Linda Baum, M.D., Ph.D.

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Work Titles
CTSI Member, CTSI
California NanoSystems Institute Member, California NanoSystems Institute
UCLA Division Chief, Laboratory Medicine Professor, Pathology and Laboratory Medicine Professor, Hematopathology & Hematology Executive Committee, Center for Duchenne Muscular Dystrophy Member, Cell & Developmental Biology GPB Home Area Member, Immunity, Microbes & Molecular Pathogenesis GPB Home Area Member, Tumor Immunology Program at the Jonsson Comprehensive Cancer Center (JCCC) Faculty, Cellular and Molecular Pathology PhD Program
Education:
Degrees:
M.D., Duke University School of Medicine, 1986
Ph.D., Duke University, 1985
B.S., Stanford University, 1975 - 1979
Internship:
1986 - 1987 UCLA School of Medicine
Academic Experience:
1987 - 1989 University of California, Los Angeles, Biochemistry
Residency:
1987 - 1991 UCLA School of Medicine
Certifications:
Certifications:
1989 American Board of Pathology
Honors and Awards:
2006 Society for Glycobiology, President Society for Glycobiology

Contact Information:

Work Email Address:

lbaum@mednet.ucla.edu


Website:

Web-Profile

Lab Number:

(310) 206-6329

Work Phone Number:

(310) 206-5985

Mailing Address:

BOX 951732, 4-730 MRL
Los Angeles, CA 90095

Mail Code: 173216
Los Angeles, CA 90095


Office Address:

Main Office
675 Charles E. Young Dr., South
MRL 4-730
Los Angeles, CA 90095


Work Address:

MRL 4730


Detailed Biography:

Linda Baum is an immunologist and pathologist who joined the UCLA Dept. of Pathology and Laboratory Medicine in 1989 as an Assistant Professor. Dr. Baum became a full Professor in 2002. Dr. Baum attended Stanford University, where she received a B.S. in Biology in 1979. She received her Ph.D., with Peter Cresswell in Immunology, and M.D. degrees from Duke University in 1986. Dr. Baum completed her residency in Clinical Pathology at UCLA in 1989, and is Board Certified in Clinical Pathology. She was a post-doctoral fellow in James Paulson's lab during her residency, where she investigated host effects on influenza virus tropism. As a faculty member at UCLA, Dr. Baum teaches in the Medical School and the Graduate School, and received the Excellence in Education Award. She is the Division Chief of Laboratory Medicine. Her current research focuses on the biochemistry of cell-cell interactions, especially those mediated by protein-saccharide interactions, in immune system and cancer models. She collaborates with UCLA investigators in the California Nanoscience Institute, the Center for Muscular Dystrophy, and the Dept. of Microbiology, Immunology and Molecular Genetics. She is a member of several training programs, including the Hematology/ Oncology, Tumor Cell Biology, and Tumor Immunology programs. She is also a member of the Medical Scientist Training Program Steering Committee, the Jonsson Comprehensive Cancer Center, and the Molecular Biology Institute.

Publications:

A selected list of publications:

