Fibrosis is a leading cause of organ failure and inflammation worldwide. Understanding the mechanisms that lead or prevent fibrosis will allow easier and more practical therapies to ameliorate this Multi-System Pathology (MSP). Our results indicate that vitamin D induces the promotion of an anti-inflammatory/anti-fibrotic phenotype in mesenchymal multipotent cells suggesting that vitamin D supplementation could be a valid anti-inflammatory/ fibrosis strategy in therapeutic treatment of chronic diseases such as renal or cardiac fibrosis. Our goal is to develop a therapeutically approach more easily translatable to the clinic and in that respect, we have identified factors or genes such as myostatin, follistatin and vitamin D that can be responsible for promoting or inhibiting fibrosis. We are also interested in the mechanism of myogenic and cardiac differentiation mediated by Vitamin D supplementation.
Ferrini Monica G, Garcia Eduardo, Abraham Andrea, Artaza Jorge N, Nguyen Sabine, Rajfer Jacob Effect of ginger, Paullinia cupana, muira puama and L- citrulline, singly or in combination, on modulation of the inducible nitric oxide- NO-cGMP pathway in rat penile smooth muscle cells Nitric oxide : biology and chemistry, 2018; .
Braga Melissa, Simmons Zena, Norris Keith C, Ferrini Monica G, Artaza Jorge N Vitamin D induces myogenic differentiation in skeletal muscle derived stem cells Endocrine connections, 2017; Apr; 6(3): 139-150.
Kim Irene M, Norris Keith C, Artaza Jorge N Vitamin D and Cardiac Differentiation Vitamins and hormones, 2016; 100: 299-320.
Ferrini Monica G, Hlaing Su M, Chan Andre, Artaza Jorge N Treatment with a combination of ginger, L-citrulline, muira puama and Paullinia cupana can reverse the progression of corporal smooth muscle loss, fibrosis and veno-occlusive dysfunction in the aging rat Andrology : open access, 2015; 4(1): .
Ramaraj P, Artaza JN, Sinha-Hikim I, Taylor WE Effect of Androstenedione on Adipogenesis in Murine C3H10T1/2 Mesenchymal Cells, Open Journal of Endocrine & Metabolic Diseases, 2015; 5(Feb): 9-18.
Hlaing SM, Garcia LA, Contreras JR, Norris KC, Ferrini MG, Artaza JN 1,25-vitamin-D3 promotes cardiac differentiation through modulation of the Wnt signaling pathway J Mol Endocrinol, 2014; .
Garcia Leah A, Hlaing Su M, Gutierrez Richard A, Sanchez Maria D, Kovanecz Istvan, Artaza Jorge N, Ferrini Monica G Sildenafil Attenuates Inflammation and Oxidative Stress in Pelvic Ganglia Neurons after Bilateral Cavernosal Nerve Damage International journal of molecular sciences, 2014; 15(10): 17204-17220.
Martins D, Meng Y, Tareen N, Artaza J, Lee J E,Farodolu C, Gibbons G, Norris K. The Effect of Short Term Vitamin D Supplementation on the Inflammatory and Oxidative Mediators of Arterial Stiffness, Health, 2014; (6): 1503-1511.
Hlaing Su M, Garcia Leah A, Kovanecz Istvan, Martinez Ramon A, Shah Sanjana, Artaza Jorge N, Ferrini Monica G Sildenafil promotes neuroprotection of the pelvic ganglia neurones after bilateral cavernosal nerve resection in the rat BJU Int, 2013; 111(1): 159-70.
Garcia Leah A, Ferrini Monica G, Norris Keith C, Artaza Jorge N 1,25(OH)(2)vitamin D(3) Enhances Myogenic Differentiation by Modulating the Expression of Key Angiogenic Growth factors and Angiogenic Inhibitors in C(2)C(12) Skeletal Muscle Cells J Steroid Biochem Mol Biol, 2013; 133: 1-11.
Garcia Leah A, King Keisha K, Ferrini Monica G, Norris Keith C, Artaza Jorge N 1,25(OH)2vitamin D3 stimulates myogenic differentiation by inhibiting cell proliferation and modulating the expression of promyogenic growth factors and myostatin in C2C12 skeletal muscle cells Endocrinology, 2011; 152(8): 2976-86.
