4): 213-24.
Guo Deliang, Reinitz Felicia, Youssef Mary, Hong Cynthia, Nathanson David, Akhavan David, Kuga Daisuke, Amzajerdi Ali Nael, Soto Horacio, Zhu Shaojun, Babic Ivan, Tanaka Kazuhiro, Dang Julie, Iwanami Akio, Gini Beatrice, Dejesus Jason, Lisiero Dominique D, Huang Tiffany T, Prins Robert M, Wen Patrick Y, Robins H Ian, Prados Michael D, Deangelis Lisa M, Mellinghoff Ingo K, Mehta Minesh P, James C David, Chakravarti Arnab, Cloughesy Timothy F, Tontonoz Peter, Mischel Paul S   An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway Cancer Discovery, 2011; 1(5): 442-56.
Hong Cynthia, Walczak Robert, Dhamko Helena, Bradley Michelle N, Marathe Chaitra, Boyadjian Rima, Salazar Jon V, Tontonoz Peter   Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target Journal of Lipid Research, 2011; 52(3): 531-9.
Calkin Anna C, Goult Benjamin T, Zhang Li, Fairall Louise, Hong Cynthia, Schwabe John W R, Tontonoz Peter   FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(50): 20107-12.
Beaven, S.W., Wroblewski, K., Wang, J., Bensinger, S.J., Tsukamoto, H. and Tontonoz, P.   LXR signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease. , Gastroenterology, 2011; 140: 1052-62.
Beaven Simon W, Wroblewski Kevin, Wang Jiaohong, Hong Cynthia, Bensinger Steven, Tsukamoto Hide, Tontonoz Peter   Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease Gastroenterology, 2011; 140(3): 1052-62.
Villanueva Claudio J, Waki Hironori, Godio Cristina, Nielsen Ronni, Chou Wen-Ling, Vargas Leo, Wroblewski Kevin, Schmedt Christian, Chao Lily C, Boyadjian Rima, Mandrup Susanne, Hevener Andrea, Saez Enrique, Tontonoz Peter   TLE3 is a dual-function transcriptional coregulator of adipogenesis Cell Metabolism, 2011; 13(4): 413-27.
Scotti Elena, Hong Cynthia, Yoshinaga Yuko, Tu Yiping, Hu Yan, Zelcer Noam, Boyadjian Rima, de Jong Pieter J, Young Stephen G, Fong Loren G, Tontonoz Peter   Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists Molecular and Cellular Biology, 2011; 31(9): 1885-93.
Zhang Li, Fairall Louise, Goult Benjamin T, Calkin Anna C, Hong Cynthia, Millard Christopher J, Tontonoz Peter, Schwabe John W R   The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor Genes & Development, 2011; 25(12): 1262-74.
Weissglas-Volkov Daphna, Calkin Anna C, Tusie-Luna Teresa, Sinsheimer Janet S, Zelcer Noam, Riba Laura, Tino Ana Maria Vargas, Ordoñez-Sánchez Maria Luisa, Cruz-Bautista Ivette, Aguilar-Salinas Carlos A, Tontonoz Peter, Pajukanta Päivi   The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans The Journal of Clinical Investigation, 2011; 121(8): 3062-71.
Feig Jonathan E, Pineda-Torra Ines, Sanson Marie, Bradley Michelle N, Vengrenyuk Yuliya, Bogunovic Dusan, Gautier Emmanuel L, Rubinstein Daniel, Hong Cynthia, Liu Jianhua, Wu Chaowei, van Rooijen Nico, Bhardwaj Nina, Garabedian Michael, Tontonoz Peter, Fisher Edward A   LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression The Journal of Clinical Investigation, 2010; 120(12): 4415-24.
Calkin Anna C, Tontonoz Peter   Liver x receptor signaling pathways and atherosclerosis Arteriosclerosis, Thrombosis, and Vascular Biology, 2010; 30(8): 1513-8.
Hong Cynthia, Duit Sarah, Jalonen Pilvi, Out Ruud, Scheer Lilith, Sorrentino Vincenzo, Boyadjian Rima, Rodenburg Kees W, Foley Edan, Korhonen Laura, Lindholm Dan, Nimpf Johannes, van Berkel Theo J C, Tontonoz Peter, Zelcer Noam   The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2 The Journal of Biological Chemistry, 2010; 285(26): 19720-6.