Marshall Jamie L, Kwok Yukwah, McMorran Brian J, Baum Linda G, Crosbie-Watson Rachelle H   The potential of sarcospan in adhesion complex replacement therapeutics for the treatment of muscular dystrophy The FEBS journal, 2013; .
Clark Mary C, Pang Mabel, Hsu Daniel K, Liu Fu-Tong, de Vos Sven, Gascoyne Randy D, Said Jonathan, Baum Linda G   Galectin-3 binds to CD45 on diffuse large B-cell lymphoma cells to regulate susceptibility to cell death Blood, 2012; 120(23): 4635-44.
Cabrera Paula V, Pang Mabel, Marshall Jamie L, Kung Raymond, Nelson Stanley F, Stalnaker Stephanie H, Wells Lance, Crosbie-Watson Rachelle H, Baum Linda G   High throughput screening for compounds that alter muscle cell glycosylation identifies new role for N-glycans in regulating sarcolemmal protein abundance and laminin binding The Journal of biological chemistry, 2012; 287(27): 22759-70.
Clark Mary C, Baum Linda G   T cells modulate glycans on CD43 and CD45 during development and activation, signal regulation, and survival Annals of the New York Academy of Sciences, 2012; 1253(1): 58-67.
Baum Linda G   Burn control, an adipocyte-specific function for galectin-12 Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(46): 18575-6.
Earl Lesley A, Bi Shuguang, Baum Linda G   Galectin multimerization and lattice formation are regulated by linker region structure Glycobiology, 2011; 21(1): 6-12.
Bi Shuguang, Hong Patrick W, Lee Benhur, Baum Linda G   Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(26): 10650-5.
Miller Michelle C, Ribeiro João P, Roldós Virginia, Martín-Santamaría Sonsoles, Cañada F Javier, Nesmelova Irina A, André Sabine, Pang Mabel, Klyosov Anatole A, Baum Linda G, Jiménez-Barbero Jesús, Gabius Hans-Joachim, Mayo Kevin H   Structural aspects of binding of α-linked digalactosides to human galectin-1 Glycobiology, 2011; 21(12): 1627-41.
Thiemann Sandra, Baum Linda G   The road less traveled: regulation of leukocyte migration across vascular and lymphatic endothelium by galectins Journal of clinical immunology, 2011; 31(1): 2-9.
Pang M, Cabrera P, Kung R, Marshall J, Holmberg J, Hammond S, Wells L, Crosbie R, Baum L   A Novel Approach to Altering Muscle Cell Glycosylation and Function in Muscular Dystrophy Glycobiology, 2010; 20(11): 1488.
Garner Omai B, Aguilar Hector C, Fulcher Jennifer A, Levroney Ernest L, Harrison Rebecca, Wright Lacey, Robinson Lindsey R, Aspericueta Vanessa, Panico Maria, Haslam Stuart M, Morris Howard R, Dell Anne, Lee Benhur, Baum Linda G   Endothelial galectin-1 binds to specific glycans on nipah virus fusion protein and inhibits maturation, mobility, and function to block syncytia formation PLoS pathogens, 2010; 6(7): e1000993.
Baum LG   Galectin-Glycan Regulation of Immune Cell Differentiation, Migration and Survival Glycobiology, 2010; 20(11): 1461-2.
Clark M, Pang M, Hsu D, Liu FT, Baum L   Interaction of Cell Surface Galectin-3 with CD45 on B-Lymphoma Cells Regulates CD45 Phosphatase Activity to Promote Lymphoma Cell Apoptosis Resistance Glycobiology, 2010; 20(11): 1522-3.
Nesmelova Irina V, Ermakova Elena, Daragan Vladimir A, Pang Mabel, Menéndez Margarita, Lagartera Laura, Solís Dolores, Baum Linda G, Mayo Kevin H   Lactose binding to galectin-1 modulates structural dynamics, increases conformational entropy, and occurs with apparent negative cooperativity Journal of molecular biology, 2010; 397(5): 1209-30.
Earl Lesley A, Bi Shuguang, Baum Linda G   N- and O-glycans modulate galectin-1 binding, CD45 signaling, and T cell death The Journal of biological chemistry, 2010; 285(4): 2232-44.
Pang Mabel, He Jiale, Johnson Pauline, Baum Linda G   CD45-mediated fodrin cleavage during galectin-1 T cell death promotes phagocytic clearance of dying cells Journal of immunology (Baltimore, Md. : 1950), 2009; 182(11): 7001-8.
