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Shaping the Future

Heather Maynard, Ph.D.

Contact Information:

Fax Number:

(310) 206-4038

Lab Number:

(310) 206-1102
(310) 825-8785
1 (310) 825-7385
1 (310) 825-8092

Work Phone Number:

1 (310) 267-5162

Laboratory Address:

Mol Sci Bldg 4234
Mol Sci Bldg 4221
Los Angeles, CA 90095
UNITED STATES
Mol Sci Bldg 4230
Los Angeles, CA 90095
UNITED STATES

Work Address:

Mol Sci Bldg 4505B

Work Email Address:

maynard@chem.ucla.edu

Website:

  

Home Page:

     homepage


Professor, Chemistry and Biochemistry

Organic Chemistry

Member, California NanoSystems Institute

Researcher, Nanoscience and Materials

Organic

Synthesis


Detailed Biography:

Heather D. Maynard received a B.S. with Honors in Chemistry from the University of North Carolina at Chapel Hill in 1992 and her Ph.D. from the California Institute of Technology in the summer of 2000. She then moved to the Swiss Federal Institute of Technology in Zurich (ETH), where from 2000-2002 she was an American Cancer Society Postdoctoral Fellow. Dr. Maynard joined the UCLA faculty as an Assistant Professor in August 2002 as the first Howard Reiss Career Development Chair in the Department of Chemistry and Biochemistry and as a member of the California NanoSystems Institute. She is now a full Professor and Director of the Chemistry Biology Interface Training Program. Since arriving at UCLA, Maynard has given 165 invited lectures. Maynard has been selected as an Outstanding Emerging Investigator by the Journal of Materials Chemistry and has received the Amgen New Faculty Award, NSF Career Award, Seaborg Award for Outstanding Research, the Hanson-Dow Award for Excellence in Teaching, and an Alfred P. Sloan Fellowship. Maynard is a Leverhulme, Kavli Frontiers, and Royal Society of Chemistry Fellow. Maynard is on the editorial board of Polymer Chemistry and the editorial advisory boards of Macromolecules, Organic & Biomolecular Chemistry, J. of Polymer Chemistry, Langmuir, Macromolecular Biosciences, Bioconjugate Chemistry, and Biomacromolecules. Her research interests focus on combining polymers with biomolecules for applications in biotechnology, nanotechnology, and medicine.

For a Full List of Publications, please visit: http://www.chem.ucla.edu/dept/Faculty/maynard/Publications.htm

Publications:

