corneal structure, diseases and stem cells; gene therapy for diabetic corneal disease, retinal angiogenesis, nanotechnology for cancer treatment
Alexander V. Ljubimov is Director of Regenerative Medicine Institute Eye Program at Cedars-Sinai Medical Center and Professor of Medicine at the David Geffen School of Medicine at the University of California, Los Angeles.
Dr. Ljubimov is an internationally recognized eye researcher who has written many peer-reviewed papers, reviews, and book chapters. His primary research interests include investigating new promising inhibitors of a key cellular enzyme that block abnormal retinal vessel growth and using gene therapy to restore normal corneal structure and function in patients with diabetic retinopathy.
Dr. Ljubimov has been fully funded by NIH since 1998 (two current R01 grants). In 2006, he received a Winnick Family Clinical Research Scholar award from Cedars-Sinai. He has been serving on many NIH Study Sections and was a member of the American Diabetes Association Grant Review Panel. He is an editorial board member of 10 scientific journals.
Dr. Ljubimov received his master's of science degree from Moscow State University in Russia and received his PhD and D.Sc. degrees from the Russian Cancer Research Center. He completed postdoctoral training in the International Agency for Research on Cancer in Lyon, France. Before coming to Cedars-Sinai in 1993 he worked in the Burnham Institute in La Jolla, California, as a UICC-Eleanor Roosevelt Cancer Research Fellow.
Dr. Alexander Ljubimov is an internationally recognized eye researcher, with over 100 peer-reviewed papers, reviews, and book chapters published. He is Adjunct Professor of Medicine at the David Geffen School of Medicine at UCLA. Dr. Ljubimov is also Director of Regenerative Institute Eye Program at Cedars-Sinai Medical Center, and Professor of Biomedical Sciences and Neurosurgery. His research interests include using innovative gene therapy to restore normal stem cell functions in diabetic corneas, and studying new inhibitors of a key cellular enzyme CK2 that block abnormal retinal vessel growth in diabetic retinopathy. He is also involved in developing new targeted nanotherapeutics for cancer and eye diseases, and directs studies aiming at making corneal cells from induced pluripotent stem cells. Dr. Ljubimov's research has been funded by NIH since 1995 (with two current R01 grants). In 2006-2009, he was a recipient of the Winnick Family Clinical Research Scholar award from Cedars-Sinai Medical Center. He has served on numerous NIH Study Sections, was a member of the American Diabetes Association Grant Review Panel, and is a grant reviewer for various agencies in U.S. and abroad. He currently is a standing member on the NIH DPVS Study Section. Dr. Ljubimov is an Editorial Board member of 10 scientific journals including Investigative Ophthalmology and Visual Science, Experimental Eye Research, Molecular Vision, Brain Research Bulletin, Experimental Biology and Medicine, Vascular Cell, Conference Papers in Medicine, The Open Ophthalmology Journal, PLoS One, and Frontiers in Bioscience. In 2010, he was named Silver Fellow of the Association for Research in Vision and Ophthalmology (ARVO), and Gold Fellow in 2014. In 2008-2010 he was an elected chair of the membership committee of the International Society for Eye Research. Dr. Ljubimov received his summa cum laude M.S. degree from Moscow State University (Moscow, Russia), and his Ph.D. and D.Sc. degrees from the Russian Cancer Research Center. He completed postdoctoral training in the International Agency for Research on Cancer in Lyon, France. Before coming to Cedars-Sinai Medical Center in 1993 he worked in the Sanford-Burnham Institute in La Jolla, California, as a UICC-Eleanor Roosevelt Cancer Research Fellow. He has a background in cancer research and is working on eye diseases since 1993.
Kramerov AA, Ahmed K, Ljubimov AV Cell rounding in cultured human astrocytes and vascular endothelial cells upon inhibition of CK2 is mediated by actomyosin cytoskeleton alterations Journal of cellular biochemistry. 2012 May 2. doi: 10.1002/jcb.24171, 2012; .