Park Kye Won, Waki Hironori, Choi Sung-Pil, Park Ki-Moon, Tontonoz Peter   The small molecule phenamil is a modulator of adipocyte differentiation and PPARgamma expression Journal of lipid research, 2010; 51(9): 2775-84.
Bensinger Steven J, Tontonoz Peter   A Nurr1 pathway for neuroprotection Cell, 2009; 137(1): 26-8.
A-Gonzalez Noelia, Bensinger Steven J, Hong Cynthia, Beceiro Susana, Bradley Michelle N, Zelcer Noam, Deniz Jose, Ramirez Cristina, Díaz Mercedes, Gallardo German, de Galarreta Carlos Ruiz, Salazar Jon, Lopez Felix, Edwards Peter, Parks John, Andujar Miguel, Tontonoz Peter, Castrillo Antonio   Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR Immunity, 2009; 31(2): 245-58.
Chao Lily C, Wroblewski Kevin, Zhang Zidong, Pei Liming, Vergnes Laurent, Ilkayeva Olga R, Ding Shi Ying, Reue Karen, Watt Matthew J, Newgard Christopher B, Pilch Paul F, Hevener Andrea L, Tontonoz Peter   Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77 Diabetes, 2009; 58(12): 2788-96.
Zelcer Noam, Hong Cynthia, Boyadjian Rima, Tontonoz Peter   LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor Science (New York, N.Y.), 2009; 325(5936): 100-4.
Marathe Chaitra, Bradley Michelle N, Hong Cynthia, Chao Lily, Wilpitz Damien, Salazar Jon, Tontonoz Peter   Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARgamma-/-, PPARdelta-/-, PPARgammadelta-/-, or LXRalphabeta-/- bone marrow Journal of lipid research, 2009; 50(2): 214-24.
Dean Jason T, Tran Linh, Beaven Simon, Tontonoz Peter, Reue Karen, Dipple Katrina M, Liao James C   Resistance to diet-induced obesity in mice with synthetic glyoxylate shunt Cell metabolism, 2009; 9(6): 525-36.
Hsu Jeffrey J, Lu Jinxiu, Huang Michael S, Geng Yifan, Sage Andrew P, Bradley Michelle N, Tontonoz Peter, Demer Linda L, Tintut Yin   T0901317, an LXR agonist, augments PKA-induced vascular cell calcification FEBS letters, 2009; 583(8): 1344-8.
Park Kye Won, Waki Hironori, Kim Woo-Kyun, Davies Brandon S J, Young Stephen G, Parhami Farhad, Tontonoz Peter   The small molecule phenamil induces osteoblast differentiation and mineralization Molecular and cellular biology, 2009; 29(14): 3905-14.
Hummasti Sarah, Tontonoz Peter   Adopting new orphans into the family of metabolic regulators Molecular endocrinology (Baltimore, Md.), 2008; 22(8): 1743-53.
Jiang Qingguang, Lee C Y Daniel, Mandrekar Shweta, Wilkinson Brandy, Cramer Paige, Zelcer Noam, Mann Karen, Lamb Bruce, Willson Timothy M, Collins Jon L, Richardson Jill C, Smith Jonathan D, Comery Thomas A, Riddell David, Holtzman David M, Tontonoz Peter, Landreth Gary E   ApoE promotes the proteolytic degradation of Abeta Neuron, 2008; 58(5): 681-93.
Gallardo-Soler Alejandro, Gómez-Nieto Carlos, Campo María Luisa, Marathe Chaitra, Tontonoz Peter, Castrillo Antonio, Corraliza Inés   Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity Molecular endocrinology (Baltimore, Md.), 2008; 22(6): 1394-402.
Park Kye Won, Halperin Daniel S, Tontonoz Peter   Before they were fat: adipocyte progenitors Cell metabolism, 2008; 8(6): 454-7.
Tontonoz, P. and Spiegelman, B.M.   Beyond fat: the diverse biology of PPARgamma, Ann Rev Biochem, 2008; 77: 289-312.
Hong Cynthia, Tontonoz Peter   Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors Current opinion in genetics & development, 2008; 18(5): 461-7.
Tontonoz Peter, Spiegelman Bruce M   Fat and beyond: the diverse biology of PPARgamma Annual review of biochemistry, 2008; 77(6): 289-312.
