Brennan Spiegel, M.D., M.S.H.S.

A Short Biography:

Dr. Brennan Spiegel is the Director of Health Services Research for Cedars-Sinai Health System and Professor of Medicine and Public Health at UCLA, where he teaches digital health science, health analytics, and health economics.

Dr. Spiegel directs the Cedars-Sinai Center for Outcomes Research and Education (CS-CORE), a multidisciplinary team that investigates how digital health technologies, including wearable biosensors, smartphone applications, virtual reality, and social media, can strengthen the patient-doctor bond, improve outcomes, and save money. CS-CORE unites clinicians, computer scientists, engineers, statisticians and health services researchers to invent, test, and implement digital innovations for the clinical trenches, always focusing on the value of technology to patient and provider end-users.

Dr. Spiegel has published numerous best-selling medical textbooks, editorials, and more than 160 articles in peer-reviewed journals. He is listed in the 2016 Onalytica "Top 100 Influencer" lists for digital health (#13) and virtual reality (#14). His digital health research has been featured by major media outlets, including NBC News, PBS, Forbes, Bloomberg, NPR, and Reuters.

Beyond his focus on digital health innovations, Dr. Spiegel conducts psychometric, health-economic, epidemiologic, and qualitative research across a wide range of healthcare topics. As a member of the U.S. Food and Drug Administration (FDA) Field Advisory Committee, Dr. Spiegel also develops endpoints for clinical trials. His research team receives funding from the NIH, Robert Wood Johnson Foundation, Hearst Foundation, Veterans Administration, and industry sources. Dr. Spiegel is Editor-in-Chief of the American Journal of Gastroenterology – the leading clinical gastroenterology journal in North America. He continues to practice clinical medicine and maintains a busy academic teaching practice at Cedars-Sinai Medical Center. A prolific speaker, Dr. Spiegel is frequently invited to present on his areas of expertise at national and international events.

Dr. Spiegel Co-Founded My Total Health, a digital health company developing novel smartphone applications, such as MyGiHealth, that provide value to patients, physicians, and healthcare systems. He also invented AbStats, an FDA-cleared wearable biosensor that non-invasively monitors human digestion.


Work Titles
UCLA Director, Center for Outcomes Research and Education (CORE) Professor In-Residence, School of Public Health Professor In-Residence, Medicine
Education:
Degrees:
M.S.H.S., UCLA, 2004
M.D., New York Medical College, 1998
B.A., Tufts University, 1994 -
Certifications:
Certifications:
2004 American Board of Internal Medicine
2001 American Board of Internal Medicine
Honors and Awards:
2016 - Onalytica Top 100 Virtual Reality Influencer (#14)
2016 - Onalytica Top 100 Digital Health Influencer (#13)
2015 - Appointed Editor-in-Chief, American Journal of Gastroenterology
2012 Appointed as a Fellow of the American Gastroenterological Association (AGA).
2011 American Gastroenterological Association Distinguished Presidential Plenary Abstract
2011 Director the 2013 Annual AGA Postgraduate Course
2009 One of 8 “Key Leaders” in Gastroenterology to receive the American College of Gastroenterology Leadership Training Award.
2009 VA Health Services Research and Development (HSR&D) National Meeting Plenary Abstract
2009 Appointed as Council Member of the American Neurogastroenterology and Motility Society (ANMS).
2008 American Gastroenterological Association Clinical Plenary Abstract
2008 “Breath of Fresh Air Award” from the UCLA GI Fellowship Program for enthusiasm and novelty in teaching
2008 Appointed as a Fellow of the American College of Gastroenterology (FACG)
2008 Appointed to United Stated Food and Drug Administration (FDA) Gastroenterology Field Advisory Board
2007 American Gastroenterological Association Distinguished Plenary Abstract
2007 International Foundation for Functional Gastrointestinal Disorders (IFFGD) Distinguished Clinical Investigator Award
2006 UCLA Department of Medicine Research Day – Plenary Abstract Speaker
2005 UCLA Department of Medicine Research Day – First Place Award
2005 AstraZeneca Emerging Leader in Gastroenterology Award
2005 American Gastroenterological Association Outcomes Research Award
2004 NIH CURE Center Named New Investigator Award
2003 Janssen Research Excellence in Gastroenterology and Liver (REGAL) Award
2002 Rubenstein Award for excellence in research, Cedars-Sinai Medical Center
2000 Solomon's Scholar's Research Award
1999 Leo G. Rigler Award for academic achievement, Cedars-Sinai Medical Center
1997 Alpha Omega Alpha Honors Medical Society

Contact Information:

Mailing Address:

116 N. Robertson Blvd
4th floor suite
Los Angeles, CA 90048


Publications:

Wang Hank S, Pisegna Joseph, Modi Rusha, Liang Li-Jung, Atia Mary, Nguyen Minh, Cohen Hartley, Ohning Gordon, van Oijen Martijn, Spiegel Brennan M R   Adenoma detection rate is necessary but insufficient for distinguishing high versus low endoscopist performance Gastrointestinal endoscopy, 2013; 77(1): 71-8.
Spiegel Brennan M R   Burden of illness in irritable bowel syndrome: looking beyond the patient Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2013; 11(2): 156-7.
