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Shaping the Future

Julian Whitelegge, Ph.D.

Contact Information:

Work Phone Number:

(310) 794-5156

Mailing Address:

Office
Box 42
NPI-Semel Insititute
760 Westwood Plaza,
University of California, Los Angeles
Los Angeles, CA 90024
UNITED STATES

Office Address:

NPI-Semel Institute for Neuroscience & Human Behavior
Department of Psychiatry and Biobehavioral Sciences
760 Westwood Plaza
Room 68-146
Los Angeles, CA 90095
UNITED STATES

Work Email Address:

jpw@chem.ucla.edu

Websites:

  

Laboratory:

     UCLA Molecular Instrumentation Center
     PMSL


Member, Brain Research Institute

CTSI

JCCC Patients and Survivors Program Area

Adjunct Professor, Psychiatry and Biobehavioral Sciences


Detailed Biography:

Julian Whitelegge received his Ph.D. from Imperial College of Science and Technology, University of London in 1989 and became heavily involved in mass spectrometry research in the mid nineties publishing his most cited paper on "electrospray-ionization mass spectrometry of intact intrinsic membrane proteins" in 1998. Dr. Whitelegge developed a keen interest in Fourier-transform mass spectrometry (FT-MS) while a Visiting Scientist in the Department of Chemistry and Chemical Biology, Cornell University working with Professor Fred McLafferty in 1999 and has nurtured this expertise since returning to UCLA. Currently, Dr. Whitelegge directs the proteomics activities of the Pasarow Mass Spectrometry Laboratory at UCLA, appointed as Adjunct Professor III in the NPI-Semel Institute in the David Geffen School of Medicine. He oversees both top-down and bottom-up mass spectrometry projects and trains post-graduate and post-doctoral associates in protein and peptide mass spectrometry and data interpretation. Dr. Whitelegge has authored and co-authored over one hundred and fifty original research papers. He edited the recently published, five-hundred page, book Protein Mass Spectrometry in Elsevier's analytical chemistry series and is a member of the editorial board of Molecular and Cellular Proteomics.

Publications:

