James Economou, M.D., Ph.D.

A Short Biography:

James S. Economou, M.D., Ph.D. is Vice Chancellor for Research at UCLA.He received all of his education from the Johns Hopkins University, completed his general surgical training at the University of California, San Francisco and joined the UCLA faculty in 1986. He is the Beaumont Professor of Surgery and Chief of the Division of Surgical Oncology. He has joint appointments in the Departments of Microbiology, Immunology and Molecular Genetics, and Molecular and Medical Pharmacology. A tumor immunologist, Dr. Economou has been continuously funded by the National Institutes of Health (NIH) since joining the faculty and has chaired two NIH study sections.

Work Titles
UCLA Chief, Surgical Oncology Director, Melanoma Program Vice Chancellor for Research, UCLA Professor, Surgery Faculty, Molecular & Medical Pharmacology Professor, Microbiology, Immunology & Molecular Genetics
Education:
Degrees:
M.D., The Johns Hopkins Medical School, Baltimore, MD, 1972 - 1980
Ph.D., Johns Hopkins University, 1980
B.A., The Johns Hopkins University, Baltimore, Maryland, 1972
Internship:
1980 - 1981 UCLA School of Medicine
Residency:
1983 - 1986 UCSF/Mount Zion Medical Center
1982 - 1983 UCLA School of Medicine
1981 - 1982 UCLA School of Medicine
Certifications:
Certifications:
2004 American Board of Surgery
1987 American Board of Surgery

Contact Information:

Work Email Address:

jeconomou@conet.ucla.edu

Work Email Address:

jeconomou@mednet.ucla.edu


Website:

Web-Profile 2

Web-Profile

Fax Number:

310-825-7575

Work Phone Number:

(310) 825-2644

310-825-7943

Mailing Address:

UCLA V Chancellor for Research/Surg-Onc
BOX 951405
2147 Murphy Hall
Los Angeles, CA 90095


Work Address:

10833 Le Conte Ave.
54-124 CHS
Los Angeles, CA 90095


Detailed Biography:

James Economou, M.D., Ph.D., received his doctorate in Immunology at the Johns Hopkins University in Baltimore. He is the chief of the Division of Surgical Oncology at UCLA. As deputy director of UCLA's Jonsson Comprehensive Cancer Center (JCCC), Economou ensures collaborations between departments, oversees two Specialized Programs of Research Excellence (SPORE) in prostate and lung cancers, supervises seed grants, and helps coordinate National Institutes of Health training programs. A coordinator (with Dr. William McBride) of the Human Gene Medicine Program, he works with the cancer center senior leadership to identify program goals, provide funding and space support and give academic oversight. Economou performs about 400 surgeries a year, specializing in melanoma, primary and metastatic liver cancer and sarcomas. Along with Drs. John Glaspy and Antoni Ribas, he leads a laboratory that is developing gene therapy treatments for melanoma and liver cancer. In addition to his administrative duties in the cancer center, surgical oncology and the Human Gene Medicine Program, Economou also sits on two National Cancer Institute (NCI) study sections boards composed of senior investigators who review grant applications. His NCI responsibilities give him valuable insight into the peer review process, information he passes along to young cancer center scientists who must rely on grant funding to support their research.

Publications:

Giannoni Francesca, Hardee Cinnamon L, Wherley Jennifer, Gschweng Eric, Senadheera Shantha, Kaufman Michael L, Chan Rebecca, Bahner Ingrid, Gersuk Vivian, Wang Xiaoyan, Gjertson David, Baltimore David, Witte Owen N, Economou James S, Ribas Antoni, Kohn Donald B   Allelic Exclusion and Peripheral Reconstitution by TCR Transgenic T Cells Arising From Transduced Human Hematopoietic Stem/Progenitor Cells Molecular therapy : the journal of the American Society of Gene Therapy, 2013; 21(5): 1044-54.
Ma Chao, Cheung Ann F, Chodon Thinle, Koya Richard C, Wu Zhongqi, Ng Charles, Avramis Earl, Cochran Alistair J, Witte Owen N, Baltimore David, Chmielowski Bartosz, Economou James S, Comin-Anduix Begonya, Ribas Antoni, Heath James R   Multifunctional T-cell analyses to study response and progression in adoptive cell transfer immunotherapy Cancer discovery, 2013; 3(4): 418-29.
Economou James S   A society in transition: presidential remarks at the 65th Annual SSO Cancer Symposium Annals of surgical oncology, 2012; 19(11): 3293-7.
Quatromoni Jon G, Wang Yue, Vo Dan D, Morris Lilah F, Jazirehi Ali R, McBride William, Chatila Talal, Koya Richard C, Economou James S   T cell receptor (TCR)-transgenic CD8 lymphocytes rendered insensitive to transforming growth factor beta (TGFβ) signaling mediate superior tumor regression in an animal model of adoptive cell therapy Journal of translational medicine, 2012; 10(11): 127.
Huang Rong Rong, Jalil Jason, Economou James S, Chmielowski Bartosz, Koya Richard C, Mok Stephen, Sazegar Hooman, Seja Elizabeth, Villanueva Arturo, Gomez-Navarro Jesus, Glaspy John A, Cochran Alistair J, Ribas Antoni   CTLA4 blockade induces frequent tumor infiltration by activated lymphocytes regardless of clinical responses in humans Clinical cancer research : an official journal of the American Association for Cancer Research, 2011; 17(12): 4101-9.
Narayan Rupa, Nguyen Hong, Bentow Jason J, Moy Lauren, Lee Diana K, Greger Stephanie, Haskell Jacquelyn, Vanchinathan Veena, Chang Pei-Lin, Tsui Shanli, Konishi Tamiko, Comin-Anduix Begonya, Dauphine Christine, Vargas Hernan I, Economou James S, Ribas Antoni, Bruhn Kevin W, Craft Noah   Immunomodulation by Imiquimod in Patients with High-Risk Primary Melanoma The Journal of investigative dermatology, 2011; .
Jazirehi Ali R, Baritaki Stavroula, Koya Richard C, Bonavida Benjamin, Economou James S   Molecular mechanism of MART-1+/A*0201+ human melanoma resistance to specific CTL-killing despite functional tumor-CTL interaction Cancer research, 2011; 71(4): 1406-17.
Quatromoni Jon G, Morris Lilah F, Donahue Timothy R, Wang Yue, McBride William, Chatila Talal, Economou James S   T cell receptor transgenic lymphocytes infiltrating murine tumors are not induced to express foxp3 Journal of hematology & oncology, 2011; 4: 48.
Ray Swagatam, Chhabra Arvind, Chakraborty Nitya G, Hegde Upendra, Dorsky David I, Chodon Thinle, von Euw Erika, Comin-Anduix Begonya, Koya Richard C, Ribas Antoni, Economou James S, Rosenberg Steven A, Mukherji Bijay, Mukherji Bijay   MHC-I-restricted melanoma antigen specific TCR-engineered human CD4+ T cells exhibit multifunctional effector and helper responses, in vitro Clinical immunology (Orlando, Fla.), 2010; 136(3): 338-47.
Ray Swagatam, Chhabra Arvind, Mehrotra Shikhar, Chakraborty Nitya G, Ribas Antoni, Economou James, Mukherji Bijay   Obstacles to and opportunities for more effective peptide-based therapeutic immunization in human melanoma Clinics in dermatology, 2010; 27(6): 603-13.
