Publications:
A selected list of publications:
Mineharu Yohei, Muhammad A K M Ghulam, Yagiz Kader, Candolfi Marianela, Kroeger Kurt M, Xiong Weidong, Puntel Mariana, Liu Chunyan, Levy Eva, Lugo Claudia, Kocharian Adrina, Allison James P, Curran Michael A, Lowenstein Pedro R, Castro Maria G
Gene therapy-mediated reprogramming tumor infiltrating T cells using
IL-2 and inhibiting NF-κB signaling improves the efficacy of
immunotherapy in a brain cancer model
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics,
2012; 9(4):
827-43.
Zirger Jeffrey M, Puntel Mariana, Bergeron Josee, Wibowo Mia, Moridzadeh Rameen, Bondale Niyati, Barcia Carlos, Kroeger Kurt M, Liu Chunyan, Castro Maria G, Lowenstein Pedro R
Immune-mediated loss of transgene expression from virally transduced
brain cells is irreversible, mediated by IFNγ, perforin, and TNFα,
and due to the elimination of transduced cells
Molecular therapy : the journal of the American Society of Gene Therapy,
2012; 20(4):
808-19.
Candolfi Marianela, King Gwendalyn D, Yagiz Kader, Curtin James F, Mineharu Yohei, Muhammad A K M Ghulam, Foulad David, Kroeger Kurt M, Barnett Nick, Josien Regis, Lowenstein Pedro R, Castro Maria G
Plasmacytoid dendritic cells in the tumor microenvironment: immune
targets for glioma therapeutics
Neoplasia (New York, N.Y.),
2012; 14(8):
757-70.
Muhammad A K M Ghulam, Xiong Weidong, Puntel Mariana, Farrokhi Catherine, Kroeger Kurt M, Salem Alireza, Lacayo Liliana, Pechnick Robert N, Kelson Kyle R, Palmer Donna, Ng Philip, Liu Chunyan, Lowenstein Pedro R, Castro Maria G
Safety profile of gutless adenovirus vectors delivered into the normal
brain parenchyma: implications for a glioma phase 1 clinical trial
Human gene therapy methods,
2012; 23(4):
271-84.
Candolfi Marianela, Curtin James F, Yagiz Kader, Assi Hikmat, Wibowo Mia K, Alzadeh Gabrielle E, Foulad David, Muhammad A K M G, Salehi Sofia, Keech Naomi, Puntel Mariana, Liu Chunyan, Sanderson Nicholas R, Kroeger Kurt M, Dunn Robert, Martins Gislaine, Lowenstein Pedro R, Castro Maria G
B cells are critical to T-cell-mediated antitumor immunity induced by
a combined immune-stimulatory/conditionally cytotoxic therapy for
glioblastoma
Neoplasia (New York, N.Y.),
2011; 13(10):
947-60.
King Gwendalyn D, Muhammad A K M Ghulam, Larocque Daniel, Kelson Kyle R, Xiong Weidong, Liu Chunyan, Sanderson Nicholas S R, Kroeger Kurt M, Castro Maria G, Lowenstein Pedro R
Combined Flt3L/TK gene therapy induces immunological surveillance
which mediates an immune response against a surrogate brain tumor
neoantigen
Molecular therapy : the journal of the American Society of Gene Therapy,
2011; 19(10):
1793-801.
Castro Maria G, Candolfi Marianela, Kroeger Kurt, King Gwendalyn D, Curtin James F, Yagiz Kader, Mineharu Yohei, Assi Hikmat, Wibowo Mia, Ghulam Muhammad A K M, Foulad David, Puntel Mariana, Lowenstein Pedro R
Gene therapy and targeted toxins for glioma
Current gene therapy,
2011; 11(3):
155-80.
Puntel Mariana, Barrett Robert, Sanderson Nicholas S R, Kroeger Kurt M, Bondale Niyati, Wibowo Mia, Kennedy Sean, Liu Chunyan, Castro Maria G, Lowenstein Pedro R
Identification and visualization of CD8+ T cell mediated IFN-γ
signaling in target cells during an antiviral immune response in the
brain
PloS one,
2011; 6(8):
e23523.
Puntel Mariana, Muhammad A K M G, Candolfi Marianela, Salem Alireza, Yagiz Kader, Farrokhi Catherine, Kroeger Kurt M, Xiong Weidong, Curtin James F, Liu Chunyan, Bondale Niyati S, Lerner Jonathan, Pechnick Robert N, Palmer Donna, Ng Philip, Lowenstein Pedro R, Castro Maria G
A novel bicistronic high-capacity gutless adenovirus vector that
drives constitutive expression of herpes simplex virus type 1
thymidine kinase and tet-inducible expression of Flt3L for glioma
therapeutics
Journal of virology,
2010; 84(12):
6007-17.
Larocque Daniel, Sanderson Nicholas S R, Bergeron Josée, Curtin James F, Girton Joe, Wibowo Mia, Bondale Niyati, Kroeger Kurt M, Yang Jieping, Lacayo Liliana M, Reyes Kevin C, Farrokhi Catherine, Pechnick Robert N, Castro Maria G, Lowenstein Pedro R
Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune
privilege and facilitates recognition of a neo-antigen without causing
autoimmune neuropathology
Proceedings of the National Academy of Sciences of the United States of America,
2010; 107(32):
14443-8.