Yang Hanjing, Yung Madeline, Li Lei, Hoch James A, Ryan Christopher M, Kar Upendra K, Souda Puneet, Whitelegge Julian P, Miller Jeffrey H   Evidence that YycJ is a novel 5'-3' double-stranded DNA exonuclease acting in Bacillus anthracis mismatch repair DNA repair, 2013; 12(5): 334-46.
Sarafian Theodore A, Ryan Christopher M, Souda Puneet, Masliah Eliezer, Kar Upendra K, Vinters Harry V, Mathern Gary W, Faull Kym F, Whitelegge Julian P, Watson Joseph B   Impairment of Mitochondria in Adult Mouse Brain Overexpressing Predominantly Full-Length, N-Terminally Acetylated Human α-Synuclein PloS one, 2013; 8(5): e63557.
Whitelegge Julian   Intact protein mass spectrometry and top-down proteomics Expert review of proteomics, 2013; 10(2): 127-9.
Whitelegge Julian P   Integral membrane proteins and bilayer proteomics Analytical chemistry, 2013; 85(5): 2558-68.
Howery Andrew E, Elvington Shelley, Abraham Sherwin J, Choi Kee-Hyun, Dworschak-Simpson Sierra, Phillips Sabrina, Ryan Christopher M, Sanford R Lea, Almqvist Jonas, Tran Kevin, Chew Thomas A, Zachariae Ulrich, Andersen Olaf S, Whitelegge Julian, Matulef Kimberly, Du Bois Justin, Maduke Merritt C   A designed inhibitor of a CLC antiporter blocks function through a unique binding mode Chemistry & biology, 2012; 19(11): 1460-70.
Prudencio Mercedes, Lelie Herman, Brown Hilda H, Whitelegge Julian P, Valentine Joan S, Borchelt David R   A novel variant of human superoxide dismutase 1 harboring amyotrophic lateral sclerosis-associated and experimental mutations in metal-binding residues and free cysteines lacks toxicity in vivo Journal of neurochemistry, 2012; 121(3): 475-85.
O'Brien Jose A, Daudi Arsalan, Finch Paul, Butt Vernon S, Whitelegge Julian P, Souda Puneet, Ausubel Frederick M, Bolwell G Paul   A peroxidase-dependent apoplastic oxidative burst in cultured Arabidopsis cells functions in MAMP-elicited defense Plant physiology, 2012; 158(4): 2013-27.
Laganowsky Arthur, Liu Cong, Sawaya Michael R, Whitelegge Julian P, Park Jiyong, Zhao Minglei, Pensalfini Anna, Soriaga Angela B, Landau Meytal, Teng Poh K, Cascio Duilio, Glabe Charles, Eisenberg David   Atomic view of a toxic amyloid small oligomer Science (New York, N.Y.), 2012; 335(6073): 1228-31.
Ziegler Mary E, Souda Puneet, Jin Yi-Ping, Whitelegge Julian P, Reed Elaine F   Characterization of the endothelial cell cytoskeleton following HLA class I ligation PloS one, 2012; 7(1): e29472.
Fluman Nir, Ryan Christopher M, Whitelegge Julian P, Bibi Eitan   Dissection of mechanistic principles of a secondary multidrug efflux protein Molecular cell, 2012; 47(5): 777-87.
Puppione Donald L, Della Donna Lorenza, Bassilian Sara, Souda Puneet, MacDonald Melinda H, Whitelegge Julian P   Mass spectral measurements of the apoHDL in horse (Equus caballus) cerebrospinal fluid Comparative biochemistry and physiology. Part D, Genomics & proteomics, 2012; 7(2): 172-4.
Della Donna Lorenza, Bassilian Sara, Souda Puneet, Nebbia Carlo, Whitelegge Julian P, Puppione Donald L   Mass spectrometric measurements of the apolipoproteins of bovine (Bos taurus) HDL Comparative biochemistry and physiology. Part D, Genomics & proteomics, 2012; 7(1): 9-13.
Whelan Stephen A, He Jianbo, Lu Ming, Souda Puneet, Saxton Romaine E, Faull Kym F, Whitelegge Julian P, Chang Helena R   Mass spectrometry (LC-MS/MS) identified proteomic biosignatures of breast cancer in proximal fluid Journal of proteome research, 2012; 11(10): 5034-45.
Hajagos Bettina E, Turetzky Jay M, Peng Eric D, Cheng Stephen J, Ryan Christopher M, Souda Puneet, Whitelegge Julian P, Lebrun Maryse, Dubremetz Jean-Francois, Bradley Peter J   Molecular dissection of novel trafficking and processing of the Toxoplasma gondii rhoptry metalloprotease toxolysin-1 Traffic (Copenhagen, Denmark), 2012; 13(2): 292-304.
Nazmi Ali Reza, Ozorowski Gabriel, Pejic Milena, Whitelegge Julian P, Gerke Volker, Luecke Hartmut   N-terminal acetylation of annexin A2 is required for S100A10 binding Biological chemistry, 2012; 393(10): 1141-50.
Ahuja Umesh, Liu Minghsun, Tomida Shuta, Park Jihye, Souda Puneet, Whitelegge Julian, Li Huiying, Harvill Eric T, Parkhill Julian, Miller Jeff F   Phenotypic and genomic analysis of hypervirulent human-associated Bordetella bronchiseptica BMC microbiology, 2012; 12(5): 167.
Sheng Yuewei, Chattopadhyay Madhuri, Whitelegge Julian, Valentine Joan Selverstone   SOD1 aggregation and ALS: role of metallation states and disulfide status Current topics in medicinal chemistry, 2012; 12(22): 2560-72.
Ozorowski Gabriel, Ryan Christopher M, Whitelegge Julian P, Luecke Hartmut   Withaferin A binds covalently to the N-terminal domain of annexin A2 Biological chemistry, 2012; 393(10): 1151-63.
Marques Patricia X, O'Donovan James, Souda Puneet, Gutierrez Jorge, Williams Erin J, Worrall Sheila, McElroy Maire, Proctor Aisling, Brady Colm, Sammin Donal, Basset Hugh, Whitelegge Julian P, Markey Bryan K, Nally Jarlath E   Amniotic and allantoic fluids from experimentally infected sheep contain immunoglobulin specific for Chlamydophila abortus Veterinary immunology and immunopathology, 2011; 140(1-2): 1-9.
Nally Jarlath E, Monahan Avril M, Miller Ian S, Bonilla-Santiago Ruben, Souda Puneet, Whitelegge Julian P   Comparative proteomic analysis of differentially expressed proteins in the urine of reservoir hosts of leptospirosis PloS one, 2011; 6(10): e26046.
Hasan S Saif, Yamashita Eiki, Ryan Christopher M, Whitelegge Julian P, Cramer William A   Conservation of lipid functions in cytochrome bc complexes Journal of molecular biology, 2011; 414(1): 145-62.
