Ronald Mitsuyasu, M.D.

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A Short Biography:

Dr. Ronald T. Mitsuyasu is the Director of the Center for Clinical AIDS Research and Education at UCLA (CARE), a Professor of Medicine in Residence at the UCLA David Geffen School of Medicine, and an Associate Director of the UCLA AIDS Institute. A graduate of UC Berkeley, Dr. Mitsuyasu went on to receive an MD degree from the UCLA School of Medicine in 1978. He completed his residency in Internal Medicine at Rush University in 1981, and a fellowship in Hematology-Oncology at UCLA in 1984. He joined the UCLA faculty in 1984 in the Division of Hematology-Oncology, and is an expert on immune-based therapies for HIV and on AIDS-related malignancies. He is a major investigator of the role of interleukin-2 and other cytokines and vaccines as treatments for HIV, a pioneer in the clinical evaluation of gene therapy for HIV, and the principal investigator for an international Phase III gene-therapy study, which is the first of its kind. He has research and clinical background in hematology-oncology as well as in immunology and immunotherapeutics. In addition, he is the current chair of the AIDS Malignancy Consortium, which is a collaborative network funded by the National Cancer Institute to conduct clinical trials in subjects with AIDS-related malignancies.
Work Titles
UCLA Professor, Medicine Professor, Hematology-Oncology Director, CARE Center Associate Director for Clinical Programs, UCLA AIDS Institute
Education:
Degrees:
M.D., University of California, Los Angeles, 1973 - 1978
B.A., University of California, Berkeley, 1969 - 1973
Fellowship:
1981 - 1984 University of California, Los Angeles
Internship:
1978 - 1979 Rush Presbyterian - St. Lukes Medical Center
Residency:
1979 - 1981 Rush Presbyterian - St. Lukes Medical Center
Certifications:
Certifications:
1981 American Board of Internal Medicine

Contact Information:

Work Email Address:

rmitsuya@mednet.ucla.edu


Website:

http://people.healthsciences.ucla.edu/community/institution/personnel?personnel_id=8352
Web-Profile

Work Phone Number:

(310) 557-2273

310-557-1891

Office Address:

Main Office
1399 S. Roxbury Drive
Suite 100
Los Angeles, CA 90035


Work Address:

BH-412 CHS
CAMPUS - 179320
Los Angeles, CA 90095


Publications:

A selected list of publications:

