Thomas Drake, M.D.


Work Titles
UCLA Professor, Pathology and Laboratory Medicine Associate Director, Clinical Laboratory Professor, Clinical Chemistry Protein electrophoresis and hemoglobinopathy screening, Pathology and Laboratory Medicine Faculty, Cellular and Molecular Pathology PhD Program
Education:
Degrees:
M.D., University of Pennsylvania School of Medicine, 1977
Fellowship:
1982 - 1984 UCSF Department of Lab Medicine (Clin Pathology)
Internship:
1977 - 1978 SUNY Health Science Center at Stony Brook
Residency:
1980 - 1982 UCSF Department of Pathology (Anatomic)
1979 - 1980 UCSF Department of Pathology (Anatomic)
1978 - 1979 UCSF Department of Lab Medicine (Clin Pathology)
Certifications:
Certifications:
1982 American Board of Pathology

Contact Information:

Work Email Address:

tdrake@mednet.ucla.edu


Website:

Web-Profile

Work Phone Number:

310-825-6975

Work Address:

Office
UCLA
Los Angeles, CA 90095


Detailed Biography:

Dr. Drake received his M.D. degree from the University of Pennsylvania in 1977, and completed residency and fellowship/research training in Pathology and Laboratory Medicine at UCSF in 1984. He has been at UCLA since then in the Department of Pathology and Laboratory Medicine, and is currently Professor and Vice-chair. Outside of his research activities, he is Co-chair of the "Foundations of Medicine I" course for 1st year students in the School of Medicine, and oversees outpatient laboratory services and information services for the Department of Pathology and Laboratory Medicine.

Publications:

Parks Brian W, Nam Elizabeth, Org Elin, Kostem Emrah, Norheim Frode, Hui Simon T, Pan Calvin, Civelek Mete, Rau Christoph D, Bennett Brian J, Mehrabian Margarete, Ursell Luke K, He Aiqing, Castellani Lawrence W, Zinker Bradley, Kirby Mark, Drake Thomas A, Drevon Christian A, Knight Rob, Gargalovic Peter, Kirchgessner Todd, Eskin Eleazar, Lusis Aldons J   Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice Cell metabolism, 2013; 17(1): 141-52.
Lagarrigue Sandrine, Hormozdiari Farhad, Martin Lisa J, Lecerf Frédéric, Hasin Yehudit, Rau Christoph, Hagopian Raffi, Xiao Yu, Yan Jun, Drake Thomas A, Ghazalpour Anatole, Eskin Eleazar, Lusis Aldons J   Limited RNA editing in exons of mouse liver and adipose Genetics, 2013; 193(4): 1107-15.
Martin Lisa J, Lau Edward, Singh Harpreet, Vergnes Laurent, Tarling Elizabeth J, Mehrabian Margarete, Mungrue Imran, Xiao Sheila, Shih Diana, Castellani Lawrence, Ping Peipei, Reue Karen, Stefani Enrico, Drake Thomas A, Bostrom Kristina, Lusis Aldons J   Response to Pomozi et al's research commentary Circulation research, 2013; 112(11): e152-3.
van Nas Atila, Pan Calvin, Ingram-Drake Leslie A, Ghazalpour Anatole, Drake Thomas A, Sobel Eric M, Papp Jeanette C, Lusis Aldons J   The systems genetics resource: a web application to mine global data for complex disease traits Frontiers in genetics, 2013; 4(1): 84.
Martin Lisa J, Lau Edward, Singh Harpreet, Vergnes Laurent, Tarling Elizabeth J, Mehrabian Margarete, Mungrue Imran, Xiao Sheila, Shih Diana, Castellani Lawrence, Ping Peipei, Reue Karen, Stefani Enrico, Drake Thomas A, Bostrom Kristina, Lusis Aldons J   ABCC6 localizes to the mitochondria-associated membrane Circulation research, 2012; 111(5): 516-20.
Ghazalpour Anatole, Rau Christoph D, Farber Charles R, Bennett Brian J, Orozco Luz D, van Nas Atila, Pan Calvin, Allayee Hooman, Beaven Simon W, Civelek Mete, Davis Richard C, Drake Thomas A, Friedman Rick A, Furlotte Nick, Hui Simon T, Jentsch J David, Kostem Emrah, Kang Hyun Min, Kang Eun Yong, Joo Jong Wha, Korshunov Vyacheslav A, Laughlin Rick E, Martin Lisa J, Ohmen Jeffrey D, Parks Brian W, Pellegrini Matteo, Reue Karen, Smith Desmond J, Tetradis Sotirios, Wang Jessica, Wang Yibin, Weiss James N, Kirchgessner Todd, Gargalovic Peter S, Eskin Eleazar, Lusis Aldons J, LeBoeuf Renée C   Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits Mammalian genome : official journal of the International Mammalian Genome Society, 2012; 23(9-10): 680-92.
Mungrue Imran N, Zhao Peng, Yao Yucheng, Meng Haijin, Rau Christoph, Havel Jocelyn V, Gorgels Theo G M F, Bergen Arthur A B, MacLellan W Robb, Drake Thomas A, Boström Kristina I, Lusis Aldons J   Abcc6 deficiency causes increased infarct size and apoptosis in a mouse cardiac ischemia-reperfusion model Arteriosclerosis, thrombosis, and vascular biology, 2011; 31(12): 2806-12.
Farber Charles R, Bennett Brian J, Orozco Luz, Zou Wei, Lira Ana, Kostem Emrah, Kang Hyun Min, Furlotte Nicholas, Berberyan Ani, Ghazalpour Anatole, Suwanwela Jaijam, Drake Thomas A, Eskin Eleazar, Wang Q Tian, Teitelbaum Steven L, Lusis Aldons J   Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis PLoS genetics, 2011; 7(4): e1002038.
Bennett Brian J, Farber Charles R, Orozco Luz, Kang Hyun Min, Ghazalpour Anatole, Siemers Nathan, Neubauer Michael, Neuhaus Isaac, Yordanova Roumyana, Guan Bo, Truong Amy, Yang Wen-pin, He Aiqing, Kayne Paul, Gargalovic Peter, Kirchgessner Todd, Pan Calvin, Castellani Lawrence W, Kostem Emrah, Furlotte Nicholas, Drake Thomas A, Eskin Eleazar, Lusis Aldons J   A high-resolution association mapping panel for the dissection of complex traits in mice Genome research, 2010; 20(2): 281-90.
