Monica Ferrini, Ph.D.

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Work Titles
CTSI Member, CTSI
Charles Drew University Course Director, Assistant Professor, Department of Biomedical Sciences Assistant Professor, Internal Medicine
The Lundquist Institute for Biomedical Innovation Assistant Professor, SURGERY
UCLA Professor, Pathology and Laboratory Medicine Member, Molecular Biology Institute
Education:
Degrees:
Ph.D., School of Pharmacy & Biochemistry, University of Buenos Aires, Argentina., 1991 - 1995
M.S., School of Pharmacy & Biochemistry, University of Buenos Aires, Argentina., 1982 - 1986

Contact Information:

Email Address:

mferrini@lundquist.org

Work Email Address:

mferrini@lundquist.org

Work Email Address:

monicaferrini@cdrewu.edu


Website:

Web-Profile

Fax Number:

(310) 222-1914

(323) 563-9352

Work Phone Number:

(310) 222-4199

(323) 563-9332

Mailing Address:

1124 West Carson Street
Torrance, CA


Publications:

A selected list of publications:

Garcia Leah A, Ferrini Monica G, Norris Keith C, Artaza Jorge N   1,25(OH)(2)vitamin D(3) enhances myogenic differentiation by modulating the expression of key angiogenic growth factors and angiogenic inhibitors in C(2)C(12) skeletal muscle cells The Journal of steroid biochemistry and molecular biology, 2013; 133(1): 1-11.
Hlaing Su M, Garcia Leah A, Kovanecz Istvan, Martinez Ramon A, Shah Sanjana, Artaza Jorge N, Ferrini Monica G   Sildenafil promotes neuroprotection of the pelvic ganglia neurones after bilateral cavernosal nerve resection in the rat BJU international, 2013; 111(1): 159-70.
Garcia Leah A, King Keisha K, Ferrini Monica G, Norris Keith C, Artaza Jorge N   1,25(OH)2vitamin D3 stimulates myogenic differentiation by inhibiting cell proliferation and modulating the expression of promyogenic growth factors and myostatin in C2C12 skeletal muscle cells Endocrinology, 2011; 152(8): 2976-86.
Ferrini Monica G, Moon Joanne, Rivera Steve, Rajfer Jacob, Gonzalez-Cadavid Nestor F   Amelioration of diabetes-induced cavernosal fibrosis by antioxidant and anti-transforming growth factor-β1 therapies in inducible nitric oxide synthase-deficient mice BJU international, 2011; .
Sirad Fara, Hlaing Su, Kovanecz Istvan, Artaza Jorge N, Garcia Leah A, Rajfer Jacob, Ferrini Monica G   Sildenafil promotes smooth muscle preservation and ameliorates fibrosis through modulation of extracellular matrix and tissue growth factor gene expression after bilateral cavernosal nerve resection in the rat The journal of sexual medicine, 2011; 8(4): 1048-60.
Artaza Jorge N, Sirad Fara, Ferrini Monica G, Norris Keith C   1,25(OH)2vitamin D3 inhibits cell proliferation by promoting cell cycle arrest without inducing apoptosis and modifies cell morphology of mesenchymal multipotent cells The Journal of steroid biochemistry and molecular biology, 2010; 119(1-2): 73-83.
Ferrini Monica G, Rivera Steve, Moon Joanne, Vernet Dolores, Rajfer Jacob, Gonzalez-Cadavid Nestor F   The genetic inactivation of inducible nitric oxide synthase (iNOS) intensifies fibrosis and oxidative stress in the penile corpora cavernosa in type 1 diabetes The journal of sexual medicine, 2010; 7(9): 3033-44.
Toblli Jorge E, Ferrini Monica G, Cao Gabriel, Vernet Dolores, Angerosa Margarita, Gonzalez-Cadavid Nestor F   Antifibrotic effects of pioglitazone on the kidney in a rat model of type 2 diabetes mellitus Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009; 24(8): 2384-91.
