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Keith Nuechterlein, Ph.D.
Contact Information:
Office Phone Number:
(310) 825-0036
Work Phone Number:
(310) 206-3142
Office Address:
300 UCLA Medical Plaza Room 2251 Los Angeles, CA 90095 UNITED STATES
Professor,
Psychiatry and Biobehavioral Sciences
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Professor in Residence,
Clinical Psychology
Semel Institute for Neuroscience and Human Behavior
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Detailed Biography:
Keith H. Nuechterlein, Ph.D., is a Professor in the Departments of Psychiatry and Biobehavioral Sciences and of Psychology at the University of California, Los Angeles. He serves as the Director of the UCLA Center for Neurocognition and Emotion in Schizophrenia, an NIMH-funded Translational Research Center in Behavioral Science. He also is the Director of the UCLA Aftercare Research Program, a research clinic devoted to research and treatment with patients who have had a recent onset of schizophrenia. Dr. Nuechterlein received his B.A. in psychology in 1970 and his Ph.D. in Psychology (Clinical) in 1978 from the University of Minnesota. His expertise focuses on cognitive deficits in schizophrenia, their role as genetic vulnerability factors, their connections to functional outcome, and their remediation. Dr. Nuechterlein has authored more than 235 journal articles and is among the scientists on the ISI Web of Knowledge Highly Cited list for Psychology/Psychiatry. He has been on the editorial boards of the Journal of Abnormal Psychology and Schizophrenia Bulletin and is currently on the editorial board of Psychological Medicine. He has received numerous research grants from NIMH and other sources. Dr. Nuechterlein served as the Co-Chair of the Neurocognition Committee for the NIMH-funded initiative, Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS). This group guided the development of the MATRICS Consensus Cognitive Battery, a standardized outcome measure for clinical trials to assess the impact of new interventions on core cognitive deficits in schizophrenia. Dr. Nuechterlein is a past-president of the Society for Research in Psychopathology.
Publications:
Velligan Dawn I, Rubin Maureen, Fredrick Megan M, Mintz Jim, Nuechterlein Keith H, Schooler Nina R, Jaeger Judith, Peters Nancy M, Buller Raimund, Marder Stephen R, Dube Sanjay
The cultural adaptability of intermediate measures of functional
outcome in schizophrenia.
Schizophrenia bulletin,
2012; 38(3):
630-41.
Bartzokis George, Lu Po H, Amar Chetan P, Raven Erika P, Detore Nicole R, Altshuler Lori L, Mintz Jim, Ventura Joseph, Casaus Laurie R, Luo John S, Subotnik Kenneth L, Nuechterlein Keith H
Long acting injection versus oral risperidone in first-episode
schizophrenia: differential impact on white matter myelination
trajectory.
Schizophrenia research,
2011; 132(1):
35-41.
Greenwood Tiffany A, Lazzeroni Laura C, Murray Sarah S, Cadenhead Kristin S, Calkins Monica E, Dobie Dorcas J, Green Michael F, Gur Raquel E, Gur Ruben C, Hardiman Gary, Kelsoe John R, Leonard Sherry, Light Gregory A, Nuechterlein Keith H, Olincy Ann, Radant Allen D, Schork Nicholas J, Seidman Larry J, Siever Larry J, Silverman Jeremy M, Stone William S, Swerdlow Neal R, Tsuang Debby W, Tsuang Ming T, Turetsky Bruce I, Freedman Robert, Braff David L
Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia
from the Consortium on the Genetics of Schizophrenia.
The American journal of psychiatry,
2011; 168(9):
930-46.
Yang Yaling, Nuechterlein Keith H, Phillips Owen R, Gutman Boris, Kurth Florian, Dinov Ivo, Thompson Paul M, Asarnow Robert F, Toga Arthur W, Narr Katherine L
Disease and genetic contributions toward local tissue volume
disturbances in schizophrenia: A tensor-based morphometry study.
Human brain mapping,
2011; 37 Suppl 2(9):
.