Hummasti Sarah, Hong Cynthia, Bensinger Steven J, Tontonoz Peter   HRASLS3 is a PPARgamma-selective target gene that promotes adipocyte differentiation Journal of lipid research, 2008; 49(12): 2535-44.
Park, K.W., Waki, H., Villanueva, C.J., Monticelli, L., Hong, C., Kang, S., MacDougald, O.A., Goldrath, A.W., and Tontonoz, P.   Id2 is a small molecule-inducible modulator of PPARgamma expression and adipocyte differentiation, Molecular Endocrinology, 2008; 22: 2038-2048.
Chao Lily C, Bensinger Steven J, Villanueva Claudio J, Wroblewski Kevin, Tontonoz Peter   Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1 Molecular endocrinology (Baltimore, Md.), 2008; 22(12): 2596-608.
Park Kye Won, Waki Hironori, Villanueva Claudio J, Monticelli Laurel A, Hong Cynthia, Kang Sona, MacDougald Ormond A, Goldrath Ananda W, Tontonoz Peter   Inhibitor of DNA binding 2 is a small molecule-inducible modulator of peroxisome proliferator-activated receptor-gamma expression and adipocyte differentiation Molecular endocrinology (Baltimore, Md.), 2008; 22(9): 2038-48.
Bensinger Steven J, Tontonoz Peter   Integration of metabolism and inflammation by lipid-activated nuclear receptors Nature, 2008; 454(7203): 470-7.
Bensinger Steven J, Bradley Michelle N, Joseph Sean B, Zelcer Noam, Janssen Edith M, Hausner Mary Ann, Shih Roger, Parks John S, Edwards Peter A, Jamieson Beth D, Tontonoz Peter   LXR signaling couples sterol metabolism to proliferation in the acquired immune response Cell, 2008; 134(1): 97-111.
Marathe C, Bradley MN, Hong C, Chao LC, Wilpitz D, Salazar J, and Tontonoz P.   Preserved glucose tolerance in high fat diet fed C57BL/6 mice transplanted with PPARγ-/-, PPARδ-/-, PPARγδ-/- or LXRαβ-/- bone marrow, J. Lipid Res. , 2008; 50: 214-224.
Naiki Yoshikazu, Sorrentino Rosalinda, Wong Michelle H, Michelsen Kathrin S, Shimada Kenichi, Chen Shuang, Yilmaz Atilla, Slepenkin Anatoly, Schröder Nicolas W J, Crother Timothy R, Bulut Yonca, Doherty Terence M, Bradley Michelle, Shaposhnik Zory, Peterson Ellena M, Tontonoz Peter, Shah Prediman K, Arditi Moshe   TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis Journal of immunology (Baltimore, Md. : 1950), 2008; 181(10): 7176-85.
Davies Brandon S J, Waki Hironori, Beigneux Anne P, Farber Emily, Weinstein Michael M, Wilpitz Damien C, Tai Li-Jung, Evans Ronald M, Fong Loren G, Tontonoz Peter, Young Stephen G   The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma Molecular endocrinology (Baltimore, Md.), 2008; 22(11): 2496-504.
Zelcer Noam, Khanlou Negar, Clare Ryan, Jiang Qingguang, Reed-Geaghan Erin G, Landreth Gary E, Vinters Harry V, Tontonoz Peter   Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors Proceedings of the National Academy of Sciences of the United States of America, 2007; 104(25): 10601-6.
Cao Fei, Castrillo Antonio, Tontonoz Peter, Re Fabio, Byrne Gerald I   Chlamydia pneumoniae--induced macrophage foam cell formation is mediated by Toll-like receptor 2 Infection and immunity, 2007; 75(2): 753-9.
Waki Hironori, Tontonoz Peter   Endocrine functions of adipose tissue Annual review of pathology, 2007; 2(2): 31-56.
Bradley Michelle N, Hong Cynthia, Chen Mingyi, Joseph Sean B, Wilpitz Damien C, Wang Xuping, Lusis Aldons J, Collins Allan, Hseuh Willa A, Collins Jon L, Tangirala Rajendra K, Tontonoz Peter   Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE The Journal of clinical investigation, 2007; 117(8): 2337-46.
