Lawrence Castellani


Work Titles
UCLA Researcher, Cardiology

Contact Information:

Work Email Address:

lcastellani@mednet.ucla.edu


Work Phone Number:

(310) 825-5778

Mailing Address:

UCLA Med-Cardio
BOX 951679, 3-535 MRL
Los Angeles, CA 90095


Publications:

A selected list of publications:

Parks Brian W, Nam Elizabeth, Org Elin, Kostem Emrah, Norheim Frode, Hui Simon T, Pan Calvin, Civelek Mete, Rau Christoph D, Bennett Brian J, Mehrabian Margarete, Ursell Luke K, He Aiqing, Castellani Lawrence W, Zinker Bradley, Kirby Mark, Drake Thomas A, Drevon Christian A, Knight Rob, Gargalovic Peter, Kirchgessner Todd, Eskin Eleazar, Lusis Aldons J   Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice Cell metabolism, 2013; 17(1): 141-52.
Kim Juyong Brian, Deluna Andres, Mungrue Imran N, Vu Christine, Pouldar Delila, Civelek Mete, Orozco Luz, Wu Judy, Wang Xuping, Charugundla Sarada, Castellani Lawrence W, Rusek Marta, Jakubowski Hieronim, Jakobowski Hieronim, Lusis Aldons J   Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice Circulation, 2012; 126(15): 1896-906.
Martin Lisa J, Lau Edward, Singh Harpreet, Vergnes Laurent, Tarling Elizabeth J, Mehrabian Margarete, Mungrue Imran, Xiao Sheila, Shih Diana, Castellani Lawrence, Ping Peipei, Reue Karen, Stefani Enrico, Drake Thomas A, Bostrom Kristina, Lusis Aldons J   ABCC6 localizes to the mitochondria-associated membrane Circulation research, 2012; 111(5): 516-20.
Hong Cynthia, Bradley Michele N, Rong Xin, Wang Xuping, Wagner Alan, Grijalva Victor, Castellani Lawrence W, Salazar Jon, Realegeno Susan, Boyadjian Rima, Fogelman Alan M, Van Lenten Brian J, Reddy Srinivasa T, Lusis Aldons J, Tangirala Rajendra K, Tontonoz Peter   LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice Journal of lipid research, 2012; 53(6): 1126-33.
Langfelder Peter, Castellani Lawrence W, Zhou Zhiqiang, Paul Eric, Davis Richard, Schadt Eric E, Lusis Aldons J, Horvath Steve, Mehrabian Margarete   A systems genetic analysis of high density lipoprotein metabolism and network preservation across mouse models Biochimica et biophysica acta, 2012; 1821(3): 435-47.
Davis Richard C, van Nas Atila, Castellani Lawrence W, Zhao Yi, Zhou Zhiqiang, Wen Pingzi, Yu Suzanne, Qi Hongxiu, Rosales Melenie, Schadt Eric E, Broman Karl W, Péterfy Miklós, Lusis Aldons J   Systems genetics of susceptibility to obesity-induced diabetes in mice Physiological genomics, 2012; 44(1): 1-13.
Barajas Berenice, Che Nam, Yin Fen, Rowshanrad Amir, Orozco Luz D, Gong Ke Wei, Wang Xuping, Castellani Lawrence W, Reue Karen, Lusis Aldons J, Araujo Jesus A   NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protection Arteriosclerosis, thrombosis, and vascular biology, 2011; 31(1): 58-66.
Davis Richard C, Castellani Lawrence W, Hosseini Maryam, Ben-Zeev Osnat, Mao Hui Z, Weinstein Michael M, Jung Dae Young, Jun John Y, Kim Jason K, Lusis Aldons J, Péterfy Miklós   Early hepatic insulin resistance precedes the onset of diabetes in obese C57BLKS-db/db mice Diabetes, 2010; 59(7): 1616-25.