Clark Kristi A, Nuechterlein Keith H, Asarnow Robert F, Hamilton Liberty S, Phillips Owen R, Hageman Nathan S, Woods Roger P, Alger Jeffry R, Toga Arthur W, Narr Katherine L
Mean diffusivity and fractional anisotropy as indicators of disease
and genetic liability to schizophrenia.
Journal of psychiatric research,
2011; 45(7):
980-8.
Stone William S, Giuliano Anthony J, Tsuang Ming T, Braff David L, Cadenhead Kristin S, Calkins Monica E, Dobie Dorcas J, Faraone Stephen V, Freedman Robert, Green Michael F, Greenwood Tiffany A, Gur Raquel E, Gur Ruben C, Light Gregory A, Mintz Jim, Nuechterlein Keith H, Olincy Ann, Radant Allen D, Roe Andrea H, Schork Nicholas J, Siever Larry J, Silverman Jeremy M, Swerdlow Neal R, Thomas Alison R, Tsuang Debby W, Turetsky Bruce I, Seidman Larry J
Group and site differences on the California Verbal Learning Test in
persons with schizophrenia and their first-degree relatives: findings
from the Consortium on the Genetics of Schizophrenia (COGS).
Schizophrenia research,
2011; 128(1-3):
102-10.
Reise Steven P, Ventura Joseph, Keefe Richard S E, Baade Lyle E, Gold James M, Green Michael F, Kern Robert S, Mesholam-Gately Raquelle, Nuechterlein Keith H, Seidman Larry J, Bilder Robert
Bifactor and item response theory analyses of interviewer report
scales of cognitive impairment in schizophrenia.
Psychological assessment,
2011; 23(1):
245-61.
Horan William P, Green Michael F, Degroot Michael, Fiske Alan, Hellemann Gerhard, Kee Kimmy, Kern Robert S, Lee Junghee, Sergi Mark J, Subotnik Kenneth L, Sugar Catherine A, Ventura Joseph, Nuechterlein Keith H
Social Cognition in Schizophrenia, Part 2: 12-Month Stability and
Prediction of Functional Outcome in First-Episode Patients.
Schizophrenia bulletin,
2011; 127(1-3):
.
Kern Robert S, Gold James M, Dickinson Dwight, Green Michael F, Nuechterlein Keith H, Baade Lyle E, Keefe Richard S E, Mesholam-Gately Raquelle I, Seidman Larry J, Lee Cathy, Sugar Catherine A, Marder Stephen R
The MCCB impairment profile for schizophrenia outpatients: results
from the MATRICS psychometric and standardization study.
Schizophrenia research,
2011; 126(1-3):
124-31.
Masten Ann S, Nuechterlein Keith H, Wright Margaret O'Dougherty
Norman Garmezy (1918-2009).
The American psychologist,
2011; 66(2):
140-1.
Green Michael F, Bearden Carrie E, Cannon Tyrone D, Fiske Alan P, Hellemann Gerhard S, Horan William P, Kee Kimmy, Kern Robert S, Lee Junghee, Sergi Mark J, Subotnik Kenneth L, Sugar Catherine A, Ventura Joseph, Yee Cindy M, Nuechterlein Keith H
Social Cognition in Schizophrenia, Part 1: Performance Across Phase of
Illness.
Schizophrenia bulletin,
2011; 126(1-3):
.
Radant Allen D, Dobie Dorcas J, Calkins Monica E, Olincy Ann, Braff David L, Cadenhead Kristin S, Freedman Robert, Green Michael F, Greenwood Tiffany A, Gur Raquel E, Gur Ruben C, Light Gregory A, Meichle Sean P, Millard Steve P, Mintz Jim, Nuechterlein Keith H, Schork Nicholas J, Seidman Larry J, Siever Larry J, Silverman Jeremy M, Stone William S, Swerdlow Neal R, Tsuang Ming T, Turetsky Bruce I, Tsuang Debby W
Antisaccade performance in schizophrenia patients, their first-degree
biological relatives, and community comparison subjects: data from the
COGS study.