Lelie Herman L, Liba Amir, Bourassa Megan W, Chattopadhyay Madhuri, Chan Pik K, Gralla Edith B, Miller Lisa M, Borchelt David R, Valentine Joan Selverstone, Whitelegge Julian P   Copper and zinc metallation status of copper-zinc superoxide dismutase from amyotrophic lateral sclerosis transgenic mice The Journal of biological chemistry, 2011; 286(4): 2795-806.
Tullius Michael V, Harmston Christine A, Owens Cedric P, Chim Nicholas, Morse Robert P, McMath Lisa M, Iniguez Angelina, Kimmey Jacqueline M, Sawaya Michael R, Whitelegge Julian P, Horwitz Marcus A, Goulding Celia W   Discovery and characterization of a unique mycobacterial heme acquisition system Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(12): 5051-6.
Whitelegge Julian P, Komatsu Setsuko, Jorrin-Novo Jesus   Diverse facets of plant proteomics Phytochemistry, 2011; 72(10): 961-2.
Thangaraj Balakumar, Jolley Craig C, Sarrou Iosifina, Bultema Jelle B, Greyslak Jason, Whitelegge Julian P, Lin Su, Kouřil Roman, Subramanyam Rajagopal, Boekema Egbert J, Fromme Petra   Efficient light harvesting in a dark, hot, acidic environment: the structure and function of PSI-LHCI from Galdieria sulphuraria Biophysical journal, 2011; 100(1): 135-43.
Tokhtaeva Elmira, Sachs George, Souda Puneet, Bassilian Sara, Whitelegge Julian P, Shoshani Liora, Vagin Olga   Epithelial junctions depend on intercellular trans-interactions between the Na,K-ATPase β₁ subunits The Journal of biological chemistry, 2011; 286(29): 25801-12.
Nowaczyk Marc M, Wulfhorst Hannes, Ryan Christopher M, Souda Puneet, Zhang Huamin, Cramer William A, Whitelegge Julian P   NdhP and NdhQ: two novel small subunits of the cyanobacterial NDH-1 complex Biochemistry, 2011; 50(7): 1121-4.
Souda Puneet, Ryan Christopher M, Cramer William A, Whitelegge Julian   Profiling of integral membrane proteins and their post translational modifications using high-resolution mass spectrometry Methods (San Diego, Calif.), 2011; 55(4): 330-6.
He Jianbo, Whelan Stephen A, Lu Ming, Shen Dejun, Chung Debra U, Saxton Romaine E, Faull Kym F, Whitelegge Julian P, Chang Helena R   Proteomic-based biosignatures in breast cancer classification and prediction of therapeutic response International journal of proteomics, 2011; 2011(1): 896476.
Whitelegge Julian   Structural biology. Up close with membrane lipid-protein complexes Science (New York, N.Y.), 2011; 334(6054): 320-1.
Webb Kristofor J, Zurita-Lopez Cecilia I, Al-Hadid Qais, Laganowsky Arthur, Young Brian D, Lipson Rebecca S, Souda Puneet, Faull Kym F, Whitelegge Julian P, Clarke Steven G   A novel 3-methylhistidine modification of yeast ribosomal protein Rpl3 is dependent upon the YIL110W methyltransferase The Journal of biological chemistry, 2010; 285(48): 37598-606.
Srikanth Sonal, Jung Hea-Jin, Kim Kyun-Do, Souda Puneet, Whitelegge Julian, Gwack Yousang   A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells Nature cell biology, 2010; 12(5): 436-46.
de Vries Simon, Momcilovic Milica, Strampraad Marc J F, Whitelegge Julian P, Baghai Ashkan, Schröder Imke   Adaptation to a high-tungsten environment: Pyrobaculum aerophilum contains an active tungsten nitrate reductase Biochemistry, 2010; 49(45): 9911-21.
Prudencio Mercedes, Durazo Armando, Whitelegge Julian P, Borchelt David R   An examination of wild-type SOD1 in modulating the toxicity and aggregation of ALS-associated mutant SOD1 Human molecular genetics, 2010; 19(24): 4774-89.
Chim Nicholas, Riley Robert, The Juliana, Im Soyeon, Segelke Brent, Lekin Tim, Yu Minmin, Hung Li Wei, Terwilliger Tom, Whitelegge Julian P, Goulding Celia W   An extracellular disulfide bond forming protein (DsbF) from Mycobacterium tuberculosis: structural, biochemical, and gene expression analysis Journal of molecular biology, 2010; 396(5): 1211-26.
Leuchter Andrew F, Cook Ian A, Hamilton Steven P, Narr Katherine L, Toga Arthur, Hunter Aimee M, Faull Kym, Whitelegge Julian, Andrews Anne M, Loo Joseph, Way Baldwin, Nelson Stanley F, Horvath Steven, Lebowitz Barry D   Biomarkers to predict antidepressant response Current psychiatry reports, 2010; 12(6): 553-62.
Ryan Christopher M, Souda Puneet, Halgand Frederic, Wong David T, Loo Joseph A, Faull Kym F, Whitelegge Julian P   Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry Journal of the American Society for Mass Spectrometry, 2010; 21(6): 908-17.
Gundersen Cameron B, Kohan Sirus A, Souda Puneet, Whitelegge Julian P, Umbach Joy A   Cysteine string protein beta is prominently associated with nerve terminals and secretory organelles in mouse brain Brain research, 2010; 1332(6): 1-11.
Thangaraj Balakumar, Ryan Christopher M, Souda Puneet, Krause Kirsten, Faull Kym F, Weber Andreas P M, Fromme Petra, Whitelegge Julian P   Data-directed top-down Fourier-transform mass spectrometry of a large integral membrane protein complex: photosystem II from Galdieria sulphuraria Proteomics, 2010; 10(20): 3644-56.
Liu Xiaowen, Inbar Yuval, Dorrestein Pieter C, Wynne Colin, Edwards Nathan, Souda Puneet, Whitelegge Julian P, Bafna Vineet, Pevzner Pavel A   Deconvolution and database search of complex tandem mass spectra of intact proteins: a combinatorial approach Molecular & cellular proteomics : MCP, 2010; 9(12): 2772-82.
Puppione Donald L, Ryan Christopher M, Bassilian Sara, Souda Puneet, Xiao Xinshu, Ryder Oliver A, Whitelegge Julian P   Detection of two distinct forms of apoC-I in great apes Comparative biochemistry and physiology. Part D, Genomics & proteomics, 2010; 5(1): 73-9.
