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Kathy Sakamoto, M.D., Ph.D.

Contact Information:

Work Phone Number:

(310) 794-7007
310-206-5626

Office Address:

Main Office
700 Tiverton Ave
Factor 11-234
Los Angeles, CA 90095
UNITED STATES

Work Address:

Office
Pediatrics
10833 Le Conte Avenue
Los Angeles, CA 90095
UNITED STATES

Chief, Pediatric Hematology/Oncology

Co-Chair, Research Education, Training, and Career Development Program (CTSI-ED)

Co-Associate Director, JCCC Signal Transduction and Therapeutics Program Area

Professor, Pathology and Laboratory Medicine

Pediatrics

A Short Biography:

Dr. Sakamoto received her B.A. in Biology from Williams College with Honors and her M.D. from the University of Cincinnati College of Medicine. She did her Pediatric Residency and Hematology-Oncology fellowship at the Children's Hospital of Los Angeles. During her research fellowship, Dr. Sakamoto worked in the laboratory of Dr. Judith Gasson (Department of Medicine, UCLA) studying the role of signal transduction pathways in myeloid leukemia. After her fellowship, Dr. Sakamoto was appointed as an Assistant Professor of Pediatrics at UCLA.

Awards and Honors:

Childrens Hospital of Los Angeles
Childrens Hospital of Los Angeles
Childrens Hospital of Los Angeles

Detailed Biography:

Dr. Sakamoto joined the Division of Hematology/Oncology, Department of Pediatrics at the David Geffen School of Medicine at UCLA in 1993. Dr. Sakamoto has continued to study the signaling pathways that control leukemia cell growth. After her sabbatical, Dr. Sakamoto decided to pursue her Ph.D. degree at the California Institute of Technology, where she developed a new approach to cancer therapy that targets the cell?s own destruction machinery. Dr. Sakamoto is currently Professor and Chief of Pediatric Hematology/Oncology, Vice-Chair of Research at the Mattel Children?s Hospital UCLA, and Program Director of the Fellowship Program. Dr. Sakamoto has been supported by the American Cancer Society, NIH, Leukemia and Lymphoma Society of America, William Lawrence Foundation, and St. Baldrick?s Foundation. She served on several grant review committees, including the American Cancer Society, NIH Hematopoiesis Study Section, Translation Research Program Review Subcommittee for the Leukemia and Lymphoma Society of America, and St. Balderick?s Foundation Scientific Advisory Board. Dr. Sakamoto has been named in Who?s Who in America and Best Doctors in America. She has received numerous awards including Young Investigator Award in Oncology, American Society for Pediatric Hematology-Oncology Western Society of Pediatric Research Young Investigator award, UCLA STOP Cancer Career Development Award, Pediatric Cancer Research Foundation ?Gift of Hope? award, and a Leukemia and Lymphoma Society Scholar Award.

Publications:

Frugé E, Lakoski JM, Luban N, Lipton JM, Poplack DG, Hagey A, Felgenhauer J, Hilden J, Margolin J, Vaiselbuh SR, Sakamoto KM   Increasing diversity in pediatric hematology/oncology Pediatr Blood Cancer, 2011; Epub ahead of print: .
Danilova N, Sakamoto KM, Lin S   Ribosomal protein L11 mutation in zebrafish leads to haematopoietic and metabolic defects Br J Haematol, 2011; 152(2): 217-28.
Aldana-Masangkay GI, Sakamoto KM   The role of HDAC6 in cancer J Biomed Biotechnol, 2011; 2011: 875825.
Rodriguez-Gonzalez A, Cyrus K, Salcius M, Kim K, Crews CM, Deshaies RJ, Sakamoto KM.   Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer. Oncogene, 2008; 27(57): 7201-11.
Esparza S, Chang J, Shankar D, Zhang B, Nelson S, and KM Sakamoto   CREB regulates Meis1 Expression in Normal and Malignant Hematopoietic Cells Leukemia, 2007; 22(3): 665-667.
Ikeda, A. Shankar, D. B. Watanabe, M. Tamanoi, F. Moore, T. B. Sakamoto, K. M.   Molecular targets and the treatment of myeloid leukemia Mol Genet Metab, 2006; 88(3): 216-24.
Esparza, S. D. Sakamoto, K. M.   Topics in pediatric leukemia--acute lymphoblastic leukemia MedGenMed, 2005; 7(1): 23.
Schneekloth JS, Fonseca F, Koldobskiy M, Mandal A, Deshaies RJ, Sakamoto KM, and CM Crews   A Chemical Genetic Strategy for in vivo Loss of Protein Function J Amer Chem Soc, 2004; 126(12): 3748-3754.
Hsu H, Rainov NG, Quinones A, Eling DJ, Sakamoto KM, Spear MA   Combined radiation and cytochrome CYP4B1/4-ipomeanol gene therapy using the EGR1 promoter. Anticancer research. , 2003; 23(3B): 2723-8.
Sakamoto KM   Ubiquitin-dependent proteolysis: its role in human diseases and the design of therapeutic strategies. Molecular genetics and metabolism. , 2002; 77(1-2): 44-56.
Schmid I and KM Sakamoto   Analysis of DNA Content and Green Fluorescent Protein Expression Current Protocols in Flow Cytometry, 2001; 7.16.1-7.16.10.
Sakamoto KM, Kim KB, Kumagai A, Mercurio F, Crews CM, and RJ Deshaies   Protacs: Chimeric Molecules That Target Proteins to the Skp1-Cullin-F Box Complex for Ubiquitination and Degradation Proc Natl Acad Sci USA, 2001; 98(15): 8554-8559.
Shou W, Sakamoto KM, Keener J, Morimoto KW, Hoppe GJ, Azzam R, Traverso EE, Feldman RFR, DeModena J, Charbonneau H, Moazed D, Nomura M, and RJ Deshaies.   RENT complex stimulates RNA PolI transcription and regulates nucleolar structure independently of controlling mitotic exit., Mol Cell, 2001; 8: 45-55.
Crans H and KM Sakamoto   Transcription factors and Translocations in lymphoid and myeloid leukemia Leukemia, 2001; 15(3): 313-331.
Lin M and KM Sakamoto   p55Cdc/Cdc20 overexpression promotes premature G1/S transition in myeloid cells Stem Cells, 2001; 19(3): 205-211.
Li W, Lan Z, Wu H, Wu S, Weinstein J, Sakamoto KM, Dai W   BUBR1 Interacts with and phosphorylates p55Cdc/hCdc20 in a Spindle Checkpoint-dependent manner, Oncogene, 2000; 19: 4557-4562.
Chu, Y. W. Korb, J. Sakamoto, K. M.   Idiopathic thrombocytopenic purpura Pediatr Rev, 2000; 21(3): 95-104.
Wen Andy Y, Sakamoto Kathleen M, Miller Lloyd S   The Role of the Transcription Factor CREB in Immune Function Journal of Immunology, 2010; 185(11): 6413-6419.
Niemeyer Charlotte M, Kang Michelle W, Shin Danielle H, Furlan Ingrid, Erlacher Miriam, Bunin Nancy J, Bunda Severa, Finklestein Jerry Z, Sakamoto Kathleen M, Gorr Thomas A, Mehta Parinda, Schmid Irene, Kropshofer Gabriele, Corbacioglu Selim, Lang Peter J, Klein Christoph, Schlegel Paul-Gerhard, Heinzmann Andrea, Schneider Michaela, Starý Jan, van den Heuvel-Eibrink Marry M, Hasle Henrik, Locatelli Franco, Sakai Debbie, Archambeault Sophie, Chen Leslie, Russell Ryan C, Sybingco Stephanie S, Ohh Michael, Braun Benjamin S, Flotho Christian, Loh Mignon L   Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia Nature genetics, 2010; 42(9): 794-800.
Xiao Xiangshu, Li Bingbing X, Mitton Bryan, Ikeda Alan, Sakamoto Kathleen M   Targeting CREB for cancer therapy: friend or foe? Current cancer drug targets, 2010; 10(4): 384-91.