Kovanecz Istvan, Nolazco Gaby, Ferrini Monica G, Toblli Jorge E, Heydarkhan Sanaz, Vernet Dolores, Rajfer Jacob, Gonzalez-Cadavid Nestor F   Early onset of fibrosis within the arterial media in a rat model of type 2 diabetes mellitus with erectile dysfunction BJU international, 2009; 103(10): 1396-404.
Ferrini Monica G, Kovanecz Istvan, Sanchez Sandra, Umeh Chiome, Rajfer Jacob, Gonzalez-Cadavid Nestor F   Fibrosis and loss of smooth muscle in the corpora cavernosa precede corporal veno-occlusive dysfunction (CVOD) induced by experimental cavernosal nerve damage in the rat The journal of sexual medicine, 2009; 6(2): 415-28.
Ho Matthew H, Heydarkhan Sanaz, Vernet Dolores, Kovanecz Istvan, Ferrini Monica G, Bhatia Narender N, Gonzalez-Cadavid Nestor F   Stimulating vaginal repair in rats through skeletal muscle-derived stem cells seeded on small intestinal submucosal scaffolds Obstetrics and gynecology, 2009; 114(2 Pt 1): 300-9.
Kovanecz Istvan, Rambhatla Amarnath, Ferrini Monica G, Vernet Dolores, Sanchez Sandra, Rajfer Jacob, Gonzalez-Cadavid Nestor   Chronic daily tadalafil prevents the corporal fibrosis and veno-occlusive dysfunction that occurs after cavernosal nerve resection BJU international, 2008; 101(2): 203-10.
Nolazco Gaby, Kovanecz Istvan, Vernet Dolores, Gelfand Robert A, Tsao James, Ferrini Monica G, Magee Thomas, Rajfer Jacob, Gonzalez-Cadavid Nestor F   Effect of muscle-derived stem cells on the restoration of corpora cavernosa smooth muscle and erectile function in the aged rat BJU international, 2008; 101(9): 1156-64.
Braga Melissa, Sinha Hikim Amiya P, Datta Sanjit, Ferrini Monica G, Brown Danielle, Kovacheva Ekaterina L, Gonzalez-Cadavid Nestor F, Sinha-Hikim Indrani   Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice Apoptosis : an international journal on programmed cell death, 2008; 13(6): 822-32.
Artaza Jorge N, Singh Rajan, Ferrini Monica G, Braga Melissa, Tsao James, Gonzalez-Cadavid Nestor F   Myostatin promotes a fibrotic phenotypic switch in multipotent C3H 10T1/2 cells without affecting their differentiation into myofibroblasts The Journal of endocrinology, 2008; 196(2): 235-49.
Cantini LP, Ferrini MG, Vernet D, Magee TR, Qian A, Gelfand RA, Rajfer J, Gonzalez-Cadavid NF   Profibrotic role of myostatin in Peyronie's disease The journal of sexual medicine, 2008; 5(7): 1607-22.
Kovanecz Istvan, Ferrini Monica G, Vernet Dolores, Nolazco Gaby, Rajfer Jacob, Gonzalez-Cadavid Nestor F   Ageing-related corpora veno-occlusive dysfunction in the rat is ameliorated by pioglitazone BJU international, 2007; 100(4): 867-74.
Magee Thomas R, Kovanecz Istvan, Davila Hugo H, Ferrini Monica G, Cantini Liliana, Vernet Dolores, Zuniga Freddi I, Rajfer Jacob, Gonzalez-Cadavid Nestor F   Antisense and short hairpin RNA (shRNA) constructs targeting PIN (Protein Inhibitor of NOS) ameliorate aging-related erectile dysfunction in the rat The journal of sexual medicine, 2007; 4(3): 633-43.
Espinosa Veronica Paez, Ferrini Monica, Shen Xiaoxiong, Lutfy Kabirullah, Nillni Eduardo A, Friedman Theodore C   Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism American journal of physiology. Endocrinology and metabolism, 2007; 292(1): E175-86.
Khorram Omid, Momeni Mazdak, Ferrini Monica, Desai Mina, Ross Michael G   In utero undernutrition in rats induces increased vascular smooth muscle content in the offspring American journal of obstetrics and gynecology, 2007; 196(5): 486.e1-8.
Ferrini Monica G, Kovanecz Istvan, Nolazco Gaby, Rajfer Jacob, Gonzalez-Cadavid Nestor F   Effects of long-term vardenafil treatment on the development of fibrotic plaques in a rat model of Peyronie's disease BJU international, 2006; 97(3): 625-33.