Mitsuyasu Ronald   Curing HIV: lessons from cancer therapy Current opinion in HIV and AIDS, 2013; 8(3): 224-9.
Gabrielian Anna, MacCumber Mathew M, Kukuyev Alla, Mitsuyasu Ronald, Holland Gary N, Sarraf David   Didanosine-associated retinal toxicity in adults infected with human immunodeficiency virus JAMA ophthalmology, 2013; 131(2): 255-9.
Wilkin Timothy, Lee Jeannette Y, Lensing Shelly Y, Stier Elizabeth A, Goldstone Stephen E, Berry Michael J, Jay Naomi, Aboulafia David M, Einstein Mark H, Saah Alfred, Mitsuyasu Ronald T, Palefsky Joel M   High-grade anal intraepithelial neoplasia among HIV-1-infected men screening for a multicenter clinical trial of a human papillomavirus vaccine HIV clinical trials, 2013; 14(2): 75-9.
Unemori Patrick A, Leslie Kieron S, Hunt Peter W, Sinclair Elizabeth, Epling Lorrie, Mitsuyasu Ronald, Effros Rita B, Dock Jeffrey, Dollard Sheila G, Deeks Steven G, Martin Jeffrey N, Maurer Toby S   Immunosenescence is associated with presence of Kaposi's sarcoma in antiretroviral treated human immunodeficiency virus infection AIDS (London, England), 2013; 14(2): .
Levine Alexandra M, Noy Ariela, Lee Jeannette Y, Tam Wayne, Ramos Juan Carlos, Henry David H, Parekh Samir, Reid Erin G, Mitsuyasu Ronald, Cooley Timothy, Dezube Bruce J, Ratner Lee, Cesarman Ethel, Tulpule Anil   Pegylated liposomal doxorubicin, rituximab, cyclophosphamide, vincristine, and prednisone in AIDS-related lymphoma: AIDS Malignancy Consortium Study 047 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013; 31(1): 58-64.
Cillo Anthony R, Krishnan Amrita, Mitsuyasu Ronald T, McMahon Deborah K, Li Shirley, Rossi John J, Zaia John A, Mellors John W   Plasma Viremia and Cellular HIV-1 DNA Persist Despite Autologous Hematopoietic Stem Cell Transplantation for HIV-Related Lymphoma Journal of acquired immune deficiency syndromes (1999), 2013; 8(3): .
Scholler John, Brady Troy L, Binder-Scholl Gwendolyn, Hwang Wei-Ting, Plesa Gabriela, Hege Kristen M, Vogel Ashley N, Kalos Michael, Riley James L, Deeks Steven G, Mitsuyasu Ronald T, Bernstein Wendy B, Aronson Naomi E, Levine Bruce L, Bushman Frederic D, June Carl H   Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells Science translational medicine, 2012; 4(132): 132ra53.
Sinha Sanjeev, Shekhar Rahul C, Singh Gurjeet, Shah Nipam, Ahmad Hafiz, Kumar Narendra, Sharma Surendra K, Samantaray J C, Ranjan Sanjai, Ekka Meera, Sreenivas Vishnu, Mitsuyasu Ronald T   Early versus delayed initiation of antiretroviral therapy for Indian HIV-Infected individuals with tuberculosis on antituberculosis treatment BMC infectious diseases, 2012; 12(12): 168.
Bayraktar Ulas D, Ramos Juan Carlos, Petrich Adam, Gupta Neel, Lensing Shelly, Moore P C, Reid Erin G, Aboulafia David M, Ratner Lee, Mitsuyasu Ronald, Cooley Timothy, Henry David H, Barr Paul, Noy Ariela   Outcome of patients with relapsed/refractory acquired immune deficiency syndrome-related lymphoma diagnosed 1999-2008 and treated with curative intent in the AIDS Malignancy Consortium Leukemia & lymphoma, 2012; 53(12): 2383-9.
Bosch Ronald J, Pollard Richard B, Landay Alan, Aga Evgenia, Fox Lawrence, Mitsuyasu Ronald, Mitsuyasu Ronald   A randomized trial of interleukin-2 during withdrawal of antiretroviral treatment Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2011; 31(6): 481-3.
Hoffman Risa M, Jamieson Beth D, Bosch Ronald J, Currier Judith, Kitchen Christina M R, Schmid Ingrid, Zhu Yuda, Bennett Kara, Mitsuyasu Ronald   Baseline immune phenotypes and CD4+ T lymphocyte responses to antiretroviral therapy in younger versus older HIV-infected individuals Journal of clinical immunology, 2011; 31(5): 873-81.
Mitsuyasu Ronald   Challenges for conducting clinical trials for AIDS malignancies in resource-limited settings Current opinion in oncology, 2011; 23(5): 461-2.
