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Hong, C., Kitani, Y., A-Gonzalez, N., Castrillo, A., Tontonoz, P., and Bensinger, S.J.
An LXR-dependent pathway modulates neutrophil homeostasis in mice. ,
J. Clin. Invest.,
2012; 122:
337-47.
Hong, C., Walczak, R., Dhamko, H., Bradley, M.N., Boyadjian, R., Salazar, J.V. and Tontonoz, P.
Constitutive activation of LXR signaling in macrophages regulates lipid metabolic and inflammatory gene expression: Identification of ARL7 as a direct target. ,
J. Lipid Res. ,
2011; 52:
531-9.
Calkin, A.C, Goult, B.T., Zhang, L., Fairall, L., Hong, C., Schwabe, J.W.R., and Tontonoz, P.
FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors. ,
Proc Nat Acad Sci USA,
2011; 108:
20107-12.
Beaven, S.W., Wroblewski, K., Wang, J., Bensinger, S.J., Tsukamoto, H. and Tontonoz, P.
LXR signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease. ,
Gastroenterology,
2011; 140:
1052-62.
Villanueva, C.J., Waki, H., Godio, C., Nielsen, R., Chou, W-L, Vargas, L., Wroblewski, K., Schmedt, C., Boyadjian, R., Mandrup, S., Hevener, A., Saez, E. and Tontonoz, P.
TLE3 is a dual function transcriptional coregulator of adipogenesis,
Cell Metabolism,
2011; 13:
413-27.
Scotti, E., Hong, C., Yoshinaga, Y., Fong, L., Noam Zelcer, Boyadjian, R., de Jong, P.J., Young, S.G. and Tontonoz, P.
Targeted disruption of the Idol gene alters cellular regulation of the LDLR by sterols and LXR agonists,
Mol. Cell. Biol. ,
2011; 31:
1885-93.
Zhang, L., Fairall, L., Goult, B.T., Calkin, A.C., Hong, C., Millard, C.J., Tontonoz, P., and Schwabe, J.W.R
The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor,
Genes & Development,
2011; 15:
1262-74.
Weisglass-Volkov, D., Calkin, A.C, Tusie-Luna, T., Sinsheimer, J.S., Zelcer, N., Riba, L., Vargas Tino, M., Ordoñez-Sánchez, M.L, Cruz-Bautista, I., Aguilar-Salinas, C.A., Tontonoz, P. and Pajukanta, P.
The asparagine allele of N342S polymorphism in the human MYLIP(IDOL) gene is associated with high serum total cholesterol levels and increased low-density lipoprotein receptor degradation,
J. Clin. Invest.,
2011; 121:
3062-71.
Calkin, A.C. and Tontonoz, P.
Genome-wide association studies identify new targets in cardiovascular disease,
Science Transl. Med. ,
2010; 2:
48-49.
Feig, J.E., Pineda-Torra, I., Sanson, M., Bradley, M.N., Vengrenyuk, Y., Gautier, E.L., Rubinstein, D., Hong, C., Liu, J., Rooijen, N., Bogunovic, D., Bhardwaj, N., Garabedian, M.J., Tontonoz, P., and Fisher, E.A.
LXR promotes maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression,
J. Clin. Invest. ,
2010; 120:
4415-24.
Hong, C., Duit, S., Jalonen, P., Out, R., Scheer, L., Boyadjian, R., Rodenburg, K., Foley, E., Korhonen, L., Lindholm, D., Nimph, J., Van Berkel, T.J.M. Tontonoz, P and Zelcer, N.
The E3-ubiquitin ligase IDOL induces the degradation of the low-density lipoprotein receptor family members VLDLR and ApoER2,
J. Biol. Chem.,
2010; 285:
19720-6.
Park, K.W., Waki, H., Choi, S.P., Park, K.M. and Tontonoz P
The small molecule phenamil is a modulator of adipocyte differentiation and PPAR? expressionThe small molecule phenamil is a modulator of adipocyte differentiation and PPAR? expression,
J. Lipid. Res.,
2010; 51:
2775-84.