Kramerov AA, Golub AG, Bdzhola VG, Yarmoluk SM, Ahmed K, Bretner M, Ljubimov AV Treatment of cultured human astrocytes and vascular endothelial cells with protein kinase CK2 inhibitors induces early changes in cell shape and cytoskeleton Molecular and cellular biochemistry, 2011; 349(1-2): 125-37.
Saghizadeh M, Soleymani S, Harounian A, Bhakta B, Troyanovsky SM, Brunken WJ, Pellegrini G, Ljubimov AV Alterations of epithelial stem cell marker patterns in human diabetic corneas and effects of c-met gene therapy Molecular vision, 2011; 17(4): 2177-90.
Inoue S, Ding H, Portilla-Arias J, Hu J, Konda B, Fujita M, Espinoza A, Suhane S, Riley M, Gates M, Patil R, Penichet ML, Ljubimov AV, Black KL, Holler E, Ljubimova JY Polymalic acid-based nanobiopolymer provides efficient systemic breast cancer treatment by inhibiting both HER2/neu receptor synthesis and activity Cancer research, 2011; 71(4): 1454-64.
Koronyo-Hamaoui M, Koronyo Y, Ljubimov AV, Miller CA, Ko MK, Black KL, Schwartz M, Farkas DL Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model NeuroImage, 2011; 54 Suppl 1(4): S204-17.
Kramerov AA, Ljubimov AV Focus on Molecules: Protein kinase CK2 Experimental eye research, 2010; 54 Suppl 1(4): .
Ding H, Inoue S, Ljubimov AV, Patil R, Portilla-Arias J, Hu J, Konda B, Wawrowsky KA, Fujita M, Karabalin N, Sasaki T, Black KL, Holler E, Ljubimova JY Inhibition of brain tumor growth by intravenous poly (β-L-malic acid) nanobioconjugate with pH-dependent drug release [corrected] Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(42): 18143-8.
Hu J, Ljubimova JY, Inoue S, Konda B, Patil R, Ding H, Espinoza A, Wawrowsky KA, Patil C, Ljubimov AV, Black KL Phosphodiesterase type 5 inhibitors increase Herceptin transport and treatment efficacy in mouse metastatic brain tumor models PloS one, 2010; 5(4): e10108.
Saghizadeh M, Kramerov AA, Yu FX, Castro MG, Ljubimov AV Normalization of wound healing and diabetic markers in organ cultured human diabetic corneas by adenoviral delivery of c-Met gene Investigative ophthalmology & visual science, 2010; 51(4): 1970-80.
Allen SJ, Mott KR, Ljubimov AV, Ghiasi H Exacerbation of corneal scarring in HSV-1 gK-immunized mice correlates with elevation of CD8+CD25+ T cells in corneas of ocularly infected mice Virology, 2010; 399(1): 11-22.
Saghizadeh M, Kramerov AA, Yaghoobzadeh Y, Hu J, Ljubimova JY, Black KL, Castro MG, Ljubimov AV Adenovirus-driven overexpression of proteinases in organ-cultured normal human corneas leads to diabetic-like changes Brain research bulletin, 2010; 81(2-3): 262-72.
Ljubimov AV Editorial for the special issue of Brain Research Bulletin "Advances in corneal and retinal research" Brain research bulletin, 2010; 81(2-3): 197.
Saghizadeh M, Akhmedov NB, Yamashita CK, Gribanova Y, Theendakara V, Mendoza E, Nelson SF, Ljubimov AV, Farber DB ZBED4, a BED-type zinc-finger protein in the cones of the human retina Investigative ophthalmology & visual science, 2009; 50(8): 3580-8.
Xu KP, Li Y, Ljubimov AV, Yu FX High glucose suppresses epidermal growth factor receptor/phosphatidylinositol 3-kinase/Akt signaling pathway and attenuates corneal epithelial wound healing Diabetes, 2009; 58(5): 1077-85.