Broyer, R. M.; Scopf, E.; Kolodziej, C. M.; Chen, Y.; Maynard, H. D.   Dual Click Reactions to Micropattern Proteins, Soft Matter, ; DOI: 10.1039/C1SM05991B, published online.: .
Tao, L.; Maynard, H. D.   Efficient Synthesis of Protein Dimers by RAFT Polymerization, J. Am. Chem. Soc, ; To be Submitted: .
Vazquez-Dorbatt, V.; Tolstyka, Z. P.; Tao, L.; Grover, G.; Maynard, H. D   Protein Homodimers and Heterodimers by RAFT Polymerization, Angew. Chem. , ; To be Submitted: .
Heredia, K. L.; Grover, G.; Maynard, H. D.   Synthesis of Protein Star Polymers with a Streptavidin Core by RAFT Polymerization, Angew. Chem, ; To be Submitted: .
Tolstyka, Z. P.; Kopping, J.; Maynard, H. D.   Telechelic Polymers Using a Combination of ATRP and ATRC for Protein Dimer Formation, J. Am. Chem. Soc, ; To be Submitted.: .
Nguyen, T. H.; Kim, S. H.; Wong, D. Y.; Decker, C. G.; Loo, J. A.; Maynard, H. D.   Heparin Mimicking Polymer Conjugate Stabilizes bFGF to Environmental Stressors, Nature Chemistry, 2013; (5): 221-227.
Matsumoto, N. M.; Prabhakaran, P.; Rome, L. H.; Maynard, H. D   Smart Vaults: Thermally-Responsive Protein Nanocapsules, ACS Nano, 2013; (7): 867-874.
Matsumoto, N. M.; González-Toro, D. C.; Chacko, R. T.; Maynard, H. D.; Thayumanavan, S.   Synthesis of Nanogel-Protein Conjugates, Polymer Chemistry, 2013; (4): 2464-2469.
Rock J. Mancini, Juneyoung Lee, and Heather D. Maynard   Trehalose Glycopolymers for Stabilization of Protein Conjugates to Environmental Stressors Journal of the American Chemical Society, 2012; 134(20): 8474-8479.
Broyer RM, Grover GN, Maynard HD   Emerging synthetic approaches for protein-polymer conjugations Chem Commun (Camb), 2011; 47(8): 2212-26.
Alconcel, S. N. S.; Baas, A. S.; Maynard, H. D.   FDA-Approved Poly(ethylene glycol)-Protein Conjugates, Polymer Chemistry, 2011; 2: 1442-1448.
Kolodziej, C. M.; Chang, C. –W.; Maynard, H. D.   Glutathione S-Transferase as a General and Reversible Tag for Surface Immobilization of Proteins, J. Mater. Chem, 2011; 21: 1457-1461.
Gunasekaran Karthikeyan, Nguyen Thi H, Maynard Heather D, Davis Thomas P, Bulmus Volga   Conjugation of siRNA with Comb-Type PEG Enhances Serum Stability and Gene Silencing Efficiency Macromolecular rapid communications, 2011; 32(8): 654-9.
Christman Karen L, Broyer Rebecca M, Schopf Eric, Kolodziej Christopher M, Chen Yong, Maynard Heather D   Protein nanopatterns by oxime bond formation Langmuir : the ACS journal of surfaces and colloids, 2011; 27(4): 1415-8.
Chang, C.-W., Nguyen, T. H., Maynard, H. D.   Thermoprecipitation of Glutathione S-Transferase by Glutathione-Poly(N-isopropylacrylamide) Prepared by RAFT Polymerization Macromolecular Rapid Communications, 2010; Advanced Online Publication: .
Heredia, K. L.; Tao, L.; Grover, G. N.; Maynard, H. D.   Heterotelechelic Polymers for Capture and Release of Protein-Polymer Conjugates Polymer Chemistry, 2010; 1: 168 - 170.
Christman KL, Maynard HD   Surface patterning for generating defined nanoscale matrices Methods Mol Biol, 2010; 660: 255-63.
Stuckel, J. M.; Li, R. C.; Maynard, H. D.; Caplan, M. R.   Two-step Synthesis of Multivalent Cancer-Targeting Constructs Biomacromolecules, 2010; 11(1): 160-7.
Chang, C. W. Bays, E. Tao, L. Alconcel, S. N. Maynard, H. D.   Differences in cytotoxicity of poly(PEGA)s synthesized by reversible addition-fragmentation chain transfer polymerization Chem Commun (Camb), 2009; (24): 3580-2.
