William Shields, M.D.

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Work Titles
UCLA Chief, Clinical Trials in Pediatric Neurology Director, Pediatric Epilepsy Program Member, The Ketogenic Diet Program Professor Emeritus, Pediatrics Professor Emeritus, Pediatric Neurology
Education:
Degrees:
M.D., University of Utah School of Medicine, 1971
Internship:
1971 - 1972 LAC + USC Medical Center
Residency:
1973 - 1976 University of Utah Hospital & Clinics
1972 - 1973 LAC + USC Medical Center
Certifications:
Certifications:
1978 American Board of Pediatrics
1977 American Board of Psychiatry and Neurology

Contact Information:

Email Address:

wshields@mednet.ucla.edu


Website:

Web-Profile

Publications:

A selected list of publications:

Pellock John M, Faught Edward, Sergott Robert C, Shields W Donald, Burkhart Gregory A, Krauss Gregory L, Foroozan Rod, Wesche David L, Weinberg Mark A   Registry initiated to characterize vision loss associated with vigabatrin therapy Epilepsy & behavior : E&B, 2011; 22(4): 710-7.
O'Neill Joseph, Seese Ronald, Hudkins Matthew, Siddarth Prabha, Levitt Jennifer, Tseng Pengju Benjamin, Wu Keng Nei, Gurbani Suresh, Shields W Donald, Caplan Rochelle   1H MRSI and social communication deficits in pediatric complex partial seizures Epilepsia, 2011; 52(9): 1705-14.
Shields W D, Pellock J M   Vigabatrin 35 years later - from mechanism of action to benefit-risk considerations Acta neurologica Scandinavica. Supplementum, 2011; 52(192): 1-4.
Elterman Roy D, Shields W Donald, Bittman Richard M, Torri Sarah A, Sagar Stephen M, Collins Stephen D   Vigabatrin for the treatment of infantile spasms: final report of a randomized trial Journal of child neurology, 2010; 25(11): 1340-7.
Pellock John M, Hrachovy Richard, Shinnar Shlomo, Baram Tallie Z, Bettis David, Dlugos Dennis J, Gaillard William D, Gibson Patricia A, Holmes Gregory L, Nordl Douglas R, O'Dell Christine, Shields W Donald, Trevathan Edwin, Wheless James W   Infantile spasms: a U.S. consensus report Epilepsia, 2010; 51(10): 2175-89.
Caplan Rochelle, Siddarth Prabha, Levitt Jennifer, Gurbani Suresh, Shields W Donald, Sankar Raman   Suicidality and brain volumes in pediatric epilepsy Epilepsy & behavior : E&B, 2010; 18(3): 286-90.
Hemb M, Velasco T R, Parnes M S, Wu J Y, Lerner J T, Matsumoto J H, Yudovin S, Shields W D, Sankar R, Salamon N, Vinters H V, Mathern G W   Improved outcomes in pediatric epilepsy surgery: the UCLA experience, 1986-2008 Neurology, 2010; 74(22): 1768-75.
Caplan Rochelle, Levitt Jennifer, Siddarth Prabha, Wu Keng Nei, Gurbani Suresh, Shields W Donald, Sankar Raman   Language and brain volumes in children with epilepsy Epilepsy & behavior : E&B, 2010; 17(3): 402-7.
Wu J Y, Salamon N, Kirsch H E, Mantle M M, Nagarajan S S, Kurelowech L, Aung M H, Sankar R, Shields W D, Mathern G W   Noninvasive testing, early surgery, and seizure freedom in tuberous sclerosis complex Neurology, 2010; 74(5): 392-8.
Schreibman Cohen Ayelet, Daley Melita, Siddarth Prabha, Levitt Jennifer, Loesch Ingrid K, Altshuler Lori, Ly Ronald, Shields W Donald, Gurbani Suresh, Caplan Rochelle   Amygdala volumes in childhood absence epilepsy Epilepsy & behavior : E&B, 2009; 16(3): 436-41.
Caplan Rochelle, Levitt Jennifer, Siddarth Prabha, Wu Keng Nei, Gurbani Suresh, Sankar Raman, Shields W Donald   Frontal and temporal volumes in Childhood Absence Epilepsy Epilepsia, 2009; 50(11): 2466-72.