Baltimore David, Witte Owen N, Yang Lili, Economou James, Ribas Antoni   Overcoming barriers to programming a therapeutic cellular immune response to fight melanoma Pigment cell & melanoma research, 2010; 23(2): 288-9.
Kachikwu Evelyn L, Iwamoto Keisuke S, Liao Yu-Pei, Demarco John J, Agazaryan Nzhde, Economou James S, McBride William H, Schaue Dörthe   Radiation Enhances Regulatory T Cell Representation International journal of radiation oncology, biology, physics, 2010; 71(4): .
Ribas Antoni, Comin-Anduix Begoña, Chmielowski Bartosz, Jalil Jason, de la Rocha Pilar, McCannel Tara A, Ochoa Maria Teresa, Seja Elizabeth, Villanueva Arturo, Oseguera Denise K, Straatsma Bradley R, Cochran Alistair J, Glaspy John A, Hui Liu, Marincola Francesco M, Wang Ena, Economou James S, Gomez-Navarro Jesus   Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma Clinical cancer research : an official journal of the American Association for Cancer Research, 2009; 15(19): 6267-76.
Vo Dan D, Prins Robert M, Begley Jonathan L, Donahue Timothy R, Morris Lilah F, Bruhn Kevin W, de la Rocha Pilar, Yang Meng-Yin, Mok Stephen, Garban Hermes J, Craft Noah, Economou James S, Marincola Francesco M, Wang Ena, Ribas Antoni   Enhanced antitumor activity induced by adoptive T-cell transfer and adjunctive use of the histone deacetylase inhibitor LAQ824 Cancer research, 2009; 69(22): 8693-9.
Ribas Antoni, Comin-Anduix Begoña, Economou James S, Donahue Timothy R, de la Rocha Pilar, Morris Lilah F, Jalil Jason, Dissette Vivian B, Shintaku Itsushi Peter, Glaspy John A, Gomez-Navarro Jesus, Cochran Alistair J   Intratumoral immune cell infiltrates, FoxP3, and indoleamine 2,3-dioxygenase in patients with melanoma undergoing CTLA4 blockade Clinical cancer research : an official journal of the American Association for Cancer Research, 2009; 15(1): 390-9.
Butterfield Lisa H, Comin-Anduix Begonya, Vujanovic Lazar, Lee Yohan, Dissette Vivian B, Yang Jin-Quan, Vu Hong T, Seja Elizabeth, Oseguera Denise K, Potter Douglas M, Glaspy John A, Economou James S, Ribas Antoni   Adenovirus MART-1-engineered autologous dendritic cell vaccine for metastatic melanoma Journal of immunotherapy (Hagerstown, Md. : 1997), 2008; 31(3): 294-309.
Chhabra Arvind, Yang Lili, Wang Pin, Comin-Anduix Begoña, Das Raja, Chakraborty Nitya G, Ray Swagatam, Mehrotra Shikhar, Yang Haiguang, Hardee Cinnamon L, Hollis Roger, Dorsky David I, Koya Richard, Kohn Donald B, Ribas Antoni, Economou James S, Baltimore David, Mukherji Bijay   CD4+CD25- T cells transduced to express MHC class I-restricted epitope-specific TCR synthesize Th1 cytokines and exhibit MHC class I-restricted cytolytic effector function in a human melanoma model Journal of immunology (Baltimore, Md. : 1950), 2008; 181(2): 1063-70.
Comin-Anduix Begoña, Lee Yohan, Jalil Jason, Algazi Alain, de la Rocha Pilar, Camacho Luis H, Bozon Viviana A, Bulanhagui Cecile A, Seja Elisabeth, Villanueva Arturo, Straatsma Bradley R, Gualberto Antonio, Economou James S, Glaspy John A, Gomez-Navarro Jesus, Ribas Antoni   Detailed analysis of immunologic effects of the cytotoxic T lymphocyte-associated antigen 4-blocking monoclonal antibody tremelimumab in peripheral blood of patients with melanoma Journal of translational medicine, 2008; 6(2): 22.
Butterfield Lisa H, Ribas Antoni, Potter Douglas M, Economou James S   Spontaneous and vaccine induced AFP-specific T cell phenotypes in subjects with AFP-positive hepatocellular cancer Cancer immunology, immunotherapy : CII, 2007; 56(12): 1931-43.