Drake Thomas A   Genes and pathways contributing to obesity: a systems biology view Progress in molecular biology and translational science, 2010; 94(2): 9-38.
Wu Sulin, Mar-Heyming Rebecca, Dugum Eric Z, Kolaitis Nicholas A, Qi Hongxiu, Pajukanta Päivi, Castellani Lawrence W, Lusis Aldons J, Drake Thomas A   Upstream transcription factor 1 influences plasma lipid and metabolic traits in mice Human molecular genetics, 2010; 19(4): 597-608.
Wu Sulin, Lusis Aldons J, Drake Thomas A   A systems-based framework for understanding complex metabolic and cardiovascular disorders Journal of lipid research, 2009; 50 Suppl(6): S358-63.
Farber Charles R, van Nas Atila, Ghazalpour Anatole, Aten Jason E, Doss Sudheer, Sos Brandon, Schadt Eric E, Ingram-Drake Leslie, Davis Richard C, Horvath Steve, Smith Desmond J, Drake Thomas A, Lusis Aldons J   An integrative genetics approach to identify candidate genes regulating BMD: combining linkage, gene expression, and association Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2009; 24(1): 105-16.
Wang Susanna S, Martin Lisa J, Schadt Eric E, Meng Haijin, Wang Xuping, Zhao Wei, Ingram-Drake Leslie, Nebohacova Martina, Mehrabian Margarete, Drake Thomas A, Lusis Aldons J   Disruption of the aortic elastic lamina and medial calcification share genetic determinants in mice Circulation. Cardiovascular genetics, 2009; 2(6): 573-82.
van Nas Atila, Guhathakurta Debraj, Wang Susanna S, Yehya Nadir, Horvath Steve, Zhang Bin, Ingram-Drake Leslie, Chaudhuri Gautam, Schadt Eric E, Drake Thomas A, Arnold Arthur P, Lusis Aldons J   Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks Endocrinology, 2009; 150(3): 1235-49.
Yang Xia, Deignan Joshua L, Qi Hongxiu, Zhu Jun, Qian Su, Zhong Judy, Torosyan Gevork, Majid Sana, Falkard Brie, Kleinhanz Robert R, Karlsson Jenny, Castellani Lawrence W, Mumick Sheena, Wang Kai, Xie Tao, Coon Michael, Zhang Chunsheng, Estrada-Smith Daria, Farber Charles R, Wang Susanna S, van Nas Atila, Ghazalpour Anatole, Zhang Bin, Macneil Douglas J, Lamb John R, Dipple Katrina M, Reitman Marc L, Mehrabian Margarete, Lum Pek Y, Schadt Eric E, Lusis Aldons J, Drake Thomas A   Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks Nature genetics, 2009; 41(4): 415-23.
Ghazalpour Anatole, Doss Sudheer, Kang Hyun, Farber Charles, Wen Ping-Zi, Brozell Alec, Castellanos Ruth, Eskin Eleazar, Smith Desmond J, Drake Thomas A, Lusis Aldons J   High-resolution mapping of gene expression using association in an outbred mouse stock PLoS genetics, 2008; 4(8): e1000149.
Schadt Eric E, Molony Cliona, Chudin Eugene, Hao Ke, Yang Xia, Lum Pek Y, Kasarskis Andrew, Zhang Bin, Wang Susanna, Suver Christine, Zhu Jun, Millstein Joshua, Sieberts Solveig, Lamb John, GuhaThakurta Debraj, Derry Jonathan, Storey John D, Avila-Campillo Iliana, Kruger Mark J, Johnson Jason M, Rohl Carol A, van Nas Atila, Mehrabian Margarete, Drake Thomas A, Lusis Aldons J, Smith Ryan C, Guengerich F Peter, Strom Stephen C, Schuetz Erin, Rushmore Thomas H, Ulrich Roger   Mapping the genetic architecture of gene expression in human liver PLoS biology, 2008; 6(5): e107.
Chen Yanqing, Zhu Jun, Lum Pek Yee, Yang Xia, Pinto Shirly, MacNeil Douglas J, Zhang Chunsheng, Lamb John, Edwards Stephen, Sieberts Solveig K, Leonardson Amy, Castellini Lawrence W, Wang Susanna, Champy Marie-France, Zhang Bin, Emilsson Valur, Doss Sudheer, Ghazalpour Anatole, Horvath Steve, Drake Thomas A, Lusis Aldons J, Schadt Eric E   Variations in DNA elucidate molecular networks that cause disease Nature, 2008; 452(7186): 429-35.