Molteni Valentina, Li Xiaolin, Nabakka Juliet, Liang Fang, Wityak John, Koder Alan, Vargas Leo, Romeo Russell, Mitro Nico, Mak Puiying A, Seidel H Martin, Haslam Jennifer A, Chow Donald, Tuntland Tove, Spalding Tracy A, Brock Ansgar, Bradley Michelle, Castrillo Antonio, Tontonoz Peter, Saez Enrique   N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta Journal of medicinal chemistry, 2007; 50(17): 4255-9.
Chao Lily C, Zhang Zidong, Pei Liming, Saito Tsugumichi, Tontonoz Peter, Pilch Paul F   Nur77 coordinately regulates expression of genes linked to glucose metabolism in skeletal muscle Molecular endocrinology (Baltimore, Md.), 2007; 21(9): 2152-63.
Waki Hironori, Tontonoz Peter   STAMPing out Inflammation Cell, 2007; 129(3): 451-2.
Waki Hironori, Park Kye Won, Mitro Nico, Pei Liming, Damoiseaux Robert, Wilpitz Damien C, Reue Karen, Saez Enrique, Tontonoz Peter   The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression Cell metabolism, 2007; 5(5): 357-70.
Chow Edward K, Castrillo Antonio, Shahangian Arash, Pei Liming, O'Connell Ryan M, Modlin Robert L, Tontonoz Peter, Cheng Genhong   A role for IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections The Journal of experimental medicine, 2006; 203(12): 2589-602.
Chow, E.K., Castrillo, A., Shahangian, A., O'Connell, R.M., Pei, L., Tontonoz, P., and Cheng, G.   Critical role of IRF3-dependent RXRa repression in hepatotoxicity associated with viral infections, J. Exp Med, 2006; 203: 2589-2602.
Baldán Angel, Pei Liming, Lee Richard, Tarr Paul, Tangirala Rajendra K, Weinstein Michael M, Frank Joy, Li Andrew C, Tontonoz Peter, Edwards Peter A   Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow Arteriosclerosis, thrombosis, and vascular biology, 2006; 26(10): 2301-7.
Zelcer Noam, Tontonoz Peter   Liver X receptors as integrators of metabolic and inflammatory signaling The Journal of clinical investigation, 2006; 116(3): 607-14.
Pei Liming, Waki Hironori, Vaitheesvaran Bhavapriya, Wilpitz Damien C, Kurland Irwin J, Tontonoz Peter   NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism Nature medicine, 2006; 12(9): 1048-55.
Beaven Simon W, Tontonoz Peter   Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia Annual review of medicine, 2006; 57(3): 313-29.
Chen Mingyi, Bradley Michelle N, Beaven Simon W, Tontonoz Peter   Phosphorylation of the liver X receptors FEBS letters, 2006; 580(20): 4835-41.
Pei Liming, Castrillo Antonio, Tontonoz Peter   Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77 Molecular endocrinology (Baltimore, Md.), 2006; 20(4): 786-94.
Hummasti S and Tontonoz P   The PPAR N-terminal domain controls isotype-selective gene expression and adipogenesis, Molecular Endocrinology, 2006; 20: 1261-1275.
Marathe Chaitra, Bradley Michelle N, Hong Cynthia, Lopez Felix, Ruiz de Galarreta Carlos M, Tontonoz Peter, Castrillo Antonio   The arginase II gene is an anti-inflammatory target of liver X receptor in macrophages The Journal of biological chemistry, 2006; 281(43): 32197-206.
Hummasti Sarah, Tontonoz Peter   The peroxisome proliferator-activated receptor N-terminal domain controls isotype-selective gene expression and adipogenesis Molecular endocrinology (Baltimore, Md.), 2006; 20(6): 1261-75.
Arai Satoko, Shelton John M, Chen Mingyi, Bradley Michelle N, Castrillo Antonio, Bookout Angie L, Mak Puiying A, Edwards Peter A, Mangelsdorf David J, Tontonoz Peter, Miyazaki Toru   A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development Cell metabolism, 2005; 1(3): 201-13.
Lin Jiandie, Yang Ruojing, Tarr Paul T, Wu Pei-Hsuan, Handschin Christoph, Li Siming, Yang Wenli, Pei Liming, Uldry Marc, Tontonoz Peter, Newgard Christopher B, Spiegelman Bruce M   Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP Cell, 2005; 120(2): 261-73.
Chen Mingyi, Beaven Simon, Tontonoz Peter   Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha Journal of lipid research, 2005; 46(12): 2570-9.