Bennett Brian J, Farber Charles R, Orozco Luz, Kang Hyun Min, Ghazalpour Anatole, Siemers Nathan, Neubauer Michael, Neuhaus Isaac, Yordanova Roumyana, Guan Bo, Truong Amy, Yang Wen-pin, He Aiqing, Kayne Paul, Gargalovic Peter, Kirchgessner Todd, Pan Calvin, Castellani Lawrence W, Kostem Emrah, Furlotte Nicholas, Drake Thomas A, Eskin Eleazar, Lusis Aldons J   A high-resolution association mapping panel for the dissection of complex traits in mice Genome research, 2010; 20(2): 281-90.
Gargalovic Peter S, Erbilgin Ayça, Kohannim Omid, Pagnon Joanne, Wang Xuping, Castellani Lawrence, LeBoeuf Renee, Peterson Martha L, Spear Brett T, Lusis Aldons J   Quantitative trait locus mapping and identification of Zhx2 as a novel regulator of plasma lipid metabolism Circulation. Cardiovascular genetics, 2010; 3(1): 60-7.
Wu Sulin, Mar-Heyming Rebecca, Dugum Eric Z, Kolaitis Nicholas A, Qi Hongxiu, Pajukanta Päivi, Castellani Lawrence W, Lusis Aldons J, Drake Thomas A   Upstream transcription factor 1 influences plasma lipid and metabolic traits in mice Human molecular genetics, 2010; 19(4): 597-608.
Weinstein Michael M, Yin Liya, Tu Yiping, Wang Xuping, Wu Xiaohui, Castellani Lawrence W, Walzem Rosemary L, Lusis Aldons J, Fong Loren G, Beigneux Anne P, Young Stephen G   Chylomicronemia elicits atherosclerosis in mice--brief report Arteriosclerosis, thrombosis, and vascular biology, 2010; 30(1): 20-3.
Woo Jennifer M P, Lin Zhuofeng, Navab Mohamad, Van Dyck Casey, Trejo-Lopez Yvette, Woo Krystal M T, Li Hongyun, Castellani Lawrence W, Wang Xuping, Iikuni Noriko, Rullo Ornella J, Wu Hui, La Cava Antonio, Fogelman Alan M, Lusis Aldons J, Tsao Betty P   Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis Arthritis research & therapy, 2010; 12(3): R93.
Yang Xia, Deignan Joshua L, Qi Hongxiu, Zhu Jun, Qian Su, Zhong Judy, Torosyan Gevork, Majid Sana, Falkard Brie, Kleinhanz Robert R, Karlsson Jenny, Castellani Lawrence W, Mumick Sheena, Wang Kai, Xie Tao, Coon Michael, Zhang Chunsheng, Estrada-Smith Daria, Farber Charles R, Wang Susanna S, van Nas Atila, Ghazalpour Anatole, Zhang Bin, Macneil Douglas J, Lamb John R, Dipple Katrina M, Reitman Marc L, Mehrabian Margarete, Lum Pek Y, Schadt Eric E, Lusis Aldons J, Drake Thomas A   Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks Nature genetics, 2009; 41(4): 415-23.
Castellani Lawrence W, Nguyen Cara N, Charugundla Sarada, Weinstein Michael M, Doan Chau X, Blaner William S, Wongsiriroj Nuttaporn, Lusis Aldons J   Apolipoprotein AII is a regulator of very low density lipoprotein metabolism and insulin resistance The Journal of biological chemistry, 2008; 283(17): 11633-44.
Feng Xuebing, Li Hongyun, Rumbin Alexis A, Wang Xuping, La Cava Antonio, Brechtelsbauer Katherine, Castellani Lawrence W, Witztum Joseph L, Lusis Aldons J, Tsao Betty P   ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia Journal of lipid research, 2007; 48(4): 794-805.
Estrada-Smith Daria, Collins Alan R, Wang Xuping, Crockett Craig, Castellani Lawrence, Lusis Aldons J, Davis Richard C   Impact of chromosome 2 obesity loci on cardiovascular complications of insulin resistance in LDL receptor-deficient C57BL/6 mice Diabetes, 2006; 55(8): 2265-71.
Castellani Lawrence W, Chang James J, Wang Xuping, Lusis Aldons J, Reynolds Wanda F   Transgenic mice express human MPO -463G/A alleles at atherosclerotic lesions, developing hyperlipidemia and obesity in -463G males Journal of lipid research, 2006; 47(7): 1366-77.
