David Krantz, M.D., Ph.D.


Work Titles and Affiliation
UCLA Professor in Residence, Psychiatry and Biobehavioral Sciences
Education:
Degrees:
M.D., UCLA School of Medicine, 1991
Ph.D., UCLA School of Medicine, 1991
Fellowship:
1995 - 2000 UCSF Department of Neurology
Residency:
1991 - 1995 UCLA Neuropsychiatric Hospital
Certifications:
Certifications:
1996 American Board of Psychiatry and Neurology

Contact Information:

Work Email Address:

dkrantz@ucla.edu


Website:

Home Page

Lab Number:

310 206-8323

Office Phone Number:

310-206-8508

Work Phone Number:

(310) 206-8508

Work Address:

Office
Gonda Building, Rm 3357C
695 Charles Young Drive
Los Angeles, CA 90095

Detailed Biography:

David Krantz is Professor in Residence in the Department of Psychiatry and Biobehavioral Sciences at the David Geffen School of Medicine at UCLA. An undergraduate at Brown University, he completed an MD/PhD in the Medical Scientist Training Program at UCLA in 1991, where he performed his dissertation on Drosophila eye development with Larry Zipursky. After a residency in psychiatry at UCLA, he was awarded a Howard Hughes Postdoctoral Fellowship for Physicians to investigate the regulation of vesicular neurotransmitter transporters in Robert Edwards' laboratory at UCSF. He returned to UCLA in 2000, and is currently using Drosophila to study how changes in the function of neurotransmitter transporters may influence synaptic transmission and behavior.

Publications:

Wu Ting-Han, Lu Yu-Ning, Chuang Chia-Lung, Wu Chia-Lin, Chiang Ann-Shyn, Krantz David E, Chang Hui-Yun   Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau Acta neuropathologica, 2013; 125(5): 711-25.
Lawal Hakeem O, Krantz David E   SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine Molecular aspects of medicine, 2013; 34(2-3): 360-72.
Chen Audrey, Ng Fanny, Lebestky Tim, Grygoruk Anna, Djapri Christine, Lawal Hakeem O, Zaveri Harshul A, Mehanzel Filmon, Najibi Rod, Seidman Gabriel, Murphy Niall P, Kelly Rachel L, Ackerson Larry C, Maidment Nigel T, Jackson F Rob, Krantz David E   Dispensable, redundant, complementary, and cooperative roles of dopamine, octopamine, and serotonin in Drosophila melanogaster Genetics, 2013; 193(1): 159-76.
Brooks Elizabeth S, Greer Christina L, Romero-Calderón Rafael, Serway Christine N, Grygoruk Anna, Haimovitz Jasmine M, Nguyen Bac T, Najibi Rod, Tabone Christopher J, de Belle J Steven, Krantz David E   A putative vesicular transporter expressed in Drosophila mushroom bodies that mediates sexual behavior may define a neurotransmitter system Neuron, 2011; 72(2): 316-29.
Grygoruk Anna, Fei Hao, Daniels Richard W, Miller Bradley R, Chen Audrey, DiAntonio Aaron, Krantz David E   Vesicular neurotransmitter transporter trafficking in vivo: moving from cells to flies Fly, 2011; 4(4): 302-5.
Lawal Hakeem O, Chang Hui-Yun, Terrell Ashley N, Brooks Elizabeth S, Pulido Dianne, Simon Anne F, Krantz David E   The Drosophila vesicular monoamine transporter reduces pesticide-induced loss of dopaminergic neurons Neurobiology of disease, 2010; 40(1): 102-12.
Fei Hao, Chow Dawnis M, Chen Audrey, Romero-Calderón Rafael, Ong Wei S, Ackerson Larry C, Maidment Nigel T, Simpson Julie H, Frye Mark A, Krantz David E   Mutation of the Drosophila vesicular GABA transporter disrupts visual figure detection The Journal of experimental biology, 2010; 213(Pt 10): 1717-30.
Bahadorani Sepehr, Cho Jaehyoung, Lo Thomas, Contreras Heidy, Lawal Hakeem O, Krantz David E, Bradley Timothy J, Walker David W   Neuronal expression of a single-subunit yeast NADH-ubiquinone oxidoreductase (Ndi1) extends Drosophila lifespan Aging cell, 2010; 9(2): 191-202.
Grygoruk Anna, Fei Hao, Daniels Richard W, Miller Bradley R, Diantonio Aaron, Krantz David E   A tyrosine-based motif localizes a Drosophila vesicular transporter to synaptic vesicles in vivo The Journal of biological chemistry, 2010; 285(10): 6867-78.
Cheli Verónica T, Daniels Richard W, Godoy Ruth, Hoyle Diego J, Kandachar Vasundhara, Starcevic Marta, Martinez-Agosto Julian A, Poole Stephen, DiAntonio Aaron, Lloyd Vett K, Chang Henry C, Krantz David E, Dell'Angelica Esteban C   Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency Human molecular genetics, 2010; 19(5): 861-78.
Mosharov Eugene V, Larsen Kristin E, Kanter Ellen, Phillips Kester A, Wilson Krystal, Schmitz Yvonne, Krantz David E, Kobayashi Kazuto, Edwards Robert H, Sulzer David   Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons Neuron, 2009; 62(2): 218-29.
Simon, Daniels, Romero-Calderòn, Grygoruk, Chang, Najibi, Shamouelian, Salazar, Solomon, Ackerson, Maidment, Diantonio, Krantz   Drosophila Vesicular Monoamine Transporter Mutants can adapt to Reduced or Eliminated Vesicular Stores of Dopamine and Serotonin Genetics, 2008; .
Romero-Calderón Rafael, Uhlenbrock Guido, Borycz Jolanta, Simon Anne F, Grygoruk Anna, Yee Susan K, Shyer Amy, Ackerson Larry C, Maidment Nigel T, Meinertzhagen Ian A, Hovemann Bernhard T, Krantz David E   A glial variant of the vesicular monoamine transporter is required to store histamine in the Drosophila visual system PLoS genetics, 2008; 4(11): e1000245.
Fei Hao, Grygoruk Anna, Brooks Elizabeth S, Chen Audrey, Krantz David E   Trafficking of vesicular neurotransmitter transporters Traffic (Copenhagen, Denmark), 2008; 9(9): 1425-36.
Fei Hao, Karnezis Tara, Reimer Richard J, Krantz David E   Membrane topology of the Drosophila vesicular glutamate transporter Journal of neurochemistry, 2007; 101(6): 1662-71.
Simon Anne F, Krantz David E   Road rage and fruit flies Nature genetics, 2007; 39(5): 581-2.
Romero-Calderón Rafael, Shome Ratula M, Simon Anne F, Daniels Richard W, DiAntonio Aaron, Krantz David E   A screen for neurotransmitter transporters expressed in the visual system of Drosophila melanogaster identifies three novel genes Developmental neurobiology, 2007; 67(5): 550-69.
Falcón-Pérez Juan M, Romero-Calderón Rafael, Brooks Elizabeth S, Krantz David E, Dell'Angelica Esteban C   The Drosophila pigmentation gene pink (p) encodes a homologue of human Hermansky-Pudlak syndrome 5 (HPS5) Traffic (Copenhagen, Denmark), 2007; 8(2): 154-68.
Sang Tzu-Kang, Chang Hui-Yun, Lawless George M, Ratnaparkhi Anuradha, Mee Lisa, Ackerson Larry C, Maidment Nigel T, Krantz David E, Jackson George R   A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(5): 981-92.
Simon Anne F, Liang Debbie T, Krantz David E   Differential decline in behavioral performance of Drosophila melanogaster with age Mechanisms of ageing and development, 2006; 127(7): 647-51.
Romero-Calderón Rafael, Krantz David E   Transport of polyamines in Drosophila S2 cells: kinetics, pharmacology and dependence on the plasma membrane proton gradient The Biochemical journal, 2006; 393(Pt 2): 583-9.
Krantz David E   Vesicular monogamy? Neuron, 2006; 49(1): 1-2.
Greer Christina L, Grygoruk Anna, Patton David E, Ley Brett, Romero-Calderon Rafael, Chang Hui-Yun, Houshyar Roozbeh, Bainton Roland J, Diantonio Aaron, Krantz David E   A splice variant of the Drosophila vesicular monoamine transporter contains a conserved trafficking domain and functions in the storage of dopamine, serotonin, and octopamine Journal of neurobiology, 2005; 64(3): 239-58.
Daniels Richard W, Collins Catherine A, Gelfand Maria V, Dant Jaime, Brooks Elizabeth S, Krantz David E, DiAntonio Aaron   Increased expression of the Drosophila vesicular glutamate transporter leads to excess glutamate release and a compensatory decrease in quantal content The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004; 24(46): 10466-74.