Pei Liming, Castrillo Antonio, Chen Mingyi, Hoffmann Alexander, Tontonoz Peter   Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli The Journal of biological chemistry, 2005; 280(32): 29256-62.
Bradley Michelle N, Tontonoz Peter   Lesion macrophages are a key target for the antiatherogenic effects of LXR agonists Arteriosclerosis, thrombosis, and vascular biology, 2005; 25(1): 10-1.
Zelcer Noam, Tontonoz Peter   SUMOylation and PPARgamma: wrestling with inflammatory signaling Cell metabolism, 2005; 2(5): 273-5.
Sheth Sonal S, Castellani Lawrence W, Chari Soumya, Wagg Cory, Thipphavong Christopher K, Bodnar Jackie S, Tontonoz Peter, Attie Alan D, Lopaschuk Gary D, Lusis Aldons J   Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition Journal of lipid research, 2005; 46(1): 123-34.
Pei Liming, Tontonoz Peter   Fat's loss is bone's gain The Journal of clinical investigation, 2004; 113(6): 805-6.
Joseph Sean B, Bradley Michelle N, Castrillo Antonio, Bruhn Kevin W, Mak Puiying A, Pei Liming, Hogenesch John, O'connell Ryan M, Cheng Genhong, Saez Enrique, Miller Jeffery F, Tontonoz Peter   LXR-dependent gene expression is important for macrophage survival and the innate immune response Cell, 2004; 119(2): 299-309.
Hummasti Sarah, Laffitte Bryan A, Watson Michael A, Galardi Cristin, Chao Lily C, Ramamurthy Lakshman, Moore John T, Tontonoz Peter   Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target Journal of lipid research, 2004; 45(4): 616-25.
Castrillo Antonio, Tontonoz Peter   Nuclear receptors in macrophage biology: at the crossroads of lipid metabolism and inflammation Annual review of cell and developmental biology, 2004; 20(6): 455-80.
Castrillo Antonio, Tontonoz Peter   PPARs in atherosclerosis: the clot thickens The Journal of clinical investigation, 2004; 114(11): 1538-40.
Walczak Robert, Joseph Sean B, Laffitte Bryan A, Castrillo Antonio, Pei Liming, Tontonoz Peter   Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors The Journal of biological chemistry, 2004; 279(11): 9905-11.
Laffitte Bryan A, Chao Lily C, Li Jing, Walczak Robert, Hummasti Sarah, Joseph Sean B, Castrillo Antonio, Wilpitz Damien C, Mangelsdorf David J, Collins Jon L, Saez Enrique, Tontonoz Peter   Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue Proceedings of the National Academy of Sciences of the United States of America, 2003; 100(9): 5419-24.
Castrillo Antonio, Joseph Sean B, Vaidya Sagar A, Haberland Margaret, Fogelman Alan M, Cheng Genhong, Tontonoz Peter   Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism Molecular cell, 2003; 12(4): 805-16.
Joseph Sean B, Tontonoz Peter   LXRs: new therapeutic targets in atherosclerosis? Current opinion in pharmacology, 2003; 3(2): 192-7.
Castrillo A, Joseph SB, Marathe C, Mangelsdorf DJ and Tontonoz P   Liver X receptor dependent inhibition of MMP-9 gene expression in macrophages, J. Biol. Chem, 2003; 278: 10443-10449.
Tontonoz Peter, Mangelsdorf David J   Liver X receptor signaling pathways in cardiovascular disease Molecular endocrinology (Baltimore, Md.), 2003; 17(6): 985-93.
Castrillo Antonio, Joseph Sean B, Marathe Chaitra, Mangelsdorf David J, Tontonoz Peter   Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages The Journal of biological chemistry, 2003; 278(12): 10443-9.
Joseph Sean B, Castrillo Antonio, Laffitte Bryan A, Mangelsdorf David J, Tontonoz Peter   Reciprocal regulation of inflammation and lipid metabolism by liver X receptors Nature medicine, 2003; 9(2): 213-9.
Walczak Robert, Tontonoz Peter   Setting fat on fire Nature medicine, 2003; 9(11): 1348-9.
Laffitte Bryan A, Joseph Sean B, Chen Mingyi, Castrillo Antonio, Repa Joyce, Wilpitz Damien, Mangelsdorf David, Tontonoz Peter   The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions Molecular and cellular biology, 2003; 23(6): 2182-91.