Fulcher Jennifer A, Chang Margaret H, Wang Shuo, Almazan Tim, Hashimi Sara T, Eriksson Anna U, Wen Xiangshu, Pang Mabel, Baum Linda G, Singh Ram Raj, Lee Benhur   Galectin-1 co-clusters CD43/CD45 on dendritic cells and induces cell activation and migration through Syk and protein kinase C signaling The Journal of biological chemistry, 2009; 284(39): 26860-70.
Baum Linda G, Crocker Paul R   Glycoimmunology: ignore at your peril! Immunological reviews, 2009; 230(1): 5-8.
Bi Shuguang, Baum Linda G   Sialic acids in T cell development and function Biochimica et biophysica acta, 2009; 1790(12): 1599-610.
Perone Marcelo J, Bertera Suzanne, Shufesky William J, Divito Sherrie J, Montecalvo Angela, Mathers Alicia R, Larregina Adriana T, Pang Mabel, Seth Nilufer, Wucherpfennig Kai W, Trucco Massimo, Baum Linda G, Morelli Adrian E   Suppression of autoimmune diabetes by soluble galectin-1 Journal of immunology (Baltimore, Md. : 1950), 2009; 182(5): 2641-53.
Nesmelova Irina V, Pang Mabel, Baum Linda G, Mayo Kevin H   1H, 13C, and 15N backbone and side-chain chemical shift assignments for the 29 kDa human galectin-1 protein dimer Biomolecular NMR assignments, 2008; 2(2): 203-5.
Earl, L. A., Baum, L. G.   CD45 glycosylation controls T-cell life and death Immunol Cell Biol, 2008; 86(7): 608-15.
Liu Scot D, Whiting Chan C, Tomassian Tamar, Pang Mabel, Bissel Stephanie J, Baum Linda G, Mossine Valeri V, Poirier Françoise, Huflejt Margaret E, Miceli M Carrie   Endogenous galectin-1 enforces class I-restricted TCR functional fate decisions in thymocytes Blood, 2008; 112(1): 120-30.
Okumura Cheryl Y M, Baum Linda G, Johnson Patricia J   Galectin-1 on cervical epithelial cells is a receptor for the sexually transmitted human parasite Trichomonas vaginalis Cellular microbiology, 2008; 10(10): 2078-90.
Garner Omai B, Baum Linda G   Galectin-glycan lattices regulate cell-surface glycoprotein organization and signalling Biochemical Society transactions, 2008; 36(Pt 6): 1472-7.
Nesmelova, Irina V, Pang, Mabel, Baum, Linda G, Mayo, Kevin H   H-1, C-13, and N-15 backbone and side-chain chemical shift assignments for the 29 kDa human galectin-1 protein dimer Biomolecular NMR Assignments , 2008; 2(2): 203-205 .
Bi Shuguang, Earl Lesley A, Jacobs Linsey, Baum Linda G   Structural features of galectin-9 and galectin-1 that determine distinct T cell death pathways The Journal of biological chemistry, 2008; 283(18): 12248-58.
Varki Ajit P, Baum Linda G, Bellis Susan L, Cummings Richard D, Esko Jeffrey D, Hart Gerald W, Linhardt Robert J, Lowe John B, McEver Rodger P, Srivastava Arun, Sarkar Rita   Working group report: the roles of glycans in hemostasis, inflammation and vascular biology Glycobiology, 2008; 18(10): 747-9.
Toscano Marta A, Bianco Germán A, Ilarregui Juan M, Croci Diego O, Correale Jorge, Hernandez Joseph D, Zwirner Norberto W, Poirier Francoise, Riley Eleanor M, Baum Linda G, Rabinovich Gabriel A   Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death Nature immunology, 2007; 8(8): 825-34.
Thijssen Victor L J L, Poirier Françoise, Baum Linda G, Griffioen Arjan W   Galectins in the tumor endothelium: opportunities for combined cancer therapy Blood, 2007; 110(8): 2819-27.
Belitsky Jason M, Nelson Alshakim, Hernandez Joseph D, Baum Linda G, Stoddart J Fraser   Multivalent interactions between lectins and supramolecular complexes: Galectin-1 and self-assembled pseudopolyrotaxanes Chemistry & biology, 2007; 14(10): 1140-51.
Valenzuela Hector F, Pace Karen E, Cabrera Paula V, White Rachel, Porvari Katja, Kaija Helena, Vihko Pirkko, Baum Linda G   O-glycosylation regulates LNCaP prostate cancer cell susceptibility to apoptosis induced by galectin-1 Cancer research, 2007; 67(13): 6155-62.
Hernandez Joseph D, Klein Jeffrey, Van Dyken Stephen J, Marth Jamey D, Baum Linda G   T-cell activation results in microheterogeneous changes in glycosylation of CD45 International immunology, 2007; 19(7): 847-56.
Cabrera Paula V, Baum Linda G   The emerging field of glycoimmunology: highlights from the Society for Glycobiology meeting, 2006 Expert review of clinical immunology, 2007; 3(1): 7-9.