Drake Thomas A, Braun Jonathan, Marchevsky Alberto, Kohane Isaac S, Fletcher Christopher, Chueh Henry, Beckwith Bruce, Berkowicz David, Kuo Frank, Zeng Qing T, Balis Ulysses, Holzbach Ana, McMurry Andrew, Gee Connie E, McDonald Clement J, Schadow Gunther, Davis Mary, Hattab Eyas M, Blevins Lonnie, Hook John, Becich Michael, Crowley Rebecca S, Taube Sheila E, Berman Jules, Berman Jules   A system for sharing routine surgical pathology specimens across institutions: the Shared Pathology Informatics Network Human pathology, 2007; 38(8): 1212-25.
Meng Haijin, Vera Iset, Che Nam, Wang Xuping, Wang Susanna S, Ingram-Drake Leslie, Schadt Eric E, Drake Thomas A, Lusis Aldons J   Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics Proceedings of the National Academy of Sciences of the United States of America, 2007; 104(11): 4530-5.
Wang Susanna S, Schadt Eric E, Wang Hui, Wang Xuping, Ingram-Drake Leslie, Shi Weibin, Drake Thomas A, Lusis Aldons J   Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data Circulation research, 2007; 101(3): e11-30.
Wang Susanna S, Shi Weibin, Wang Xuping, Velky Leandra, Greenlee Sarah, Wang Min T, Drake Thomas A, Lusis Aldons J   Mapping, genetic isolation, and characterization of genetic loci that determine resistance to atherosclerosis in C3H mice Arteriosclerosis, thrombosis, and vascular biology, 2007; 27(12): 2671-6.
Fuller Tova F, Ghazalpour Anatole, Aten Jason E, Drake Thomas A, Lusis Aldons J, Horvath Steve   Weighted gene coexpression network analysis strategies applied to mouse weight Mammalian genome : official journal of the International Mammalian Genome Society, 2007; 18(6-7): 463-72.
Krasne Sally, Wimmers Paul F, Relan Anju, Drake Thomas A   Differential effects of two types of formative assessment in predicting performance of first-year medical students Advances in health sciences education : theory and practice, 2006; 11(2): 155-71.
Wang Susanna, Yehya Nadir, Schadt Eric E, Wang Hui, Drake Thomas A, Lusis Aldons J   Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity PLoS genetics, 2006; 2(2): e15.
Drake Thomas A, Schadt Eric E, Davis Richard C, Lusis Aldons J   Integrating genetic and gene expression data to study the metabolic syndrome and diabetes in mice American journal of therapeutics, 2006; 12(6): 503-11.
Drake TA Schadt EE Lusis AJ   Integrating genetic and gene expression data: application to cardiovascular and metabolic traits in mice Mammalian Genome, 2006; 17(6): 466-79.
Drake Thomas A, Schadt Eric E, Lusis Aldons J   Integrating genetic and gene expression data: application to cardiovascular and metabolic traits in mice Mammalian genome : official journal of the International Mammalian Genome Society, 2006; 17(6): 466-79.
Ghazalpour Anatole, Doss Sudheer, Zhang Bin, Wang Susanna, Plaisier Christopher, Castellanos Ruth, Brozell Alec, Schadt Eric E, Drake Thomas A, Lusis Aldons J, Horvath Steve   Integrating genetic and network analysis to characterize genes related to mouse weight PLoS genetics, 2006; 2(8): e130.
Yang Xia, Schadt Eric E, Wang Susanna, Wang Hui, Arnold Arthur P, Ingram-Drake Leslie, Drake Thomas A, Lusis Aldons J   Tissue-specific expression and regulation of sexually dimorphic genes in mice Genome research, 2006; 16(8): 995-1004.
Schadt Eric E, Lamb John, Yang Xia, Zhu Jun, Edwards Steve, Guhathakurta Debraj, Sieberts Solveig K, Monks Stephanie, Reitman Marc, Zhang Chunsheng, Lum Pek Yee, Leonardson Amy, Thieringer Rolf, Metzger Joseph M, Yang Liming, Castle John, Zhu Haoyuan, Kash Shera F, Drake Thomas A, Sachs Alan, Lusis Aldons J   An integrative genomics approach to infer causal associations between gene expression and disease Nature genetics, 2005; 37(7): 710-7.
Schadt, EE Lamb, J Yang, X Zhu, J Edwards, S Guhathakurta, D Sieberts, SK Monks, S Reitman, M Zhang, C Lum, PY Leonardson, A Thieringer, R Metzger, JM Yang, L Castle, J Zhu, H Kash, SF Drake, TA Sachs, A Lusis, AJ   An integrative genomics approach to infer causal associations between gene expression and disease Nature genetics. , 2005; 37(7): 710-7.