Kroeger Kurt M, Muhammad A K M Ghulam, Baker Gregory J, Assi Hikmat, Wibowo Mia K, Xiong Weidong, Yagiz Kader, Candolfi Marianela, Lowenstein Pedro R, Castro Maria G
Gene therapy and virotherapy: novel therapeutic approaches for brain
tumors
Discovery medicine,
2010; 10(53):
293-304.
Candolfi Marianela, Xiong Weidong, Yagiz Kader, Liu Chunyan, Muhammad A K M G, Puntel Mariana, Foulad David, Zadmehr Ali, Ahlzadeh Gabrielle E, Kroeger Kurt M, Tesarfreund Matthew, Lee Sharon, Debinski Waldemar, Sareen Dhruv, Svendsen Clive N, Rodriguez Ron, Lowenstein Pedro R, Castro Maria G
Gene therapy-mediated delivery of targeted cytotoxins for glioma
therapeutics
Proceedings of the National Academy of Sciences of the United States of America,
2010; 107(46):
20021-6.
Puntel Mariana, Kroeger Kurt M, Sanderson Nicholas S R, Thomas Clare E, Castro Maria G, Lowenstein Pedro R
Gene transfer into rat brain using adenoviral vectors
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.],
2010; Chapter 4(2-3):
Unit 4.24.
Xiong Weidong, Candolfi Marianela, Liu Chunyan, Muhammad A K M Ghulam, Yagiz Kader, Puntel Mariana, Moore Peter F, Avalos Julie, Young John D, Khan Dorothy, Donelson Randy, Pluhar G Elizabeth, Ohlfest John R, Wawrowsky Kolja, Lowenstein Pedro R, Castro Maria G
Human Flt3L generates dendritic cells from canine peripheral blood
precursors: implications for a dog glioma clinical trial
PloS one,
2010; 5(6):
e11074.
Muhammad AKM, Candolfi M, King GD, Foulad D, Yagiz K, Mineharu Y, Kroeger K, Treuer KA, Nichols S, Sanderson NS, Lowenstein PR, Castro MG.
Anti-glioma immunological memory in response to conditional cytotoxic/immune-stimulatory gene therapy: humoral and cellular immunity lead to tumor regression,
Clinical Cancer Research,
2009; In Press:
.
Curtin JF, Liu N, Candolfi M, Xiong W, Assi H, Yagiz K, Edwards MR, Michelsen KS, Kroeger KM, Liu C, Muhammad AKM, Clark MC, Arditi M, Comin-Anduix B, Ribas A, Lowenstein PR, Castro MG
HMGB1 mediates endogenous TLR2 activation and brain tumor regression
PLoS Medicine,
2009; 6(1):
e10.
Candolfi M, Yagiz K, Foulad D, Alzadeh G, Tesarfreund M, Muhammad AKM, Puntel M, Kroeger KM, Liu C, Lee S, Curtin JF, King G, Lerner J, Sato K, Mineharu Y, Xiong W, Lowenstein PR, Castro MG
Release of HMGB1 in response to pro-apoptotic glioma killing strategies: efficacy and neurotoxicity
Clinical Cancer Research,
2009; 15(13):
4401-4414.
Candolfi Marianela, Yagiz Kader, Foulad David, Alzadeh Gabrielle E, Tesarfreund Matthew, Muhammad A K M Ghulam, Puntel Mariana, Kroeger Kurt M, Liu Chunyan, Lee Sharon, Curtin James F, King Gwendalyn D, Lerner Jonathan, Sato Katsuaki, Mineharu Yohei, Xiong Weidong, Lowenstein Pedro R, Castro Maria G
Release of HMGB1 in response to proapoptotic glioma killing
strategies: efficacy and neurotoxicity
Clinical cancer research : an official journal of the American Association for Cancer Research,
2009; 15(13):
4401-14.
King GD, Muhammad AK, Xiong W, Kroeger KM, Puntel M, Larocque D, Palmer D, Ng P, Lowenstein PR, Castro MG
High-Capacity adenoviral vector-mediated 1 anti-glioma gene therapy in the presence of systemic anti-adenovirus immunity
Journal of Virology,
2008; 82(9):
4680-4684.
Curtin JF, King GD, Barcia C, Liu C, Hubert FX, Guillonneau C, Josien R, Anegon I, Lowenstein PR, Castro MG.
Fms-like tyrosine kinase 3 ligand recruits plasmacytoid dendritic cells to the brain
Journal of Immunology,
2006; 176(6):
3566-77.
Ali S, King GD, Curtin JF, Candolfi M, Xiong W, Liu C, Puntel M, Cheng Q, Prieto J, Ribas A, Kupiec-Weglinski J, van Rooijen N, Lassmann H, Lowenstein PR, Castro MG.
Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model
Cancer Research,
2005; 65(16):
7194-204.
Dewey RA, Morrissey G, Cowsill C, Stone D, Dodd NJF, Bolognani F, Southgate TD, Klatzmann D, Castro MG, Lowenstein PR.
Chronic brain inflammation and persistent HSV1-TK expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: Implications for clinical trials
Nature Medicine,
1999; 5(11):
1256-1263.