Perone Marcelo J, Bertera Suzanne, Tawadrous Zakaria S, Shufesky William J, Piganelli Jon D, Baum Linda G, Trucco Massimo, Morelli Adrian E   Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice Journal of immunology (Baltimore, Md. : 1950), 2006; 177(8): 5278-89.
He Jiale, Baum Linda G   Endothelial cell expression of galectin-1 induced by prostate cancer cells inhibits T-cell transendothelial migration Laboratory investigation; a journal of technical methods and pathology, 2006; 86(6): 578-90.
He Jiale, Baum Linda G   Galectin interactions with extracellular matrix and effects on cellular function Methods in enzymology, 2006; 417(2): 247-56.
Hernandez Joseph D, Nguyen Julie T, He Jiale, Wang Wei, Ardman Blair, Green Jonathan M, Fukuda Minoru, Baum Linda G   Galectin-1 binds different CD43 glycoforms to cluster CD43 and regulate T cell death Journal of immunology (Baltimore, Md. : 1950), 2006; 177(8): 5328-36.
Thijssen Victor L J L, Postel Ruben, Brandwijk Ricardo J M G E, Dings Ruud P M, Nesmelova Irina, Satijn Sietske, Verhofstad Nicole, Nakabeppu Yusaku, Baum Linda G, Bakkers Jeroen, Mayo Kevin H, Poirier Françoise, Griffioen Arjan W   Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy Proceedings of the National Academy of Sciences of the United States of America, 2006; 103(43): 15975-80.
Fulcher Jennifer A, Hashimi Sara T, Levroney Ernest L, Pang Mabel, Gurney Kevin B, Baum Linda G, Lee Benhur   Galectin-1-matured human monocyte-derived dendritic cells have enhanced migration through extracellular matrix Journal of immunology (Baltimore, Md. : 1950), 2006; 177(1): 216-26.
Stillman Brianna N, Hsu Daniel K, Pang Mabel, Brewer C Fred, Johnson Pauline, Liu Fu-Tong, Baum Linda G   Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death Journal of immunology (Baltimore, Md. : 1950), 2006; 176(2): 778-89.
Kohatsu Luciana, Hsu Daniel K, Jegalian Armin G, Liu Fu-Tong, Baum Linda G   Galectin-3 induces death of Candida species expressing specific beta-1,2-linked mannans Journal of immunology (Baltimore, Md. : 1950), 2006; 177(7): 4718-26.
Cabrera Paula V, Amano Maho, Mitoma Junya, Chan Jessica, Said Jonathan, Fukuda Minoru, Baum Linda G   Haploinsufficiency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell death Blood, 2006; 108(7): 2399-406.
Aguilar Hector C, Matreyek Kenneth A, Filone Claire Marie, Hashimi Sara T, Levroney Ernest L, Negrete Oscar A, Bertolotti-Ciarlet Andrea, Choi Daniel Y, McHardy Ian, Fulcher Jennifer A, Su Stephen V, Wolf Mike C, Kohatsu Luciana, Baum Linda G, Lee Benhur   N-glycans on Nipah virus fusion protein protect against neutralization but reduce membrane fusion and viral entry Journal of virology, 2006; 80(10): 4878-89.
Perone Marcelo J, Larregina Adriana T, Shufesky William J, Papworth Glenn D, Sullivan Mara L G, Zahorchak Alan F, Stolz Donna Beer, Baum Linda G, Watkins Simon C, Thomson Angus W, Morelli Adrian E   Transgenic galectin-1 induces maturation of dendritic cells that elicit contrasting responses in naive and activated T cells Journal of immunology (Baltimore, Md. : 1950), 2006; 176(12): 7207-20.
Baum Linda G   Women editors: change comes from focused action Nature, 2006; 441(7095): 812.
Stillman Brianna N, Mischel Paul S, Baum Linda G   New roles for galectins in brain tumors--from prognostic markers to therapeutic targets Brain pathology (Zurich, Switzerland), 2005; 15(2): 124-32.
Levroney Ernest L, Aguilar Hector C, Fulcher Jennifer A, Kohatsu Luciana, Pace Karen E, Pang Mabel, Gurney Kevin B, Baum Linda G, Lee Benhur   Novel innate immune functions for galectin-1: galectin-1 inhibits cell fusion by Nipah virus envelope glycoproteins and augments dendritic cell secretion of proinflammatory cytokines Journal of immunology (Baltimore, Md. : 1950), 2005; 175(1): 413-20.
Nelson Alshakim, Belitsky Jason M, Vidal Sébastien, Joiner C Steven, Baum Linda G, Stoddart J Fraser   A self-assembled multivalent pseudopolyrotaxane for binding galectin-1 Journal of the American Chemical Society, 2004; 126(38): 11914-22.