Joseph Sean B, Laffitte Bryan A, Patel Parthive H, Watson Michael A, Matsukuma Karen E, Walczak Robert, Collins Jon L, Osborne Timothy F, Tontonoz Peter   Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors The Journal of biological chemistry, 2002; 277(13): 11019-25.
Tangirala Rajendra K, Bischoff Eric D, Joseph Sean B, Wagner Brandee L, Walczak Robert, Laffitte Bryan A, Daige Chris L, Thomas Diane, Heyman Richard A, Mangelsdorf David J, Wang Xuping, Lusis Aldons J, Tontonoz Peter, Schulman Ira G   Identification of macrophage liver X receptors as inhibitors of atherosclerosis Proceedings of the National Academy of Sciences of the United States of America, 2002; 99(18): 11896-901.
Laffitte Bryan A, Tontonoz Peter   Orphan nuclear receptors find a home in the arterial wall Current atherosclerosis reports, 2002; 4(3): 213-21.
Walczak Robert, Tontonoz Peter   PPARadigms and PPARadoxes: expanding roles for PPARgamma in the control of lipid metabolism Journal of lipid research, 2002; 43(2): 177-86.
Xu Jun, Xiao Gary, Trujillo Chuck, Chang Vicky, Blanco Lilia, Joseph Sean B, Bassilian Sara, Saad Mohammed F, Tontonoz Peter, Lee W N Paul, Kurland Irwin J   Peroxisome proliferator-activated receptor alpha (PPARalpha) influences substrate utilization for hepatic glucose production The Journal of biological chemistry, 2002; 277(52): 50237-44.
Mak Puiying A, Laffitte Bryan A, Desrumaux Catherine, Joseph Sean B, Curtiss Linda K, Mangelsdorf David J, Tontonoz Peter, Edwards Peter A   Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta The Journal of biological chemistry, 2002; 277(35): 31900-8.
Kast Heidi R, Goodwin Bryan, Tarr Paul T, Jones Stacey A, Anisfeld Andrew M, Stoltz Catherine M, Tontonoz Peter, Kliewer Steve, Willson Timothy M, Edwards Peter A   Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor The Journal of biological chemistry, 2002; 277(4): 2908-15.
Joseph Sean B, McKilligin Elaine, Pei Liming, Watson Michael A, Collins Alan R, Laffitte Bryan A, Chen Mingyi, Noh Grace, Goodman Joanne, Hagger Graham N, Tran Jonathan, Tippin Tim K, Wang Xuping, Lusis Aldons J, Hsueh Willa A, Law Ronald E, Collins Jon L, Willson Timothy M, Tontonoz Peter   Synthetic LXR ligand inhibits the development of atherosclerosis in mice Proceedings of the National Academy of Sciences of the United States of America, 2002; 99(11): 7604-9.
Chawla A, Boisvert WA, Lee C, Laffitte BA, Barak Y, Joseph SB, Nagy L, Liao D, Edwards PA, Curtiss LK, Evans RM and Tontonoz P   A PPARg-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis, Molecular Cell , 2001; 7: 161-171.
Laffitte BA, Joseph SB, Walczak R, Pei L, Wilpitz DC, Collins JL and Tontonoz P   Autoregulation of the human LXRa promoter, Mol. Cell. Biol, 2001; 21: 7558-7568.
Laffitte BA, Repa JJ, Joseph SB, Wilpitz DC, Kast HR, Mangelsdorf DJ, Tontonoz P   LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes Proceedings of the National Academy of Sciences of the United States of America, 2001; 98(2): 507-12.
Chawla A, Barak Y, Nagy L, Liao D, Tontonoz P and Evans RM   PPARg dependent and independent effects on macrophage gene expression in lipid metabolism and inflammation, Nature Medicine , 2001; 7: 48-52.
Ahuja HS, Crombie DL, Boehm M, Leibowitz MD, Heyman RA, Depre C, Nagy L, Tontonoz P and Davies P   Tissue-specific effects of RXR and PPARg ligands on metabolic gene expression in diabetic rodents, Mol. Pharmacol, 2001; 59: 765-773.
Venkateswaren A, Laffitte B, Joseph S, Mak A, Edwards PA and Tontonoz P   Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXRa, Proc. Natl. Acad. Sci. U.S.A, 2000; 97: 12097-12102.