Artaza Jorge N, Contreras Sandra, Garcia Leah A, Mehrotra Rajnish, Gibbons Gary, Shohet Ralph, Martins David, Norris Keith C Vitamin D and cardiovascular disease: potential role in health disparities Journal of health care for the poor and underserved, 2011; 22(4 Suppl): 23-38.
Sirad F., Hlaing S., Kovanecz I., Artaza J. N., Garcia L. A., Rajfer J., Ferrini M. G. Sildenafil Promotes Smooth Muscle Preservation and Ameliorates Fibrosis Through Modulation of Extracellular Matrix and Tissue Growth Factor Gene Expression After Bilateral Cavernosal Nerve Resection in the Rat J. Sex. Med, 2011; 8(4): 1048-1060.
Artaza J N, Sirad F, Ferrini M G, Norris K C 1,25(OH)(2)vitamin D(3) inhibits cell proliferation by promoting cell cycle arrest without inducing apoptosis and modifies cell morphology of mesenchymal multipotent cells J Steroid Biochem Mol Biol, 2010; 119(1-2): 73-83.
Artaza Jorge N, Mehrotra Rajnish, Norris Keith C Vitamin D and the cardiovascular system Clinical journal of the American Society of Nephrology : CJASN, 2009; 4(9): 1515-22.
Singh Rajan, Bhasin Shalender, Braga Melissa, Artaza Jorge N, Pervin Shehla, Taylor Wayne E, Krishnan Venkatesh, Sinha Satyesh K, Rajavashisth Tripathi B, Jasuja Ravi Regulation of myogenic differentiation by androgens: cross talk between androgen receptor/ beta-catenin and follistatin/transforming growth factor-beta signaling pathways Endocrinology, 2009; 150(3): 1259-68.
Artaza Jorge N, Norris Keith C Vitamin D reduces the expression of collagen and key profibrotic factors by inducing an antifibrotic phenotype in mesenchymal multipotent cells The Journal of endocrinology, 2009; 200(2): 207-21.
Artaza Jorge N, Singh Rajan, Ferrini Monica G, Braga Melissa, Tsao James, Gonzalez-Cadavid Nestor F Myostatin promotes a fibrotic phenotypic switch in multipotent C3H 10T1/2 cells without affecting their differentiation into myofibroblasts The Journal of endocrinology, 2008; 196(2): 235-49.
Artaza Jorge N, Reisz-Porszasz Suzanne, Dow Joan S, Kloner Robert A, Tsao James, Bhasin Shalender, Gonzalez-Cadavid Nestor F Alterations in myostatin expression are associated with changes in cardiac left ventricular mass but not ejection fraction in the mouse The Journal of endocrinology, 2007; 194(1): 63-76.
Magee Thomas R, Artaza Jorge N, Ferrini Monica G, Vernet Dolores, Zuniga Freddi I, Cantini Liliana, Reisz-Porszasz Suzanne, Rajfer Jacob, Gonzalez-Cadavid Nestor F Myostatin short interfering hairpin RNA gene transfer increases skeletal muscle mass The journal of gene medicine, 2006; 8(9): 1171-81.
Singh Rajan, Artaza Jorge N, Taylor Wayne E, Braga Melissa, Yuan Xin, Gonzalez-Cadavid Nestor F, Bhasin Shalender Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors Endocrinology, 2006; 147(1): 141-54.
Artaza Jorge N, Bhasin Shalender, Magee Thomas R, Reisz-Porszasz Suzanne, Shen Ruoquin, Groome Nigel P, Meerasahib Mohamed Fareez, Fareez Meerasaluh M, Gonzalez-Cadavid Nestor F Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells Endocrinology, 2005; 146(8): 3547-57.
Jasuja R, Catlin DH, Miller A, Chang YC, Herbst KL, Starcevic B, Artaza JN, Singh R, Datta G, Sarkissian A, Chandsawangbhuwana C, Baker M, Bhasin S Tetrahydrogestrinone is an androgenic steroid that stimulates androgen receptor-mediated, myogenic differentiation in C3H10T1/2 multipotent mesenchymal cells and promotes muscle accretion in orchidectomized male rats, Endocrinology, 2005; 146(10): 4472-8.
