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Shaping the Future

Yin Tintut, Ph.D.

Contact Information:

Work Phone Number:

310-206-9964
310-794-7846

Department Address:

Medicine/Cardiology A2-237

UNITED STATES

Laboratory Address:

Laboratory
CHS 42-171, 17-067

UNITED STATES

Office Address:

Office
CHS 17-050
David Geffen School of Medicine
10833 Le Conte Avenue
Los Angeles, CA 90095
UNITED STATES

Email Address:

ytintut@mednet.ucla.edu

Professor, Department of Medicine

Affiliate, California NanoSystems Institute

Faculty, Cardiology


A Short Biography:

Dr. Yin Tintut earned her B.S. in Chemistry at California State University, Los Angeles and her Ph.D. in Biochemistry at University of California, Los Angeles in 1995. She has since joined the David Geffen School of Medicine faculty. Her research focuses on understanding molecular mechanisms of inflammatory lipid-induced bone loss and resistance to intermittent PTH treatment.

Publications:

van Venrooij Natalie A, Pereira Renata C, Tintut Yin, Fishbein Michael C, Tumber Navdeep, Demer Linda L, Salusky Isidro B, Wesseling-Perry Katherine   FGF23 protein expression in coronary arteries is associated with impaired kidney function Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2014; .
Keuroghlian Armand, Barroso Ana Dilza, Kirikian Gary, Bezouglaia Olga, Tintut Yin, Tetradis Sotirios, Pirih Flavia Q, Aghaloo Tara   The Effects of Hyperlipidemia on Implant Osseointegration in the Mouse Femur The Journal of oral implantology, 2013; .
Tintut Yin, Demer Linda L   Effects of bioactive lipids and lipoproteins on bone Trends in endocrinology and metabolism: TEM, 2013; .
Li Xin, Garcia Jamie, Lu Jinxiu, Iriana Sidney, Kalajzic Ivo, Rowe David, Demer Linda, Tintut Yin   Mechanism of hyperlipidemia-induced parathyroid hormone (PTH) resistance: A role of PTH receptor and reactive oxygen species in preosteoblasts Journal of cellular biochemistry, 2013; .
Lu Jinxiu, Cheng Henry, Atti Elisa, Shih Diana M, Demer Linda L, Tintut Yin   Role of paraoxonase-1 in bone anabolic effects of parathyroid hormone in hyperlipidemic mice Biochemical and biophysical research communications, 2013; 431(1): 19-24.
Li Rongsong, Mittelstein David, Kam Winnie, Pakbin Payam, Du Yunfeng, Tintut Yin, Navab Mohamad, Sioutas Constantinos, Hsiai Tzung   Atmospheric Ultrafine Particles Promote Vascular Calcification via the NF-?B Signaling Pathway American journal of physiology. Cell physiology, 2012; .
Chen Ting-Hsuan, Zhu Xiaolu, Pan Leiting, Zeng Xingjuan, Garfinkel Alan, Tintut Yin, Demer Linda L, Zhao Xin, Ho Chih-Ming   Directing tissue morphogenesis via self-assembly of vascular mesenchymal cells Biomaterials, 2012; 33(35): 9019-26.
Wong Margaret N, Nguyen Timothy P, Chen Ting-Hsuan, Hsu Jeffrey J, Zeng Xingjuan, Saw Aman, Demer Eric M, Zhao Xin, Tintut Yin, Demer Linda L   Preferred mitotic orientation in pattern formation by vascular mesenchymal cells American journal of physiology. Heart and circulatory physiology, 2012; 303(12): H1411-7.
Sallam Tamer, Cheng Henry, Demer Linda L, Tintut Yin   Regulatory circuits controlling vascular cell calcification Cellular and molecular life sciences : CMLS, 2012; .
Cheng Henry, Reddy Aneela, Sage Andrew, Lu Jinxiu, Garfinkel Alan, Tintut Yin, Demer Linda L   Focal high cell density generates a gradient of patterns in self-organizing vascular mesenchymal cells Journal of vascular research, 2012; 49(5): 441-6.
Chen Ting-Hsuan, Guo Chunyan, Zhao Xin, Yao Yucheng, Bostr÷m Kristina I, Wong Margaret N, Tintut Yin, Demer Linda L, Ho Chih-Ming, Garfinkel Alan   Patterns of periodic holes created by increased cell motility Interface focus, 2012; 2(4): 457-64.
Li Rongsong, Mittelstein David, Lee Juhyun, Fang Karen, Majumdar Rohit, Tintut Yin, Demer Linda L, Hsiai Tzung K   A dynamic model of calcific nodule destabilization in response to monocyte- and oxidized lipid-induced matrix metalloproteinases American journal of physiology. Cell physiology, 2012; 302(4): C658-65.