Lu Ming, Whitelegge Julian P, Whelan Stephen A, He Jianbo, Saxton Romaine E, Faull Kym F, Chang Helena R   Hydrophobic Fractionation Enhances Novel Protein Detection by Mass Spectrometry in Triple Negative Breast Cancer Journal of proteomics & bioinformatics, 2010; 3(2): 1-10.
Lu Ming, Whelan Stephen A, He Jianbo, Saxton Romaine E, Faull Kym F, Whitelegge Julian P, Chang Helena R   Hydrophobic Proteome Analysis of Triple Negative and Hormone-Receptor-Positive-Her2-Negative Breast Cancer by Mass Spectrometer Clinical proteomics, 2010; 6(3): 93-103.
Shoemaker Lorelei D, Orozco Nicholas M, Geschwind Daniel H, Whitelegge Julian P, Faull Kym F, Kornblum Harley I   Identification of differentially expressed proteins in murine embryonic and postnatal cortical neural progenitors PloS one, 2010; 5(2): e9121.
Marques P X, Souda Puneet, O'Donovan J, Gutierrez J, Gutierrez E J, Worrall S, McElroy M, Proctor A, Brady C, Sammin D, Basset H F, Whitelegge Julian P, Markey B E, Nally J E   Identification of immunologically relevant proteins of Chlamydophila abortus using sera from experimentally infected pregnant ewes Clinical and vaccine immunology : CVI, 2010; 17(8): 1274-81.
Webb Kristofor J, Lipson Rebecca S, Al-Hadid Qais, Whitelegge Julian P, Clarke Steven G   Identification of protein N-terminal methyltransferases in yeast and humans Biochemistry, 2010; 49(25): 5225-35.
Crofts Andrew J, Crofts Naoko, Whitelegge Julian P, Okita Thomas W   Isolation and identification of cytoskeleton-associated prolamine mRNA binding proteins from developing rice seeds Planta, 2010; 231(6): 1261-76.
Halgand Frédéric, Zabrouskov Vlad, Bassilian Sara, Souda Puneet, Wong David T, Loo Joseph A, Faull Kym F, Whitelegge Julian P   Micro-heterogeneity of human saliva Peptide P-C characterized by high-resolution top-down Fourier-transform mass spectrometry Journal of the American Society for Mass Spectrometry, 2010; 21(5): 868-77.
Keire David A, Whitelegge Julian P, Souda Puneet, Faull Kym F, Bassilian Sara, Reidelberger Roger D, Haver Alvin C, Reeve Joseph R   PYY(1-36) is the major form of PYY in rat distal small intestine: quantification using high-resolution mass spectrometry Regulatory peptides, 2010; 165(2-3): 151-7.
Ryan Christopher M, Souda Puneet, Bassilian Sara, Ujwal Rachna, Zhang Jun, Abramson Jeff, Ping Peipei, Durazo Armando, Bowie James U, Hasan S Saif, Baniulis Danas, Cramer William A, Faull Kym F, Whitelegge Julian P   Post-translational modifications of integral membrane proteins resolved by top-down Fourier transform mass spectrometry with collisionally activated dissociation Molecular & cellular proteomics : MCP, 2010; 9(5): 791-803.
Yuan Quan, Kaylor Joanna J, Miu Anh, Bassilian Sara, Whitelegge Julian P, Travis Gabriel H   Rpe65 isomerase associates with membranes through an electrostatic interaction with acidic phospholipid headgroups The Journal of biological chemistry, 2010; 285(2): 988-99.
Sun Siyang, La Scola Bernard, Bowman Valorie D, Ryan Christopher M, Whitelegge Julian P, Raoult Didier, Rossmann Michael G   Structural studies of the Sputnik virophage Journal of virology, 2010; 84(2): 894-7.
Shaw Bryan F, Moustakas Demetri T, Whitelegge Julian P, Faull Kym F   Taking charge of proteins from neurodegeneration to industrial biotechnology Advances in protein chemistry and structural biology, 2010; 79(2): 127-64.
Averette Kathleen M, Pratt Matthew R, Yang Yanan, Bassilian Sara, Whitelegge Julian P, Loo Joseph A, Muir Tom W, Bradley Kenneth A   Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent PloS one, 2009; 4(11): e7913.
Doolittle David R, Ben-Zeev David R, Bassilian David R, Whitelegge David R, Pterfy David R, Wong David R   Hepatic lipase maturation:A partial proteome of interacting factors Journal of lipid research, 2009; 108(4): .
Laganowsky Arthur, Gómez Stephen M, Whitelegge Julian P, Nishio John N   Hydroponics on a chip: analysis of the Fe deficient Arabidopsis thylakoid membrane proteome Journal of proteomics, 2009; 72(3): 397-415.
Budzik Jonathan M, Poor Catherine B, Faull Kym F, Whitelegge Julian P, He Chuan, Schneewind Olaf   Intramolecular amide bonds stabilize pili on the surface of bacilli Proceedings of the National Academy of Sciences of the United States of America, 2009; 106(47): 19992-7.
Puppione Donald L, Donna Lorenza Della, Laganowsky Arthur D, Bassilian Sara, Souda Puneet, Ryder Oliver A, Whitelegge Julian P   Mass spectral analyses of the two major apolipoproteins of great ape high density lipoproteins Comparative biochemistry and physiology. Part D, Genomics & proteomics, 2009; 4(4): 305-9.
Whelan Stephen A, Lu Ming, He Jianbo, Yan Weihong, Saxton Romaine E, Faull Kym F, Whitelegge Julian P, Chang Helena R   Mass spectrometry (LC-MS/MS) site-mapping of N-glycosylated membrane proteins for breast cancer biomarkers Journal of proteome research, 2009; 8(8): 4151-60.
Durazo Armando, Shaw Bryan F, Chattopadhyay Madhuri, Faull Kym F, Nersissian Aram M, Valentine Joan Selverstone, Whitelegge Julian P   Metal-free superoxide dismutase-1 and three different amyotrophic lateral sclerosis variants share a similar partially unfolded beta-barrel at physiological temperature The Journal of biological chemistry, 2009; 284(49): 34382-9.
Prudencio Mercedes, Durazo Armando, Whitelegge Julian P, Borchelt David R   Modulation of mutant superoxide dismutase 1 aggregation by co-expression of wild-type enzyme Journal of neurochemistry, 2009; 108(4): 1009-18.
Joh Nathan H, Oberai Amit, Yang Duan, Whitelegge Julian P, Bowie James U   Similar energetic contributions of packing in the core of membrane and water-soluble proteins Journal of the American Chemical Society, 2009; 131(31): 10846-7.
