Miklos Peterfy, Ph.D.

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A Short Biography:

Dr Peterfy is Associate Professor at the Medical Genetics Research Institute at Cedars-Sinai Medical Center, where he is Director of the Laboratory of Murine Models for Metabolic Disease. Dr Peterfy has been serving on the UCLA School of Medicine faculty since 1998.
Work Titles
UCLA Adjunct Professor, Medicine
Education:
Degrees:
Ph.D.

Contact Information:

Email Address:

mpeterfy@ucla.edu


Website:

Peterfy lab web-site

Work Phone Number:

310-423-0314

Mailing Address:

Cedars-Sinai Medical Center
8700 Beverly Blvd.
Los Angeles, CA 90048


Research Interest:

Molecular mechanisms in metabolic diseases

Dr Peterfy's research focuses on common metabolic diseases associated with the Metabolic Syndrome including obesity, diabetes and dyslipidemia. Using molecular, cellular and in vivo approaches in mouse models, he investigates the genetic determinants and mechanisms underlying metabolic abnormalities. His current research focuses on genes responsible for hyperlipidemia in mouse models and human populations. Dr Peterfy's significant research contributions include the discovery and characterization of LMF1 and a novel molecular mechanism in hypertriglyceridemia.

Detailed Biography:

Dr Peterfy earned his bachelor's degree in chemical engineering and doctorate in molecular biology at Budapest University of Technology in Hungary. He was postdoctoral fellow at the National Institutes of Health and Research Scientist at Amgen, Inc. Dr Peterfy joined the UCLA School of Medicine faculty in 1998 and was promoted to Associate Professor in 2007. He became faculty at Cedars-Sinai Medical Center in 2007. Dr Peterfy is actively involved in undergraduate and graduate teaching at UCLA and CSMC.

Publications:

A selected list of publications:

Ehrhardt N, Bedoya C, Péterfy M.   Embryonic viability, lipase deficiency, hypertriglyceridemia and neonatal lethality in a novel LMF1-deficient mouse model Nutr Metab, 2014; 11: 37.
Mao HZ, Ehrhardt N, Bedoya C, Gomez JA, DeZwaan-McCabe D, Mungrue IN, Kaufman RJ, Rutkowski DT, Péterfy M   Lipase maturation factor 1 (lmf1) is induced by endoplasmic reticulum stress through activating transcription factor 6α (Atf6α) signaling J Biol Chem, 2014; 289(35): 24417-24427.
Sha H, Sun S, Francisco AB, Ehrhardt N, Xue Z, Liu L, Lawrence P, Mattijssen F, Guber RD, Panhwar MS, Brenna JT, Shi H, Xue B, Kersten S, Bensadoun A, Péterfy M*, Long Q*, Qi L*.   The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism Cell Metab, 2014; 20(3): 458-470.
Johansen Christopher T, Wang Jian, McIntyre Adam D, Martins Rebecca A, Ban Matthew R, Lanktree Matthew B, Huff Murray W, Peterfy Miklos, Mehrabian Margarete, Lusis Aldons J, Kathiresan Sekar, Anand Sonia S, Yusuf Salim, Lee Ann-Hwee, Glimcher Laurie H, Cao Henian, Hegele Robert A   Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia Circ Cardiovasc Genet, 2012; 5(1): 66-72.
Miklos Peterfy   Lipase maturation factor 1: a lipase chaperone involved in lipid metabolism Biochim Biophys Acta, 2012; 1821(5): 790-4.
Davis Richard C, van Nas Atila, Castellani Lawrence W, Zhao Yi, Zhou Zhiqiang, Wen Pingzi, Yu Suzanne, Qi Hongxiu, Rosales Melenie, Schadt Eric E, Broman Karl W, Peterfy Miklos, Lusis Aldons J   Systems genetics of susceptibility to obesity-induced diabetes in mice Physiol Genomics, 2012; 44(1): 1-13.
Hosseini Maryam, Ehrhardt Nicole, Weissglas-Volkov Daphna, Lai Ching-Mei, Mao Hui Z, Liao Jo-Ling, Nikkola Elina, Bensadoun Andre, Taskinen Marja-Riitta, Doolittle Mark H, Pajukanta Paivi, Peterfy Miklos   Transgenic expression and genetic variation of Lmf1 affect LPL activity in mice and humans Arterioscler Thromb Vasc Biol, 2012; 32(5): 1204-10.
Ben-Zeev Osnat, Hosseini Maryam, Lai Ching-Mei, Ehrhardt Nicole, Wong Howard, Cefalu Angelo B, Noto Davide, Averna Maurizio R, Doolittle Mark H, Peterfy Miklos   Lipase maturation factor 1 is required for endothelial lipase activity J Lipid Res, 2011; 52(6): 1162-9.
Davis Richard C, Castellani Lawrence W, Hosseini Maryam, Ben-Zeev Osnat, Mao Hui Z, Weinstein Michael M, Jung Dae Young, Jun John Y, Kim Jason K, Lusis Aldons J, Peterfy Miklos   Early hepatic insulin resistance precedes the onset of diabetes in obese C57BLKS-db/db mice Diabetes, 2010; 59(7): 1616-25.
Peterfy Miklos, Harris Thurl E, Fujita Naoya, Reue Karen   Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes J Biol Chem, 2010; 285(6): 3857-64.
Doolittle Mark H, Ehrhardt Nicole, Peterfy Miklos   Lipase maturation factor 1: structure and role in lipase folding and assembly Curr Opin Lipidol, 2010; 21(3): 198-203.
Doolittle Mark H, Peterfy Miklos   Mechanisms of lipase maturation Clinical Lipidology, 2010; 5(1): 71-85.
Dallinga-Thie Geesje M, Franssen Remco, Mooij Hans L, Visser Maartje E, Hassing H Carlijne, Peelman Frank, Kastelein John J P, Peterfy Miklos, Nieuwdorp Max   The metabolism of triglyceride-rich lipoproteins revisited: new players, new insight Atherosclerosis, 2010; 211(1): 1-8.
Yin Fen, Doolittle Mark H, Peterfy Miklos   A quantitative assay measuring the function of lipase maturation factor 1 J Lipid Res, 2009; 50(11): 2265-9.
Doolittle Mark H, Ben-Zeev Osnat, Bassilian Sara, Whitelegge Julian P, Peterfy Miklos, Wong Howard   Hepatic lipase maturation: a partial proteome of interacting factors J Lipid Res, 2009; 50(6): 1173-84.
Doolittle Mark H, Neher Saskia B, Ben-Zeev Osnat, Ling-Liao Jo, Gallagher Ciara M, Hosseini Maryam, Yin Fen, Wong Howard, Walter Peter, Peterfy Miklos   Lipase maturation factor LMF1, membrane topology and interaction with lipase proteins in the endoplasmic reticulum J Biol Chem, 2009; 284(48): 33623-33.
Cefalu Angelo B, Noto Davide, Arpi Maria Luisa, Yin Fen, Spina Rossella, Hilden Hannele, Barbagallo Carlo M, Carroccio Antonio, Tarugi Patrizia, Squatrito Sebastiano, Vigneri Riccardo, Taskinen Marja-Riitta, Peterfy Miklos, Averna Maurizio R   Novel LMF1 nonsense mutation in a patient with severe hypertriglyceridemia J Clin Endocrinol Metab, 2009; 94(11): 4584-90.
Doolittle, M.H., Peterfy, M.   Lipase maturation factor 1 (LMF1), a new gene in hypertriglyceridemia, Future Lipidology, 2008; 3(2): 119-122.
Peterfy, M., Davis, R.C., Lusis, A.J.   Metabolic syndrome as a modifier of atherosclerosis in murine models, Current Drug Targets, 2007; 8: 1215-1220.
Peterfy, M., Ben-Zeev, O., Mao, H.Z., Weissglas-Volkov, D., Aouizerat, B.E., Pullinger, C.R., Frost, P.H., Kane, J.P., Malloy, M.J., Reue, K., Pajukanta, P. and Doolittle, M.   Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia Nature Genetics, 2007; 39(12): 1483-1487.
Mao, H. Z., Roussos, E. T., Peterfy, M.   Genetic analysis of the diabetes-prone C57BLKS/J mouse strain reveals genetic contribution from multiple strains Biochim Biophys Acta, 2006; 1762: 440-446.
Peterfy, M., Mao, H. Z., Doolittle, M. H.   The cld mutation: narrowing the critical region and selecting candidate genes Mammalian Genome, 2006; 17(10): 1013-24.
Peterfy, M., Phan, J., Reue, K.   Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis J Biol Chem, 2005; 280: 32883-32889.
Davis Richard C, Schadt Eric E, Cervino Alessandra C L, Peterfy Miklos, Lusis Aldons J   Ultrafine mapping of SNPs from mouse strains C57BL/6J, DBA/2J, and C57BLKS/J for loci contributing to diabetes and atherosclerosis susceptibility Diabetes, 2005; 54(4): 1191-9.
Vergnes Laurent, Peterfy Miklos, Bergo Martin O, Young Stephen G, Reue Karen   Lamin B1 is required for mouse development and nuclear integrity Proc Natl Acad Sci U S A, 2004; 101(28): 10428-33.
Peterfy, M., Phan, J., Xu, P., Reue, K.   Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin Nature Genetics, 2001; 27: 121-124.
Phan, J., Reue, K., Peterfy, M.   MS-IRS PCR: A simple method for the isolation of microsatellites, Biotechniques, 2000; 28: 18-20.
Peterfy, M., Gyuris, T., Takacs, L.   Signal-exon trap: A novel method for the identification of signal sequences from genomic DNA Nucl Acids Res, 2000; 28: E26.
Peterfy, M., Phan, J., Oswell, G. M., Xu, P., Reue, K.   Genetic, physical, and transcript map of the fld region on mouse chromosome 12 Genomics, 1999; 62: 436-444.

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