Reddy Deepa, Mitsuyasu Ronald   HIV-associated multicentric Castleman disease Current opinion in oncology, 2011; 23(5): 475-81.
Krishnan Supriya, Schouten Jeffrey T, Jacobson Denise L, Benson Constance A, Collier Ann C, Koletar Susan L, Santana Jorge, Sattler Fred R, Mitsuyasu Ronald, Mitsuyasu Ronald   Incidence of non-AIDS-defining cancer in antiretroviral treatment-naïve subjects after antiretroviral treatment initiation: an ACTG longitudinal linked randomized trials analysis Oncology, 2011; 80(1-2): 42-9.
Mitsuyasu Ronald T, Zack Jerome A, Macpherson Janet L, Symonds Geoff P   Phase I/II Clinical Trials Using Gene-Modified Adult Hematopoietic Stem Cells for HIV: Lessons Learnt Stem cells international, 2011; 2011(1-2): 393698.
Sinha Sanjeev, Dhooria Sahajal, Kumar Sanjiv, Shah Nipam, Velpandian T, Ravi Ak, Kumar Narendra, Ahmad Hafeez, Bhargwa Akshat, Chug Karan, Bumma Naresh, Chandrashekhar Rahul, Ekka Meera, Sreenivas Vishnu, Sharma Surendra K, Samantaray Jc, Mitsuyasu Ronald   The antiretroviral efficacy of highly active antiretroviral therapy and plasma nevirapine concentrations in HIV-TB co-infected Indian patients receiving rifampicin based antituberculosis treatment AIDS research and therapy, 2011; 8(1): 41.
Ambinder Richard F, Bhatia Kishor, Martinez-Maza Otoniel, Mitsuyasu Ronald   Cancer biomarkers in HIV patients Current opinion in HIV and AIDS, 2010; 5(6): 531-7.
Bosch Ronald J, Pollard Richard B, Landay Alan, Aga Evgenia, Fox Lawrence, Mitsuyasu Ronald   Continuing or adding IL-2 in patients treated with antiretroviral therapy (ACTG Protocol A5051, a rollover trial of ACTG Protocol A328) AIDS research and therapy, 2010; 7(8): 30.
Yu Jing Jie, Fu Pingfu, Pink John J, Dawson Dawn, Wasman Jay, Orem Jackson, Mwanda Walter O, Zhu Honglan, Liang Xiaobing, Guo Yi, Petros William P, Mitsuyasu Ronald T, Wabinga Henry, Remick Scot C   HPV infection and EGFR activation/alteration in HIV-infected East African patients with conjunctival carcinoma PloS one, 2010; 5(5): e10477.
King William Douglas, Wyatt Gail E, Liu Honghu, Williams John K, DiNardo Anthony D, Mitsuyasu Ronald T   Pilot assessment of HIV gene therapy-hematopoietic stem cell clinical trial acceptability among minority patients and their advisors Journal of the National Medical Association, 2010; 102(12): 1123-8.
Sparano Joseph A, Lee Jeannette Y, Kaplan Lawrence D, Levine Alexandra M, Ramos Juan Carlos, Ambinder Richard F, Wachsman William, Aboulafia David, Noy Ariela, Henry David H, Von Roenn Jamie, Dezube Bruce J, Remick Scot C, Shah Manisha H, Leichman Lawrence, Ratner Lee, Cesarman Ethel, Chadburn Amy, Mitsuyasu Ronald, Mitsuyasu Ronald   Rituximab plus concurrent infusional EPOCH chemotherapy is highly effective in HIV-associated B-cell non-Hodgkin lymphoma Blood, 2010; 115(15): 3008-16.
Wilkin Timothy, Lee Jeannette Y, Lensing Shelly Y, Stier Elizabeth A, Goldstone Stephen E, Berry J Michael, Jay Naomi, Aboulafia David, Cohn David L, Einstein Mark H, Saah Alfred, Mitsuyasu Ronald T, Palefsky Joel M   Safety and immunogenicity of the quadrivalent human papillomavirus vaccine in HIV-1-infected men The Journal of infectious diseases, 2010; 202(8): 1246-53.
Chiao Elizabeth Y, Dezube Bruce J, Krown Susan E, Wachsman William, Brock Malcolm V, Giordano Thomas P, Mitsuyasu Ronald, Pantanowitz Liron   Time for oncologists to opt in for routine opt-out HIV testing? JAMA : the journal of the American Medical Association, 2010; 304(3): 334-9.
Stapleton Jack T, Chaloner Kathryn, Zhang Jingyang, Klinzman Donna, Souza Inara E, Xiang Jinhua, Landay Alan, Fahey John, Pollard Richard, Mitsuyasu Ronald   GBV-C viremia is associated with reduced CD4 expansion in HIV-infected people receiving HAART and interleukin-2 therapy AIDS (London, England), 2009; 23(5): 605-10.