Pirih Flavia, Lu Jinxiu, Ye Fei, Bezouglaia Olga, Atti Elisa, Ascenzi Maria-Grazia, Tetradis Sotirios, Demer Linda, Aghaloo Tara, Tintut Yin   Adverse effects of hyperlipidemia on bone regeneration and strength Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2012; 27(2): 309-18.
Chen Ting-Hsuan, Hsu Jeffrey J, Zhao Xin, Guo Chunyan, Wong Margaret N, Huang Yi, Li Zongwei, Garfinkel Alan, Ho Chih-Ming, Tintut Yin, Demer Linda L   Left-right symmetry breaking in tissue morphogenesis via cytoskeletal mechanics Circulation research, 2012; 110(4): 551-9.
Geng Yifan, Hsu Jeffrey J, Lu Jinxiu, Ting Tabitha C, Miyazaki Makoto, Demer Linda L, Tintut Yin   Role of cellular cholesterol metabolism in vascular cell calcification The Journal of biological chemistry, 2011; 286(38): 33701-6.
Ting Tabitha C, Miyazaki-Anzai Shinobu, Masuda Masashi, Levi Moshe, Demer Linda L, Tintut Yin, Miyazaki Makoto   Increased lipogenesis and stearate accelerate vascular calcification in calcifying vascular cells The Journal of biological chemistry, 2011; 286(27): 23938-49.
Sage Andrew P, Lu Jinxiu, Atti Elisa, Tetradis Sotirios, Ascenzi Maria-Grazia, Adams Douglas J, Demer Linda L, Tintut Yin   Hyperlipidemia induces resistance to PTH bone anabolism in mice via oxidized lipids Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011; 26(6): 1197-206.
Byon Chang Hyun, Sun Yong, Chen Jianfeng, Yuan Kaiyu, Mao Xia, Heath Jack M, Anderson Peter G, Tintut Yin, Demer Linda L, Wang Deli, Chen Yabing   Runx2-upregulated receptor activator of nuclear factor ╬║B ligand in calcifying smooth muscle cells promotes migration and osteoclastic differentiation of macrophages Arteriosclerosis, thrombosis, and vascular biology, 2011; 31(6): 1387-96.
Tintut Yin, Demer Linda   The hemosteoblast: friend or foe? Circulation research, 2011; 108(9): 1038-9.
Sage Andrew P, Lu Jinxiu, Atti Elisa, Tetradis Sotirios, Ascenzi Maria-Grazia, Adams Douglas J, Demer Linda L, Tintut Yin   Hyperlipidemia induces resistance to PTH bone anabolism in mice via oxidized lipids Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2010; 79(4): .
Tseng Wendy, Graham Lucia S, Geng Yifan, Reddy Aneela, Lu Jinxiu, Effros Rita B, Demer Linda, Tintut Yin   PKA-induced receptor activator of NF-kappaB ligand (RANKL) expression in vascular cells mediates osteoclastogenesis but not matrix calcification The Journal of biological chemistry, 2010; 285(39): 29925-31.
Sage Andrew P, Tintut Yin, Demer Linda L   Regulatory mechanisms in vascular calcification Nature reviews. Cardiology, 2010; 7(9): 528-36.
Demer Linda, Tintut Yin   The bone-vascular axis in chronic kidney disease Current opinion in nephrology and hypertension, 2010; 19(4): 349-53.
Graham Lucia S, Tintut Yin, Parhami Farhad, Kitchen Christina M R, Ivanov Yevgeniv, Tetradis Sotirios, Effros Rita B   Bone density and hyperlipidemia: the T lymphocyte connection Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2010; 19(4): .
Tseng Wendy, Lu Jinxiu, Bishop Gail A, Watson Andrew D, Sage Andrew P, Demer Linda, Tintut Yin   Regulation of interleukin-6 expression in osteoblasts by oxidized phospholipids Journal of lipid research, 2010; 51(5): 1010-6.
Graham Lucia S, Parhami Farhad, Tintut Yin, Kitchen Christina M R, Demer Linda L, Effros Rita B   Oxidized lipids enhance RANKL production by T lymphocytes: implications for lipid-induced bone loss Clinical immunology (Orlando, Fla.), 2009; 133(2): 265-75.
Hoshino Tetsuya, Chow Lori A, Hsu Jeffrey J, Perlowski Alice A, Abedin Moeen, Tobis Jonathan, Tintut Yin, Mal Ajit K, Klug William S, Demer Linda L   Mechanical stress analysis of a rigid inclusion in distensible material: a model of atherosclerotic calcification and plaque vulnerability American journal of physiology. Heart and circulatory physiology, 2009; 297(2): H802-10.
Demer Linda L, Tintut Yin   Mechanisms linking osteoporosis with cardiovascular calcification Current osteoporosis reports, 2009; 7(2): 42-6.
Sage Andrew, Tintut Yin, Garfinkel Alan, Demer Linda   Systems biology of vascular calcification Trends in cardiovascular medicine, 2009; 19(4): 118-23.