Bensinger, S. J. Tontonoz, P.
A Nurr1 pathway for neuroprotection,
Cell,
2009; 137:
26-28.
A-Gonzalez, N., Bensinger, S.J., Bradley, M.N., Zelcer, N., Beceiro, S., Hong, C., Deniz, J., Ramirez, C.M., Gallardo, G., Galarreta, C., Salazar, J., Lopez, F., Parks, J., Edwards, P.A., Andujar, M., Tontonoz, P. and Castrillo, A.
Apoptotic cells promote their own clearance and immune tolerance through activation of LXR signaling,
Immunity,
2009; 31:
245-58.
Chao LC, Wroblewski K, Zhang Z, Pei L, Vergnes L, Ilkayeva OR, Ding SY, Reue K, Watt MJ, Newgard CB, Pilch PF, Hevener AL and Tontonoz P
Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77,
Diabetes,
2009; 58:
2788-96.
Zelcer, N., Hong, C., Boyadjian, R., and Tontonoz, P.
LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor,
Science,
2009; 325:
100-104.
Dean, J.T., Tran, L., Beaven, S., Tontonoz, P., Reue, K., Dipple, K.M., Liao, J.C.
Resistance to Diet-Induced Obesity in Mice with Synthetic Glyoxylate Shunt,
Cell Metabolism,
2009; 9:
525-536.
Park, K.W., Waki, H., Kim, W-K., Davies, B.S.J., Young, S.G., Parhami, F. and Tontonoz, P.
The small molecule phenamil induces osteoblast differentiation and mineralization.,
Mol. Cell. Biol.,
2009; 29:
3905-3914.
Hummasti, S., and Tontonoz, P.
Adopting new orphans into the family of metabolic regulators,
Molecular Endocrinology,
2008; 22:
1743-1753.
Jiang, Q., Mandrekar, S., Lee, C.Y.D., Wilkinson, B., Cramer, P., Zelcer, N., Mann, K., Lamb, B., Willson, T.M., Collins, J.L., Richardson, J.C., Holtzman, D., Tontonoz, P., and Landreth, G.E.
ApoE promotes the proteolytic degradation of Abeta,
Neuron,
2008; 58:
681-693.
Gallardo-Soler, A., Gomez-Nieto, C., Luisa Campo, M., Marathe, C., Tontonoz, P., Castrillo, A., Corraliza, I.
Arginase I induction by modified lipoproteins in macrophages: A PPARgamma/delta-mediated effect that links lipid metabolism and immunity,
Molecular Endocrinology,
2008; 22:
1394-402.
Tontonoz, P. and Spiegelman, B.M.
Beyond fat: the diverse biology of PPARgamma,
Ann Rev Biochem,
2008; 77:
289-312.
Hummasti, S., Hong, C., Bensinger, S.J., and Tontonoz, P
HRASLS3 is a PPAR?-selective target gene that promotes adipocyte differentiation ,
J. Lipid Res. ,
2008; 49:
2535-44.
Park, K.W., Waki, H., Villanueva, C.J., Monticelli, L., Hong, C., Kang, S., MacDougald, O.A., Goldrath, A.W., and Tontonoz, P.
Id2 is a small molecule-inducible modulator of PPARgamma expression and adipocyte differentiation,
Molecular Endocrinology,
2008; 22:
2038-2048.
Chao, L.C., Bensinger, S.J., Wroblewski, K., and Tontonoz, P.
Inhibition of adipocyte differentiation by Nur77, Nurr1 and Nor-1,
Molecular Endocrinology,
2008; 22:
2596-608.
Bensinger, S.J. and Tontonoz, P.
Integration of metabolism and inflammation by lipid-activated nuclear receptors,
Nature,
2008; 454:
470-477.
Bensinger, S.J., Bradley, M.N., Joseph, S.B., Zelcer, N., Janssen, E.M., Hausner, M.A., Shih, R., Parks, J., Edwards, P.A., Jamieson, B.D., and Tontonoz, P.
LXR signaling couples sterol metabolism to proliferation in the acquired immune response,
Cell,
2008; 134:
97-111.