Cohen Erica, Fuller Garth, Bolus Roger, Modi Rusha, Vu Michelle, Shahedi Kamyar, Shah Rena, Atia Mary, Kurzbard Nicole, Sheen Victoria, Agarwal Nikhil, Kaneshiro Marc, Yen Linnette, Hodgkins Paul, Erder M Haim, Spiegel Brennan   Increased Risk for Irritable Bowel Syndrome Following Acute Diverticulitis Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2013; 19(2): .
Simrén Magnus, Barbara Giovanni, Flint Harry J, Spiegel Brennan M R, Spiller Robin C, Vanner Stephen, Verdu Elena F, Whorwell Peter J, Zoetendal Erwin G, Zoetendal Erwin G   Intestinal microbiota in functional bowel disorders: a Rome foundation report Gut, 2013; 62(1): 159-76.
Spiegel Brennan M R   Patient-reported outcomes in gastroenterology: clinical and research applications Journal of neurogastroenterology and motility, 2013; 19(2): 137-48.
Melmed Gil Y, Siegel Corey Allan, Spiegel Brennan M, Allen John I, Cima Robert, Colombel Jean-Frederic, Dassopoulos Themistocles, Denson Lee A, Dudley-Brown Sharon, Garb Andrew, Hanauer Stephen B, Kappelman Michael D, Lewis James D, Lynch Isabelle, Moynihan Amy, Rubin David T, Sartor R Balfour, Schwartz Ronald M, Wolf Douglas C, Ullman Thomas A   Quality indicators for inflammatory bowel disease: development of process and outcome measures Inflammatory bowel diseases, 2013; 19(3): 662-8.
Surti Bijal, Spiegel Brennan, Ippoliti Andrew, Vasiliauskas Eric A, Simpson Peter, Shih David Q, Targan Stephan R, McGovern Dermot P B, Melmed Gil Y   Assessing Health Status in Inflammatory Bowel Disease Using a Novel Single-Item Numeric Rating Scale Digestive diseases and sciences, 2012; 62(1): .
Strate Lisa L, Modi Rusha, Cohen Erica, Spiegel Brennan M R   Diverticular disease as a chronic illness: evolving epidemiologic and clinical insights The American journal of gastroenterology, 2012; 107(10): 1486-93.
Khanna Dinesh, Maranian Paul, Rothrock Nan, Cella David, Gershon Richard, Khanna Puja P, Spiegel Brennan, Furst Daniel E, Clements Phil J, Bechtel Amber, Hays Ron D   Feasibility and construct validity of PROMIS and "legacy" instruments in an academic scleroderma clinic Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 2012; 15(1): 128-34.
Spiegel Brennan   H. pylori: should we still be looking for it? What should we be doing about it? A case-based approach Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 2012; 24(3): 208.
Spiegel Brennan M R   Treatment center characteristics associated with better outcomes: a role for the medical director? Seminars in dialysis, 2012; 25(3): 296-8.
Au Karen, Singh Manjit K, Bodukam Vijay, Bae Sangmee, Maranian Paul, Ogawa Rikke, Spiegel Brennan, McMahon Maureen, Hahn Bevra, Khanna Dinesh   Atherosclerosis in systemic sclerosis- A systematic review and meta analysis Arthritis and rheumatism, 2011; 106(5): .
Spiegel Brennan M R, Talley Jennifer, Shekelle Paul, Agarwal Nikhil, Snyder Bradley, Bolus Roger, Kurzbard Nicole, Chan Michael, Ho Andrew, Kaneshiro Marc, Cordasco Kristina, Cohen Hartley   Development and validation of a novel patient educational booklet to enhance colonoscopy preparation The American journal of gastroenterology, 2011; 106(5): 875-83.
Spiegel Brennan M R   Does time of day affect polyp detection rates from colonoscopy? Gastrointestinal endoscopy, 2011; 73(3): 476-9.
Huang Edward S, Karsan Sundip, Kanwal Fasiha, Singh Inder, Makhani Marc, Spiegel Brennan M   Impact of nasogastric lavage on outcomes in acute GI bleeding Gastrointestinal endoscopy, 2011; 74(5): 971-80.
Khanna Dinesh, Krishnan Eswar, Dewitt Esi Morgan, Khanna Puja P, Spiegel Brennan, Hays Ron D   Patient-Reported Outcomes Measurement Information System (PROMIS®) -- The future of measuring patient reported outcomes in rheumatology Arthritis care & research, 2011; 63(S11): S486-S490.
Spiegel Brennan M R   Questioning the Bacterial Overgrowth Hypothesis of Irritable Bowel Syndrome: An Epidemiologic and Evolutionary Perspective Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2011; 9(6): 461-469.
Foster Temitope, Hon Huiming, Kanwal Fasiha, Han Steven, Spiegel Brennan   Screening high risk individuals for hepatitis B: physician knowledge, attitudes, and beliefs Digestive diseases and sciences, 2011; 56(12): 3471-87.
Agarwal Nikhil, Spiegel Brennan M R   The effect of irritable bowel syndrome on health-related quality of life and health care expenditures Gastroenterology clinics of North America, 2011; 40(1): 11-9.
Khanna Dinesh, Krishnan Eswar, Dewitt Esi Morgan, Khanna Puja P, Spiegel Brennan, Hays Ron D   The future of measuring patient-reported outcomes in rheumatology: Patient-Reported Outcomes Measurement Information System (PROMIS) Arthritis care & research, 2011; 63 Suppl 11(12): S486-90.