Ferrini Monica G, Nolazco Gaby, Vernet Dolores, Gonzalez-Cadavid Nestor F, Berman Jennifer   Increased vaginal oxidative stress, apoptosis, and inducible nitric oxide synthase in a diabetic rat model: implications for vaginal fibrosis Fertility and sterility, 2006; 86(4 Suppl): 1152-63.
Magee Thomas R, Artaza Jorge N, Ferrini Monica G, Vernet Dolores, Zuniga Freddi I, Cantini Liliana, Reisz-Porszasz Suzanne, Rajfer Jacob, Gonzalez-Cadavid Nestor F   Myostatin short interfering hairpin RNA gene transfer increases skeletal muscle mass The journal of gene medicine, 2006; 8(9): 1171-81.
Kovanecz Istvan, Ferrini Monica G, Vernet Dolores, Nolazco Gaby, Rajfer Jacob, Gonzalez-Cadavid Nestor F   Pioglitazone prevents corporal veno-occlusive dysfunction in a rat model of type 2 diabetes mellitus BJU international, 2006; 98(1): 116-24.
Ferrini Monica G, Davila Hugo H, Kovanecz Istvan, Sanchez Sandra P, Gonzalez-Cadavid Nestor F, Rajfer Jacob   Vardenafil prevents fibrosis and loss of corporal smooth muscle that occurs after bilateral cavernosal nerve resection in the rat Urology, 2006; 68(2): 429-35.
Hikim Amiya P Sinha, Vera Yanira, Vernet Dolores, Castanares Mark, Diaz-Romero Maruja, Ferrini Monica, Swerdloff Ronald S, Gonzalez-Cadavid Nestor F, Wang Christina   Involvement of nitric oxide-mediated intrinsic pathway signaling in age-related increase in germ cell apoptosis in male Brown-Norway rats The journals of gerontology. Series A, Biological sciences and medical sciences, 2005; 60(6): 702-8.
Ferrini Monica G, Davila Hugo H, Valente Eliane G A, Gonzalez-Cadavid Nestor F, Rajfer Jacob   Aging-related induction of inducible nitric oxide synthase is vasculo-protective to the arterial media Cardiovascular research, 2004; 61(4): 796-805.
Valente Eliane G A, Vernet Dolores, Ferrini Monica G, Qian Ansha, Rajfer Jacob, Gonzalez-Cadavid Nestor F   L-arginine and phosphodiesterase (PDE) inhibitors counteract fibrosis in the Peyronie's fibrotic plaque and related fibroblast cultures Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society, 2003; 9(4): 229-44.
Ferrini Monica G, Magee Thomas R, Vernet Dolores, Rajfer Jacob, González-Cadavid Nestor F   Penile neuronal nitric oxide synthase and its regulatory proteins are present in hypothalamic and spinal cord regions involved in the control of penile erection The Journal of comparative neurology, 2003; 458(1): 46-61.
Vernet Dolores, Ferrini Monica G, Valente Eliane G, Magee Thomas R, Bou-Gharios George, Rajfer Jacob, Gonzalez-Cadavid Nestor F   Effect of nitric oxide on the differentiation of fibroblasts into myofibroblasts in the Peyronie's fibrotic plaque and in its rat model Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society, 2002; 7(4): 262-76.
Magee Thomas R, Ferrini Monica, Garban Hermes J, Vernet Dolores, Mitani Kohnosuke, Rajfer Jacob, Gonzalez-Cadavid Nestor F   Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase Biology of reproduction, 2002; 67(3): 1033-41.
Magee Thomas R, Ferrini Monica, Garban Hermes J, Vernet Dolores, Mitani Kohnosuke, Rajfer Jacob, Gonzalez-Cadavid Nestor F   Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase Biology of reproduction, 2002; 67(1): 20-8.
Wang Christina, Hikim Amiva Sinha, Ferrini Monica, Bonavera Juan J, Vernet Dolores, Leung Andrew, Lue Yan-He, Gonzalez-Cadavid Nestor F, Swerdloff Ronald S   Male reproductive ageing: using the brown Norway rat as a model for man Novartis Foundation symposium, 2002; 242(3): 82-95; discussion 95-7.

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