Psychophysiology,
2010; 47(5):
846-56.
Ventura Joseph, Reise Steven P, Keefe Richard S E, Baade Lyle E, Gold James M, Green Michael F, Kern Robert S, Mesholam-Gately Raquelle, Nuechterlein Keith H, Seidman Larry J, Bilder Robert M
The Cognitive Assessment Interview (CAI): development and validation
of an empirically derived, brief interview-based measure of cognition.
Schizophrenia research,
2010; 121(1-3):
24-31.
Olincy Ann, Braff David L, Adler Lawrence E, Cadenhead Kristin S, Calkins Monica E, Dobie Dorcas J, Green Michael F, Greenwood Tiffany A, Gur Raquel E, Gur Reuben C, Light Gregory A, Mintz James, Nuechterlein Keith H, Radant Allen D, Schork Nicholas J, Seidman Larry J, Siever Larry J, Silverman Jeremy M, Stone William S, Swerdlow Neal R, Tsuang Debby W, Tsuang Ming T, Turetsky Bruce I, Wagner Brandie D, Freedman Robert
Inhibition of the P50 cerebral evoked response to repeated auditory
stimuli: results from the Consortium on Genetics of Schizophrenia.
Schizophrenia research,
2010; 119(1-3):
175-82.
Yee Cindy M, Mathis Kristopher Ian, Sun Jane C, Sholty Gretchen L, Lang Peter J, Bachman Peter, Williams Terrance J, Bearden Carrie E, Cannon Tyrone D, Green Michael F, Subotnik Kenneth L, Ventura Joseph, Nuechterlein Keith H
Integrity of emotional and motivational states during the prodromal,
first-episode, and chronic phases of schizophrenia.
Journal of abnormal psychology,
2010; 119(1):
71-82.
Hamilton Liberty S, Altshuler Lori L, Townsend Jennifer, Bookheimer Susan Y, Phillips Owen R, Fischer Jeffrey, Woods Roger P, Mazziotta John C, Toga Arthur W, Nuechterlein Keith H, Narr Katherine L
Alterations in functional activation in euthymic bipolar disorder and
schizophrenia during a working memory task.
Human brain mapping,
2009; 30(12):
3958-69.
Sun Daqiang, van Erp Theo G M, Thompson Paul M, Bearden Carrie E, Daley Melita, Kushan Leila, Hardt Molly E, Nuechterlein Keith H, Toga Arthur W, Cannon Tyrone D
Elucidating a magnetic resonance imaging-based neuroanatomic biomarker
for psychosis: classification analysis using probabilistic brain atlas
and machine learning algorithms.
Biological psychiatry,
2009; 66(11):
1055-60.
Bartzokis George, Lu Po H, Stewart Stephanie B, Oluwadara Bolanle, Lucas Andrew J, Pantages Joanna, Pratt Erika, Sherin Jonathan E, Altshuler Lori L, Mintz Jim, Gitlin Michael J, Subotnik Kenneth L, Nuechterlein Keith H
In vivo evidence of differential impact of typical and atypical
antipsychotics on intracortical myelin in adults with schizophrenia.
Schizophrenia research,
2009; 113(2-3):
322-31.
Narr Katherine L, Hageman Nathan, Woods Roger P, Hamilton Liberty S, Clark Kristi, Phillips Owen, Shattuck David W, Asarnow Robert F, Toga Arthur W, Nuechterlein Keith H
Mean diffusivity: a biomarker for CSF-related disease and genetic
liability effects in schizophrenia.
Psychiatry research,
2009; 171(1):
20-32.
Turetsky Bruce I, Greenwood Tiffany A, Olincy Ann, Radant Allen D, Braff David L, Cadenhead Kristin S, Dobie Dorcas J, Freedman Robert, Green Michael F, Gur Raquel E, Gur Ruben C, Light Gregory A, Mintz James, Nuechterlein Keith H, Schork Nicholas J, Seidman Larry J, Siever Larry J, Silverman Jeremy M, Stone William S, Swerdlow Neal R, Tsuang Debby W, Tsuang Ming T, Calkins Monica E
Abnormal auditory N100 amplitude: a heritable endophenotype in
first-degree relatives of schizophrenia probands.