Marathe C, Bradley MN, Hong C, Chao LC, Wilpitz D, Salazar J, and Tontonoz P.
Preserved glucose tolerance in high fat diet fed C57BL/6 mice transplanted with PPAR?-/-, PPAR?-/-, PPAR??-/- or LXR??-/- bone marrow,
J. Lipid Res. ,
2008; 50:
214-224.
Davies, B.S.J., Waki, H., Beigneux, A.P., Farber, E., Weinstein, M.M., Wilpitz, D.C., Tai, L., Evans, R.M., Fong, L.G., Tontonoz, P., and Young, S.G.
The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by PPAR?,
Molecular Endocrinology,
2008; 22:
2496-504.
Zelcer, N., Khanlou, N., Clare, R., Jiang, Q., Reed-Geaghan, E.G., Landreth, G.E., Vinters, H.V.V., and Tontonoz, P.
Attenuation of neuroinflammation and Alzehimer's disease pathology by liver X receptors,
Proc Nat Acad Sci USA,
2007; 104:
10601-10606.
Bradley, M.N., Hong, C., Joseph, S.B., Chen, M., Wang. X., Lusis, J., Collins, A., Hseuh, W.A. Collins, J.L., Tangirala, R. and Tontonoz, P.
Ligand activation of LXRb reverses whole body cholesterol overload and atherosclerosis in mie lacking LXRa and apoE,
J. Clin. Invest,
2007; 117:
2337-2346.
Molteni ,V., Li, X., Nabakka, J., Liang, F., Wityak, J., Koder, A., Vargas, L., Romeo, R., Mitro, N., Mak, P.A., Seidel, H.M., Haslam, J.A., Chow, D., Tuntland, T., Spalding, T.A., Brock, A., Bradley, M., Castrillo, A., Tontonoz, P., and Saez, E.
N-Acylthiadiazolines, a new class of Liver X Receptor agonists with selectivity for LXRbeta,
J Med Chem,
2007; 50:
4255-4259.
Chao, L.C., Zhang, Z., Tsugumichi, S., Tontonoz, P. and Pilch, P.
Nur77 coordinately regulates expression of genes linked to glucose metabolism in skeletal muscle,
Molecular Endocrinology,
2007; 21:
2152-2163.
Waki, H., Park, K.W., Mitro, N., Pei, L., Damoiseaux, R., Wilpitz. D., Reue, K., Saez, E., Tontonoz, P.
The small molecule harmine is an anti-diabetic cell-type specific regulator of PPARg expression,
Cell Metabolism,
2007; 5:
357-370.
Chow, E.K., Castrillo, A., Shahangian, A., O'Connell, R.M., Pei, L., Tontonoz, P., and Cheng, G.
Critical role of IRF3-dependent RXRa repression in hepatotoxicity associated with viral infections,
J. Exp Med.,
2006; 203:
2589-2602.
Baldan A, Pei L, Lee R, Tarr P, Tangirala RK, Weinstein MM, Frank J, Li AC, Tontonoz P, Edwards PA.
Impaired Development of Atherosclerosis in Hyperlipidemic Ldlr-/- and ApoE-/- Mice Transplanted With Abcg1-/- Bone Marrow,
Arterioscler Thromb Vasc Biol,
2006; 26:
2301-2307.
Pei L, Waki H, Vaitheesvaran B, Wilpitz DC, Kurland I and Tontonoz P
NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism,
Nature Medicine,
2006; 12:
1048-1055.
Hummasti S and Tontonoz P
The PPAR N-terminal domain controls isotype-selective gene expression and adipogenesis,
Molecular Endocrinology,
2006; 20:
1261-1275.
Marathe, C., Bradley, M.N., Hong, C., Lopez, F., Ruiz de Galaraeta, C.M., Tontonoz, P., and Castrillo, A.
The arginase II gene is an anti-inflammatory target of LXR in macrophages,
J. Biol. Chem.,
2006; 281:
32197-32206.
Arai S, Shelton JM, Chen M, Bradley MN, Castrillo A, Bookout AL, Mak PA, Edwards PA, Mangelsdorf DJ, Tontonoz P, Miyazaki T
A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development
Cell Metabolism,
2005; 1(3):
201-13.