Spiegel Brennan M R, Khanna Dinesh, Bolus Roger, Agarwal Nikhil, Khanna Puja, Chang Lin   Understanding gastrointestinal distress: a framework for clinical practice The American journal of gastroenterology, 2011; 106(3): 380-5.
Chang Lin, Lacy Brian E, Spiegel Brennan M R   An Evidence-based Approach to Therapy in IBS-D: A Case Study Compendium Gastroenterology & hepatology, 2010; 6(9 Suppl 15): 1-12.
Kanwal Fasiha, Kramer Jennifer, Asch Steven M, El-Serag Hashem, Spiegel Brennan M R, Edmundowicz Steven, Sanyal Arun J, Dominitz Jason A, McQuaid Kenneth R, Martin Paul, Keeffe Emmet B, Friedman Lawrence S, Ho Samuel B, Durazo Francisco, Bacon Bruce R   An explicit quality indicator set for measurement of quality of care in patients with cirrhosis Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2010; 8(8): 709-17.
Weinberg Benjamin M, Spiegel Brennan M R, Tomlinson James S, Farrell James J   Asymptomatic pancreatic cystic neoplasms: maximizing survival and quality of life using Markov-based clinical nomograms Gastroenterology, 2010; 138(2): 531-40.
Kaneshiro Marc, Ho Andrew, Chan Michael, Cohen Hartley, Spiegel Brennan M R   Colonoscopy yields fewer polyps as the day progresses despite using social influence theory to reverse the trend Gastrointestinal endoscopy, 2010; 72(6): 1233-40.
Spiegel Brennan, Bolus Roger, Desai Amar A, Zagar Philip, Parker Tom, Moran John, Solomon Matthew D, Khawar Osman, Gitlin Matthew, Talley Jennifer, Nissenson Allen   Dialysis practices that distinguish facilities with below- versus above-expected mortality Clinical journal of the American Society of Nephrology : CJASN, 2010; 5(11): 2024-33.
Spiegel Brennan M R, Bolus Roger, Desai Amar A, Zager Philip, Parker Tom, Moran John, Bolus Sally, Solomon Matthew D, Khawar Osman, Gitlin Matthew, Sul Hack, Talley Jennifer, Nissenson Allen   Dialysis practices that distinguish top- versus bottom-performing facilities by hemoglobin outcomes American journal of kidney diseases : the official journal of the National Kidney Foundation, 2010; 56(1): 86-94.
Spiegel Brennan M R   How and when to prepare for the GI board examination Gastrointestinal endoscopy, 2010; 72(6): 1250-2.
Spiegel Brennan M R, Farid Mary, Esrailian Eric, Talley Jennifer, Chang Lin   Is irritable bowel syndrome a diagnosis of exclusion?: a survey of primary care providers, gastroenterologists, and IBS experts The American journal of gastroenterology, 2010; 105(4): 848-58.
Kanwal Fasiha, Barkun Alan, Gralnek Ian M, Asch Steven M, Kuipers Ernst J, Bardou Marc, Sung Joseph, Enns Robert, Agreus Lars, Armstrong David, Spiegel Brennan M R   Measuring quality of care in patients with nonvariceal upper gastrointestinal hemorrhage: development of an explicit quality indicator set The American journal of gastroenterology, 2010; 105(8): 1710-8.
Laine Loren, Spiegel Brennan, Rostom Alaa, Moayyedi Paul, Kuipers Ernst J, Bardou Marc, Sung Joseph, Barkun Alan N   Methodology for randomized trials of patients with nonvariceal upper gastrointestinal bleeding: recommendations from an international consensus conference The American journal of gastroenterology, 2010; 105(3): 540-50.
Chey William D, Spiegel Brennan   Proton pump inhibitors, irritable bowel syndrome, and small intestinal bacterial overgrowth: coincidence or Newton's third law revisited? Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2010; 8(6): 480-2.
Melmed Gil Y, Spiegel Brennan M, Bressler Brian, Cheifetz Adam S, Devlin Shane M, Harrell Laura E, Irving Peter M, Jones Jennifer, Kaplan Gilaad G, Kozuch Patricia L, Velayos Fernando S, Baidoo Leonard, Sparrow Miles P, Siegel Corey A   The appropriateness of concomitant immunomodulators with anti-tumor necrosis factor agents for Crohn's disease: one size does not fit all Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2010; 8(8): 655-9.
Spiegel Brennan M R   Treatment strategies for acid reflux: EncomPASSing practical solutions for primary care The American journal of gastroenterology, 2010; 105(11): 2347-9.
Spiegel Brennan, Brandt Lawrence J, Chey William D, Foxx-Orenstein Amy E, Schiller Lawrence R, Schoenfeld Philip S, Spiegel Brennan M, Talley Nicholas J, Quigley Eamonn M M   An evidence-based position statement on the management of irritable bowel syndrome The American journal of gastroenterology, 2009; 104 Suppl 1(5): S1-35.
Spiegel Brennan M R, Ho Wayne, Esrailian Eric, Targan Stephan, Higgins Peter D R, Siegel Corey A, Dubinsky Marla, Melmed Gil Y   Controversies in ulcerative colitis: a survey comparing decision making of experts versus community gastroenterologists Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2009; 7(2): 168-74, 174.e1.