Kramerov AA, Saghizadeh M, Caballero S, Shaw LC, Li Calzi S, Bretner M, Montenarh M, Pinna LA, Grant MB, Ljubimov AV Inhibition of protein kinase CK2 suppresses angiogenesis and hematopoietic stem cell recruitment to retinal neovascularization sites Molecular and cellular biochemistry, 2008; 316(1-2): 177-86.
Maguen E, Rabinowitz YS, Regev L, Saghizadeh M, Sasaki T, Ljubimov AV Alterations of extracellular matrix components and proteinases in human corneal buttons with INTACS for post-laser in situ keratomileusis keratectasia and keratoconus Cornea, 2008; 27(5): 565-73.
Ljubimova JY, Fujita M, Ljubimov AV, Torchilin VP, Black KL, Holler E Poly(malic acid) nanoconjugates containing various antibodies and oligonucleotides for multitargeting drug delivery Nanomedicine (London, England), 2008; 3(2): 247-65.
Liu J, Saghizadeh M, Tuli SS, Kramerov AA, Lewin AS, Bloom DC, Hauswirth WW, Castro MG, Schultz GS, Ljubimov AV Different tropism of adenoviruses and adeno-associated viruses to corneal cells: implications for corneal gene therapy Molecular vision, 2008; 14(2): 2087-96.
Grant MB, Boulton ME, Ljubimov AV Erythropoietin: when liability becomes asset in neurovascular repair The Journal of clinical investigation, 2008; 118(2): 467-70.
Kabosova A, Azar DT, Bannikov GA, Campbell KP, Durbeej M, Ghohestani RF, Jones JCR, Kenney MC, Koch M, Ninomiya Y, Patton BL, Paulsson M, Sado Y, Sage EH, Sasaki T, Sorokin LM, Steiner-Champliaud MF, Sun TT, Sundarraj N, Timpl R, Virtanen I, Ljubimov AV Compositional differences between infant and adult human corneal basement membranes Investigative ophthalmology & visual science, 2007; 48(11): 4989-99.
Maguen E, Maguen B, Regev L, Ljubimov AV Immunohistochemical evaluation of two corneal buttons with post-LASIK keratectasia Cornea, 2007; 26(8): 983-91.
Afzal A, Shaw LC, Ljubimov AV, Boulton ME, Segal MS, Grant MB Retinal and choroidal microangiopathies: therapeutic opportunities Microvascular research, 2007; 74(2-3): 131-44.
Ljubimova JY, Fujita M, Khazenzon NM, Ljubimov AV, Black KL Changes in laminin isoforms associated with brain tumor invasion and angiogenesis Frontiers in bioscience, 2006; 11(4): 81-8.
Kramerov AA, Saghizadeh M, Pan H, Kabosova A, Montenarh M, Ahmed K, Penn JS, Chan CK, Hinton DR, Grant MB, Ljubimov AV Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina The American journal of pathology, 2006; 168(5): 1722-36.
Fujita M, Khazenzon NM, Ljubimov AV, Lee BS, Virtanen I, Holler E, Black KL, Ljubimova JY Inhibition of laminin-8 in vivo using a novel poly(malic acid)-based carrier reduces glioma angiogenesis Angiogenesis, 2006; 9(4): 183-91.
Saghizadeh M, Kramerov AA, Tajbakhsh J, Aoki AM, Wang C, Chai NN, Ljubimova JY, Sasaki T, Sosne G, Carlson MRJ, Nelson SF, Ljubimov AV Proteinase and growth factor alterations revealed by gene microarray analysis of human diabetic corneas Investigative ophthalmology & visual science, 2005; 46(10): 3604-15.