Doss Sudheer, Schadt Eric E, Drake Thomas A, Lusis Aldons J   Cis-acting expression quantitative trait loci in mice Genome research, 2005; 15(5): 681-91.
Doss, S Schadt, EE Drake, TA Lusis, AJ   Cis-acting expression quantitative trait loci in mice Genome research. , 2005; 15(5): 681-91.
Ghazalpour, A Doss, S Sheth, SS Ingram-Drake, LA Schadt, EE Lusis, AJ Drake, TA   Genomic analysis of metabolic pathway gene expression in mice Genome biology , 2005; 6(7): R59.
Ghazalpour Anatole, Doss Sudheer, Sheth Sonal S, Ingram-Drake Leslie A, Schadt Eric E, Lusis Aldons J, Drake Thomas A   Genomic analysis of metabolic pathway gene expression in mice Genome biology, 2005; 6(7): R59.
Mehrabian Margarete, Allayee Hooman, Stockton Jirina, Lum Pek Yee, Drake Thomas A, Castellani Lawrence W, Suh Michael, Armour Christopher, Edwards Stephen, Lamb John, Lusis Aldons J, Schadt Eric E   Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits Nature genetics, 2005; 37(11): 1224-33.
Ghazalpour Anatole, Doss Sudheer, Yang Xia, Aten Jason, Toomey Edward M, Van Nas Atila, Wang Susanna, Drake Thomas A, Lusis Aldons J   Thematic review series: The pathogenesis of atherosclerosis. Toward a biological network for atherosclerosis Journal of lipid research, 2004; 45(10): 1793-805.
Ghazalpour, A Doss, S Yang, X Aten, J Toomey, EM Van Nas, A Wang, S Drake, TA Lusis, AJ   Thematic review series: The pathogenesis of atherosclerosis. Toward a biological network for atherosclerosis Journal of lipid research. , 2004; 45(10): 1793-805.
Nishimura Ichiro, Drake Thomas A, Lusis Aldons J, Lyons Karen M, Nadeau Joseph H, Zernik Joseph   ENU large-scale mutagenesis and quantitative trait linkage (QTL) analysis in mice: novel technologies for searching polygenetic determinants of craniofacial abnormalities Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists, 2003; 14(5): 320-30.
Shi Weibin, Brown Morry D, Wang Xuping, Wong Jack, Kallmes David F, Matsumoto Alan H, Helm Gregory A, Drake Thomas A, Lusis Aldons J   Genetic backgrounds but not sizes of atherosclerotic lesions determine medial destruction in the aortic root of apolipoprotein E-deficient mice Arteriosclerosis, thrombosis, and vascular biology, 2003; 23(10): 1901-6.
Krass Kelly L, Colinayo Veronica, Ghazalpour Anatole, Vinters Harry V, Lusis Aldons J, Drake Thomas A   Genetic loci contributing to age-related hippocampal lesions in mice Neurobiology of disease, 2003; 13(2): 102-8.
Colinayo Veronica V, Qiao Jian-Hua, Wang Xuping, Krass Kelly L, Schadt Eric, Lusis Aldons J, Drake Thomas A   Genetic loci for diet-induced atherosclerotic lesions and plasma lipids in mice Mammalian genome : official journal of the International Mammalian Genome Society, 2003; 14(7): 464-71.
Schadt, EE Monks, SA Drake, TA Lusis, AJ Che, N Colinayo, V Ruff, TG Milligan, SB Lamb, JR Cavet, G Linsley, PS Mao, M Stoughton, RB Friend, SH   Genetics of gene expression surveyed in maize, mouse and man Nature. , 2003; 422(6929): 297-302.
Schadt Eric E, Monks Stephanie A, Drake Thomas A, Lusis Aldons J, Che Nam, Colinayo Veronica, Ruff Thomas G, Milligan Stephen B, Lamb John R, Cavet Guy, Linsley Peter S, Mao Mao, Stoughton Roland B, Friend Stephen H   Genetics of gene expression surveyed in maize, mouse and man Nature, 2003; 422(6929): 297-302.
Colinayo Veronica V, Qiao Jian-Hua, Demant Peter, Krass Kelly, Lusis Aldons J, Drake Thomas A   Genetic characterization of the Dyscalc locus Mammalian genome : official journal of the International Mammalian Genome Society, 2002; 13(6): 283-8.

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