Baniulis, Yamashita, Whitelegge, Zatsman, Hendrich, Hasan, Ryan, Cramer   Structure-function, stability, and chemical modification of the cyanobacterial cytochrome B6F complex from nostoc sp. PCC 7120 The Journal of biological chemistry, 2009; .
Millar David J, Whitelegge Julian P, Bindschedler Laurence V, Rayon Catherine, Boudet Alain-Michel, Rossignol Michel, Borderies Gisèle, Bolwell G Paul   The cell wall and secretory proteome of a tobacco cell line synthesising secondary wall Proteomics, 2009; 9(9): 2355-72.
He Jianbo, Shen Dejun, Chung Debra U, Saxton Romaine E, Whitelegge Julian P, Faull Kym F, Chang Helena R   Tumor proteomic profiling predicts the susceptibility of breast cancer to chemotherapy International journal of oncology, 2009; 35(4): 683-92.
Keire David A, Whitelegge Julian P, Bassilian Sara, Faull Kym F, Wiggins Brian W, Mehdizadeh Omid B, Reidelberger Roger D, Haver Alvin C, Sayegh Ayman I, Reeve Joseph R   A new endogenous form of PYY isolated from canine ileum: Gly-extended PYY(1-36) Regulatory peptides, 2008; 151(1-3): 61-70.
Budzik Jonathan M, Marraffini Luciano A, Souda Puneet, Whitelegge Julian P, Faull Kym F, Schneewind Olaf   Amide bonds assemble pili on the surface of bacilli Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(29): 10215-20.
Shaw Bryan F, Lelie Herman L, Durazo Armando, Nersissian Aram M, Xu Guillan, Chan Pik K, Gralla Edith B, Tiwari Ashutosh, Hayward Lawrence J, Borchelt David R, Valentine Joan S, Whitelegge Julian P   Detergent-insoluble aggregates associated with amyotrophic lateral sclerosis in transgenic mice contain primarily full-length, unmodified superoxide dismutase-1 The Journal of biological chemistry, 2008; 283(13): 8340-50.
Webb Kristofor J, Laganowsky Arthur, Whitelegge Julian P, Clarke Steven G   Identification of two SET domain proteins required for methylation of lysine residues in yeast ribosomal protein Rpl42ab The Journal of biological chemistry, 2008; 283(51): 35561-8.
Chattopadhyay Madhuri, Durazo Armando, Sohn Se Hui, Strong Cynthia D, Gralla Edith B, Whitelegge Julian P, Valentine Joan Selverstone   Initiation and elongation in fibrillation of ALS-linked superoxide dismutase Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(48): 18663-8.
Shaw Bryan F, Schneider Gregory F, Bilgier Basar, Kaufman George K, Neveu John M, Lane William S, Whitelegge Julian P, Whitesides George M   Lysine acetylation can generate highly charged enzymes with increased resistance toward irreversible inactivation Protein science : a publication of the Protein Society, 2008; 17(8): 1446-55.
Erales David R, Gontero David R, Whitelegge David R, Halgand David R   Mapping of a copper binding site on the small CP12 chloroplastic protein, using top down mass spectrometry and site- directed mutageneses The Biochemical journal, 2008; 108(4): .
Grintsevich Elena E, Benchaar Sabrina A, Warshaviak Dora, Boontheung Pinmanee, Halgand Frdric, Whitelegge Julian P, Faull Kym F, Loo Rachel R Ogorzalek, Sept David, Loo Joseph A, Reisler Emil   Mapping the cofilin binding site on yeast G-actin by chemical cross-linking Journal of molecular biology, 2008; 377(2): 395-409.
Puppione Donald L, Bassilian Sara, Souda Puneet, MacDonald Melinda H, Halgand Frederic, Hagland Frederic, Whitelegge Julian P   Mass spectral analysis of the apolipoproteins on dog (Canis lupus familiaris) high density lipoproteins. Detection of apolipoprotein A-II Comparative biochemistry and physiology. Part D, Genomics & proteomics, 2008; 3(4): 290-6.
Joh Nathan Hyunjoong, Min Andrew, Faham Salem, Whitelegge Julian P, Yang Duan, Woods Virgil L, Bowie James U   Modest stabilization by most hydrogen-bonded side-chain interactions in membrane proteins Nature, 2008; 453(7199): 1266-70.
Farrokhi Naser, Whitelegge Julian P, Brusslan Judy A   Plant peptides and peptidomics Plant biotechnology journal, 2008; 6(2): 105-34.
Lu Haojie, Zong Chenggong, Wang Yueju, Young Glen W, Deng Ning, Souda Pete, Li Xiaohai, Whitelegge Julian, Drews Oliver, Yang Peng-Yuan, Ping Peipei   Revealing the dynamics of the 20 S proteasome phosphoproteome: a combined CID and electron transfer dissociation approach Molecular & cellular proteomics : MCP, 2008; 7(11): 2073-89.
Fujishige Nancy A, Lum Michelle R, De Hoff Peter L, Whitelegge Julian P, Faull Kym F, Hirsch Ann M   Rhizobium common nod genes are required for biofilm formation Molecular microbiology, 2008; 67(3): 504-15.
Denny Paul, Hagen Fred K, Hardt Markus, Liao Lujian, Yan Weihong, Arellanno Martha, Bassilian Sara, Bedi Gurrinder S, Boontheung Pinmannee, Cociorva Daniel, Delahunty Claire M, Denny Trish, Dunsmore Jason, Faull Kym F, Gilligan Joyce, Gonzalez-Begne Mireya, Halgand Frdric, Hall Steven C, Han Xuemei, Henson Bradley, Hewel Johannes, Hu Shen, Jeffrey Sherry, Jiang Jiang, Loo Joseph A, Ogorzalek Loo Rachel R, Malamud Daniel, Melvin James E, Miroshnychenko Olga, Navazesh Mahvash, Niles Richard, Park Sung Kyu, Prakobphol Akraporn, Ramachandran Prasanna, Richert Megan, Robinson Sarah, Sondej Melissa, Souda Puneet, Sullivan Mark A, Takashima Jona, Than Shawn, Wang Jianghua, Whitelegge Julian P, Witkowska H Ewa, Wolinsky Lawrence, Xie Yongming, Xu Tao, Yu Weixia, Ytterberg Jimmy, Wong David T, Yates John R, Fisher Susan J   The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions Journal of proteome research, 2008; 7(5): 1994-2006.
Kawaguchi Riki, Yu Jiamei, Honda Jane, Hu Jane, Whitelegge Julian, Ping Peipei, Wiita Patrick, Bok Dean, Sun Hui   A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A Science (New York, N.Y.), 2007; 315(5813): 820-5.