Shields W Donald, Snead Orlando Carter   Benign epilepsy with centrotemporal spikes Epilepsia, 2009; 50 Suppl 8(3): 10-5.
Willmore L James, Abelson Mark B, Ben-Menachem Elinor, Pellock John M, Shields W Donald   Vigabatrin: 2008 update Epilepsia, 2009; 50(2): 163-73.
Caplan Rochelle, Siddarth Prabha, Stahl Lesley, Lanphier Erin, Vona Pamela, Gurbani Suresh, Koh Susan, Sankar Raman, Shields W Donald   Childhood absence epilepsy: behavioral, cognitive, and linguistic comorbidities Epilepsia, 2008; 49(11): 1838-46.
Salamon N, Kung J, Shaw S J, Koo J, Koh S, Wu J Y, Lerner J T, Sankar R, Shields W D, Engel J, Fried I, Miyata H, Yong W H, Vinters H V, Mathern G W   FDG-PET/MRI coregistration improves detection of cortical dysplasia in patients with epilepsy Neurology, 2008; 71(20): 1594-601.
Caplan Rochelle, Levitt Jennifer, Siddarth Prabha, Taylor Janelle, Daley Melita, Wu Keng Nei, Gurbani Suresh, Shields W Donald, Sankar Raman   Thought disorder and frontotemporal volumes in pediatric epilepsy Epilepsy & behavior : E&B, 2008; 13(4): 593-9.
Daley Melita, Siddarth Prabha, Levitt Jennifer, Gurbani Suresh, Shields W Donald, Sankar Raman, Toga Arthur, Caplan Rochelle   Amygdala volume and psychopathology in childhood complex partial seizures Epilepsy & behavior : E&B, 2008; 13(1): 212-7.
Shields W Donald   Children get their due: A study of pediatric epilepsy patients before drug approval Neurology, 2008; 70(21): 1946-7.
Daley Melita, Levitt Jennifer, Siddarth Prabha, Mormino Elizabeth, Hojatkashani Cornelius, Gurbani Suresh, Shields W Donald, Sankar Raman, Toga Arthur, Caplan Rochelle   Frontal and temporal volumes in children with epilepsy Epilepsy & behavior : E&B, 2007; 10(3): 470-6.
Ramsay R Eugene, Shields W Donald, Shinnar Shlomo   Special issues in the management of young children, older adults, and the developmentally disabled Journal of child neurology, 2007; 22(5 Suppl): 53S-60S.
Daley Melita, Ott Derek, Blanton Rebecca, Siddarth Prabha, Levitt Jennifer, Mormino Elizabeth, Hojatkashani Cornelius, Tenorio Raquel, Gurbani Suresh, Shields W Donald, Sankar Raman, Toga Arthur, Caplan Rochelle   Hippocampal volume in childhood complex partial seizures Epilepsy research, 2006; 72(1): 57-66.
Morrison Peter F, Sankar Raman, Shields W Donald   Valproate-induced chorea and encephalopathy in atypical nonketotic hyperglycinemia Pediatric neurology, 2006; 35(5): 356-8.
Van Hirtum-Das Michele, Licht Eliot A, Koh Susan, Wu Joyce Y, Shields W Donald, Sankar Raman   Children with ESES: variability in the syndrome Epilepsy research, 2006; 70 Suppl 1(5): S248-58.
Shields W Donald   Infantile spasms: little seizures, BIG consequences Epilepsy currents / American Epilepsy Society, 2006; 6(3): 63-9.
Wu J Y, Sutherling W W, Koh S, Salamon N, Jonas R, Yudovin S, Sankar R, Shields W D, Mathern G W   Magnetic source imaging localizes epileptogenic zone in children with tuberous sclerosis complex Neurology, 2006; 66(8): 1270-2.
Kearney Jennifer A, Wiste Anna K, Stephani Ulrich, Trudeau Michelle M, Siegel Anne, RamachandranNair Rajesh, Elterman Roy D, Muhle Hiltrud, Reinsdorf Juliane, Shields W Donald, Meisler Miriam H, Escayg Andrew   Recurrent de novo mutations of SCN1A in severe myoclonic epilepsy of infancy Pediatric neurology, 2006; 34(2): 116-20.