Wu William K K, Sakamoto Kathleen M, Milani Manuela, Aldana-Masankgay Grace, Fan Daiming, Wu Kaichun, Lee Chung W, Cho Chi H, Yu Jun, Sung Joseph J Y   Macroautophagy modulates cellular response to proteasome inhibitors in cancer therapy Drug resistance updates, 2010; 10(4): .
Sakamoto Kathleen M   Protacs for treatment of cancer. Pediatric research, 2010; 67(5): 505-8.
Ikeda Alan K, Judelson Dejah R, Federman Noah, Glaser Keith B, Landaw Elliot M, Denny Christopher T, Sakamoto Kathleen M   ABT-869 inhibits the proliferation of Ewing Sarcoma cells and suppresses platelet-derived growth factor receptor beta and c-KIT signaling pathways. Molecular cancer therapeutics, 2010; 9(3): 653-60.
Sakamoto Kathleen M, Shimamura Akiko, Davies Stella   Congenital disorders of ribosome biogenesis and bone marrow failure Biology of blood and marrow transplantation, 2010; 16(1): S12-S17.
Sakamoto Kathleen   Balancing work and life: an interview with Kathleen Sakamoto. Stem cells, 2009; 27(9): 2053-5.
Sakamoto Kathleen M, Dipple Katrina M   Becoming a woman physician scientist. Academic medicine : journal of the Association of American Medical Colleges, 2009; 84(7): 817.
Sakamoto Kathleen M, Frank David A   CREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapy. Clinical cancer research : an official journal of the American Association for Cancer Research, 2009; 15(8): 2583-7.
Sandoval Salemiz, Pigazzi Martina, Sakamoto Kathleen M   CREB: A Key Regulator of Normal and Neoplastic Hematopoiesis. Advances in hematology, 2009; 2009(8): 634292.
Pellegrini Matteo, Cheng Jerry C, Voutila Jon, Judelson Dejah, Taylor Julie, Nelson Stanley F, Sakamoto Kathleen M   Expression profile of CREB knockdown in myeloid leukemia cells. BMC cancer, 2008; 8(11-12): 264.
Danilova Nadia, Sakamoto Kathleen M, Lin Shuo   p53 family in development. Mechanisms of development, 2008; 125(11-12): 919-31.
Danilova Nadia, Sakamoto Kathleen M, Lin Shuo   Role of p53 family in birth defects: lessons from zebrafish. Birth defects research. Part C, Embryo today : reviews, 2008; 84(3): 215-27.
Rajasekaran Sigrid A, Christiansen Jason J, Schmid Ingrid, Oshima Eri, Ryazantsev Sergey, Sakamoto Kathleen, Weinstein Jasminder, Rao Nagesh P, Rajasekaran Ayyappan K   Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability. Molecular cancer therapeutics, 2008; 7(7): 2142-51.
Simms-Waldrip Tiffany, Rodriguez-Gonzalez Agustin, Lin Tara, Ikeda Alan K, Fu Cecilia, Sakamoto Kathleen M   The aggresome pathway as a target for therapy in hematologic malignancies. Molecular genetics and metabolism, 2008; 94(3): 283-6.
Rodriguez-Gonzalez Agustin, Lin Tara, Ikeda Alan K, Simms-Waldrip Tiffany, Fu Cecilia, Sakamoto Kathleen M   Role of the aggresome pathway in cancer: targeting histone deacetylase 6-dependent protein degradation. Cancer research, 2008; 68(8): 2557-60.
Esparza S D, Chang J, Shankar D B, Zhang B, Nelson S F, Sakamoto K M   CREB regulates Meis1 expression in normal and malignant hematopoietic cells. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008; 22(3): 665-7.
Cheng Jerry C, Kinjo Kentaro, Judelson Dejah R, Chang Jenny, Wu Winston S, Schmid Ingrid, Shankar Deepa B, Kasahara Noriyuki, Stripecke Renata, Bhatia Ravi, Landaw Elliot M, Sakamoto Kathleen M   CREB is a critical regulator of normal hematopoiesis and leukemogenesis. Blood, 2008; 111(3): 1182-92.
Yang Zhongan, Jiang Hong, Zhao Fang, Shankar Deepa B, Sakamoto Kathleen M, Zhang Michael Q, Lin Shuo   A highly conserved regulatory element controls hematopoietic expression of GATA-2 in zebrafish. BMC developmental biology, 2007; 7(3): 97.
Lin Tara L, Fu Cecilia, Sakamoto Kathleen M   Cancer stem cells: the root of the problem. Pediatric research, 2007; 62(3): 239.
Fu Cecilia H, Sakamoto Kathleen M   PEG-asparaginase. Expert opinion on pharmacotherapy, 2007; 8(12): 1977-84.