Nally Jarlath E, Whitelegge Julian P, Bassilian Sara, Blanco David R, Lovett Michael A   Characterization of the outer membrane proteome of Leptospira interrogans expressed during acute lethal infection Infection and immunity, 2007; 75(2): 766-73.
He Jianbo, Gornbein Jeffrey, Shen Dejun, Lu Ming, Rovai Leonor E, Shau Hungyi, Katz John, Whitelegge Julian P, Faull Kym F, Chang Helena R   Detection of breast cancer biomarkers in nipple aspirate fluid by SELDI-TOF and their identification by combined liquid chromatography-tandem mass spectrometry International journal of oncology, 2007; 30(1): 145-54.
Watanabe Junji, Chou Katherine J, Liao James C, Miao Yunan, Meng Hsiang-Hui, Ge Helen, Grijalva Victor, Hama Susan, Kozak Kathy, Buga Georgette, Whitelegge Julian P, Lee Terry D, Farias-Eisner Robin, Navab Mohamad, Fogelman Alan M, Reddy Srinivasa T   Differential association of hemoglobin with proinflammatory high density lipoproteins in atherogenic/hyperlipidemic mice. A novel biomarker of atherosclerosis The Journal of biological chemistry, 2007; 282(32): 23698-707.
Boutz Daniel R, Cascio Duilio, Whitelegge Julian, Perry L Jeanne, Yeates Todd O   Discovery of a thermophilic protein complex stabilized by topologically interlinked chains Journal of molecular biology, 2007; 368(5): 1332-44.
Waldron Richard T, Whitelegge Julian P, Faull Kym F, Rozengurt Enrique   Identification of a novel phosphorylation site in c-jun directly targeted in vitro by protein kinase D Biochemical and biophysical research communications, 2007; 356(2): 361-7.
Banci Lucia, Bertini Ivano, Durazo Armando, Girotto Stefania, Gralla Edith Butler, Martinelli Manuele, Valentine Joan Selverstone, Vieru Miguela, Whitelegge Julian P   Metal-free superoxide dismutase forms soluble oligomers under physiological conditions: a possible general mechanism for familial ALS Proceedings of the National Academy of Sciences of the United States of America, 2007; 104(27): 11263-7.
Bortz Eric, Wang Lili, Jia Qingmei, Wu Ting-Ting, Whitelegge Julian P, Deng Hongyu, Zhou Z Hong, Sun Ren   Murine gammaherpesvirus 68 ORF52 encodes a tegument protein required for virion morphogenesis in the cytoplasm Journal of virology, 2007; 81(18): 10137-50.
Whitelegge Judy A, Zabrouskov Judy A, Halgand Judy A, Souda Judy A, Bassilian Judy A, Yan Judy A, Wolinsky Judy A, Loo Judy A, Wong Judy A, Faull Judy A   Protein-Sequence Polymorphisms and Post-translational Modifications in Proteins from Human Saliva using Top-Down Fourier-transform Ion Cyclotron Resonance Mass Spectrometry International journal of mass spectrometry, 2007; 268(2-3): 190-197.
Nally Jarlath E, Whitelegge Julian P, Carroll James A   Proteomic strategies to elucidate pathogenic mechanisms of spirochetes Proteomics. Clinical applications, 2007; 1(9): 1185-97.
Lu Ming, Faull Kym F, Whitelegge Julian P, He Jianbo, Shen Dejun, Saxton Romaine E, Chang Helena R   Proteomics and mass spectrometry for cancer biomarker discovery Biomarker insights, 2007; 2(4): 347-60.
Taylor Chris F, Paton Norman W, Lilley Kathryn S, Binz Pierre-Alain, Julian Randall K, Jones Andrew R, Zhu Weimin, Apweiler Rolf, Aebersold Ruedi, Deutsch Eric W, Dunn Michael J, Heck Albert J R, Leitner Alexander, Macht Marcus, Mann Matthias, Martens Lennart, Neubert Thomas A, Patterson Scott D, Ping Peipei, Seymour Sean L, Souda Puneet, Tsugita Akira, Vandekerckhove Joel, Vondriska Thomas M, Whitelegge Julian P, Wilkins Marc R, Xenarios Ioannnis, Yates John R, Hermjakob Henning   The minimum information about a proteomics experiment (MIAPE) Nature biotechnology, 2007; 25(8): 887-93.
Xie Jing, Marusich Michael F, Souda Puneet, Whitelegge Julian, Capaldi Roderick A   The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11 FEBS letters, 2007; 581(18): 3545-9.
Porras-Yakushi Tanya R, Whitelegge Julian P, Clarke Steven   Yeast ribosomal/cytochrome c SET domain methyltransferase subfamily: identification of Rpl23ab methylation sites and recognition motifs The Journal of biological chemistry, 2007; 282(17): 12368-76.
Porras-Yakushi Tanya R, Whitelegge Julian P, Clarke Steven   A novel SET domain methyltransferase in yeast: Rkm2-dependent trimethylation of ribosomal protein L12ab at lysine 10 The Journal of biological chemistry, 2006; 281(47): 35835-45.
Bindschedler Laurence V, Whitelegge Julian P, Millar David J, Bolwell G Paul   A two component chitin-binding protein from French bean -- association of a proline-rich protein with a cysteine-rich polypeptide FEBS letters, 2006; 580(6): 1541-6.
Ding Qinxue, Vaynman Shoshanna, Souda Puneet, Whitelegge Julian P, Gomez-Pinilla Fernando   Exercise affects energy metabolism and neural plasticity-related proteins in the hippocampus as revealed by proteomic analysis The European journal of neuroscience, 2006; 24(5): 1265-76.
Shaw Bryan Francis, Durazo Armando, Nersissian Aram M, Whitelegge Julian P, Faull Kym F, Valentine Joan Selverstone   Local unfolding in a destabilized, pathogenic variant of superoxide dismutase 1 observed with H/D exchange and mass spectrometry The Journal of biological chemistry, 2006; 281(26): 18167-76.
Qiao Feng, Harada Bryan, Song Haiyun, Whitelegge Julian, Courey Albert J, Bowie James U   Mae inhibits Pointed-P2 transcriptional activity by blocking its MAPK docking site The EMBO journal, 2006; 25(1): 70-9.
Puppione Donald L, Yam Lang M, Bassilian Sara, Souda Puneet, Castellani Lawrence W, Schumaker Verne N, Whitelegge Julian P   Mass spectral analysis of the apolipoproteins on mouse high density lipoproteins. Detection of post-translational modifications Biochimica et biophysica acta, 2006; 1764(8): 1363-71.