Greengold Barbara, Nyamathi Adeline, Kominski Gerald, Wiley Dorothy, Lewis Mary Ann, Hodge Felicia, Singer Mendel, Spiegel Brennan   Cost-effectiveness analysis of behavioral interventions to improve vaccination compliance in homeless adults Vaccine, 2009; 27(5): 718-25.
Spiegel Brennan, Harris Lucinda, Lucak Susan, Mayer Emeran, Naliboff Bruce, Bolus Roger, Esrailian Eric, Chey William D, Lembo Anthony, Karsan Hetal, Tillisch Kirsten, Dulai Gareth, Talley Jennifer, Chang Lin   Developing valid and reliable health utilities in irritable bowel syndrome: results from the IBS PROOF Cohort The American journal of gastroenterology, 2009; 104(8): 1984-91.
Spiegel Brennan M R   Endoscopy for acute upper GI tract hemorrhage: sooner is better Gastrointestinal endoscopy, 2009; 70(2): 236-9.
Chan Michael Y, Cohen Hartley, Spiegel Brennan M R   Fewer polyps detected by colonoscopy as the day progresses at a Veteran's Administration teaching hospital Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2009; 7(11): 1217-23; quiz 1143.
Kanwal Fasiha, Gralnek Ian M, Hays Ron D, Zeringue Angelique, Durazo Francisco, Han Steven B, Saab Sammy, Bolus Roger, Spiegel Brennan M R   Health-related quality of life predicts mortality in patients with advanced chronic liver disease Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2009; 7(7): 793-9.
Desai Amar A, Bolus Roger, Nissenson Allen, Chertow Glenn M, Bolus Sally, Solomon Matthew D, Khawar Osman S, Talley Jennifer, Spiegel Brennan M R   Is there "cherry picking" in the ESRD Program? Perceptions from a Dialysis Provider Survey Clinical journal of the American Society of Nephrology : CJASN, 2009; 4(4): 772-7.
Spiegel Brennan, Camilleri Michael, Bolus Roger, Andresen Viola, Chey William D, Fehnel Sheri, Mangel Allen, Talley Nicholas J, Whitehead William E   Psychometric evaluation of patient-reported outcomes in irritable bowel syndrome randomized controlled trials: a Rome Foundation report Gastroenterology, 2009; 137(6): 1944-53.e1-3.
Ford Alexander C, Spiegel Brennan M R, Talley Nicholas J, Moayyedi Paul   Small intestinal bacterial overgrowth in irritable bowel syndrome: systematic review and meta-analysis Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2009; 7(12): 1279-86.
Spiegel Brennan M R   The burden of IBS: looking at metrics Current gastroenterology reports, 2009; 11(4): 265-9.
Desai Amar A, Nissenson Allen, Chertow Glenn M, Farid Mary, Singh Inder, Van Oijen Martijn G H, Esrailian Eric, Solomon Matthew D, Spiegel Brennan M R   The relationship between laboratory-based outcome measures and mortality in end-stage renal disease: a systematic review Hemodialysis international. International Symposium on Home Hemodialysis, 2009; 13(3): 347-59.
Ford Alexander C, Chey William D, Talley Nicholas J, Malhotra Ashish, Spiegel Brennan M R, Moayyedi Paul   Yield of diagnostic tests for celiac disease in individuals with symptoms suggestive of irritable bowel syndrome: systematic review and meta-analysis Archives of internal medicine, 2009; 169(7): 651-8.
Spiegel Brennan M R, Chey William D, Chang Lin   Bacterial overgrowth and irritable bowel syndrome: unifying hypothesis or a spurious consequence of proton pump inhibitors? The American journal of gastroenterology, 2008; 103(12): 2972-6.
Spiegel Brennan M R, Melmed Gil, Robbins Sean, Esrailian Eric   Biomarkers and health-related quality of life in end-stage renal disease: a systematic review Clinical journal of the American Society of Nephrology : CJASN, 2008; 3(6): 1759-68.
Slavenburg Serena, van Oijen Martijn G H, Spiegel Brennan M R   Comparison of health-related quality of life between populations Liver international : official journal of the International Association for the Study of the Liver, 2008; 28(2): 285-6; author reply 286-7.
Ford Alexander C, Talley Nicholas J, Spiegel Brennan M R, Foxx-Orenstein Amy E, Schiller Lawrence, Quigley Eamonn M M, Moayyedi Paul   Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis BMJ (Clinical research ed.), 2008; 337(12): a2313.
Desai Amar A, Bolus Roger, Nissenson Allen, Bolus Sally, Solomon Matthew D, Khawar Osman, Gitlin Matthew, Talley Jennifer, Spiegel Brennan M R   Identifying best practices in dialysis care: results of cognitive interviews and a national survey of dialysis providers Clinical journal of the American Society of Nephrology : CJASN, 2008; 3(4): 1066-76.
Spiegel Brennan, Strickland Amy, Naliboff Bruce D, Mayer Emeran A, Chang Lin   Predictors of patient-assessed illness severity in irritable bowel syndrome The American journal of gastroenterology, 2008; 103(10): 2536-43.
Ho Wayne, Spiegel Brennan M R   The relationship between obesity and functional gastrointestinal disorders: causation, association, or neither? Gastroenterology & hepatology, 2008; 4(8): 572-8.
