VIDEO: Dr. Edward McCabe - Our New Hospital
Dr. McCabe received his undergraduate education at Johns Hopkins University (1963-1967). He earned a Ph.D. (1972) and an M.D. (1974) at the University of Southern California. He completed a Pediatric Residency (1974-1976) at the University of Minnesota, and a Metabolism Fellowship (1976-1978) at the University of Colorado Health Science Center (UCHSC). As a Fellow, he discovered Glycerol Kinase Deficiency, and proceeded to characterize the biochemical nature of this disorder while an Instructor (1977-1978), Assistant Professor (1978-1982), and Associate Professor (1982-1986) at UCHSC. In 1986 he moved to Baylor College of Medicine as Associate Professor (1986-1988) and Professor (1988-1994). At Baylor, Dr. McCabe cloned the gene involved in Glycerol Kinase Deficiency and the gene for Adrenal Hypoplasia Congenita. He moved to UCLA as Professor and Executive Chair of the Department of Pediatrics (1994-Present) and joined the Department of Human Genetics (2000 to Present). Noting a lack of genotype/phenotype correlation for these single gene disorders, his research focuses on them as complex traits and explores the systems biology of each disorder.
Zhang, Y. H. Huang, B. L. Jialal, I. Northrup, H. McCabe, E. R. Dipple, K. M. Asymptomatic isolated human glycerol kinase deficiency associated with splice-site mutations and nonsense-mediated decay of mutant RNA Pediatr Res, 2006; 59(4 Pt 1): 590-2.
Iyer, A. K. Zhang, Y. H. McCabe, E. R. DAX1 (NR0B1) and SHP (NR0B2) form homodimers individually, as well as DAX1-SHP heterodimers Mol Endocrinol, 2006; .
Niakan, K. K. Davis, E. C. Clipsham, R. C. Jiang, M. Dehart, D. B. Sulik, K. K. McCabe, E. R. Novel role for the orphan nuclear receptor Dax1 in embryogenesis, different from steroidogenesis Mol Genet Metab, 2006; .
McCabe, L. L. McCabe, E. R. Complexity in genetic diseases: how patients inform the science by ignoring the dogma Am J Med Genet A, 2006; 140(2): 160-1.
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