Whitelegge Julian P, Laganowsky Arthur, Nishio John, Souda Puneet, Zhang Huamin, Cramer William A   Sequencing covalent modifications of membrane proteins Journal of experimental botany, 2006; 57(7): 1515-22.
Whitelegge Julian, Halgand Frederic, Souda Puneet, Zabrouskov Vlad   Top-down mass spectrometry of integral membrane proteins Expert review of proteomics, 2006; 3(6): 585-96.
Blanco David R, Champion Cheryl I, Dooley Alek, Cox David L, Whitelegge Julian P, Faull Kym, Lovett Michael A   A monoclonal antibody that conveys in vitro killing and partial protection in experimental syphilis binds a phosphorylcholine surface epitope of Treponema pallidum Infection and immunity, 2005; 73(5): 3083-95.
Porras-Yakushi Tanya R, Whitelegge Julian P, Miranda Tina Branscombe, Clarke Steven   A novel SET domain methyltransferase modifies ribosomal protein Rpl23ab in yeast The Journal of biological chemistry, 2005; 280(41): 34590-8.
Norris Andrew J, Whitelegge Julian P, Yaghoubian Arman, Alattia Jean-Rene, Priv Gilbert G, Toyokuni Tatsushi, Sun Hubert, Brooks Mai N, Panza Luigi, Matto Pamela, Compostella Federica, Remmel Natascha, Klingenstein Ralf, Sandhoff Konrad, Fluharty Claire, Fluharty Arvan, Faull Kym F   A novel mass spectrometric assay for the cerebroside sulfate activator protein (saposin B) and arylsulfatase A Journal of lipid research, 2005; 46(10): 2254-64.
Berhane Beniam T, Zong Chenggong, Liem David A, Huang Aaron, Le Steven, Edmondson Ricky D, Jones Richard C, Qiao Xin, Whitelegge Julian P, Ping Peipei, Vondriska Thomas M   Cardiovascular-related proteins identified in human plasma by the HUPO Plasma Proteome Project pilot phase Proteomics, 2005; 5(13): 3520-30.
Kozak Katherine R, Su Feng, Whitelegge Julian P, Faull Kym, Reddy Srinivasa, Farias-Eisner Robin   Characterization of serum biomarkers for detection of early stage ovarian cancer Proteomics, 2005; 5(17): 4589-96.
Weinglass Adam B, Soskine Misha, Vazquez-Ibar Jose-Luis, Whitelegge Julian P, Faull Kym F, Kaback H Ronald, Schuldiner Shimon   Exploring the role of a unique carboxyl residue in EmrE by mass spectrometry The Journal of biological chemistry, 2005; 280(9): 7487-92.
Kozak Natalia A, Mattoo Seema, Foreman-Wykert Amy K, Whitelegge Julian P, Miller Jeff F   Interactions between partner switcher orthologs BtrW and BtrV regulate type III secretion in Bordetella Journal of bacteriology, 2005; 187(16): 5665-76.
Liu Cuimin, Willmund Felix, Whitelegge Julian P, Hawat Susan, Knapp Bettina, Lodha Mukesh, Schroda Michael   J-domain protein CDJ2 and HSP70B are a plastidic chaperone pair that interacts with vesicle-inducing protein in plastids 1 Molecular biology of the cell, 2005; 16(3): 1165-77.
Puppione Donald L, Whitelegge Julian P, Yam Lang M, Bassilian Sara, Schumaker Verne N, MacDonald Melinda H   Mass spectral analysis of domestic and wild equine apoA-I and A-II: detection of unique dimeric forms of apoA-II Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 2005; 142(4): 369-73.
Puppione Donald L, Whitelegge Julian P, Yam Lang M, Schumaker Verne N   Mass spectral analysis of pig (Sus scrofa) apo HDL: Identification of pig apoA-II, a dimeric apolipoprotein Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 2005; 141(1): 89-94.
Barwe Sonali P, Anilkumar Gopalakrishnapillai, Moon Sun Y, Zheng Yi, Whitelegge Julian P, Rajasekaran Sigrid A, Rajasekaran Ayyappan K   Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility Molecular biology of the cell, 2005; 16(3): 1082-94.
Nally Jarlath E, Whitelegge Julian P, Aguilera Rodrigo, Pereira Martha M, Blanco David R, Lovett Michael A   Purification and proteomic analysis of outer membrane vesicles from a clinical isolate of Leptospira interrogans serovar Copenhageni Proteomics, 2005; 5(1): 144-52.
Gomes Aldrin V, Zong Chenggong, Edmondson Ricky D, Berhane Beniam T, Wang Guang-Wu, Le Steven, Young Glen, Zhang Jun, Vondriska Thomas M, Whitelegge Julian P, Jones Richard C, Joshua Irving G, Thyparambil Sheeno, Pantaleon Dawn, Qiao Joe, Loo Joseph, Ping Peipei   The murine cardiac 26S proteasome: an organelle awaiting exploration Annals of the New York Academy of Sciences, 2005; 1047(14): 197-207.
Lu Ming, Zhang Liping, Maul Raymond Scott, Sartippour Maryam R, Norris Andrew, Whitelegge Julian, Rao Jian Yu, Brooks Mai N   The novel gene EG-1 stimulates cellular proliferation Cancer research, 2005; 65(14): 6159-66.
Chun Helen H, Cary Robert B, Lansigan Fredrick, Whitelegge Julian, Rawlings David J, Gatti Richard A   ATM protein purified from vaccinia virus expression system: DNA binding requirements for kinase activation Biochemical and biophysical research communications, 2004; 322(1): 74-81.
Whitelegge Julian P   HPLC and mass spectrometry of intrinsic membrane proteins Methods in molecular biology (Clifton, N.J.), 2004; 251(1): 323-40.
Norris Andrew J, Whitelegge Julian P, Strouse M Jane, Faull Kym F, Toyokuni Tatsushi   Inhibition kinetics of carba- and C-fucosyl analogues of GDP-fucose against fucosyltransferase V: implication for the reaction mechanism Bioorganic & medicinal chemistry letters, 2004; 14(3): 571-3.
Weinglass Adam B, Whitelegge Julian P, Kaback H Ronald   Integrating mass spectrometry into membrane protein drug discovery Current opinion in drug discovery & development, 2004; 7(5): 589-99.
Whitelegge Julian P   Mass spectrometry for high throughput quantitative proteomics in plant research: lessons from thylakoid membranes Plant physiology and biochemistry : PPB / Socit franaise de physiologie vgtale, 2004; 42(12): 919-27.