Biological psychiatry,
2008; 64(12):
1051-9.
Horan William P, Braff David L, Nuechterlein Keith H, Sugar Catherine A, Cadenhead Kristin S, Calkins Monica E, Dobie Dorcas J, Freedman Robert, Greenwood Tiffany A, Gur Raquel E, Gur Ruben C, Light Gregory A, Mintz James, Olincy Ann, Radant Allan D, Schork Nicholas J, Seidman Larry J, Siever Larry J, Silverman Jeremy M, Stone William S, Swerdlow Neal R, Tsuang Debbie W, Tsuang Ming T, Turetsky Bruce I, Green Michael F
Verbal working memory impairments in individuals with schizophrenia
and their first-degree relatives: findings from the Consortium on the
Genetics of Schizophrenia.
Schizophrenia research,
2008; 103(1-3):
218-28.
Carter Cameron S, Barch Deanna M, Buchanan Robert W, Bullmore Ed, Krystal John H, Cohen Jonathan, Geyer Mark, Green Michael, Nuechterlein Keith H, Robbins Trevor, Silverstein Steven, Smith Edward E, Strauss Milton, Wykes Til, Heinssen Robert
Identifying cognitive mechanisms targeted for treatment development in
schizophrenia: an overview of the first meeting of the Cognitive
Neuroscience Treatment Research to Improve Cognition in Schizophrenia
Initiative.
Biological psychiatry,
2008; 64(1):
4-10.
Green Michael F, Nuechterlein Keith H, Kern Robert S, Baade Lyle E, Fenton Wayne S, Gold James M, Keefe Richard S E, Mesholam-Gately Raquelle, Seidman Larry J, Stover Ellen, Marder Stephen R
Functional co-primary measures for clinical trials in schizophrenia:
results from the MATRICS Psychometric and Standardization Study.
The American journal of psychiatry,
2008; 165(2):
221-8.
Nuechterlein Keith H, Green Michael F, Kern Robert S, Baade Lyle E, Barch Deanna M, Cohen Jonathan D, Essock Susan, Fenton Wayne S, Frese Frederick J, Gold James M, Goldberg Terry, Heaton Robert K, Keefe Richard S E, Kraemer Helena, Mesholam-Gately Raquelle, Seidman Larry J, Stover Ellen, Weinberger Daniel R, Young Alexander S, Zalcman Steven, Marder Stephen R
The MATRICS Consensus Cognitive Battery, part 1: test selection,
reliability, and validity.
The American journal of psychiatry,
2008; 165(2):
203-13.
Kern Robert S, Nuechterlein Keith H, Green Michael F, Baade Lyle E, Fenton Wayne S, Gold James M, Keefe Richard S E, Mesholam-Gately Raquelle, Mintz Jim, Seidman Larry J, Stover Ellen, Marder Stephen R
The MATRICS Consensus Cognitive Battery, part 2: co-norming and
standardization.
The American journal of psychiatry,
2008; 165(2):
214-20.
Foerde Karin, Poldrack Russell A, Khan Barbara J, Sabb Fred W, Bookheimer Susan Y, Bilder Robert M, Guthrie Don, Granholm Eric, Nuechterlein Keith H, Marder Stephen R, Asarnow Robert F
Selective corticostriatal dysfunction in schizophrenia: examination of
motor and cognitive skill learning.
Neuropsychology,
2008; 22(1):
100-9.
Greenwood Tiffany A, Braff David L, Light Gregory A, Cadenhead Kristin S, Calkins Monica E, Dobie Dorcas J, Freedman Robert, Green Michael F, Gur Raquel E, Gur Ruben C, Mintz Jim, Nuechterlein Keith H, Olincy Ann, Radant Allen D, Seidman Larry J, Siever Larry J, Silverman Jeremy M, Stone William S, Swerdlow Neal R, Tsuang Debby W, Tsuang Ming T, Turetsky Bruce I, Schork Nicholas J
Initial heritability analyses of endophenotypic measures for
schizophrenia: the consortium on the genetics of schizophrenia.