Lin J, Yang R, Tarr PT, Wu PH, Handschin C, Yang W, Pei L, Uldry M, Tontonoz P, Newgard CB and Spiegelman BM
Hyperlipidemic effects of dietary saturated fats mediated through PGC-1b coactivation of SREBP,
Cell,
2005; 120:
261-273.
Sheth SS, Castellani LW, Chari S, Wagg C, Thipphavong CK, Bodnar JS, Tontonoz P, Attie AD, Lopaschuk GD, Lusis AJ
Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition.
Journal of Lipid Research. ,
2005; 46(1):
123-34.
Joseph, S.B., Bradley, M., Castrillo, A., Bruhn, K., Mak, P.A., Pei, L., Hogenesch, J., O'Connell, R.M., Cheng, G., Saez, E., Miller, J.F., and Tontonoz, P.
LXR-dependent gene expression is important for macrophage survival and the innate immune response,
Cell,
2004; 119:
299-309.
Laffitte BA, Chao LC, Li J, Walczak R, Hummasti S, Joseph SB, Castrillo A, Wilpitz DC, Mangelsdorf DJ, Collins JL, Saez E, Tontonoz P
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue.
Proceedings of the National Academy of Sciences of the United States of America. ,
2003; 100(9):
5419-24.
Castrillo A, Joseph SB, Marathe C, Mangelsdorf DJ and Tontonoz P
Liver X receptor dependent inhibition of MMP-9 gene expression in macrophages,
J. Biol. Chem.,
2003; 278:
10443-10449.
Tangirala RK, Bischoff ED, Joseph SB, Wagner BL, Walczak R, Laffitte BA, Daige CL, Thomas D, Heyman RA, Mangelsdorf DJ, Wang X, Lusis AJ, Tontonoz P, Schulman IG
Identification of macrophage liver X receptors as inhibitors of atherosclerosis.
Proceedings of the National Academy of Sciences of the United States of America. ,
2002; 99(18):
11896-901.
Laffitte BA and Tontonoz P
Orphan nuclear receptors find a home in the arterial wall,
Curr. Atheroscler. Rep. ,
2002; 4:
213-221.
Walczk R and Tontonoz P
PPARadigms and PPARadoxes: expanding roles for PPARg in the control of lipid metabolism,
J. Lipid Res. ,
2002; 43:
177-186.
Mak PA, Laffitte BA, Desrumaux C, Joseph SB, Curtiss L, Mangelsdorf DJ, Tontonoz P and Edwards PA
Regulated expression of the apoE/C-I/C-IV/C-II gene cluster in murine and human macrophages: a critical role for the nuclear receptors LXRa and LXRb,
J. Biol. Chem.,
2002; 277:
31900-31908.
Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor
The Journal of biological chemistry,
2002; 277(4):
2908-15.
Joseph SB, McKilligin E, Pei L, Watson MA, Collins AR, Laffitte BA, Chen M, Noh G, Goodman J, Hagger GN, Tran J, Tippin TK, Wang X, Lusis AJ, Hsueh WA, Law RE, Collins JL, Willson TM, Tontonoz P
Synthetic LXR ligand inhibits the development of atherosclerosis in mice.
Proceedings of the National Academy of Sciences of the United States of America. ,
2002; 99(11):
7604-9.
Chawla A, Boisvert WA, Lee C, Laffitte BA, Barak Y, Joseph SB, Nagy L, Liao D, Edwards PA, Curtiss LK, Evans RM and Tontonoz P
A PPARg-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis,
Molecular Cell ,
2001; 7:
161-171.
Laffitte BA, Joseph SB, Walczak R, Pei L, Wilpitz DC, Collins JL and Tontonoz P
Autoregulation of the human LXRa promoter,
Mol. Cell. Biol.,
2001; 21:
7558-7568.
Chawla A, Barak Y, Nagy L, Liao D, Tontonoz P and Evans RM
PPARg dependent and independent effects on macrophage gene expression in lipid metabolism and inflammation,
Nature Medicine ,
2001; 7:
48-52.