Mitsuyasu Ronald T, Merigan Thomas C, Carr Andrew, Zack Jerome A, Winters Mark A, Workman Cassy, Bloch Mark, Lalezari Jacob, Becker Stephen, Thornton Lorna, Akil Bisher, Khanlou Homayoon, Finlayson Robert, McFarlane Robert, Smith Don E, Garsia Roger, Ma David, Law Matthew, Murray John M, von Kalle Christof, Ely Julie A, Patino Sharon M, Knop Alison E, Wong Philip, Todd Alison V, Haughton Margaret, Fuery Caroline, Macpherson Janet L, Symonds Geoff P, Evans Louise A, Pond Susan M, Cooper David A   Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells Nature medicine, 2009; 15(3): 285-92.
Tahir Mohammad, Sinha Sanjeev, Sharma S K, Mitsuyasu Ronald T   Immune reconstitution inflammatory syndrome manifesting as disseminated tuberculosis, deep venous thrombosis, encephalopathy and myelopathy The Indian journal of chest diseases & allied sciences, 2008; 50(4): 363-4.
Mitsuyasu Ronald T   Leadership in HIV: now more than ever The Indian journal of medical research, 2008; 128(6): 681.
Mitsuyasu Ronald T   Non--AIDS-defining malignancies in HIV Topics in HIV medicine : a publication of the International AIDS Society, USA, 2008; 16(4): 117-21.
Davey Richard T, Pertel Peter E, Benson Alice, Cassell Delanie J, Gazzard Brian G, Holodniy Mark, Lalezari Jacob P, Levy Yves, Mitsuyasu Ronald T, Palella Frank J, Pollard Richard B, Rajagopalan Prabhu, Saag Michael S, Salata Robert A, Sha Beverly E, Choudhri Shurjeel   Safety, tolerability, pharmacokinetics, and efficacy of an interleukin-2 agonist among HIV-infected patients receiving highly active antiretroviral therapy Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2008; 28(2): 89-100.
Fauce Steven Russell, Jamieson Beth D, Chin Allison C, Mitsuyasu Ronald T, Parish Stan T, Ng Hwee L, Kitchen Christina M Ramirez, Yang Otto O, Harley Calvin B, Effros Rita B   Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes Journal of immunology (Baltimore, Md. : 1950), 2008; 181(10): 7400-6.
Mitsuyasu Ronald, Gelman Rebecca, Cherng Deborah Weng, Landay Alan, Fahey John, Reichman Richard, Erice Alejo, Bucy R Pat, Kilby J Michael, Lederman Michael M, Hamilton Carol D, Lertora Juan, White Becky L, Tebas Pablo, Duliege Anne-Marie, Pollard Richard B, Pollard Richard B   The virologic, immunologic, and clinical effects of interleukin 2 with potent antiretroviral therapy in patients with moderately advanced human immunodeficiency virus infection: a randomized controlled clinical trial--AIDS Clinical Trials Group 328 Archives of internal medicine, 2007; 167(6): 597-605.
Kilby J Michael, Bucy R Pat, Mildvan Donna, Fischl Margaret, Santana-Bagur Jorge, Lennox Jeff, Pilcher Chris, Zolopa Andrew, Lawrence Jody, Pollard Richard B, Habib Raphaelle El, Sahner David, Fox Lawrence, Aga Evgenia, Bosch Ronald J, Mitsuyasu Ronald, Mitsuyasu Ronald   A randomized, partially blinded phase 2 trial of antiretroviral therapy, HIV-specific immunizations, and interleukin-2 cycles to promote efficient control of viral replication (ACTG A5024) The Journal of infectious diseases, 2006; 194(12): 1672-6.
Kuekrek Haydar, Schlingmann Tobias, Valdez Hernan, Boehm Bernhard O, Pollard Richard B, Mitsuyasu Ronald, Goebel Frank-Detlef, Lederman Michael M, Lehmann Paul V, Tary-Lehmann Magdalena   Differential effect of interleukin-2 treatment on primary and secondary immunizations in HIV infected individuals AIDS (London, England), 2005; 19(17): 1967-74.
Martin Barbara K, Wu Albert W, Gelman Rebecca, Mitsuyasu Ronald T, Mitsuyasu Ronald T   Quality of life in a clinical trial of highly active antiretroviral therapy alone or with intravenous or subcutaneous interleukin-2 administration Journal of acquired immune deficiency syndromes (1999), 2005; 40(4): 428-33.
Volberding Paul A, Levine Alexandra M, Dieterich Douglas, Mildvan Donna, Mitsuyasu Ronald, Saag Michael, Saag Michael   Anemia in HIV infection: clinical impact and evidence-based management strategies Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2004; 38(10): 1454-63.