Koh Susan, Mathern Gary W, Glasser Gabrielle, Wu Joyce Y, Shields W Donald, Jonas Rinat, Yudovin Sue, Cepeda Carlos, Salamon Noriko, Vinters Harry V, Sankar Raman   Status epilepticus and frequent seizures: incidence and clinical characteristics in pediatric epilepsy surgery patients Epilepsia, 2005; 46(12): 1950-4.
Waters M F, Bhidayasiri R, Shields W D   Favorable longitudinal outcome in a patient with Parry-Romberg syndrome Acta neurologica Scandinavica, 2005; 112(3): 192-3.
Caplan Rochelle, Siddarth Prabha, Gurbani Suresh, Hanson Rebecca, Sankar Ramen, Shields W Donald   Depression and anxiety disorders in pediatric epilepsy Epilepsia, 2005; 46(5): 720-30.
Jonas R, Asarnow R F, LoPresti C, Yudovin S, Koh S, Wu J Y, Sankar R, Shields W D, Vinters H V, Mathern G W   Surgery for symptomatic infant-onset epileptic encephalopathy with and without infantile spasms Neurology, 2005; 64(4): 746-50.
Shields W Donald   Effects of epilepsy surgery on psychiatric and behavioral comorbidities in children and adolescents Epilepsy & behavior : E&B, 2004; 5 Suppl 3(10): S18-24.
Caplan Rochelle, Siddarth Prabha, Gurbani Suresh, Ott Derek, Sankar Raman, Shields W Donald   Psychopathology and pediatric complex partial seizures: seizure-related, cognitive, and linguistic variables Epilepsia, 2004; 45(10): 1273-81.
Shields W. Donald   Surgical Treatment of Refractory Epilepsy Current treatment options in neurology, 2004; 6(5): 349-356.
Shields W Donald   Management of epilepsy in mentally retarded children using the newer antiepileptic drugs, vagus nerve stimulation, and surgery Journal of child neurology, 2004; 19 Suppl 1(5): S58-64.
Jonas R, Nguyen S, Hu B, Asarnow R F, LoPresti C, Curtiss S, de Bode S, Yudovin S, Shields W D, Vinters H V, Mathern G W   Cerebral hemispherectomy: hospital course, seizure, developmental, language, and motor outcomes Neurology, 2004; 62(10): 1712-21.
Koh Susan, Nguyen Snow, Asarnow Robert F, LoPresti Christine, Yudovin Sue, Shields W Donald, Vinters Harry V, Mathern Gary W   Five or more acute postoperative seizures predict hospital course and long-term seizure control after hemispherectomy Epilepsia, 2004; 45(5): 527-33.
Mackay M T, Weiss S K, Adams-Webber T, Ashwal S, Stephens D, Ballaban-Gill K, Baram T Z, Duchowny M, Hirtz D, Pellock J M, Shields W D, Shinnar S, Wyllie E, Snead O C, Snead O C, Snead O C   Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society Neurology, 2004; 62(10): 1668-81.
Cook Shon W, Nguyen Snow T, Hu Bin, Yudovin Sue, Shields W Donald, Vinters Harry V, Van de Wiele Barbara M, Harrison Rick E, Mathern Gary W   Cerebral hemispherectomy in pediatric patients with epilepsy: comparison of three techniques by pathological substrate in 115 patients Journal of neurosurgery, 2004; 100(2 Suppl Pediatrics): 125-41.
Shields W Donald   Diagnosis of infantile spasms, Lennox-Gastaut syndrome, and progressive myoclonic epilepsy Epilepsia, 2004; 45 Suppl 5(2 Suppl Pediatrics): 2-4.
Ott Derek, Siddarth Prabha, Gurbani Suresh, Koh Susan, Tournay Anne, Shields W Donald, Caplan Rochelle   Behavioral disorders in pediatric epilepsy: unmet psychiatric need Epilepsia, 2003; 44(4): 591-7.
Glauser Tracy A, Pellock John M, Bebin E Martina, Fountain Nathan B, Ritter Frank J, Jensen Christof M, Shields W Donald   Efficacy and safety of levetiracetam in children with partial seizures: an open-label trial Epilepsia, 2002; 43(5): 518-24.