Straatsma Bradley R, Nusinowitz Steven, Young Tara A, Gordon Lynn K, Chun Melissa W, Rosen Colleen, Seja Elisabeth, Economou James S, Glaspy John A, Bozon Viviana, Gomez-Navarro Jesus, Ribas Antoni   Surveillance of the eye and vision in clinical trials of CP-675,206 for metastatic melanoma American journal of ophthalmology, 2007; 143(6): 958-969.
Butterfield Lisa H, Ribas Antoni, Dissette Vivian B, Lee Yohan, Yang Jin Quan, De la Rocha Pilar, Duran Sonia D, Hernandez Jackie, Seja Elisabeth, Potter Douglas M, McBride William H, Finn Richard, Glaspy John A, Economou James S   A phase I/II trial testing immunization of hepatocellular carcinoma patients with dendritic cells pulsed with four alpha-fetoprotein peptides Clinical cancer research : an official journal of the American Association for Cancer Research, 2006; 12(9): 2817-25.
Ribas Antoni, Vo Dan D, Weeks David L, Comin-Anduix Begoña, Schumacher Lana Y, Garban Hermes J, McLean Colin, Yang Jinquan, Dissette Vivian B, Peraza Pedro, Owens Sharla K, McBride William H, Glaspy John A, Economou James S   Broad antitumor protection by dendritic cells administered to CD8alpha knock out mice Cancer immunology, immunotherapy : CII, 2006; 55(6): 663-71.
Comin-Anduix Begoña, Gualberto Antonio, Glaspy John A, Seja Elisabeth, Ontiveros Maribel, Reardon Deborah L, Renteria Roberto, Englahner Brigitte, Economou James S, Gomez-Navarro Jesus, Ribas Antoni   Definition of an immunologic response using the major histocompatibility complex tetramer and enzyme-linked immunospot assays Clinical cancer research : an official journal of the American Association for Cancer Research, 2006; 12(1): 107-16.
Schumacher Lana Y, Vo Dan D, Garban Hermes J, Comin-Anduix Begoña, Owens Sharla K, Dissette Vivian B, Glaspy John A, McBride William H, Bonavida Benjamin, Economou James S, Ribas Antoni   Immunosensitization of tumor cells to dendritic cell-activated immune responses with the proteasome inhibitor bortezomib (PS-341, Velcade) Journal of immunology (Baltimore, Md. : 1950), 2006; 176(8): 4757-65.
Prins Robert M, Vo Dan D, Khan-Farooqi Haumith, Yang Meng-Yin, Soto Horacio, Economou James S, Liau Linda M, Ribas Antoni   NK and CD4 cells collaborate to protect against melanoma tumor formation in the brain Journal of immunology (Baltimore, Md. : 1950), 2006; 177(12): 8448-55.
Wargo Jennifer A, Schumacher Lana Y, Comin-Anduix Begonya, Dissette Vivian B, Glaspy John A, McBride William H, Butterfield Lisa H, Economou James S, Ribas Antoni   Natural killer cells play a critical role in the immune response following immunization with melanoma-antigen-engineered dendritic cells Cancer gene therapy, 2005; 12(6): 516-27.
Mehrotra Shikhar, Chhabra Arvind, Chakraborty Abolokita, Chattopadhyay Subhasis, Slowik Mark, Stevens Robert, Zengou Ryan, Mathias Clinton, Butterfield Lisa H, Dorsky David I, Economou James S, Mukherji Bijay, Chakraborty Nitya G   Antigen presentation by MART-1 adenovirus-transduced interleukin-10-polarized human monocyte-derived dendritic cells Immunology, 2004; 113(4): 472-81.
Ribas Antoni, Wargo Jennifer A, Comin-Anduix Begonya, Sanetti Shelley, Schumacher Lana Y, McLean Colin, Dissette Vivian B, Glaspy John A, McBride William H, Butterfield Lisa H, Economou James S   Enhanced tumor responses to dendritic cells in the absence of CD8-positive cells Journal of immunology (Baltimore, Md. : 1950), 2004; 172(8): 4762-9.
Schumacher Lana, Ribas Antoni, Dissette Vivian B, McBride William H, Mukherji Bijay, Economou James S, Butterfield Lisa H   Human dendritic cell maturation by adenovirus transduction enhances tumor antigen-specific T-cell responses Journal of immunotherapy (Hagerstown, Md. : 1997), 2004; 27(3): 191-200.