Weinglass Adam, Whitelegge Julian P, Faull Kym F, Kaback H Ronald   Monitoring conformational rearrangements in the substrate-binding site of a membrane transport protein by mass spectrometry The Journal of biological chemistry, 2004; 279(40): 41858-65.
Yohannan Sarah, Yang Duan, Faham Salem, Boulting Gabriella, Whitelegge Julian, Bowie James U   Proline substitutions are not easily accommodated in a membrane protein Journal of molecular biology, 2004; 341(1): 1-6.
Tu Xiaolin, Huang Aaron, Bae David, Slaughter Ndaisha, Whitelegge Julian, Crother Timothy, Bickel Perry E, Nel Andre   Proteome analysis of lipid rafts in Jurkat cells characterizes a raft subset that is involved in NF-kappaB activation Journal of proteome research, 2004; 3(3): 445-54.
Puppione Donald L, Fischer Wolfgang H, Park Minkyu, Whitelegge Julian P, Schumaker Verne N, Golfeiz Shoulamit, MacDonald Melinda H   Sequence of horse (Equus caballus) apoA-II. Another example of a dimer forming apolipoprotein Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 2004; 138(3): 213-20.
Faham Salem, Yang Duan, Bare Emiko, Yohannan Sarah, Whitelegge Julian P, Bowie James U   Side-chain contributions to membrane protein structure and stability Journal of molecular biology, 2004; 335(1): 297-305.
Whitelegge Julian P, Katz Jonathan E, Pihakari Katianna A, Hale Rebecca, Aguilera Rodrigo, Gmez Stephen M, Faull Kym F, Vavilin Dmitrii, Vermaas Willem   Subtle modification of isotope ratio proteomics; an integrated strategy for expression proteomics Phytochemistry, 2004; 65(11): 1507-15.
Crother Timothy R, Champion Cheryl I, Whitelegge Julian P, Aguilera Rodrigo, Wu Xiao-Yang, Blanco David R, Miller James N, Lovett Michael A   Temporal analysis of the antigenic composition of Borrelia burgdorferi during infection in rabbit skin Infection and immunity, 2004; 72(9): 5063-72.
Yohannan Sarah, Faham Salem, Yang Duan, Whitelegge Julian P, Bowie James U   The evolution of transmembrane helix kinks and the structural diversity of G protein-coupled receptors Proceedings of the National Academy of Sciences of the United States of America, 2004; 101(4): 959-63.
Ahn Victoria E, Faull Kym F, Whitelegge Julian P, Fluharty Arvan L, Priv Gilbert G   Crystal structure of saposin B reveals a dimeric shell for lipid binding Proceedings of the National Academy of Sciences of the United States of America, 2003; 100(1): 38-43.
Weinglass Adam B, Whitelegge Julian P, Hu Yonglin, Verner Gillian E, Faull Kym F, Kaback H Ronald   Elucidation of substrate binding interactions in a membrane transport protein by mass spectrometry The EMBO journal, 2003; 22(7): 1467-77.
Ahn Victoria E, Faull Kym F, Whitelegge Julian P, Higginson Jason, Fluharty Arvan L, Priv Gilbert G   Expression, purification, crystallization, and preliminary X-ray analysis of recombinant human saposin B Protein expression and purification, 2003; 27(1): 186-93.
Bortz Eric, Whitelegge Julian P, Jia Qingmei, Zhou Z Hong, Stewart James P, Wu Ting-Ting, Sun Ren   Identification of proteins associated with murine gammaherpesvirus 68 virions Journal of virology, 2003; 77(24): 13425-32.
Kinzie Sylvia Daoud, Thevis Mario, Ngo Khanh, Whitelegge Julian, Loo Joseph A, Abu-Omar Mahdi M   Posttranslational hydroxylation of human phenylalanine hydroxylase is a novel example of enzyme self-repair within the second coordination sphere of catalytic iron Journal of the American Chemical Society, 2003; 125(16): 4710-1.
Shau Hungyi, Chandler G Scott, Whitelegge Julian P, Gornbein Jeffrey A, Faull Kym F, Chang Helena R   Proteomic profiling of cancer biomarkers Briefings in functional genomics & proteomics, 2003; 2(2): 147-58.
Whitelegge Julian P, Gmez Stephen M, Faull Kym F   Proteomics of membrane proteins Advances in protein chemistry, 2003; 65(1): 271-307.
Slaughter Ndaisha, Laux Isett, Tu Xiaolin, Whitelegge Julian, Zhu Xiaoming, Effros Rita, Bickel Perry, Nel Andre   The flotillins are integral membrane proteins in lipid rafts that contain TCR-associated signaling components: implications for T-cell activation Clinical immunology (Orlando, Fla.), 2003; 108(2): 138-51.
Whitelegge Julian P   Thylakoid membrane proteomics Photosynthesis research, 2003; 78(3): 265-77.
Gmez Stephen M, Bil' Karl Y, Aguilera Rodrigo, Nishio John N, Faull Kym F, Whitelegge Julian P   Transit peptide cleavage sites of integral thylakoid membrane proteins Molecular & cellular proteomics : MCP, 2003; 2(10): 1068-85.
Whitelegge Julian P, Zhang Huamin, Aguilera Rodrigo, Taylor Ross M, Cramer William A   Full subunit coverage liquid chromatography electrospray ionization mass spectrometry (LCMS+) of an oligomeric membrane protein: cytochrome b(6)f complex from spinach and the cyanobacterium Mastigocladus laminosus Molecular & cellular proteomics : MCP, 2002; 1(10): 816-27.
Behnam Keyvan, Murray Samuel S, Whitelegge Julian P, Brochmann Elsa J   Identification of the molecular chaperone alpha B-crystallin in demineralized bone powder and osteoblast-like cells Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2002; 20(6): 1190-6.
Whitelegge Julian P   Plant proteomics: BLASTing out of a MudPIT Proceedings of the National Academy of Sciences of the United States of America, 2002; 99(18): 11564-6.
Gmez Stephen M, Nishio John N, Faull Kym F, Whitelegge Julian P   The chloroplast grana proteome defined by intact mass measurements from liquid chromatography mass spectrometry Molecular & cellular proteomics : MCP, 2002; 1(1): 46-59.
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