Spiegel Brennan M R, Esrailian Eric, Laine Loren, Chamberlain Marc C   Clinical impact of adjuvant chemotherapy in glioblastoma multiforme : a meta-analysis CNS drugs, 2007; 21(9): 775-87.
Spiegel Brennan M R, Bolus Roger, Han Steven, Tong Myron, Esrailian Eric, Talley Jennifer, Tran Tram, Smith Jason, Karsan Hetal A, Durazo Francisco, Bacon Bruce, Martin Paul, Younossi Zobair, Hwa-Ong Siew, Kanwal Fasiha   Development and validation of a disease-targeted quality of life instrument in chronic hepatitis B: the hepatitis B quality of life instrument, version 1.0 Hepatology (Baltimore, Md.), 2007; 46(1): 113-21.
Spiegel Brennan M R   Do physicians follow evidence-based guidelines in the diagnostic work-up of IBS? Nature clinical practice. Gastroenterology & hepatology, 2007; 4(6): 296-7.
Kanwal Fasiha, Hoang Tuyen, Spiegel Brennan M R, Eisen Seth, Dominitz Jason A, Gifford Allen, Goetz Mathew, Asch Steven M   Predictors of treatment in patients with chronic hepatitis C infection - role of patient versus nonpatient factors Hepatology (Baltimore, Md.), 2007; 46(6): 1741-9.
Spiegel Brennan M R, Esrailian Eric, Eisen Glenn   The budget impact of endoscopic screening for esophageal varices in cirrhosis Gastrointestinal endoscopy, 2007; 66(4): 679-92.
Spiegel Brennan M R, Farid Mary, Dulai Gareth S, Gralnek Ian M, Kanwal Fasiha   Comparing rates of dyspepsia with Coxibs vs NSAID+PPI: a meta-analysis The American journal of medicine, 2006; 119(5): 448.e27-36.
Gralnek Ian M, Dulai Gareth S, Fennerty M Brian, Spiegel Brennan M R   Esomeprazole versus other proton pump inhibitors in erosive esophagitis: a meta-analysis of randomized clinical trials Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2006; 4(12): 1452-8.
Spiegel Brennan M R, Dulai Gareth S, Lim Brian S, Mann Neel, Kanwal Fasiha, Gralnek Ian M   The cost-effectiveness and budget impact of intravenous versus oral proton pump inhibitors in peptic ulcer hemorrhage Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2006; 4(8): 988-997.
Singh Harminder, Latosinsky Steven, Spiegel Brennan M R, Targownik Laura E   The cost-effectiveness of colonic stenting as a bridge to curative surgery in patients with acute left-sided malignant colonic obstruction: a Canadian perspective Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2006; 20(12): 779-85.
Kanwal Fasiha, Farid Mary, Martin Paul, Chen Gary, Gralnek Ian M, Dulai Gareth S, Spiegel Brennan M R   Treatment alternatives for hepatitis B cirrhosis: a cost-effectiveness analysis The American journal of gastroenterology, 2006; 101(9): 2076-89.
Bloom Michael A, Barghout Victoria, Kahler Kristijan H, Bentkover Judith, Kurth Hannah, Gralnek Ian M, Spiegel Brennan M R   Budget impact of tegaserod on a managed care organization formulary The American journal of managed care, 2005; 11(1 Suppl): S27-34.
Karsan Hetal A, Morton Sally C, Shekelle Paul G, Spiegel Brennan M R, Suttorp Marika J, Edelstein Marc A, Gralnek Ian M   Combination endoscopic band ligation and sclerotherapy compared with endoscopic band ligation alone for the secondary prophylaxis of esophageal variceal hemorrhage: a meta-analysis Digestive diseases and sciences, 2005; 50(2): 399-406.
Dulai Gareth S, Shekelle Paul G, Jensen Dennis M, Spiegel Brennan M R, Chen Jaime, Oh David, Kahn Katherine L   Dysplasia and risk of further neoplastic progression in a regional Veterans Administration Barrett's cohort The American journal of gastroenterology, 2005; 100(4): 775-83.
Spiegel Brennan M R, Chen Kristina, Chiou Chiun-Fang, Robbins Sean, Younossi Zobair M   Erythropoietic growth factors for treatment-induced anemia in hepatitis C: a cost-effectiveness analysis Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2005; 3(10): 1034-42.
Kanwal Fasiha, Gralnek Ian M, Hays Ron D, Dulai Gareth S, Spiegel Brennan M R, Bozzette Samuel, Asch Steve   Impact of chronic viral hepatitis on health-related quality of life in HIV: results from a nationally representative sample The American journal of gastroenterology, 2005; 100(9): 1984-94.
Spiegel Brennan M R, Younossi Zobair M, Hays Ron D, Revicki Dennis, Robbins Sean, Kanwal Fasiha   Impact of hepatitis C on health related quality of life: a systematic review and quantitative assessment Hepatology (Baltimore, Md.), 2005; 41(4): 790-800.
Spiegel Brennan M R, Gralnek Ian M, Bolus Roger, Chang Lin, Dulai Gareth S, Naliboff Bruce, Mayer Emeran A   Is a negative colonoscopy associated with reassurance or improved health-related quality of life in irritable bowel syndrome? Gastrointestinal endoscopy, 2005; 62(6): 892-9.