Hsu Jeffrey J, Lu Jinxiu, Huang Michael S, Geng Yifan, Sage Andrew P, Bradley Michelle N, Tontonoz Peter, Demer Linda L, Tintut Yin   T0901317, an LXR agonist, augments PKA-induced vascular cell calcification FEBS letters, 2009; 583(8): 1344-8.
Demer Linda L, Sage Andrew P, Tintut Yin   Nanoscale architecture in atherosclerotic calcification Arteriosclerosis, thrombosis, and vascular biology, 2008; 28(11): 1882-4.
Huang Michael S, Lu Jinxiu, Ivanov Yevgeniy, Sage Andrew P, Tseng Wendy, Demer Linda L, Tintut Yin   Hyperlipidemia impairs osteoanabolic effects of PTH Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2008; 23(10): 1672-9.
Huang Michael S, Sage Andrew P, Lu Jinxiu, Demer Linda L, Tintut Yin   Phosphate and pyrophosphate mediate PKA-induced vascular cell calcification Biochemical and biophysical research communications, 2008; 374(3): 553-8.
Hsu Jeffrey J, Tintut Yin, Demer Linda L   Vitamin D and osteogenic differentiation in the artery wall Clinical journal of the American Society of Nephrology : CJASN, 2008; 3(5): 1542-7.
Demer Linda L, Tintut Yin   Vascular calcification: pathobiology of a multifaceted disease Circulation, 2008; 117(22): 2938-48.
Hsu Jeffrey J, Tintut Yin, Demer Linda L   Murine models of atherosclerotic calcification Current drug targets, 2008; 9(3): 224-8.
Morony Sean, Tintut Yin, Zhang Zina, Cattley Russell C, Van Gwyneth, Dwyer Denise, Stolina Marina, Kostenuik Paul J, Demer Linda L   Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice Circulation, 2008; 117(3): 411-20.
Huang Michael S, Morony Sean, Lu Jinxiu, Zhang Zina, Bezouglaia Olga, Tseng Wendy, Tetradis Sotirios, Demer Linda L, Tintut Yin   Atherogenic phospholipids attenuate osteogenic signaling by BMP-2 and parathyroid hormone in osteoblasts The Journal of biological chemistry, 2007; 282(29): 21237-43.
Jaffe Iris Z, Tintut Yin, Newfell Brenna G, Demer Linda L, Mendelsohn Michael E   Mineralocorticoid receptor activation promotes vascular cell calcification Arteriosclerosis, thrombosis, and vascular biology, 2007; 27(4): 799-805.
Tintut Yin, Demer Linda   Role of osteoprotegerin and its ligands and competing receptors in atherosclerotic calcification Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2006; 54(7): 395-401.
Lin Tiantian C, Tintut Yin, Lyman Althea, Mack Wendy, Demer Linda L, Hsiai Tzung K   Mechanical response of a calcified plaque model to fluid shear force Annals of biomedical engineering, 2006; 34(10): 1535-41.
Demer Linda L, Tintut Yin   Pitting phosphate transport inhibitors against vascular calcification Circulation research, 2006; 98(7): 857-9.
Abedin M, Lim J, Tang T B, Park D, Demer L L, Tintut Y   N-3 fatty acids inhibit vascular calcification via the p38-mitogen-activated protein kinase and peroxisome proliferator-activated receptor-gamma pathways Circulation research, 2006; 98(6): 727-9.
Tintut Yin, Abedin Moeen, Cho John, Choe Andrea, Lim Jina, Demer Linda L   Regulation of RANKL-induced osteoclastic differentiation by vascular cells Journal of molecular and cellular cardiology, 2005; 39(2): 389-93.
Demer Linda L, Tintut Yin   Return to ectopia: stem cells in the artery wall Arteriosclerosis, thrombosis, and vascular biology, 2005; 25(7): 1307-8.
Radcliff Kristen, Tang Tri-Bang, Lim Jina, Zhang Zina, Abedin Moeen, Demer Linda L, Tintut Yin   Insulin-like growth factor-I regulates proliferation and osteoblastic differentiation of calcifying vascular cells via extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase pathways Circulation research, 2005; 96(4): 398-400.
Abedin Moeen, Tintut Yin, Demer Linda L   Mesenchymal stem cells and the artery wall Circulation research, 2004; 95(7): 671-6.
Abedin Moeen, Tintut Yin, Demer Linda L   Vascular calcification: mechanisms and clinical ramifications Arteriosclerosis, thrombosis, and vascular biology, 2004; 24(7): 1161-70.
Garfinkel Alan, Tintut Yin, Petrasek Danny, Bostr├Âm Kristina, Demer Linda L   Pattern formation by vascular mesenchymal cells Proceedings of the National Academy of Sciences of the United States of America, 2004; 101(25): 9247-50.
