Rajalingam Raja, Ph.D.

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Work Titles
CTSI Member, CTSI
UCLA Associate Director, Immunogenetics Center Health Sciences Associate Clinical Professor, Pathology and Laboratory Medicine Health Sciences Associate Clinical Professor, Transplant/Immunogenetics Testing Member, Tumor Immunology Program at the Jonsson Comprehensive Cancer Center (JCCC)
Education:
Degrees:
Ph.D.

Contact Information:

Work Email Address:

rrajalingam@mednet.ucla.edu


Work Phone Number:

(310) 825-1467

Work Address:

UCLA Immunogenetics Center
1000 Veteran Avenue
Los Angeles, CA 90095


Detailed Biography:

Rajalingam Raja is an Immunologist who has served on the UCLA School of Medicine faculty since he joined the UCLA Department of Pathology and Laboratory Medicine in 2002. He is the Associate Director of the UCLA Immunogenetics Center. Dr. Rajalingam earned his Ph.D. in Immunogenetics at All India Institute of Medical Sciences, New Delhi. He was a postdoctoral fellow at Stanford University, where he worked on the biology of natural killer (NK) cells. His laboratory research centers on understanding the complex relationship between polymorphic NK cell receptors and HLA class I ligands in human health and disease.

Publications:

A selected list of publications:

Rajalingam Raja   Overview of the killer cell immunoglobulin-like receptor system Methods in molecular biology (Clifton, N.J.), 2012; 882: 391-414.
Solgi Ghasem, Ghafari Hamidreza, Ashouri Elham, Alimoghdam Kamran, Rajalingam Raja, Amirzargar Aliakbar   Comparison of KIR gene content profiles revealed a difference between northern and southern Persians in the distribution of KIR2DS5 and its linked loci Human immunology, 2011; 72(11): 1079-83.
Bonagura Vincent R, Du Zeying, Ashouri Elham, Luo Lihui, Hatam Lynda J, DeVoti James A, Rosenthal David W, Steinberg Bettie M, Abramson Allan L, Gjertson David W, Reed Elaine F, Rajalingam Raja   Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis Human immunology, 2010; 71(2): 212-9.
Levinson Ralph D, Okada Annabelle A, Ashouri Elham, Keino Hiroshi, Rajalingam Raja   Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt-Koyanagi-Harada syndrome in Japanese individuals Human immunology, 2010; 71(2): 192-4.
Levinson Ralph D, Martin Tammy M, Luo Lihui, Ashouri Elham, Rosenbaum James T, Smith Justine R, Austin Carrie R, Lutt Joseph R, Rajalingam Raja   Killer Cell Immunoglobulin-like Receptors in HLA-B27 Associated Acute Anterior Uveitis, with and without Axial Spondyloarthropathy Investigative ophthalmology & visual science, 2009; 71(2): .
Ashouri E, Ghaderi A, Reed E F, Rajalingam R   A novel duplex SSP-PCR typing method for KIR gene profiling Tissue antigens, 2009; 74(1): 62-7.
Ashouri Elham, Farjadian Shirin, Reed Elaine F, Ghaderi Abbas, Rajalingam Raja   KIR gene content diversity in four Iranian populations Immunogenetics, 2009; 61(7): 483-92.
Rajalingam Raja   Variable interactions of recipient killer cell immunoglobulin-like receptors with self and allogenic human leukocyte antigen class I ligands may influence the outcome of solid organ transplants Current opinion in organ transplantation, 2008; 13(4): 430-7.
Du Z, Sharma S K, Spellman S, Reed E F, Rajalingam R   KIR2DL5 alleles mark certain combination of activating KIR genes Genes and immunity, 2008; 9(5): 470-80.
Levinson Ralph D, Du Zeying, Luo Lihui, Holland Gary N, Rao Narsing A, Reed Elaine F, Rajalingam Raja   KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease Human immunology, 2008; 69(6): 349-53.
Rajalingam Raja, Du Zeying, Meenagh Ashley, Luo Lihui, Kavitha Valampuri John, Pavithra-Arulvani Rajamanickam, Vidhyalakshmi Arumugam, Sharma Surendra K, Balazs Ivan, Reed Elaine F, Pitchappan Ramasamy M, Middleton Derek   Distinct diversity of KIR genes in three southern Indian populations: comparison with world populations revealed a link between KIR gene content and pre-historic human migrations Immunogenetics, 2008; 60(5): 207-17.
Levinson R D, Du Z, Luo L, Monnet D, Tabary T, Brezin A P, Zhao L, Gjertson D W, Holland G N, Reed E F, Cohen J H M, Rajalingam R   Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals Genes and immunity, 2008; 9(3): 249-58.
Luo Lihui, Du Zeying, Sharma Surendra K, Cullen Rebecca, Spellman Stephen, Reed Elaine F, Rajalingam Raja   Chain-terminating natural mutations affect the function of activating KIR receptors 3DS1 and 2DS3 Immunogenetics, 2007; 59(10): 779-92.
Rajalingam Raja   Killer cell immunoglobulin-like receptors influence the innate and adaptive immune responses Iranian journal of immunology : IJI, 2007; 4(2): 61-78.
Du Zeying, Gjertson David W, Reed Elaine F, Rajalingam Raja   Receptor-ligand analyses define minimal killer cell Ig-like receptor (KIR) in humans Immunogenetics, 2007; 59(1): 1-15.
Rajalingam R, Hong M, Adams E J, Shum B P, Guethlein L A, Parham P   Short KIR haplotypes in pygmy chimpanzee (Bonobo) resemble the conserved framework of diverse human KIR haplotypes The Journal of experimental medicine, 2001; 193(1): 135-46.
Khakoo S I, Rajalingam R, Shum B P, Weidenbach K, Flodin L, Muir D G, Canavez F, Cooper S L, Valiante N M, Lanier L L, Parham P   Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans Immunity, 2000; 12(6): 687-98.
Rajalingam R, Mehra N K, Jain R C, Myneedu V P, Pande J N   Polymerase chain reaction--based sequence-specific oligonucleotide hybridization analysis of HLA class II antigens in pulmonary tuberculosis: relevance to chemotherapy and disease severity The Journal of infectious diseases, 1996; 173(3): 669-76.
Vierra-Green Cynthia, Roe David, Hou Lihua, Hurley Carolyn Katovich, Rajalingam Raja, Reed Elaine, Lebedeva Tatiana, Yu Neng, Stewart Mary, Noreen Harriet, Hollenbach Jill A, Guethlein Lisbeth A, Wang Tao, Spellman Stephen, Maiers Martin   Allele-level haplotype frequencies and pairwise linkage disequilibrium for 14 KIR loci in 506 European-American individuals PloS one, 2012; 7(11): e47491.
Rajalingam Raja   Human diversity of killer cell immunoglobulin-like receptors and disease The Korean journal of hematology, 2011; 46(4): 216-28.
Abi-Rached Laurent, Jobin Matthew J, Kulkarni Subhash, McWhinnie Alasdair, Dalva Klara, Gragert Loren, Babrzadeh Farbod, Gharizadeh Baback, Luo Ma, Plummer Francis A, Kimani Joshua, Carrington Mary, Middleton Derek, Rajalingam Raja, Beksac Meral, Marsh Steven G E, Maiers Martin, Guethlein Lisbeth A, Tavoularis Sofia, Little Ann-Margaret, Green Richard E, Norman Paul J, Parham Peter   The shaping of modern human immune systems by multiregional admixture with archaic humans Science (New York, N.Y.), 2011; 334(6052): 89-94.
Sanchez-Mazas Alicia, Fernandez-Viña Marcelo, Middleton Derek, Hollenbach Jill A, Buhler Stéphane, Di Da, Rajalingam Raja, Dugoujon Jean-Michel, Mack Steven J, Thorsby Erik   Immunogenetics as a tool in anthropological studies Immunology, 2011; 133(2): 143-64.
Abi-Rached Laurent, Moesta Achim K, Rajalingam Raja, Guethlein Lisbeth A, Parham Peter   Human-specific evolution and adaptation led to major qualitative differences in the variable receptors of human and chimpanzee natural killer cells PLoS genetics, 2010; 6(11): e1001192.
Levinson Ralph D, See Robert F, Rajalingam Raja, Reed Elaine F, Park Min S, Rao Narsing A, Holland Gary N   HLA-DRB1 and -DQB1 alleles in mestizo patients with Vogt-Koyanagi-Harada's disease in Southern California Human immunology, 2004; 65(12): 1477-82.
Levinson Ralph D, Rajalingam Raja, Park Min S, Reed Elaine F, Gjertson David W, Kappel Peter J, See Robert F, Rao Narsing A, Holland Gary N   Human leukocyte antigen A29 subtypes associated with birdshot retinochoroidopathy American journal of ophthalmology, 2004; 138(4): 631-4.
Rajalingam Raja, Ge Ping, Reed Elaine F   A sequencing-based typing method for HLA-DQA1 alleles Human immunology, 2004; 65(4): 373-9.
Jin Yi-Ping, Fishbein Michael C, Said Jonathan W, Jindra Peter T, Rajalingam Raja, Rozengurt Enrique, Reed Elaine F   Anti-HLA class I antibody-mediated activation of the PI3K/Akt signaling pathway and induction of Bcl-2 and Bcl-xL expression in endothelial cells Human immunology, 2004; 65(4): 291-302.
Rajalingam Raja, Parham Peter, Abi-Rached Laurent   Domain shuffling has been the main mechanism forming new hominoid killer cell Ig-like receptors Journal of immunology (Baltimore, Md. : 1950), 2004; 172(1): 356-69.
Yawata Makoto, Yawata Nobuyo, McQueen Karina L, Cheng Nathalie W, Guethlein Lisbeth A, Rajalingam Raja, Shilling Heather G, Parham Peter   Predominance of group A KIR haplotypes in Japanese associated with diverse NK cell repertoires of KIR expression Immunogenetics, 2002; 54(8): 543-50.
Rajalingam Raja, Krausa Peter, Shilling Heather G, Stein Jason B, Balamurugan Arumugam, McGinnis Malcolm D, Cheng Nathalie W, Mehra Narinder K, Parham Peter   Distinctive KIR and HLA diversity in a panel of north Indian Hindus Immunogenetics, 2002; 53(12): 1009-19.
Shum Benny P, Flodin Laura R, Muir David G, Rajalingam Raja, Khakoo Salim I, Cleland Sophia, Guethlein Lisbeth A, Uhrberg Markus, Parham Peter   Conservation and variation in human and common chimpanzee CD94 and NKG2 genes Journal of immunology (Baltimore, Md. : 1950), 2002; 168(1): 240-52.

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