Cheng Jerry C, Esparza Samuel, Sandoval Salemiz, Shankar Deepa, Fu Cecilia, Sakamoto Kathleen M   Potential role of CREB as a prognostic marker in acute myeloid leukemia. Future oncology (London, England), 2007; 3(4): 475-80.
Shankar Deepa B, Li Junling, Tapang Paul, Owen McCall J, Pease Lori J, Dai Yujia, Wei Ru-Qi, Albert Daniel H, Bouska Jennifer J, Osterling Donald J, Guo Jun, Marcotte Patrick A, Johnson Eric F, Soni Niru, Hartandi Kresna, Michaelides Michael R, Davidsen Steven K, Priceman Saul J, Chang Jenny C, Rhodes Katrin, Shah Neil, Moore Theodore B, Sakamoto Kathleen M, Glaser Keith B   ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia. Blood, 2007; 109(8): 3400-8.
Cheng Jerry C, Horwitz Edwin M, Karsten Stanislav L, Shoemaker Lorelei, Kornblum Harley I, Malik Punam, Sakamoto Kathleen M   Report on the workshop "New Technologies in Stem Cell Research," Society for Pediatric Research, San Francisco, California, April 29, 2006. Stem cells (Dayton, Ohio), 2007; 25(4): 1070-88.
Morimoto Kenji, Lin Shou, Sakamoto Kathleen   The functions of RPS19 and their relationship to Diamond-Blackfan anemia: a review. Molecular genetics and metabolism, 2007; 90(4): 358-62.
Sakamoto Kathleen M   Academic training pathways in pediatric hematology-oncology. Pediatric blood & cancer, 2006; 47(3): 239-41.
Ikeda A, Shankar D B, Watanabe M, Tamanoi F, Moore T B, Sakamoto K M   Molecular targets and the treatment of myeloid leukemia. Molecular genetics and metabolism, 2006; 88(3): 216-24.
Priceman Saul J, Kirzner Jonathan D, Nary Laura J, Morris Devin, Shankar Deepa B, Sakamoto Kathleen M, Medh Rheem D   Calcium-dependent upregulation of E4BP4 expression correlates with glucocorticoid-evoked apoptosis of human leukemic CEM cells. Biochemical and biophysical research communications, 2006; 344(2): 491-9.
Parcells Bertrand W, Ikeda Alan K, Simms-Waldrip Tiffany, Moore Theodore B, Sakamoto Kathleen M   FMS-like tyrosine kinase 3 in normal hematopoiesis and acute myeloid leukemia. Stem cells (Dayton, Ohio), 2006; 24(5): 1174-84.
Shankar Deepa B, Cheng Jerry C, Sakamoto Kathleen M   Role of cyclic AMP response element binding protein in human leukemias. Cancer, 2005; 104(9): 1819-24.
Federman Noah, Sakamoto Kathleen M   The genetic basis of bone marrow failure syndromes in children. Molecular genetics and metabolism, 2005; 86(1-2): 100-9.
Kinjo Kentaro, Sandoval Salemiz, Sakamoto Kathleen M, Shankar Deepa B   The role of CREB as a proto-oncogene in hematopoiesis. Cell cycle (Georgetown, Tex.), 2005; 4(9): 1134-5.
Federman Noah, Sakamoto Kathleen M   Topics in pediatric leukemia--Fanconi's anemia: new insights. MedGenMed : Medscape general medicine, 2005; 7(2): 23.
Sakamoto Kathleen M   Chimeric molecules to target proteins for ubiquitination and degradation. Methods in enzymology, 2005; 399(1): 833-47.
Shankar Deepa B, Cheng Jerry C, Kinjo Kentaro, Federman Noah, Moore Theodore B, Gill Amandip, Rao Nagesh P, Landaw Elliot M, Sakamoto Kathleen M   The role of CREB as a proto-oncogene in hematopoiesis and in acute myeloid leukemia. Cancer cell, 2005; 7(4): 351-62.
Casillas Jacqueline, Sakamoto Kathleen M   Topics in pediatric leukemia--acute lymphoblastic leukemia and late effects in long-term survivors. MedGenMed : Medscape general medicine, 2005; 7(1): 22.
Esparza Samuel D, Sakamoto Kathleen M   Topics in pediatric leukemia--acute lymphoblastic leukemia. MedGenMed : Medscape general medicine, 2005; 7(1): 23.
Moore Theodore B, Sakamoto Kathleen M   Topics in pediatric leukemia--hematopoietic stem cell transplantation. MedGenMed : Medscape general medicine, 2005; 7(1): 19.
Lasky Joseph, Sakamoto Kathleen M   Topics in pediatric leukemia--myelodysplastic and myeloproliferative disorders of childhood. MedGenMed : Medscape general medicine, 2005; 7(1): 21.
Mora-Garcia Patricia, Wei Jolyn, Sakamoto Kathleen M   G-CSF induces stabilization of ETS protein Fli-1 during myeloid cell development. Pediatric research, 2005; 57(1): 63-6.
