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Arnie Berk, M.D.

Contact Information:

Lab Number:

(310) 825-9370

Office Phone Number:

(310) 206-6298

Laboratory Address:

Laboratory
UCLA/MBI
611 Young Dr E
Los Angeles, CA 90095
UNITED STATES

Work Address:

Office
Boyer 359
CAMPUS - 157005
CA
UNITED STATES

Work Email Address:

berk@mbi.ucla.edu

Professor, Microbiology, Immunology & Molecular Genetics

Member, ACCESS Program: MBI IDP

Access Cell and Developmental Biology Home Area

Access Gene Regulation Home Area

Access Immunity, Microbes, and Molecular Pathogenesis Home Area

JCCC Gene Regulation Program Area

Faculty, Molecular Biology IDP


Publications:

Pennella MA, Liu Y, Woo JL, Kim CA, and Berk AJ.   Adenovirus E1B-55K is a p53-SUMO1 E3 ligase that stimulates p53 nuclear export and inhibition through interactions in PML-nuclear bodies, J. Virol, 2010; in press: .
Gil JS, Gallaher SD, Berk AJ.   Delivery of an EBV episome by a self-circularizing helper- dependent adenovirus: long-term transgene expression in immunocompetent mice, Gene Therapy, 2010; May 13. [Epub ahead of print]: .
Balamotis MA, Pennella MA, Stevens JL, Wasylyk B, Belmont AS, Berk AJ.   Complexity in Transcription Control at the Activation Domain-Mediator Interface, Science Signaling, 2009; 2: ra20, 1-12.
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Sean D. Gallaher, Jose S. Gil, Oliver Dorigo, Arnold J. Berk   Robust In Vivo Transduction of a Genetically Stable EBV Episome to Hepatocytes in Mouse by a Hybrid Viral Vector, J. Virol, 2009; 83: 3249-3257.
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Ferrari R, Berk AJ, Kurdistani SK   Viral manipulation of the host epigenome for oncogenic transformation, Nature Reviews Genetics, 2009; 10: 290-294.
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Gregory A. Horwitz, Kangling Zhang, Matthew A. McBrian, Michael Grunstein, Siavash Kurdistani, and Arnold J. Berk   Adenovirus small e1a alters global patterns of histone modification, Science, 2008; 321: 1084-1085.
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Roberto Ferrari, Matteo Pellegrini, Gregory A. Horwitz, Wei Xie, Arnold J. Berk, and Siavash Kurdistani   Epigenetic reprogramming by adenovirus e1a, Science, 2008; 321: 1086-1088.
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Woo, JL, Berk AJ.   Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export, J. Virol. , 2007; 81: 575-587. [Spotlight article].
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Schwarz J, Schwarz SC, Dorigo O, Stutzer A, Wegner F, Labarca C, Deshpande, P, Gil JS, Berk AJ, Lester HA.   Enhanced Expression of L9'S Mutant nAChR in Adult Mice Increases the Loss of Midbrain Dopaminergic Neurons , FASEB Journal, 2006; 20: 935-46.
Liu, Y., Shevchenko, A., Shevchenko, A., and Berk, A.J.   Adenovirus exploits the cellular aggresome response to inactivate the MRN complex, J. Virol, 2005; 79: 14004-16.[Spotlight article].
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Yue, Q., Groszer M., Gil J.S., Berk, A.J., Messing A., Wu, H., Liu, X.   PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization, Development, 2005; 132: 3281-3291.
Berk, A. J.   Recent lessons from adenovirus in gene expression, cell cycle control, and cell biology, Oncogene, 2005; 21: 7673-85.
Tan BT, Wu L, Berk AJ   Adeno-Epstein-Barr Virus Hybrid Vector that Stably Transforms Cultured Cells with High Efficiency, J. Virol, 1999; 73: 7582-7589.
Lieberman JR, Lee LQ, Wu L, Finerman GAM, Berk A, Witte ON, Stevenson S   Regional gene therapy with a BMP-2 producing murine stromal cell line induces heterotropic bone formation in rodents, Journal of Orthopedic Research, 1998; 16: 330-339.
Bryant GO, Martel LS, Burley SK, Berk AJ   Radical mutagenesis reveals TATA-box binding protein surfaces required for activated transcription in vivo, Genes & Development, 1996; 10: 2491-2504.
Lieberman PM, Berk AJ   A mechansim for TAFs in transcriptional activation: activation domain enhancement of TFIID-TFIIA-promoter DNA complex formation, Genes & Development, 1994; 8: 995-1006.
