Edward R B McCabe III, M.D., Ph.D.

A Short Biography:

Dr. McCabe received his undergraduate education at Johns Hopkins University (1963-1967). He earned a Ph.D. (1972) and an M.D. (1974) at the University of Southern California. He completed a Pediatric Residency (1974-1976) at the University of Minnesota, and a Metabolism Fellowship (1976-1978) at the University of Colorado Health Science Center (UCHSC). As a Fellow, he discovered Glycerol Kinase Deficiency, and proceeded to characterize the biochemical nature of this disorder while an Instructor (1977-1978), Assistant Professor (1978-1982), and Associate Professor (1982-1986) at UCHSC. In 1986 he moved to Baylor College of Medicine as Associate Professor (1986-1988) and Professor (1988-1994). At Baylor, Dr. McCabe cloned the gene involved in Glycerol Kinase Deficiency and the gene for Adrenal Hypoplasia Congenita. He moved to UCLA as Professor and Executive Chair of the Department of Pediatrics (1994-Present) and joined the Department of Human Genetics (2000 to Present). Noting a lack of genotype/phenotype correlation for these single gene disorders, his research focuses on them as complex traits and explores the systems biology of each disorder.

Work Titles
Education:
Degrees:
M.D., USC School of Medicine, 1974 - 1974
Ph.D., University of Southern California, 1972
Fellowship:
1976 - 1978 University of Colorado Health Science Center
Internship:
1974 - 1975 University of Minnesota Hospital and Clinic
Residency:
1975 - 1976 University of Minnesota Hospital and Clinic
Certifications:
Certifications:
1982 American Board of Medical Genetics
1979 American Board of Pediatrics
Honors and Awards:
2006 Department of Pediatrics, University of Utah School of Medicine, Glasgow Visitng Professorship
2005 Japanese Society for Inherited Metabolic Disease, Membership
2005 Cedars-Sinai Medical Center, Los Angeles, California, Ben Kagan Lectureship
2005 Society for Pediatric Research, Maureen Andrew Mentorship Award
2003 Department of Pediatrics, University of California, Irvine, Dorothy Waffarn Memorial Lecture
2003 American Association for the Advancement of Science, Fellow
2001 - Institute of Medicine, Membership
2001 UCLA Department of Internal Medic ine, Los Angeles, California, Anna Borun and Harry Borun Foundation Visiting Professor
2001 Western Society for Pediatric Research, Carmel, California, Joseph W. St. Geme, Jr., Education Award
2001 Department of Pediatrics, University of Arkansas, First Florence Char, M.D., Visiting Professor
2000 Wake Forrest University School of Medicine, Winston-Salem, North Carolina, Jimmy Simons Lectureship
Professional Societies:
American Society for Human Genetics
American College of Medical Genetics -- Fellow
American Association for the Advancement of Science
American Federation for Medical Research
The Endocrine Society
Phi Kappa Phi
Society for Pediatric Research
American Federation for Clinical Research
Alpha Omega Alpha
Sigma Xi
American Society for Biochemistry and Molecular Biology
Society for the Study of Inborn Errors Of Metabolism
Western Society for Pediatric Research
American Academy of Pediatrics - Fellow
American Pediatric Society
Society for Inherited Metabolic Disorders-Charter Member

Contact Information:

Work Phone Number:

310-825-5095

Laboratory Address:

Laboratory
Gonda 4309


Mailing Address:

Department of Pediatrics
David Geffen Schoool of Medicine at UCLA
10833 Le Conte Ave.
Los Angeles, CA 90095


Work Address:

Office
MDCC 22-412


Detailed Biography:

VIDEO: Dr. Edward McCabe - Our New Hospital

Dr. McCabe received his undergraduate education at Johns Hopkins University (1963-1967). He earned a Ph.D. (1972) and an M.D. (1974) at the University of Southern California. He completed a Pediatric Residency (1974-1976) at the University of Minnesota, and a Metabolism Fellowship (1976-1978) at the University of Colorado Health Science Center (UCHSC). As a Fellow, he discovered Glycerol Kinase Deficiency, and proceeded to characterize the biochemical nature of this disorder while an Instructor (1977-1978), Assistant Professor (1978-1982), and Associate Professor (1982-1986) at UCHSC. In 1986 he moved to Baylor College of Medicine as Associate Professor (1986-1988) and Professor (1988-1994). At Baylor, Dr. McCabe cloned the gene involved in Glycerol Kinase Deficiency and the gene for Adrenal Hypoplasia Congenita. He moved to UCLA as Professor and Executive Chair of the Department of Pediatrics (1994-Present) and joined the Department of Human Genetics (2000 to Present). Noting a lack of genotype/phenotype correlation for these single gene disorders, his research focuses on them as complex traits and explores the systems biology of each disorder.

Publications:

Zhang, Y. H. Huang, B. L. Jialal, I. Northrup, H. McCabe, E. R. Dipple, K. M.   Asymptomatic isolated human glycerol kinase deficiency associated with splice-site mutations and nonsense-mediated decay of mutant RNA Pediatr Res, 2006; 59(4 Pt 1): 590-2.
Iyer, A. K. Zhang, Y. H. McCabe, E. R.   DAX1 (NR0B1) and SHP (NR0B2) form homodimers individually, as well as DAX1-SHP heterodimers Mol Endocrinol, 2006; .
Niakan, K. K. Davis, E. C. Clipsham, R. C. Jiang, M. Dehart, D. B. Sulik, K. K. McCabe, E. R.   Novel role for the orphan nuclear receptor Dax1 in embryogenesis, different from steroidogenesis Mol Genet Metab, 2006; .
McCabe, L. L. McCabe, E. R.   Complexity in genetic diseases: how patients inform the science by ignoring the dogma Am J Med Genet A, 2006; 140(2): 160-1.

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