Ahuja HS, Crombie DL, Boehm M, Leibowitz MD, Heyman RA, Depre C, Nagy L, Tontonoz P and Davies P
Tissue-specific effects of RXR and PPARg ligands on metabolic gene expression in diabetic rodents.,
Mol. Pharmacol.,
2001; 59:
765-773.
Venkateswaren A, Laffitte B, Joseph S, Mak A, Edwards PA and Tontonoz P
Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXRa,
Proc. Natl. Acad. Sci. U.S.A.,
2000; 97:
12097-12102.
Lee, H., Shi, W., Tontonoz, P., Wang, S., Evans, R.M., Berliner, J.A., and Nagy, L.
Oxidized phospholipids activate PPARa and induce endothelial synthesis of monocyte activators.,
Circulation Research ,
2000; 87:
516-521.
Tontonoz P and Nagy L
Regulation of macrophage gene expression by PPARg: implications for cardiovascular disease.,
Curr. Opin. Lipidol. ,
1999; 10:
485-490.
Saez E, Tontonoz P, Nelson M, Alvarez JGA, Baird SM, Thomazy V and Evans RM
Activators of the nuclear receptor PPARg promote colonic polyp formation in the MIN mouse,
Nature Medicine,
1998; 4:
1058-1061.
Nagy L, Tontonoz P, Alvarez JGA, Chen H and Evans RM
Oxidized LDL regulates macrophage gene expression through ligand activation of PPARg,
Cell,
1998; 93:
229-240.
Tontonoz P, Nagy L, Alvarez JGA, Thomazy V and Evans RM
PPARg promotes monocyte/macrophage differentiation and uptake of oxidized LDL,
Cell,
1998; 93:
241-252.
Devine JH, Eubank DW, Clouthier DE, Tontonoz P, Spiegelman BM, Hammer RE and Beale EG
Adipose expression of the phosphoenol-pyruvate carboxykinase promoter requires peroxisome proliferator-activated receptor gamma and 9-cis- retinoic acid receptor binding to an adipocyte-specific enhancer in vivo.,
J. Biol. Chem,
1997; 274:
13604-13612.
Hollenberg AN, Susulic VS, Madura JP, Zhang B, Moller DE, Tontonoz P, Sarraf P, Spiegelman BM and Lowell BB
Functional antagonism between C/EBPa and PPARg on the leptin promoter.,
J. Biol. Chem. ,
1997; 272:
5283-5290.
Mueller E, Saraf P, Tontonoz P, Evans RM, Martin KJ, Zhang M, Fletcher CDM, Singer S and Spiegelman BM
Terminal differentiation of human breast cancer through PPARg,
Molecular Cell ,
1997; 1:
465-470.
Tontonoz P, Singer S, Forman BM, Sarraf P, Fletcher JA, Fletcher CDM, Brun RP, Mueller E, Altiok S, Oppenheim H, Evans RM, Spiegelman BM
Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator activated receptor g- and the retinoid X receptor.,
Proc. Natl. Acad. Sci. U.S.A.,
1997; 94:
237-241.
Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM and Evans RM
15-deoxy-D12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARg,
Cell,
1995; 83:
803-812.
Tontonoz P, Hu E, Devine J, Beale EG and Spiegelman BM
PPARg2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene,
Mol. Cell. Biol.,
1995; 15:
351-357.
Hu E, Tontonoz P and Spiegelman BM
Transdifferentiation of myoblasts by the adipogenic transcription factors PPARg and C/EBPa.,
Proc. Natl. Acad. Sci. U.S.A.,
1995; 92:
9856-9860.
Tontonoz P, Hu E and Spiegelman BM
Stimulation of adipogenesis in fibroblasts by PPARg2, a lipid-activated transcription factor,
Cell,
1994; 79:
1147-1156.
Tontonoz P, Hu E, Graves RA, Budavari A, Spiegelman B
mPPARg2:tissue-specific regulator of an adipocyte enhancer.,
Genes & Development,
1994; 8:
1224-1234.
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