Spiegel Brennan M R, Chiou Chiun-Fang, Ofman Joshua J   Minimizing complications from nonsteroidal antiinflammatory drugs: cost-effectiveness of competing strategies in varying risk groups Arthritis and rheumatism, 2005; 53(2): 185-97.
Spiegel Brennan M R, Kanwal Fasiha, Naliboff Bruce, Mayer Emeran   The impact of somatization on the use of gastrointestinal health-care resources in patients with irritable bowel syndrome The American journal of gastroenterology, 2005; 100(10): 2262-73.
Kanwal Fasiha, Gralnek Ian M, Martin Paul, Dulai Gareth S, Farid Mary, Spiegel Brennan M R   Treatment alternatives for chronic hepatitis B virus infection: a cost-effectiveness analysis Annals of internal medicine, 2005; 142(10): 821-31.
Spiegel Brennan M R, Gralnek Ian M, Bolus Roger, Chang Lin, Dulai Gareth S, Mayer Emeran A, Naliboff Bruce   Clinical determinants of health-related quality of life in patients with irritable bowel syndrome Archives of internal medicine, 2004; 164(16): 1773-80.
Spiegel, BM Gralnek, IM Bolus, R Chang, L Dulai, GS Mayer, EA Naliboff, B   Clinical determinants of health-related quality of life in patients with irritable bowel syndrome Archives of internal medicine. , 2004; 164(16): 1773-80.
Targownik Laura E, Spiegel Brennan M, Sack Jonathan, Hines Oscar J, Dulai Gareth S, Gralnek Ian M, Farrell James J   Colonic stent vs. emergency surgery for management of acute left-sided malignant colonic obstruction: a decision analysis Gastrointestinal endoscopy, 2004; 60(6): 865-74.
Spiegel BMR, DeRosa VP, Gralnek IM, Wang V, Dulai GS   Testing for celiac sprue in diarrhea-predominant irritable bowel syndrome: a cost-effectiveness analysis, Gastroenterology, 2004; .
Spiegel Brennan M R, DeRosa Vincent P, Gralnek Ian M, Wang Victor, Dulai Gareth S   Testing for celiac sprue in irritable bowel syndrome with predominant diarrhea: a cost-effectiveness analysis Gastroenterology, 2004; 126(7): 1721-32.
Targownik Laura E, Spiegel Brennan M R, Dulai Gareth S, Karsan Hetal A, Gralnek Ian M   The cost-effectiveness of hepatic venous pressure gradient monitoring in the prevention of recurrent variceal hemorrhage The American journal of gastroenterology, 2004; 99(7): 1306-15.
Spiegel, BM Targownik, LE Kanwal, F Derosa, V Dulai, GS Gralnek, IM Chiou, CF   The quality of published health economic analyses in digestive diseases: a systematic review and quantitative appraisal Gastroenterology. , 2004; 127(2): 403-11.
Spiegel Brennan M R, Targownik Laura E, Kanwal Fasiha, Derosa Vincent, Dulai Gareth S, Gralnek Ian M, Chiou Chiun-Fang   The quality of published health economic analyses in digestive diseases: a systematic review and quantitative appraisal Gastroenterology, 2004; 127(2): 403-11.
Spiegel, BM Targownik, L Dulai, GS Karsan, HA Gralnek, IM   Endoscopic screening for esophageal varices in cirrhosis: Is it ever cost effective? Hepatology (Baltimore, Md.) , 2003; 37(2): 366-77.
Spiegel Brennan M r, Targownik Laura, Dulai Gareth S, Karsan Hetal A, Gralnek Ian M   Endoscopic screening for esophageal varices in cirrhosis: Is it ever cost effective? Hepatology (Baltimore, Md.), 2003; 37(2): 366-77.
Targownik Laura E, Gralnek Ian M, Dulai Gareth S, Spiegel Brennan M R, Oei Tommy, Bernstein Charles N   Management of acute nonvariceal upper gastrointestinal hemorrhage: comparison of an American and a Canadian medical centre Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2003; 17(8): 489-95.
Spiegel Brennan M R, Ofman Joshua J, Woods Karen, Vakil Nimish B   Minimizing recurrent peptic ulcer hemorrhage after endoscopic hemostasis: the cost-effectiveness of competing strategies The American journal of gastroenterology, 2003; 98(1): 86-97.
Spiegel, BM Ofman, JJ Woods, K Vakil, NB   Minimizing recurrent peptic ulcer hemorrhage after endoscopic hemostasis: the cost-effectiveness of competing strategies The American journal of gastroenterology. , 2003; 98(1): 86-97.
Spiegel Brennan M R, Targownik Laura, Dulai Gareth S, Gralnek Ian M   The cost-effectiveness of cyclooxygenase-2 selective inhibitors in the management of chronic arthritis Annals of internal medicine, 2003; 138(10): 795-806.
Spiegel BMR, Targownik LE, Dulai GS, Gralnek IM   The cost-effectiveness of cyclooxygenase-2 selective inhibitors in the management of chronic arthritis, Annals of Internal Medicine, 2003; .
Spiegel, BM Vakil, NB Ofman, JJ   Dyspepsia management in primary care: a decision analysis of competing strategies Gastroenterology. , 2002; 122(5): 1270-85.