Fujita M, Khazenzon NM, Bose S, Sekiguchi K, Sasaki T, Carter WG, Ljubimov AV, Black KL, Ljubimova JY Overexpression of β1-chain-containing laminins in capillary basement membranes of human breast cancer and its metastases Breast cancer research, 2005; 7(4): R411-21.
Ljubimov AV, Grant MB P450 in the angiogenesis affair: the unusual suspect The American journal of pathology, 2005; 166(2): 341-4.
Ljubimov AV, Caballero S, Aoki AM, Pinna LA, Grant MB, Castellon R Involvement of protein kinase CK2 in angiogenesis and retinal neovascularization Investigative ophthalmology & visual science, 2004; 45(12): 4583-91.
Kenney MC, Atilano SR, Zorapapel N, Holguin B, Gaster RN, Ljubimov AV Altered expression of aquaporins in bullous keratopathy and Fuchs' dystrophy corneas The journal of histochemistry and cytochemistry, 2004; 52(10): 1341-50.
Kenney MC, Zorapapel N, Atilano S, Chwa M, Ljubimov A, Brown D Insulin-like growth factor-I (IGF-I) and transforming growth factor-β (TGF-β) modulate tenascin-C and fibrillin-1 in bullous keratopathy stromal cells in vitro Experimental eye research, 2003; 77(5): 537-46.
Khazenzon NM, Ljubimov AV, Lakhter AJ, Fujita M, Fujiwara H, Sekiguchi K, Sorokin LM, Petäjäniemi N, Virtanen I, Black KL, Ljubimova JY Antisense inhibition of laminin-8 expression reduces invasion of human gliomas in vitro Molecular cancer therapeutics, 2003; 2(10): 985-94.
Kabosova A, Kramerov AA, Aoki AM, Murphy G, Zieske JD, Ljubimov AV Human diabetic corneas preserve wound healing, basement membrane, integrin and MMP-10 differences from normal corneas in organ culture Experimental eye research, 2003; 77(2): 211-7.
Wilson SH, Ljubimov AV, Morla AO, Caballero S, Shaw LC, Spoerri PE, Tarnuzzer RW, Grant MB Fibronectin fragments promote human retinal endothelial cell adhesion and proliferation and ERK activation through α5β1 integrin and PI 3-kinase Investigative ophthalmology & visual science, 2003; 44(4): 1704-15.
Castellon R, Caballero S, Hamdi HK, Atilano SR, Aoki AM, Tarnuzzer RW, Kenney MC, Grant MB, Ljubimov AV Effects of tenascin-C on normal and diabetic retinal endothelial cells in culture Investigative ophthalmology & visual science, 2002; 43(8): 2758-66.
Castellon R, Hamdi HK, Sacerio I, Aoki AM, Kenney MC, Ljubimov AV Effects of angiogenic growth factor combinations on retinal endothelial cells Experimental eye research, 2002; 74(4): 523-35.
Ljubimov AV, Atilano SR, Garner MH, Maguen E, Nesburn AB, Kenney MC Extracellular matrix and Na+,K+-ATPase in human corneas following cataract surgery: comparison with bullous keratopathy and Fuchs' dystrophy corneas Cornea, 2002; 21(1): 74-80.
Maguen E, Zorapapel NC, Zieske JD, Ninomiya Y, Sado Y, Kenney MC, Ljubimov AV Extracellular matrix and matrix metalloproteinase changes in human corneas after complicated laser-assisted in situ keratomileusis (LASIK) Cornea, 2002; 21(1): 95-100.
Ljubimov AV, Saghizadeh M, Pytela R, Sheppard D, Kenney MC Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas The journal of histochemistry and cytochemistry, 2001; 49(11): 1341-50.
Saghizadeh M, Chwa M, Aoki A, Lin B, Pirouzmanesh A, Brown DJ, Ljubimov AV, Kenney MC Altered expression of growth factors and cytokines in keratoconus, bullous keratopathy and diabetic human corneas Experimental eye research, 2001; 73(2): 179-89.