Hoyer Katrina K, Pang Mabel, Gui Dorina, Shintaku I Peter, Kuwabara Ichiro, Liu Fu-Tong, Said Jonathan W, Baum Linda G, Teitell Michael A   An anti-apoptotic role for galectin-3 in diffuse large B-cell lymphomas The American journal of pathology, 2004; 164(3): 893-902.
Hahn HP, Pang M, He J, Hernandez JD, Yang RY, Li LY, Wang X, Liu FT, Baum LG   Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death Cell Death and Differentiation, 2004; 11: 1277-86.
Pace Karen E, Baum Linda G   Insect galectins: roles in immunity and development Glycoconjugate journal, 2004; 19(7-9): 607-14.
He Jiale, Baum Linda G   Presentation of galectin-1 by extracellular matrix triggers T cell death The Journal of biological chemistry, 2004; 279(6): 4705-12.
Lee Jin Kyu, Baum Linda G, Moremen Kelley, Pierce Michael   The X-lectins: a new family with homology to the Xenopus laevis oocyte lectin XL-35 Glycoconjugate journal, 2004; 21(8-9): 443-50.
Lantéri Marion, Giordanengo Valérie, Hiraoka Nobuyoshi, Fuzibet Jean-Gabriel, Auberger Patrick, Fukuda Minoru, Baum Linda G, Lefebvre Jean-Claude   Altered T cell surface glycosylation in HIV-1 infection results in increased susceptibility to galectin-1-induced cell death Glycobiology, 2003; 13(12): 909-18.
Baum Linda G, Blackall Douglas P, Arias-Magallano Sarah, Nanigian Danielle, Uh Soo Y, Browne Jordan M, Hoffmann Douglas, Emmanouilides Christos E, Territo Mary C, Baldwin Gayle Cocita   Amelioration of graft versus host disease by galectin-1 Clinical immunology (Orlando, Fla.), 2003; 109(3): 295-307.
Roberts Alice A, Amano Maho, Felten Christopher, Galvan Marisa, Sulur Giri, Pinter-Brown Lauren, Dobbeling Udo, Burg Gunter, Said Jonathan, Baum Linda G   Galectin-1-mediated apoptosis in mycosis fungoides: the roles of CD7 and cell surface glycosylation Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2003; 16(6): 543-51.
Pace Karen E, Hahn Hejin P, Baum Linda G   Preparation of recombinant human galectin-1 and use in T-cell death assays Methods in enzymology, 2003; 363(12): 499-518.
He J, Baum LG   Presentation of galectin-1 by extracellular matrix triggers T cell death J Biol Chem, 2003; 279(6): 4705-12.
Amano Maho, Galvan Marisa, He Jiale, Baum Linda G   The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death The Journal of biological chemistry, 2003; 278(9): 7469-75.
Hernandez Joseph D, Baum Linda G   Ah, sweet mystery of death! Galectins and control of cell fate Glycobiology, 2002; 12(10): 127R-36R.
Pace Karen E, Lebestky Tim, Hummel Thomas, Arnoux Pascal, Kwan Kent, Baum Linda G   Characterization of a novel Drosophila melanogaster galectin. Expression in developing immune, neural, and muscle tissues The Journal of biological chemistry, 2002; 277(15): 13091-8.
Brewer C Fred, Miceli M Carrie, Baum Linda G   Clusters, bundles, arrays and lattices: novel mechanisms for lectin-saccharide-mediated cellular interactions Current opinion in structural biology, 2002; 12(5): 616-23.
Baum Linda G   Developing a taste for sweets Immunity, 2002; 16(1): 5-8.
Onami Thandi M, Harrington Laurie E, Williams Matthew A, Galvan Marisa, Larsen Christian P, Pearson Thomas C, Manjunath N, Baum Linda G, Pearce Brad D, Ahmed Rafi   Dynamic regulation of T cell immunity by CD43 Journal of immunology (Baltimore, Md. : 1950), 2002; 168(12): 6022-31.
Rabinovich Gabriel A, Baum Linda G, Tinari Nicola, Paganelli Roberto, Natoli Clara, Liu Fu Tong, Iacobelli Stefano   Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response? Trends in immunology, 2002; 23(6): 313-20.
Perillo N L, Uittenbogaart C H, Nguyen J T, Baum L G   Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes The Journal of experimental medicine, 1997; 185(10): 1851-8.
Perillo N L, Pace K E, Seilhamer J J, Baum L G   Apoptosis of T cells mediated by galectin-1 Nature, 1995; 378(6558): 736-9.

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