Caplan Rochelle, Siddarth Prabha, Mathern Gary, Vinters Harry, Curtiss Susan, Levitt Jennifer, Asarnow Robert, Shields W Donald   Developmental outcome with and without successful intervention International review of neurobiology, 2002; 49(2): 269-84.
Shields W Donald   Medical versus surgical treatment: which treatment when International review of neurobiology, 2002; 49(2): 253-67.
Caplan Rochelle, Guthrie Donald, Komo Scott, Siddarth Prabha, Chayasirisobhon Sirichai, Kornblum Harley, Sankar Ramen, Hansen Rebecca, Mitchell Wendy, Shields W Donald   Social communication in children with epilepsy Journal of child psychology and psychiatry, and allied disciplines, 2002; 43(2): 245-53.
Shields W Donald   West's syndrome Journal of child neurology, 2002; 17 Suppl 1(2): S76-9.
Pellock J M, Glauser T A, Bebin E M, Fountain N B, Ritter F J, Coupez R M, Shields W D   Pharmacokinetic study of levetiracetam in children Epilepsia, 2001; 42(12): 1574-9.
Elterman R D, Shields W D, Mansfield K A, Nakagawa J, Nakagawa J   Randomized trial of vigabatrin in patients with infantile spasms Neurology, 2001; 57(8): 1416-21.
Ott D, Caplan R, Guthrie D, Siddarth P, Komo S, Shields W D, Sankar R, Kornblum H, Chayasirisobhon S   Measures of psychopathology in children with complex partial seizures and primary generalized epilepsy with absence Journal of the American Academy of Child and Adolescent Psychiatry, 2001; 40(8): 907-14.
Caplan R, Guthrie D, Komo S, Shields W D, Chayasirisobhon S, Kornblum H I, Mitchell W, Hanson R   Conversational repair in pediatric epilepsy Brain and language, 2001; 78(1): 82-93.
Shields W D   Catastrophic epilepsy in childhood Epilepsia, 2000; 41 Suppl 2(2-3): S2-6.
Kerrigan J F, Shields W D, Nelson T Y, Bluestone D L, Dodson W E, Bourgeois B F, Pellock J M, Morton L D, Monaghan E P   Ganaxolone for treating intractable infantile spasms: a multicenter, open-label, add-on trial Epilepsy research, 2000; 42(2-3): 133-9.
Mathern G W, Giza C C, Yudovin S, Vinters H V, Peacock W J, Shewmon D A, Shields W D   Postoperative seizure control and antiepileptic drug use in pediatric epilepsy surgery patients: the UCLA experience, 1986-1997 Epilepsia, 1999; 40(12): 1740-9.
Caplan R, Guthrie D, Komo S, Shields W D, Sigmann M   Infantile spasms: the development of nonverbal communication after epilepsy surgery Developmental neuroscience, 1999; 21(3-5): 165-73.
Shields W D, Shewmon D A, Peacock W J, LoPresti C M, Nakagawa J A, Yudovin S   Surgery for the treatment of medically intractable infantile spasms: a cautionary case Epilepsia, 1999; 40(9): 1305-8.
Rintahaka P J, Nakagawa J A, Shewmon D A, Kyyronen P, Shields W D   Incidence of death in patients with intractable epilepsy during nitrazepam treatment Epilepsia, 1999; 40(4): 492-6.
Caplan R, Guthrie D, Komo S, Shields W D, Sigman M   Infantile spasms: facial expression of affect before and after epilepsy surgery Brain and cognition, 1999; 39(2): 116-32.
Caplan R, Arbelle S, Magharious W, Guthrie D, Komo S, Shields W D, Chayasirisobhon S, Hansen R   Psychopathology in pediatric complex partial and primary generalized epilepsy Developmental medicine and child neurology, 1998; 40(12): 805-11.
Caplan R, Guthrie D, Komo S, Shields W D   Blink rate in pediatric complex partial seizure disorder Journal of child psychology and psychiatry, and allied disciplines, 1998; 39(8): 1145-52.
De Vivo D C, Bohan T P, Coulter D L, Dreifuss F E, Greenwood R S, Nordli D R, Shields W D, Stafstrom C E, Tein I   L-carnitine supplementation in childhood epilepsy: current perspectives Epilepsia, 1998; 39(11): 1216-25.