Archives of general psychiatry,
2007; 64(11):
1242-50.
Swerdlow Neal R, Sprock Joyce, Light Gregory A, Cadenhead Kristin, Calkins Monica E, Dobie Dorcas J, Freedman Robert, Green Michael F, Greenwood Tiffany A, Gur Raquel E, Mintz Jim, Olincy Ann, Nuechterlein Keith H, Radant Allen D, Schork Nicholas J, Seidman Larry J, Siever Larry J, Silverman Jeremy M, Stone William S, Tsuang Debbie W, Tsuang Ming T, Turetsky Bruce I, Braff David L
Multi-site studies of acoustic startle and prepulse inhibition in
humans: initial experience and methodological considerations based on
studies by the Consortium on the Genetics of Schizophrenia.
Schizophrenia research,
2007; 92(1-3):
237-51.
Radant Allen D, Dobie Dorcas J, Calkins Monica E, Olincy Ann, Braff David L, Cadenhead Kristin S, Freedman Robert, Green Michael F, Greenwood Tiffany A, Gur Raquel E, Light Gregory A, Meichle Sean P, Mintz Jim, Nuechterlein Keith H, Schork Nicholas J, Seidman Larry J, Siever Larry J, Silverman Jeremy M, Stone William S, Swerdlow Neal R, Tsuang Ming T, Turetsky Bruce I, Tsuang Debby W
Successful multi-site measurement of antisaccade performance deficits
in schizophrenia.
Schizophrenia research,
2007; 89(1-3):
320-9.
Calkins Monica E, Dobie Dorcas J, Cadenhead Kristin S, Olincy Ann, Freedman Robert, Green Michael F, Greenwood Tiffany A, Gur Raquel E, Gur Ruben C, Light Gregory A, Mintz Jim, Nuechterlein Keith H, Radant Allen D, Schork Nicholas J, Seidman Larry J, Siever Larry J, Silverman Jeremy M, Stone William S, Swerdlow Neal R, Tsuang Debby W, Tsuang Ming T, Turetsky Bruce I, Braff David L
The Consortium on the Genetics of Endophenotypes in Schizophrenia:
model recruitment, assessment, and endophenotyping methods for a
multisite collaboration.
Schizophrenia bulletin,
2007; 33(1):
33-48.
Subotnik Kenneth L, Asarnow Robert F, Nuechterlein Keith H, Fogelson David L, Thorpe Tamsen I, Payne Diana L, Giannini Carol A, Kuppinger Heidi E, Torquato Richard D, Mintz Jim, Hwang Sun S, Gottesman Irving I
MMPI vulnerability indicators for schizophrenia and attention deficit
disorder: UCLA family study of biological parents of offspring with
childhood-onset schizophrenia or ADHD.
Behavior genetics,
2005; 35(2):
159-75.
Buchanan Robert W, Davis Miriam, Goff Donald, Green Michael F, Keefe Richard S E, Leon Andrew C, Nuechterlein Keith H, Laughren Thomas, Levin Robert, Stover Ellen, Fenton Wayne, Marder Steve R
A summary of the FDA-NIMH-MATRICS workshop on clinical trial design
for neurocognitive drugs for schizophrenia.
Schizophrenia bulletin,
2005; 31(1):
5-19.
Green Michael F, Nuechterlein Keith H, Gold James M, Barch Deanna M, Cohen Jonathan, Essock Susan, Fenton Wayne S, Frese Fred, Goldberg Terry E, Heaton Robert K, Keefe Richard S E, Kern Robert S, Kraemer Helena, Stover Ellen, Weinberger Daniel R, Zalcman Steven, Marder Stephen R
Approaching a consensus cognitive battery for clinical trials in
schizophrenia: the NIMH-MATRICS conference to select cognitive domains
and test criteria.
Biological psychiatry,
2004; 56(5):
301-7.
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