Eric Schopf, Rebecca Broyer, Lei Tao, Yong Chen and Heather D. Maynard   Directed carbon nanotube assembly using a pyrene-functionalized polymer Chem. Commun. (Camb), 2009; (32): 4818-20.
Vazquez-Dorbatt, V., Tolstyka, Z.P., Maynard, H.D.   Synthesis of Aminooxy End-functionalized pNIPAAm by RAFT Polymerization for Protein and Polysaccharide Conjugation, Macromolecules, 2009; .
Karina L. Heredia, Gregory N. Grover, Lei Tao and Heather D. Maynard   Synthesis of Heterotelechelic Polymers for Conjugation of Two Different Proteins Macromolecules, 2009; 42(7): 2360-2367.
Lei Tao, Catherine S. Kaddis, Rachel R. Ogorzalek Loo, Gregory N. Grover, Joseph A. Loo and Heather D. Maynard   Synthesis of Maleimide-End-Functionalized Star Polymers and Multimeric Protein?Polymer Conjugates Macromolecules, 2009; 42(21): 8028-8033.
Bays E, Tao L, Chang CW, Maynard HD   Synthesis of Semitelechelic Maleimide Poly(PEGA) for Protein Conjugation By RAFT Polymerization Biomacromolecules, 2009; 10(7): 1777-81.
Vimary Vazquez-Dorbatt, Zachary P. Tolstyka, Chien-Wen Chang and Heather D. Maynard   Synthesis of a Pyridyl Disulfide End-Functionalized Glycopolymer for Conjugation to Biomolecules and Patterning on Gold Surfaces Biomacromolecules, 2009; 10(8): 2207-2212.
Mancini RJ, Li RC, Tolstyka ZP, Maynard HD   Synthesis of a photo-caged aminooxy alkane thiol Org Biomol Chem, 2009; 7(23): 4954-9.
Lei Tao a, Catherine S. Kaddis b, Rachel R. Ogorzalek Loo b, Gregory N. Grover a, Joseph A. Loo b and Heather D. Maynard   Synthetic approach to homodimeric protein?polymer conjugates Chem. Commun, 2009; (16): 2148-50.
Gregory N. Grover, Steevens N. S. Alconcel, Nicholas M. Matsumoto and Heather D. Maynard   Trapping of Thiol-Terminated Acrylate Polymers with Divinyl Sulfone To Generate Well-Defined Semitelechelic Michael Acceptor Polymers Macromolecules, 2009; 42(20): 7657-7663.
Christman, K. L. Schopf, E. Broyer, R. M. Li, R. C. Chen, Y. Maynard, H. D.   Positioning multiple proteins at the nanoscale with electron beam cross-linked functional polymers J Am Chem Soc, 2009; 131(2): 521-7.
Heredia, K. L., Nguyen, T. H., Chang, C. W., Bulmus, V., Davis, T. P., Maynard, H. D.   Reversible siRNA-polymer conjugates by RAFT polymerization Chem Commun (Camb), 2008; (28): 3245-7.
Karen L. Christman, Vimary Vazquez-Dorbatt, Eric Schopf, Christopher M. Kolodziej, Ronald C. Li, Rebecca M. Broyer, Yong Chen and Heather D. Maynard   Nanoscale Growth Factor Patterns by Immobilization on a Heparin-Mimicking Polymer J. Am. Chem. Soc, 2008; 130(49): 16585-16591.
Zachary P. Tolstyka, Jordan T. Kopping, and Heather D. Maynard*   Straightforward Synthesis of Cysteine-Reactive Telechelic Polystyrene Macromolecules, 2008; 41(3): 599-606.
Broyer, R. M., Quaker, G. M., Maynard, H. D.   Designed amino acid ATRP initiators for the synthesis of biohybrid materials J Am Chem Soc, 2008; 130(3): 1041-7.
Hwang, J., Li, R. C., Maynard, H. D.   Well-defined polymers with activated ester and protected aldehyde side chains for bio-functionalization J Control Release, 2007; 122(3): 279-86.
Heredia, K. L.; Tolstyka, Z. P.; Maynard, H. D.   Aminooxy-End Functionalized Polymers Synthesized by ATRP for Chemoselective Conjugation to Proteins Macromolecules, 2007; I40(14): 4772-4779.
Mendes, P. M., Christman, K. L., Parthasarathy, P., Schopf, E., Ouyang, J., Yang, Y., Preece, J. A., Maynard, H. D., Chen, Y., Stoddart, J. F.   Electrochemically controllable conjugation of proteins on surfaces Bioconjug Chem, 2007; 18(6): 1919-23.