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Publication Characteristics or (Publication Types) describe the type of publication being indexed; i.e., what the item is, not what the article is about.

Information from U.S. National Library of Medicine.

AMP-Activated Protein Kinases Acetylcholine Active Transport, Cell Nucleus Adult Affect Age Factors Agriculture Amino Acid Sequence Amphetamines Animals Animals, Genetically Modified Attention Behavior, Animal Benomyl Biological Assay Biological Transport Blotting, Northern Brain Breeding CDC2 Protein Kinase CDC28 Protein Kinase, S cerevisiae Calcium Calcium-Calmodulin-Dependent Protein Kinase Kinase Calcium-Calmodulin-Dependent Protein Kinase Type 1 Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinase Type 4 Calcium-Calmodulin-Dependent Protein Kinases Carboxy-Lyases Carrier Proteins Cell Culture Techniques Cell Death Cell Membrane Cell Survival Cells Contracts Cyclic AMP-Dependent Protein Kinase Catalytic Subunits Cyclic AMP-Dependent Protein Kinase RIIalpha Subunit Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit Cyclic AMP-Dependent Protein Kinase RIalpha Subunit Cyclic AMP-Dependent Protein Kinase RIbeta Subunit Cyclic AMP-Dependent Protein Kinase Type I Cyclic AMP-Dependent Protein Kinase Type II Cyclic AMP-Dependent Protein Kinases Cyclic GMP-Dependent Protein Kinase Type I Cyclic GMP-Dependent Protein Kinase Type II Cyclic GMP-Dependent Protein Kinases Cyclic Nucleotide-Regulated Protein Kinases Cytosol DNA-Activated Protein Kinase Death Depression Disease Disease Models, Animal Dopamine Down-Regulation Drosophila Drosophila Proteins Drosophila melanogaster Drosophilidae Endocytosis Environment Enzyme Inhibitors Enzymes Epidemiologic Studies Epidemiology Exocytosis Eye Fertility Fluorescent Antibody Technique Gene Expression Regulation Genes Goals Hermanski-Pudlak Syndrome Histamine Histamine Release Homeostasis Humans JNK Mitogen-Activated Protein Kinases Laboratories Locomotion Longevity Membrane Transport Proteins Mice Mice, Mutant Strains Mice, Neurologic Mutants Microtubules Mitochondria Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 10 Mitogen-Activated Protein Kinase 11 Mitogen-Activated Protein Kinase 12 Mitogen-Activated Protein Kinase 13 Mitogen-Activated Protein Kinase 14 Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinase 6 Mitogen-Activated Protein Kinase 7 Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinase 9 Mitogen-Activated Protein Kinase Kinases Mitogen-Activated Protein Kinase Phosphatases Mitogen-Activated Protein Kinases Models, Genetic Molecular Sequence Data Mutant Chimeric Proteins Mutant Proteins Mutation Nerve Degeneration Nerve Tissue Proteins Neurochemistry Neuroglia Neuromuscular Junction Neurons Neuropharmacology Neurophysiology Neuroprotective Agents Neuropsychiatry Neurotransmitter Agents Neurotransmitter Transport Proteins Octopamine Oxidopamine PC12 Cells Paraquat Parkinson Disease Parkinsonian Disorders Pesticides Pharmaceutical Preparations Phenotype Phosphorylation Phylogeny Plasma Membrane Neurotransmitter Transport Proteins Positron-Emission Tomography Proline-Directed Protein Kinases Protein Isoforms Protein Kinase C Protein Kinase C-alpha Protein Kinase C-delta Protein Kinase C-epsilon Protein Kinase Inhibitors Protein Kinases Protein Transport Proteins RNA Interference RNA Splicing Rats, Mutant Strains Recycling Research Personnel Reserpine Reverse Transcriptase Polymerase Chain Reaction Risk Risk Factors Role Rotenone Secretory Vesicles Sequence Alignment Sequence Homology, Amino Acid Serine Serotonin Signal Transduction Synaptic Transmission Synaptic Vesicles Thinking Time Transfection Transgenes Ubiquitin-Activating Enzymes Ubiquitination Vesicular Glutamate Transport Proteins Vesicular Monoamine Transport Proteins Vesicular Neurotransmitter Transport Proteins Work Ziram p38 Mitogen-Activated Protein Kinases tau Proteins

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