Spiegel Brennan M R, Vakil Nimish B, Ofman Joshua J   Dyspepsia management in primary care: a decision analysis of competing strategies Gastroenterology, 2002; 122(5): 1270-85.
Spiegel BMR, Vakil NB, Ofman JJ   Endoscopy for acute non-variceal upper gastrointestinal tract hemorrhage: is sooner better? A systematic review, Archives of Internal Medicine, 2001; .
Spiegel Brennan   Diagnostic testing in extraesophageal GERD: another case of "furor medicus"? The American journal of gastroenterology, 2013; 108(6): 912-4.
Shahedi Kamyar, Fuller Garth, Bolus Roger, Cohen Erica, Vu Michelle, Shah Rena, Agarwal Nikhil, Kaneshiro Marc, Atia Mary, Sheen Victoria, Kurzbard Nicole, van Oijen Martijn G H, Yen Linnette, Hodgkins Paul, Erder M Haim, Spiegel Brennan   Long-term Risk of Acute Diverticulitis Among Patients With Incidental Diverticulosis Found During Colonoscopy Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2013; 11(12): 1609-13.
Cohen Erica, Spiegel Brennan   Reply Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2013; 11(11): 1521-2.
Whitman Cynthia B, Shreay Sanatan, Gitlin Matthew, van Oijen Martijn G H, Spiegel Brennan M R   Clinical factors and the decision to transfuse chronic dialysis patients Clinical journal of the American Society of Nephrology : CJASN, 2013; 8(11): 1942-51.
Ford Alexander C, Quigley Eamonn M M, Lacy Brian E, Lembo Anthony J, Saito Yuri A, Schiller Lawrence R, Soffer Edy E, Spiegel Brennan M R, Moayyedi Paul   Efficacy of Prebiotics, Probiotics, and Synbiotics in Irritable Bowel Syndrome and Chronic Idiopathic Constipation: Systematic Review and Meta-analysis The American journal of gastroenterology, 2014; 109(10): 1547-1561.
Cohen Erica, Bolus Roger, Khanna Dinesh, Hays Ron D, Chang Lin, Melmed Gil Y, Khanna Puja, Spiegel Brennan   GERD Symptoms in the General Population: Prevalence and Severity Versus Care-Seeking Patients Digestive diseases and sciences, 2014; 59(10): 2488-96.
Spiegel Brennan M R, Kaneshiro Marc, Russell Marcia M, Lin Anne, Patel Anish, Tashjian Vartan C, Zegarski Vincent, Singh Digvijay, Cohen Samuel E, Reid Mark W, Whitman Cynthia B, Talley Jennifer, Martinez Bibiana M, Kaiser William   Validation of an acoustic gastrointestinal surveillance biosensor for postoperative ileus Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2014; 18(10): 1795-803.
Spiegel Brennan M R, Hays Ron D, Bolus Roger, Melmed Gil Y, Chang Lin, Whitman Cynthia, Khanna Puja P, Paz Sylvia H, Hays Tonya, Reise Steve, Khanna Dinesh   Development of the NIH Patient-Reported Outcomes Measurement Information System (PROMIS) Gastrointestinal Symptom Scales The American journal of gastroenterology, 2014; 18(10): .
Moayyedi Paul, Quigley Eamonn M M, Lacy Brian E, Lembo Anthony J, Saito Yuri A, Schiller Lawrence R, Soffer Edy E, Spiegel Brennan M R, Ford Alexander C   The Effect of Fiber Supplementation on Irritable Bowel Syndrome: A Systematic Review and Meta-analysis The American journal of gastroenterology, 2014; 109(9): 1367-1374.
Ford Alexander C, Quigley Eamonn M M, Lacy Brian E, Lembo Anthony J, Saito Yuri A, Schiller Lawrence R, Soffer Edy E, Spiegel Brennan M R, Moayyedi Paul   Effect of Antidepressants and Psychological Therapies, Including Hypnotherapy, in Irritable Bowel Syndrome: Systematic Review and Meta-Analysis The American journal of gastroenterology, 2014; 109(9): 1350-1365.
Ford Alexander C, Moayyedi Paul, Lacy Brian E, Lembo Anthony J, Saito Yuri A, Schiller Lawrence R, Soffer Edy E, Spiegel Brennan M R, Quigley Eamonn M M, Quigley Eamonn M M   American College of Gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation The American journal of gastroenterology, 2014; 109 Suppl 1(9): S2-26; quiz S27.
May Folasade P, Bromley Erica G, Reid Mark W, Baek Michael, Yoon Jessica, Cohen Erica, Lee Aaron, van Oijen Martijn G H, Spiegel Brennan M R   Low uptake of colorectal cancer screening among African Americans in an integrated Veterans Affairs health care network Gastrointestinal endoscopy, 2014; 80(2): 291-8.
Spiegel Brennan M R, Reid Mark W, Bolus Roger, Whitman Cynthia B, Talley Jennifer, Dea Stanley, Shahedi Kamyar, Karsan Hetal, Teal Chassidy, Melmed Gil Y, Cohen Erica, Fuller Garth, Yen Linnette, Hodgkins Paul, Erder M Haim   Development and validation of a disease-targeted quality of life instrument for chronic diverticular disease: the DV-QOL Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2014; 80(2): .