Li, R. C., Hwang, J., Maynard, H. D.   Reactive block copolymer scaffolds Chem Commun (Camb), 2007; (35): 3631-3.
Christman, K. L.; Broyer, R. M.; Tolstyka, Z. P.; Maynard, H. D.   Site-Specific Protein Immobilization through N-Terminal Oxime Linkages J. Mater. Chem. , 2007; 17: 2021-2027.
Brough, B.; Christman, K. L.; Wong, T. S.; Kolodziej, C. M.; Forbes, J. G.; Wang, K.; Maynard, H.D.; Ho, C. M   Surface Initiated Actin Polymerization from Top-down Manufactured Nanopatterns Soft Matter, 2007; 3: 541-546.
Maynard, H. D.; Heredia, K. L.; Li, R. C.; Parra, D.; Sand, G.; Vazquez-Dorbatt, V.   Thermoresponsive Biohybrid Materials Synthesized by ATRP J. Mater. Chem, 2007; 17(38): 4015-4017.
Hwang, J.; Li, R. C.; Maynard, H. D.   Well-Defined Polymers with Activated Ester and Protected Aldehyde Side Chains for Bio-functionalization J. Controlled Release, 2007; 122(3): 279-86.
Heredia, K. L., Maynard, H. D.   Synthesis of protein-polymer conjugates Org Biomol Chem, 2007; 5(1): 45-53.
Christman, K. L. Requa, M. V. Enriquez-Rios, V. D. Ward, S. C. Bradley, K. A. Turner, K. L. Maynard, H. D.   Submicron streptavidin patterns for protein assembly Langmuir, 2006; 22(17): 7444-50.
Vazquez-Dorbatt, V. Maynard, H. D.   Biotinylated glycopolymers synthesized by atom transfer radical polymerization Biomacromolecules, 2006; 7(8): 2297-302.
Christman, K. L.; Enriquez-Rios, V. D.; Maynard, H. D.   Nanopatterning Proteins and Peptides Soft Matter, 2006; 2: 928-939.
Li RC, Broyer RM, Maynard HD   Well-Defined Polymers with Acetal Side Chains as Reactive Scaffolds Synthesized by Atom Transfer Radical Polymerization J. Polym. Sci, Part A; Polym. Chem, 2006; 44: 5004-5013.
Heredia, K. L. Bontempo, D. Ly, T. Byers, J. T. Halstenberg, S. Maynard, H. D.   In situ preparation of protein-"smart" polymer conjugates with retention of bioactivity J Am Chem Soc, 2005; 127(48): 16955-60.
Bontempo, D. Li, R. C. Ly, T. Brubaker, C. E. Maynard, H. D.   One-step synthesis of low polydispersity, biotinylated poly(N-isopropylacrylamide) by ATRP Chem Commun (Camb), 2005; volume(37): 4702-4.
Christman, K. L. Maynard, H. D.   Protein micropatterns using a pH-responsive polymer and light Langmuir, 2005; 21(18): 8389-93.
Heredia KL, Maynard HD   Aminooxy-Functionalized Semitelechelic Polymers Synthesized by Atom Transfer Radical Polymerization, Polym. Prep, 2005; 46: 593-594.
Maynard HD, Hubbell JA   Discovery of a Sulfated Tetrapeptide that Binds to Vascular Endothelial Growth Factor Acta Biomaterialia, 2005; 1(4): 451-459.
Bontempo D, Maynard HD   Protein Macroinitiators for Atom Transfer Radical Polymerization, Polym. Prep, 2005; 46(1): 78-79.
Christman KL, Maynard HD   Protein Patterning on Polymer Films Using Localized Acid Generation, Polym. Prepr, 2005; 46(2): 1286.
Bontempo D, Li RC, Maynard HD   Synthesis of Biotinylated Polymers by Atom Transfer Radical Polymerization and Bioconjugate Formation, Polym. Prepr, 2005; 46(2): 435-436.
Bontempo, D. Maynard, H. D.   Streptavidin as a macroinitiator for polymerization: in situ protein-polymer conjugate formation J Am Chem Soc, 2005; 127(18): 6508-9.
Bontempo D, Heredia KL, Fish BA, Maynard HD   Cysteine-reactive polymers synthesized by atom transfer radical polymerization for conjugation to proteins Journal of the American Chemical Society, 2004; 126(47): 15372-3.
Hwang J, Maynard HD   Multi-Functional Polymers Prepared by RAFT, Polym. Prepr, 2004; 45: 1083-1084.
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