Lee, H., Shi, W., Tontonoz, P., Wang, S., Evans, R.M., Berliner, J.A., and Nagy, L.   Oxidized phospholipids activate PPARa and induce endothelial synthesis of monocyte activators, Circulation Research , 2000; 87: 516-521.
Tontonoz P and Nagy L   Regulation of macrophage gene expression by PPARg: implications for cardiovascular disease, Curr. Opin. Lipidol. , 1999; 10: 485-490.
Saez E, Tontonoz P, Nelson M, Alvarez JGA, Baird SM, Thomazy V and Evans RM   Activators of the nuclear receptor PPARg promote colonic polyp formation in the MIN mouse, Nature Medicine, 1998; 4: 1058-1061.
Nagy L, Tontonoz P, Alvarez JGA, Chen H and Evans RM   Oxidized LDL regulates macrophage gene expression through ligand activation of PPARg, Cell, 1998; 93: 229-240.
Tontonoz P, Nagy L, Alvarez JGA, Thomazy V and Evans RM   PPARg promotes monocyte/macrophage differentiation and uptake of oxidized LDL, Cell, 1998; 93: 241-252.
Devine JH, Eubank DW, Clouthier DE, Tontonoz P, Spiegelman BM, Hammer RE and Beale EG   Adipose expression of the phosphoenol-pyruvate carboxykinase promoter requires peroxisome proliferator-activated receptor gamma and 9-cis- retinoic acid receptor binding to an adipocyte-specific enhancer in vivo, J. Biol. Chem, 1997; 274: 13604-13612.
Hollenberg AN, Susulic VS, Madura JP, Zhang B, Moller DE, Tontonoz P, Sarraf P, Spiegelman BM and Lowell BB   Functional antagonism between C/EBPa and PPARg on the leptin promoter, J. Biol. Chem. , 1997; 272: 5283-5290.
Mueller E, Saraf P, Tontonoz P, Evans RM, Martin KJ, Zhang M, Fletcher CDM, Singer S and Spiegelman BM   Terminal differentiation of human breast cancer through PPARg, Molecular Cell , 1997; 1: 465-470.
Tontonoz P, Singer S, Forman BM, Sarraf P, Fletcher JA, Fletcher CDM, Brun RP, Mueller E, Altiok S, Oppenheim H, Evans RM, Spiegelman BM   Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator activated receptor g- and the retinoid X receptor, Proc. Natl. Acad. Sci. U.S.A, 1997; 94: 237-241.
Brun RP, Tontonoz P, Forman BM, Ellis R, Chen J, Evans RM, Spiegelman BM   Differential activation of adipogenesis by multiple PPAR isoforms Genes & Development. , 1996; 10(8): 974-84.
Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM and Evans RM   15-deoxy-D12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARg, Cell, 1995; 83: 803-812.
Tontonoz P, Hu E, Devine J, Beale EG and Spiegelman BM   PPARg2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene, Mol. Cell. Biol, 1995; 15: 351-357.
Hu E, Tontonoz P and Spiegelman BM   Transdifferentiation of myoblasts by the adipogenic transcription factors PPARg and C/EBPa, Proc. Natl. Acad. Sci. U.S.A, 1995; 92: 9856-9860.
Tontonoz P, Hu E and Spiegelman BM   Stimulation of adipogenesis in fibroblasts by PPARg2, a lipid-activated transcription factor, Cell, 1994; 79: 1147-1156.
Tontonoz P, Hu E, Graves RA, Budavari A, Spiegelman B   mPPARg2:tissue-specific regulator of an adipocyte enhancer, Genes & Development, 1994; 8: 1224-1234.
Tontonoz P, Kim JB, Graves RA, Spiegelman BM   ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation Molecular and cellular biology. , 1993; 13(8): 4753-9.
Spiegelman BM, Choy L, Hotamisligil GS, Graves RA, Tontonoz P   Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes The Journal of biological chemistry , 1993; 268(10): 6823-6.
Graves RA, Tontonoz P, Spiegelman BM   Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression Molecular and cellular biology. , 1992; 12(3): 1202-8.
Graves RA, Tontonoz P, Ross SR, Spiegelman BM   Identification of a potent adipocyte-specific enhancer: involvement of an NF-1-like factor Genes & Development. , 1991; 5(3): 428-37.

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