Tintut Yin, Morony Sean, Demer Linda L   Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo Arteriosclerosis, thrombosis, and vascular biology, 2004; 24(2): e6-10.
Tintut Yin, Alfonso Zeni, Saini Trishal, Radcliff Kristen, Watson Karol, Bostr÷m Kristina, Demer Linda L   Multilineage potential of cells from the artery wall Circulation, 2003; 108(20): 2505-10.
Demer Linda L, Tintut Yin   Mineral exploration: search for the mechanism of vascular calcification and beyond: the 2003 Jeffrey M. Hoeg Award lecture Arteriosclerosis, thrombosis, and vascular biology, 2003; 23(10): 1739-43.
Mody Nilam, Tintut Yin, Radcliff Kristen, Demer Linda L   Vascular calcification and its relation to bone calcification: possible underlying mechanisms Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2003; 10(2): 177-83.
Parhami Farhad, Mody Nilam, Gharavi Nima, Ballard Alex J, Tintut Yin, Demer Linda L   Role of the cholesterol biosynthetic pathway in osteoblastic differentiation of marrow stromal cells Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2002; 17(11): 1997-2003.
Parhami Farhad, Basseri Benjamin, Hwang Jason, Tintut Yin, Demer Linda L   High-density lipoprotein regulates calcification of vascular cells Circulation research, 2002; 91(7): 570-6.
Demer Linda L, Tintut Yin, Parhami Farhad   Novel mechanisms in accelerated vascular calcification in renal disease patients Current opinion in nephrology and hypertension, 2002; 11(4): 437-43.
Tintut Yin, Parhami Farhad, Tsingotjidou Anastasia, Tetradis Sotirios, Territo Mary, Demer Linda L   8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway The Journal of biological chemistry, 2002; 277(16): 14221-6.
Tintut Yin, Patel Jignesh, Territo Mary, Saini Trishal, Parhami Farhad, Demer Linda L   Monocyte/macrophage regulation of vascular calcification in vitro Circulation, 2002; 105(5): 650-5.
Parhami F, Tintut Y, Ballard A, Fogelman A M, Demer L L   Leptin enhances the calcification of vascular cells: artery wall as a target of leptin Circulation research, 2001; 88(9): 954-60.
Parhami F, Tintut Y, Beamer W G, Gharavi N, Goodman W, Demer L L   Atherogenic high-fat diet reduces bone mineralization in mice Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2001; 16(1): 182-8.
Tintut Y, Patel J, Parhami F, Demer L L   Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway Circulation, 2000; 102(21): 2636-42.
Parhami F, Jackson S M, Tintut Y, Le V, Balucan J P, Territo M, Demer L L   Atherogenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1999; 14(12): 2067-78.
Tintut Y, Parhami F, Le V, Karsenty G, Demer L L   Inhibition of osteoblast-specific transcription factor Cbfa1 by the cAMP pathway in osteoblastic cells. Ubiquitin/proteasome-dependent regulation The Journal of biological chemistry, 1999; 274(41): 28875-9.
Tintut Y, Parhami F, Bostr÷m K, Jackson S M, Demer L L   cAMP stimulates osteoblast-like differentiation of calcifying vascular cells. Potential signaling pathway for vascular calcification The Journal of biological chemistry, 1998; 273(13): 7547-53.
Parhami F, Morrow A D, Balucan J, Leitinger N, Watson A D, Tintut Y, Berliner J A, Demer L L   Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients Arteriosclerosis, thrombosis, and vascular biology, 1997; 17(4): 680-7.
Tintut Y, Wang J T, Gralla J D   Abortive cycling and the release of polymerase for elongation at the sigma 54-dependent glnAp2 promoter The Journal of biological chemistry, 1995; 270(41): 24392-8.
Tintut Y, Gralla J D   PCR mutagenesis identifies a polymerase-binding sequence of sigma 54 that includes a sigma 70 homology region Journal of bacteriology, 1995; 177(20): 5818-25.
Tintut Y, Wang J T, Gralla J D   A novel bacterial transcription cycle involving sigma 54 Genes & development, 1995; 9(18): 2305-13.
Tintut Y, Wong C, Jiang Y, Hsieh M, Gralla J D   RNA polymerase binding using a strongly acidic hydrophobic-repeat region of sigma 54 Proceedings of the National Academy of Sciences of the United States of America, 1994; 91(6): 2120-4.
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