Sakamoto Kathleen M   Su-11248 Sugen. Current opinion in investigational drugs (London, England : 2000), 2004; 5(12): 1329-39.
Cheng Jerry C, Esparza Samuel D, Knez Virginia M, Sakamoto Kathleen M, Moore Theodore B   Severe lactic acidosis in a 14-year-old female with metastatic undifferentiated carcinoma of unknown primary. Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology, 2004; 26(11): 780-2.
Cheng Jerry C, Sakamoto Kathleen M   The emerging role of RNA interference in the design of novel therapeutics in oncology. Cell cycle (Georgetown, Tex.), 2004; 3(11): 1398-401.
Verma Rati, Peters Noel R, D'Onofrio Mariapina, Tochtrop Gregory P, Sakamoto Kathleen M, Varadan Ranjani, Zhang Mingsheng, Coffino Philip, Fushman David, Deshaies Raymond J, King Randall W   Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain. Science (New York, N.Y.), 2004; 306(5693): 117-20.
Sakamoto Kathleen M   Knocking down human disease: potential uses of RNA interference in research and gene therapy. Pediatric research, 2004; 55(6): 912-3.
Countouriotis Athena, Landaw Elliot M, Naeim Faramarz, Moore Theodore B, Sakamoto Kathleen M   Comparison of bone marrow aspirates and biopsies in pediatric patients with ALL at days 7 and 14 of induction therapy. Leukemia & lymphoma, 2004; 45(4): 745-7.
Schneekloth John S, Fonseca Fabiana N, Koldobskiy Michael, Mandal Amit, Deshaies Raymond, Sakamoto Kathleen, Crews Craig M   Chemical genetic control of protein levels: selective in vivo targeted degradation. Journal of the American Chemical Society, 2004; 126(12): 3748-54.
Wang Qi, Liu Tongyi, Fang Yuqiang, Xie Suqing, Huang Xuan, Mahmood Radma, Ramaswamy Gita, Sakamoto Kathleen M, Darzynkiewicz Zbigniew, Xu Ming, Dai Wei   BUBR1 deficiency results in abnormal megakaryopoiesis. Blood, 2004; 103(4): 1278-85.
Shankar Deepa B, Sakamoto Kathleen M   The role of cyclic-AMP binding protein (CREB) in leukemia cell proliferation and acute leukemias. Leukemia & lymphoma, 2004; 45(2): 265-70.
Sakamoto Kathleen M, Kim Kyung B, Verma Rati, Ransick Andy, Stein Bernd, Crews Craig M, Deshaies Raymond J   Development of Protacs to target cancer-promoting proteins for ubiquitination and degradation. Molecular & cellular proteomics : MCP, 2003; 2(12): 1350-8.
Cheng Jerry C, Moore Theodore B, Sakamoto Kathleen M   RNA interference and human disease. Molecular genetics and metabolism, 2003; 80(1-2): 121-8.
Lin Michael, Chang Johnny K, Shankar Deepa, Sakamoto Kathleen M   The role of p55CDC in cell cycle control and mammalian cell proliferation, differentiation, and apoptosis. Experimental and molecular pathology, 2003; 74(2): 123-8.
Mora-Garcia Patricia, Cheng Jerry, Crans-Vargas Heather N, Countouriotis Athena, Shankar Deepa, Sakamoto Kathleen M   Transcriptional regulators and myelopoiesis: the role of serum response factor and CREB as targets of cytokine signaling. Stem cells (Dayton, Ohio), 2003; 21(2): 123-30.
Sakamoto Kathleen M   Ubiquitin-dependent proteolysis: its role in human diseases and the design of therapeutic strategies. Molecular genetics and metabolism, 2003; 77(1-2): 44-56.
Mora-Garcia P, Pan R, Sakamoto KM   G-CSF regulation of SRE-binding proteins in myeloid cells. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. , 2002; 16(11): 2332-3.
Sakamoto Kathleen M   Targeting ubiquitinylation for drug discovery. IDrugs : the investigational drugs journal, 2002; 5(8): 779-81.
Countouriotis Athena, Moore Theodore B, Sakamoto Kathleen M   Cell surface antigen and molecular targeting in the treatment of hematologic malignancies. Stem cells (Dayton, Ohio), 2002; 20(3): 215-29.
Crans-Vargas Heather N, Landaw Elliot M, Bhatia Smita, Sandusky George, Moore Theodore B, Sakamoto Kathleen M   Expression of cyclic adenosine monophosphate response-element binding protein in acute leukemia. Blood, 2002; 99(7): 2617-9.
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