Amado Rafael G, Mitsuyasu Ronald T, Rosenblatt Joseph D, Ngok Frances K, Bakker Andreas, Cole Steve, Chorn Nathalie, Lin Lii-Shin, Bristol Gregory, Boyd Maureen P, MacPherson Janet L, Fanning Gregory C, Todd Alison V, Ely Julie A, Zack Jerome A, Symonds Geoff P   Anti-human immunodeficiency virus hematopoietic progenitor cell-delivered ribozyme in a phase I study: myeloid and lymphoid reconstitution in human immunodeficiency virus type-1-infected patients Human gene therapy, 2004; 15(3): 251-62.
Ngok Frances K, Mitsuyasu Ronald T, Macpherson Janet L, Boyd Maureen P, Symonds Geoff P, Amado Rafael G   Clinical gene therapy research utilizing ribozymes: application to the treatment of HIV/AIDS Methods in molecular biology (Clifton, N.J.), 2004; 252(3): 581-98.
de Boer Alberdina W, Markowitz Norman, Lane H Clifford, Saravolatz Louis D, Koletar Susan L, Donabedian Haig, Yoshizawa Carl, Duliege Anne-Marie, Fyfe Gwendolyn, Mitsuyasu Ronald T   A randomized controlled trial evaluating the efficacy and safety of intermittent 3-, 4-, and 5-day cycles of intravenous recombinant human interleukin-2 combined with antiretroviral therapy (ART) versus ART alone in HIV-seropositive patients with 100-300 CD4+ T cells Clinical immunology (Orlando, Fla.), 2003; 106(3): 188-96.
Valdez Hernan, Mitsuyasu Ronald, Landay Alan, Sevin Anne D, Chan Ellen S, Spritzler John, Kalams Spyros A, Pollard Richard B, Fahey John, Fox Lawrence, Namkung Ann, Estep Scharla, Moss Ronald, Sahner David, Lederman Michael M   Interleukin-2 Increases CD4+ lymphocyte numbers but does not enhance responses to immunization: results of A5046s The Journal of infectious diseases, 2003; 187(2): 320-5.
Anton Peter A, Mitsuyasu Ronald T, Deeks Steven G, Scadden David T, Wagner Bridget, Huang Christine, Macken Catherine, Richman Douglas D, Christopherson Cindy, Borellini Flavia, Lazar Richard, Hege Kristen M   Multiple measures of HIV burden in blood and tissue are correlated with each other but not with clinical parameters in aviremic subjects AIDS (London, England), 2003; 17(1): 53-63.
Deeks Steven G, Wagner Bridget, Anton Peter A, Mitsuyasu Ronald T, Scadden David T, Huang Christine, Macken Catherine, Richman Douglas D, Christopherson Cindy, June Carl H, Lazar Richard, Broad David F, Jalali Sayeh, Hege Kristen M   A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy Molecular therapy : the journal of the American Society of Gene Therapy, 2002; 5(6): 788-97.
Hammer Scott M, Vaida Florin, Bennett Kara K, Holohan Mary K, Sheiner Lewis, Eron Joseph J, Wheat Lawrence Joseph, Mitsuyasu Ronald T, Gulick Roy M, Valentine Fred T, Aberg Judith A, Rogers Michael D, Karol Cheryl N, Saah Alfred J, Lewis Ronald H, Bessen Laura J, Brosgart Carol, DeGruttola Victor, Mellors John W, Mellors John W   Dual vs single protease inhibitor therapy following antiretroviral treatment failure: a randomized trial JAMA : the journal of the American Medical Association, 2002; 288(2): 169-80.
Sha Beverly E, Valdez Hernan, Gelman Rebecca S, Landay Alan L, Agosti Jan, Mitsuyasu Ronald, Pollard Richard B, Mildvan Donna, Namkung Ann, Ogata-Arakaki Debra M, Fox Lawrence, Estep Scharla, Erice Alejo, Kilgo Patrick, Walker Robert E, Bancroft Lynne, Lederman Michael M   Effect of etanercept (Enbrel) on interleukin 6, tumor necrosis factor alpha, and markers of immune activation in HIV-infected subjects receiving interleukin 2 AIDS research and human retroviruses, 2002; 18(9): 661-5.
Mitsuyasu Ronald   Immune therapy: non-highly active antiretroviral therapy management of human immunodeficiency virus-infected patients The Journal of infectious diseases, 2002; 185 Suppl 2(6): S115-22.
Leibowitz Matthew R., Mitsuyasu Ronald T.   Immune Reconstitution Strategies in HIV Current infectious disease reports, 2001; 3(3): 302-308.

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