Jasuja Ravi, Ramaraj Pandurangan, Mac Ricky Phong, Singh Atam B, Storer Thomas W, Artaza Jorge, Miller Aria, Singh Rajan, Taylor Wayne E, Lee Martin L, Davidson Tina, Sinha-Hikim Indrani, Gonzalez-Cadavid Nestor, Bhasin Shalender Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men The Journal of clinical endocrinology and metabolism, 2005; 90(2): 855-63.
Bhasin Shalender, Taylor Wayne E, Singh Rajan, Artaza Jorge, Sinha-Hikim Indrani, Jasuja Ravi, Choi Helen, Gonzalez-Cadavid Nestor F The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen action The journals of gerontology. Series A, Biological sciences and medical sciences, 2003; 58(12): M1103-10.
Singh Rajan, Artaza Jorge N, Taylor Wayne E, Gonzalez-Cadavid Nestor F, Bhasin Shalender Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway Endocrinology, 2003; 144(11): 5081-8.
Reisz-Porszasz Suzanne, Bhasin Shalender, Artaza Jorge N, Shen Ruoqing, Sinha-Hikim Indrani, Hogue Aimee, Fielder Thomas J, Gonzalez-Cadavid Nestor F Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatin American journal of physiology. Endocrinology and metabolism, 2003; 285(4): E876-88.
Ma Kun, Mallidis Con, Bhasin Shalender, Mahabadi Vahid, Artaza Jorge, Gonzalez-Cadavid Nestor, Arias Jose, Salehian Behrouz Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression American journal of physiology. Endocrinology and metabolism, 2003; 285(2): E363-71.
Sinha-Hikim Indrani, Artaza Jorge, Woodhouse Linda, Gonzalez-Cadavid Nestor, Singh Atam B, Lee Martin I, Storer Thomas W, Casaburi Richard, Shen Ruoquing, Bhasin Shalender Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy American journal of physiology. Endocrinology and metabolism, 2002; 283(1): E154-64.
Sinha-Hikim I, Artaza J, Woodhouse L, Gonzalez-Cadavid N, Singh AB, Lee MI, Storer TW, Casaburi R, Shen R, Bhasin S. Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy, Am J Physiol Endocrinol Metab, 2002; 283(1): E154-64.
Artaza Jorge N, Bhasin Shalender, Mallidis Con, Taylor Wayne, Ma Kun, Gonzalez-Cadavid Nestor F Endogenous expression and localization of myostatin and its relation to myosin heavy chain distribution in C2C12 skeletal muscle cells Journal of cellular physiology, 2002; 190(2): 170-9.
Ma K, Mallidis C, Artaza J, Taylor W, Gonzalez-Cadavid N, Bhasin S. Characterization of 5'-regulatory region of human myostatin gene: regulation by dexamethasone in vitro, Am J Physiol Endocrinol Metab, 2001; 281(6): E1128-36.
Taylor WE, Bhasin S, Artaza J, Byhower F, Azam M, Willard DH Jr, Kull FC Jr, Gonzalez-Cadavid N. Myostatin inhibits cell proliferation and protein synthesis in C2C12 muscle cells, Am J Physiol Endocrinol Metab, 2001; 280(2): E221-8.
Diaz de Domingo NB, Lardo MM, Artaza J, Merelli A, Carbia CD, Sánchez Avalos JC. Immunocytochemistry techniques for the diagnosis of hematologic neoplasms, Medicina (B Aires), 1999; 59(1): 11-6.
Artaza J, Carbia CD, Ceballo MF, Díaz NB. Red cell distribution width (RDW): its use in the characterization of microcytic and hypochromic anemias, Medicina (B Aires), 1999; 59(1): 17-22.
De Domingo NBD, Carbia C, Artaza J, Lardo M, Ceballo MF. Red cell ferritin - measurement and diagnostic applications, Acta Bioquímica Clínica Latinoamericana, 1997; 31(4): 415-419 .
Lardo MM, Díaz NB, Artaza JR, Carbia CD, Nazer R, Valdez R. Vitamin E as protective agent against hemolysis in leprosy patients under dapsone treatment, Medicina (B Aires), 1997; 57(2): 150-4.
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