Caplan R, Arbelle S, Guthrie D, Komo S, Shields W D, Hansen R, Chayasirisobhon S   Formal thought disorder and psychopathology in pediatric primary generalized and complex partial epilepsy Journal of the American Academy of Child and Adolescent Psychiatry, 1997; 36(9): 1286-94.
Asarnow R F, LoPresti C, Guthrie D, Elliott T, Cynn V, Shields W D, Shewmon D A, Sankar R, Peacock W J   Developmental outcomes in children receiving resection surgery for medically intractable infantile spasms Developmental medicine and child neurology, 1997; 39(7): 430-40.
Shields W D, Sankar R   Vigabatrin Seminars in pediatric neurology, 1997; 4(1): 43-50.
Peacock W J, Wehby-Grant M C, Shields W D, Shewmon D A, Chugani H T, Sankar R, Vinters H V   Hemispherectomy for intractable seizures in children: a report of 58 cases Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 1996; 12(7): 376-84.
Rantala H, Shields W D, Christenson P D, Nielsen C, Buch D, Jacobsen V, Zachau-Christiansen B, Uhari M, Cherry J D   Risk factors of infantile spasms compared with other seizures in children under 2 years of age Epilepsia, 1996; 37(4): 362-6.
Shields W D   Investigational antiepileptic drugs for the treatment of childhood seizure disorders: a review of efficacy and safety Epilepsia, 1994; 35 Suppl 2(1): S24-9.
Chugani H T, Shewmon D A, Shields W D, Sankar R, Comair Y, Vinters H V, Peacock W J   Surgery for intractable infantile spasms: neuroimaging perspectives Epilepsia, 1994; 34(4): 764-71.
Cherry J D, Holtzman A E, Shields W D, Buch D, Nielsen C, Jacobsen V, Christenson P D, Zachau-Christiansen B   Pertussis immunization and characteristics related to first seizures in infants and children The Journal of pediatrics, 1993; 122(6): 900-3.
Caplan R, Guthrie D, Shields W D, Peacock W J, Vinters H V, Yudovin S   Communication deficits in children undergoing temporal lobectomy Journal of the American Academy of Child and Adolescent Psychiatry, 1993; 32(3): 604-11.
Shields W D, Peacock W J, Roper S N   Surgery for epilepsy. Special pediatric considerations Neurosurgery clinics of North America, 1993; 4(2): 301-10.
Caplan R, Guthrie D, Shields W D, Mori L   Formal thought disorder in pediatric complex partial seizure disorder Journal of child psychology and psychiatry, and allied disciplines, 1992; 33(8): 1399-412.
Caplan R, Guthrie D, Shields W D, Sigman M, Mundy P, Sherman T, Vinters H V   Early onset intractable seizures: nonverbal communication after hemispherectomy Journal of developmental and behavioral pediatrics : JDBP, 1992; 13(5): 348-55.
Gorman D G, Shields W D, Shewmon D A, Chugani H T, Finkel R, Comair Y G, Peacock W J   Neurosurgical treatment of refractory status epilepticus Epilepsia, 1992; 33(3): 546-9.
Shields W D   Peer review of expert medical-legal testimony: a proposal for child neurology Journal of child neurology, 1992; 7(3): 237-9.
Vinters H V, Fisher R S, Cornford M E, Mah V, Secor D L, De Rosa M J, Comair Y G, Peacock W J, Shields W D   Morphological substrates of infantile spasms: studies based on surgically resected cerebral tissue Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 1992; 8(1): 8-17.
Farrell M A, DeRosa M J, Curran J G, Secor D L, Cornford M E, Comair Y G, Peacock W J, Shields W D, Vinters H V   Neuropathologic findings in cortical resections (including hemispherectomies) performed for the treatment of intractable childhood epilepsy Acta neuropathologica, 1992; 83(3): 246-59.
Engel J, Levesque M F, Shields W D   Surgical treatment of the epilepsies: presurgical evaluation Clinical neurosurgery, 1992; 38(3): 514-34.
Adelson P D, Peacock W J, Chugani H T, Comair Y G, Vinters H V, Shields W D, Shewmon D A   Temporal and extended temporal resections for the treatment of intractable seizures in early childhood Pediatric neurosurgery, 1992; 18(4): 169-78.