Ljubimova JY, Lakhter AJ, Loksh A, Yong WH, Riedinger MS, Miner JH, Sorokin LM, Ljubimov AV, Black KL Overexpression of alpha4 chain-containing laminins in human glial tumors identified by gene microarray analysis Cancer research, 2001; 61(14): 5601-10.
Kenney MC, Chwa M, Lin B, Huang GH, Ljubimov AV, Brown DJ Identification of cell types in human diseased corneas Cornea, 2001; 20(3): 309-16.
Saghizadeh M, Brown DJ, Castellon R, Chwa M, Huang GH, Ljubimova JY, Rosenberg S, Spirin KS, Stolitenko RB, Adachi W, Kinoshita S, Murphy G, Windsor LJ, Kenney MC, Ljubimov AV Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and integrin alterations The American journal of pathology, 2001; 158(2): 723-34.
Spirin KS, Ljubimov AV, Castellon R, Wiedoeft O, Marano M, Sheppard D, Kenney MC, Brown DJ Analysis of gene expression in human bullous keratopathy corneas containing limiting amounts of RNA Investigative ophthalmology & visual science, 1999; 40(13): 3108-15.
Spirin KS, Saghizadeh M, Lewin SL, Zardi L, Kenney MC, Ljubimov AV Basement membrane and growth factor gene expression in normal and diabetic human retinas Current eye research, 1999; 18(6): 490-9.
Ljubimova JY, Wilson SE, Petrovic LM, Ehrenman K, Ljubimov AV, Demetriou AA, Geller SA, Black KL Novel human malignancy-associated gene (MAG) expressed in various tumors and in some tumor preexisting conditions Cancer research, 1998; 58(19): 4475-9.
Ljubimov AV, Alba SA, Burgeson RE, Ninomiya Y, Sado Y, Sun TT, Nesburn AB, Kenney MC, Maguen E Extracellular matrix changes in human corneas after radial keratotomy Experimental eye research, 1998; 67(3): 265-72.
Ljubimov AV, Huang ZS, Huang GH, Burgeson RE, Gullberg D, Miner JH, Ninomiya Y, Sado Y, Kenney MC Human corneal epithelial basement membrane and integrin alterations in diabetes and diabetic retinopathy The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 1998; 46(9): 1033-41.
Grant MB, Caballero S, Tarnuzzer RW, Bass KE, Ljubimov AV, Spoerri PE, Galardy RE Matrix metalloproteinase expression in human retinal microvascular cells Diabetes, 1998; 47(8): 1311-7.
Ljubimov AV, Saghizadeh M, Spirin KS, Khin HL, Lewin SL, Zardi L, Bourdon MA, Kenney MC Expression of tenascin-C splice variants in normal and bullous keratopathy human corneas Investigative ophthalmology & visual science, 1998; 39(7): 1135-42.
Ljubimov AV, Saghizadeh M, Spirin KS, Mecham RP, Sakai LY, Kenney MC Increased expression of fibrillin-1 in human corneas with bullous keratopathy Cornea, 1998; 17(3): 309-14.
Saghizadeh M, Khin HL, Bourdon MA, Kenney MC, Ljubimov AV Novel splice variants of human tenascin-C mRNA identified in normal and bullous keratopathy corneas Cornea, 1998; 17(3): 326-32.
Maguen E, Alba SA, Burgeson RE, Butkowski RJ, Michael AF, Kenney MC, Nesburn AB, Ljubimov AV Alterations of corneal extracellular matrix after multiple refractive procedures: a clinical and immunohistochemical study Cornea, 1997; 16(6): 675-82.
Kenney MC, Nesburn AB, Burgeson RE, Butkowski RJ, Ljubimov AV Abnormalities of the extracellular matrix in keratoconus corneas Cornea, 1997; 16(3): 345-51.