Cervino Alessandra C, Li Guoya, Edwards Steve, Zhu Jun, Laurie Cathy, Tokiwa George, Lum Pek Yee, Wang Susanna, Castellani Lawrence W, Castellini Lawrence W, Lusis Aldons J, Carlson Sonia, Sachs Alan B, Schadt Eric E   Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels Genomics, 2005; 86(5): 505-17.
Mehrabian Margarete, Allayee Hooman, Stockton Jirina, Lum Pek Yee, Drake Thomas A, Castellani Lawrence W, Suh Michael, Armour Christopher, Edwards Stephen, Lamb John, Lusis Aldons J, Schadt Eric E   Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits Nature genetics, 2005; 37(11): 1224-33.
Sheth Sonal S, Castellani Lawrence W, Chari Soumya, Wagg Cory, Thipphavong Christopher K, Bodnar Jackie S, Tontonoz Peter, Attie Alan D, Lopaschuk Gary D, Lusis Aldons J   Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition Journal of lipid research, 2005; 46(1): 123-34.
Castellani Lawrence W, Gargalovic Peter, Febbraio Maria, Charugundla Sarada, Jien Ming-Len, Lusis Aldons J   Mechanisms mediating insulin resistance in transgenic mice overexpressing mouse apolipoprotein A-II Journal of lipid research, 2004; 45(12): 2377-87.
Wang Xuping, Gargalovic Peter, Wong Jack, Gu Jennifer L, Wu Xiaohui, Qi Hongxiu, Wen Pingzi, Xi Li, Tan Bing, Gogliotti Rocky, Castellani Lawrence W, Chatterjee Aurobindo, Lusis Aldons J   Hyplip2, a new gene for combined hyperlipidemia and increased atherosclerosis Arteriosclerosis, thrombosis, and vascular biology, 2004; 24(10): 1928-34.
Shi Weibin, Wang Xuping, Wong Jack, Hedrick Catherine C, Wong Howard, Castellani Lawrence W, Lusis Aldons J   Effect of macrophage-derived apolipoprotein E on hyperlipidemia and atherosclerosis of LDLR-deficient mice Biochemical and biophysical research communications, 2004; 317(1): 223-9.
Estrada-Smith Daria, Castellani Lawrence W, Wong Howard, Wen Ping-Zi, Chui Aileen, Lusis Aldons J, Davis Richard C   Dissection of multigenic obesity traits in congenic mouse strains Mammalian genome : official journal of the International Mammalian Genome Society, 2004; 15(1): 14-22.
Allayee Hooman, Castellani Lawrence W, Cantor Rita M, de Bruin Tjerk W A, Lusis Aldons J   Biochemical and genetic association of plasma apolipoprotein A-II levels with familial combined hyperlipidemia Circulation research, 2003; 92(11): 1262-7.
Tward Aaron, Xia Yu-Rong, Wang Xu-Ping, Shi Yi-Shou, Park Christina, Castellani Lawrence W, Lusis Aldons J, Shih Diana M   Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice Circulation, 2002; 106(4): 484-90.
Bodnar Jackie S, Chatterjee Aurobindo, Castellani Lawrence W, Ross David A, Ohmen Jeffrey, Cavalcoli James, Wu Chenyan, Dains Katherine M, Catanese Joe, Chu Michael, Sheth Sonal S, Charugundla Kanti, Demant Peter, West David B, de Jong Pieter, Lusis Aldons J   Positional cloning of the combined hyperlipidemia gene Hyplip1 Nature genetics, 2002; 30(1): 110-6.
Miyake Jon H, Duong-Polk Xuandao T, Taylor John M, Du Emma Z, Castellani Lawrence W, Lusis Aldons J, Davis Roger A   Transgenic expression of cholesterol-7-alpha-hydroxylase prevents atherosclerosis in C57BL/6J mice Arteriosclerosis, thrombosis, and vascular biology, 2002; 22(1): 121-6.

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