Yew PR, Liu X, and Berk AJ   Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53, Genes & Development, 1994; 8: 190-202.
Zhou Q, Lieberman PM, Boyer TG, and Berk AJ   Holo TFIID supports transcriptional stimulation by diverse activators and from a TATA-less promoter, Genes & Development, 1992; 6: 1964-1974.
Yew PR, Berk AJ   Inhibition of p53 transactivation required for transformation by adenovirus early 1 B protein, Nature, 1992; 357: 82-85.
Schmidt MC, Kao CC, Pei R, Berk AJ   Yeast TATA-box transcription factor gene, Proceedings of the National Academy of Sciences USA, 1989; 86: 7785-7789.
Berk AJ, Sharp PA.   Spliced early messenger RNAs of simian virus 40, Proc. Natl. Acad. Sci. USA, 1978; 75: 1274-1278.
Berget SM, Berk AJ, Harrison T, Sharp PA   Spliced segments at the 5' termini of adenovirus 2 late mRNA: a role for heterogeneous nuclear RNA in mammalian cells, Cold Spring Harbor Symposium on Quantitative Biology, 1978; 42: 523-529.
Berk AJ, Sharp PA   Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of Sl endonuclease-digested hybrids, Cell, 1977; 12: 721-732.
Wang G, Balamotis MA, Stevens JL, Yamaguchi Y, Handa H, Berk AJ   Mediator requirement for both recruitment and postrecruitment steps in transcription initiation Molecular Cell, 2005; 17(5): 683-94.
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Fang L, Stevens JL, Berk AJ, Spindler KR   Requirement of Sur2 for efficient replication of mouse adenovirus type 1 Journal of virology. , 2004; 78(23): 12888-900.
Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ, Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M, Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP, Fukasawa T, Gustafsson CM, Han M, He X, Herman PK, Hinnebusch AG, Holmberg S, Holstege FC, Jaehning JA, Kim YJ, Kuras L, Leutz A, Lis JT, Meisterernest M, Naar AM, Nasmyth K, Parvin JD, Ptashne M, Reinberg D, Ronne H, Sadowski I, Sakurai H, Sipiczki M, Sternberg PW, Stillman DJ, Strich R, Struhl K, Svejstrup JQ, Tuck S, Winston F, Roeder RG, Kornberg RD   A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II Molecular cell. , 2004; 14(5): 553-7.
Dorigo O, Gil JS, Gallaher SD, Tan BT, Castro MG, Lowenstein PR, Calos MP, Berk AJ   Development of a novel helper-dependent adenovirus-Epstein-Barr virus hybrid system for the stable transformation of mammalian cells Journal of Virology , 2004; 78(12): 6556-66.
Cantin GT, Stevens JL, Berk AJ   Activation domain-mediator interactions promote transcription preinitiation complex assembly on promoter DNA Proceedings of the National Academy of Sciences of the United States of America, 2003; 100(21): 12003-8.
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Schroder O, Bryant GO, Geiduschek EP, Berk AJ, Kassavetis GA   A common site on TBP for transcription by RNA polymerases II and III Embo J, 2003; 22(19): 5115-24.
Stevens JL, Cantin GT, Wang G, Shevchenko A, Shevchenko A, Berk AJ   Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit Science, 2002; 296(5568): 755-8.
Martel LS, Brown HJ, Berk AJ   Evidence that TAF-TATA box-binding protein interactions are required for activated transcription in mammalian cells Molecular and cellular biology, 2002; 22(8): 2788-98.
Wang G, Cantin GT, Stevens JL, Berk AJ   Characterization of mediator complexes from HeLa cell nuclear extract Molecular and cellular biology. , 2001; 21(14): 4604-13.
Boyer TG, Martin ME, Lees E, Ricciardi RP, Berk AJ   Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein Nature. , 1999; 399(6733): 276-9.
Gambhir SS, Barrio JR, Phelps ME, Iyer M, Namavari M, Satyamurthy N, Wu L, Green LA, Bauer E, MacLaren D,C Nguyen K, Berk AJ, Cherry SR, Herschman HR   Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography Proceedings of the National Academy of Sciences of the United States of America. , 1999; 96(5): 2333-8.
Kao CC, Lieberman PM, Schmidt MC, Zhou Q, Pei R, Berk AJ   Cloning of a transcriptionally active human TATA binding factor Science. , 1990; 248(4963): 1646-50.
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