Liao Yu-Pei, Wang Chun-Chieh, Butterfield Lisa H, Economou James S, Ribas Antoni, Meng Wilson S, Iwamoto Keisuke S, McBride William H   Ionizing radiation affects human MART-1 melanoma antigen processing and presentation by dendritic cells Journal of immunology (Baltimore, Md. : 1950), 2004; 173(4): 2462-9.
Ribas Antoni, Glaspy John A, Lee Yohan, Dissette Vivian B, Seja Elisabeth, Vu Huong T, Tchekmedyian N Simon, Oseguera Denise, Comin-Anduix Begonya, Wargo Jennifer A, Amarnani Saral N, McBride William H, Economou James S, Butterfield Lisa H   Role of dendritic cell phenotype, determinant spreading, and negative costimulatory blockade in dendritic cell-based melanoma immunotherapy Journal of immunotherapy (Hagerstown, Md. : 1997), 2004; 27(5): 354-67.
Gordon Lynn K, Ribas Antoni, Nusinowitz Steven, Butterfield Lisa H, Glaspy John A, Economou James S, Straatsma Bradley R   Surveillance of the eye and vision in a clinical trial of MART1-transformed dendritic cells for metastatic melanoma Controlled clinical trials, 2004; 25(4): 400-7.
Ribas Antoni, Butterfield Lisa H, Glaspy John A, Economou James S   Current developments in cancer vaccines and cellular immunotherapy Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003; 21(12): 2415-32.
Ribas Antoni, Timmerman John M, Butterfield Lisa H, Economou James S   Determinant spreading and tumor responses after peptide-based cancer immunotherapy Trends in immunology, 2003; 24(2): 58-61.
Butterfield Lisa H, Ribas Antoni, Dissette Vivian B, Amarnani Saral N, Vu Huong T, Oseguera Denise, Wang He-Jing, Elashoff Robert M, McBride William H, Mukherji Bijay, Cochran Alistair J, Glaspy John A, Economou James S   Determinant spreading associated with clinical response in dendritic cell-based immunotherapy for malignant melanoma Clinical cancer research : an official journal of the American Association for Cancer Research, 2003; 9(3): 998-1008.
Lu David S K, Raman Steven S, Limanond Piyaporn, Aziz Donya, Economou James, Busuttil Ronald, Sayre James   Influence of large peritumoral vessels on outcome of radiofrequency ablation of liver tumors Journal of vascular and interventional radiology : JVIR, 2003; 14(10): 1267-74.
Mehrotra Shikhar, Stevens Robert, Zengou Ryan, Chakraborty Nitya G, Butterfield Lisa H, Economou James S, Dorsky David I, Mukherji Bijay   Regulation of melanoma epitope-specific cytolytic T lymphocyte response by immature and activated dendritic cells, in vitro Cancer research, 2003; 63(17): 5607-14.
Butterfield Lisa H, Ribas Antoni, Meng Wilson S, Dissette Vivian B, Amarnani Saral, Vu Huong T, Seja Elisabeth, Todd Karen, Glaspy John A, McBride William H, Economou James S   T-cell responses to HLA-A*0201 immunodominant peptides derived from alpha-fetoprotein in patients with hepatocellular cancer Clinical cancer research : an official journal of the American Association for Cancer Research, 2003; 9(16 Pt 1): 5902-8.
Ribas Antoni, Butterfield Lisa H, Glaspy John A, Economou James S   Cancer immunotherapy using gene-modified dendritic cells Current gene therapy, 2002; 2(1): 57-78.
Ribas Antoni, Amarnani Saral N, Buga Georgette M, Butterfield Lisa H, Dissette Vivian B, McBride William H, Glaspy John A, Ignarro Louis J, Economou James S   Immunosuppressive effects of interleukin-12 coexpression in melanoma antigen gene-modified dendritic cell vaccines Cancer gene therapy, 2002; 9(11): 875-83.
Wargo Jennifer A, Economou James S   The status of gene therapy for surgical disease Advances in surgery, 2002; 36(1): 223-57.

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