Ljubimov AV, Burgeson RE, Butkowski RJ, Couchman JR, Zardi L, Ninomiya Y, Sado Y, Huang ZS, Nesburn AB, Kenney MC Basement membrane abnormalities in human eyes with diabetic retinopathy The journal of histochemistry and cytochemistry, 1996; 44(12): 1469-79.
Myint E, Brown DJ, Ljubimov AV, Kyaw M, Kenney MC Cleavage of human corneal type VI collagen alpha 3 chain by matrix metalloproteinase-2 Cornea, 1996; 15(5): 490-6.
Ugarova TP, Ljubimov AV, Deng L, Plow EF Proteolysis regulates exposure of the IIICS-1 adhesive sequence in plasma fibronectin Biochemistry, 1996; 35(33): 10913-21.
Ljubimov AV, Burgeson RE, Butkowski RJ, Couchman JR, Wu RR, Ninomiya Y, Sado Y, Maguen E, Nesburn AB, Kenney MC Extracellular matrix alterations in human corneas with bullous keratopathy Investigative ophthalmology & visual science, 1996; 37(6): 997-1007.
Couchman JR, Ljubimov AV, Sthanam M, Horchar T, Hassell JR Antibody mapping and tissue localization of globular and cysteine-rich regions of perlecan domain III The journal of histochemistry and cytochemistry, 1995; 43(9): 955-63.
Ljubimov AV, Burgeson RE, Butkowski RJ, Michael AF, Sun TT, Kenney MC Human corneal basement membrane heterogeneity: topographical differences in the expression of type IV collagen and laminin isoforms Laboratory investigation, 1995; 72(4): 461-73.
Guelstein VI, Tchypysheva TA, Ermilova VD, Ljubimov AV Myoepithelial and basement membrane antigens in benign and malignant human breast tumors International journal of cancer, 1993; 53(2): 269-77.
Ljubimov AV, Bartek J, Couchman JR, Kapuller LL, Veselov VV, Kovarik J, Perevoshchikov AG, Krutovskikh VA Distribution of individual components of basement membrane in human colon polyps and adenocarcinomas as revealed by monoclonal antibodies International journal of cancer, 1992; 50(4): 562-6.
Couchman JR, Ljubimov AV Mammalian tissue distribution of a large heparan sulfate proteoglycan detected by monoclonal antibodies Matrix (Stuttgart, Germany), 1989; 9(4): 311-21.
Horiguchi Y, Couchman JR, Ljubimov AV, Yamasaki H, Fine JD Distribution, ultrastructural localization, and ontogeny of the core protein of a heparan sulfate proteoglycan in human skin and other basement membranes The journal of histochemistry and cytochemistry, 1989; 37(7): 961-70.
Horiguchi Y, Fine JD, Ljubimov AV, Yamasaki H, Couchman JR Entactin: ultrastructural localization of an ubiquitous basement membrane glycoprotein in mouse skin Archives of dermatological research, 1989; 281(6): 427-32.
Ljubimov AV, Krutovskikh VA Distribution of laminin and collagen type IV in rat colon tumors induced by 1,2-dimethylhydrazine Invasion & metastasis, 1987; 7(2): 61-72.
Ljubimov AV, Afanasjeva AV, Litvinova LV, Senin VM Basement membrane components produced by a mouse ascites teratocarcinoma TB24. Analysis with monoclonal and polyclonal antibodies Experimental cell research, 1986; 165(2): 530-40.
Ljubimov AV, Martel N, Yamasaki H Response of cultured rat liver epithelial cell lines to tumour-promoting phorbol esters Experimental cell research, 1985; 156(2): 311-26.
Vasiliev JM, Gelfand IM, Domnina LV, Zacharova OS, Ljubimov AV Contact inhibition of phagocytosis in epithelial sheets: alterations of cell surface properties induced by cell-cell contacts Proceedings of the National Academy of Sciences of the United States of America, 1975; 72(2): 719-22.
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