Shields W D, Shewmon D A, Chugani H T, Peacock W J   Treatment of infantile spasms: medical or surgical? Epilepsia, 1992; 33 Suppl 4(3): S26-31.
Caplan R, Shields W D, Mori L, Yudovin S   Middle childhood onset of interictal psychosis Journal of the American Academy of Child and Adolescent Psychiatry, 1991; 30(6): 893-6.
Vogel D G, Malekzadeh M H, Cornford M E, Schneider J A, Shields W D, Vinters H V   Central nervous system involvement in nephropathic cystinosis Journal of neuropathology and experimental neurology, 1990; 49(6): 591-9.
Gottschalk M E, Geffner M E, Yasuda P M, Shields W D   Reversal of microcephaly and developmental delay after cure of hyperinsulinemic hypoglycemia The Journal of pediatrics, 1990; 117(3): 432-4.
Chugani H T, Shields W D, Shewmon D A, Olson D M, Phelps M E, Peacock W J   Infantile spasms: I. PET identifies focal cortical dysgenesis in cryptogenic cases for surgical treatment Annals of neurology, 1990; 27(4): 406-13.
Kaleita T A, Shields W D, Tesler A, Feig S A   Normal neurodevelopment in four young children treated with bone marrow transplantation for acute leukemia or aplastic anemia Pediatrics, 1989; 83(5): 753-7.
Shields W D   Status epilepticus Pediatric clinics of North America, 1989; 36(2): 383-93.
Shields W D, Nielsen C, Buch D, Jacobsen V, Christenson P, Zachau-Christiansen B, Cherry J D   Relationship of pertussis immunization to the onset of neurologic disorders: a retrospective epidemiologic study The Journal of pediatrics, 1988; 113(5): 801-5.
Chugani H T, Shewmon D A, Peacock W J, Shields W D, Mazziotta J C, Phelps M E   Surgical treatment of intractable neonatal-onset seizures: the role of positron emission tomography Neurology, 1988; 38(8): 1178-88.
Baraff L J, Shields W D, Beckwith L, Strome G, Marcy S M, Cherry J D, Manclark C R   Infants and children with convulsions and hypotonic-hyporesponsive episodes following diphtheria-tetanus-pertussis immunization: follow-up evaluation Pediatrics, 1988; 81(6): 789-94.
Jacobson V, Nielsen C, Buch D, Shields W D, Christenson P, Zachau-Christiansen B, Cherry J D   Relationship of pertussis immunization to the onset of epilepsy, febrile convulsions and central nervous system infections: a retrospective epidemiologic study The Tokai journal of experimental and clinical medicine, 1988; 13 Suppl(6): 137-42.
Al-Mateen M, Philippart M, Shields W D   Rett syndrome. A commonly overlooked progressive encephalopathy in girls American journal of diseases of children (1960), 1986; 140(8): 761-5.
Shields W D, Lake J L, Chugani H T   Amantadine in the treatment of refractory epilepsy in childhood: an open trial in 10 patients Neurology, 1985; 35(4): 579-81.
Feldman R C, Tabsh K M, Shields W D   Correlation of ominous fetal heart rate patterns and brain-specific creatine kinase Obstetrics and gynecology, 1985; 65(4): 476-80.
Kaleita T A, Shields W D, Feig S A, Nuwer M R   Nervous system assessment with evoked potential tests in pediatric bone marrow transplant patients The American journal of pediatric hematology/oncology, 1984; 6(3): 329-32.
Cherry J D, Shields W D   Recurrent seizures after diphtheria, tetanus, and pertussis immunization. Cause and effect v temporal association American journal of diseases of children (1960), 1984; 138(10): 904-7.
Manger M N, Feldman R C, Brown W J, Mitchell L S, Waffarn F, Shields W D   Intracranial ultrasound diagnosis of neonatal periventricular leukomalacia Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 1984; 3(2): 59-63.
Shields W D, Saslow E   Myoclonic, atonic, and absence seizures following institution of carbamazepine therapy in children Neurology, 1983; 33(11): 1487-9.
Kiwak K J, Deray M J, Shields W D   Torticollis in three children with syringomyelia and spinal cord tumor Neurology, 1983; 33(7): 946-8.

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