Nagaraja Vivek, Hays Ron D, Khanna Puja P, Spiegel Brennan M R, Chang Lin, Melmed Gil Y, Bolus Roger, Khanna Dinesh   Construct validity of the Patient Reported Outcomes Measurement Information System (PROMIS®) gastrointestinal symptom scales in systemic sclerosis Arthritis care & research, 2014; 12(7): .
Lackner Jeffrey M, Gudleski Gregory D, Thakur Elyse R, Stewart Travis J, Iacobucci Gary J, Spiegel Brennan Mr   The impact of physical complaints, social environment, and psychological functioning on IBS patients' health perceptions: looking beyond GI symptom severity The American journal of gastroenterology, 2014; 109(2): 224-33.
Khanna Puja, Agarwal Nikhil, Khanna Dinesh, Hays Ron D, Chang Lin, Bolus Roger, Melmed Gil, Whitman Cynthia B, Kaplan Robert M, Ogawa Rikke, Snyder Bradley, Spiegel Brennan Mr   Development of an online library of patient-reported outcome measures in gastroenterology: the GI-PRO database The American journal of gastroenterology, 2014; 109(2): 234-48.
Reid Mark W, Cohen Samuel, Wang Hank, Kaung Aung, Patel Anish, Tashjian Vartan, Williams Demetrius L, Martinez Bibiana, Spiegel Brennan M R   Preventing patient absenteeism: validation of a predictive overbooking model The American journal of managed care, 2015; 21(12): 902-10.
Almario Christopher V, Chey William D, Iriana Sentia, Dailey Francis, Robbins Karen, Patel Anish V, Reid Mark, Whitman Cynthia, Fuller Garth, Bolus Roger, Dennis Buddy, Encarnacion Rey, Martinez Bibiana, Soares Jennifer, Modi Rushaba, Agarwal Nikhil, Lee Aaron, Kubomoto Scott, Sharma Gobind, Bolus Sally, Chang Lin, Spiegel Brennan M R   Computer versus physician identification of gastrointestinal alarm features International journal of medical informatics, 2015; 84(12): 1111-7.
May Folasade P, Reid Mark W, Cohen Samuel, Dailey Francis, Spiegel Brennan M R   Predictive overbooking and active recruitment increases uptake of endoscopy appointments among African American patients Gastrointestinal endoscopy, 2016; .
Whitman Cynthia B, Reid Mark W, Arnold Corey, Patel Haridarshan, Ursos Lyann, Sa'adon Roee, Pourmorady Jonathan, Spiegel Brennan M R   Balancing opioid-induced gastrointestinal side effects with pain management: Insights from the online community Journal of opioid management, 2015; 11(5): 383-91.
May Folasade P, Almario Christopher V, Ponce Ninez, Spiegel Brennan M R   Racial minorities are more likely than whites to report lack of provider recommendation for colon cancer screening The American journal of gastroenterology, 2015; 110(10): 1388-94.
Reid Mark W, May Folasade P, Martinez Bibiana, Cohen Samuel, Wang Hank, Williams Demetrius L, Spiegel Brennan M R   Preventing Endoscopy Clinic No-Shows: Prospective Validation of a Predictive Overbooking Model The American journal of gastroenterology, 2016; 111(9): 1267-73.
Moayyedi Paul, Quigley Eamonn M M, Lacy Brian E, Lembo Anthony J, Saito Yuri A, Schiller Lawrence R, Soffer Edy E, Spiegel Brennan M R, Ford Alexander C   The Effect of Dietary Intervention on Irritable Bowel Syndrome: A Systematic Review Clinical and translational gastroenterology, 2015; 6(5): e107.
Almario Christopher V, May Folasade P, Maxwell Allison E, Ren Wanmeng, Ponce Ninez A, Spiegel Brennan M R   Persistent racial and ethnic disparities in flu vaccination coverage: Results from a population-based study American journal of infection control, 2016; 44(9): 1004-9.
Almario Christopher V, May Folasade P, Ponce Ninez A, Spiegel Brennan M R   Racial and Ethnic Disparities in Colonoscopic Examination of Individuals With a Family History of Colorectal Cancer Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2015; 13(8): 1487-95.
May Folasade P, Whitman Cynthia B, Varlyguina Ksenia, Bromley Erica G, Spiegel Brennan M R   Addressing Low Colorectal Cancer Screening in African Americans: Using Focus Groups to Inform the Development of Effective Interventions Journal of cancer education : the official journal of the American Association for Cancer Education, 2016; 31(3): 567-74.
Spiegel Brennan M R, Hays Ron D, Bolus Roger, Melmed Gil Y, Chang Lin, Whitman Cynthia, Khanna Puja P, Paz Sylvia H, Hays Tonya, Reise Steve, Khanna Dinesh   Corrigendum: development of the NIH Patient-Reported Outcomes Measurement Information System (PROMIS) gastrointestinal symptom scales The American journal of gastroenterology, 2015; 110(4): 608.
Daskivich Timothy J, Spiegel Brennan, Kim Hyung L   Online Ratings Systems for Physicians and Institutions: Limitations of the Current State of the Art European urology, 2016; 31(3): .
Jensen Roxanne E, Rothrock Nan E, DeWitt Esi M, Spiegel Brennan, Tucker Carole A, Crane Heidi M, Forrest Christopher B, Patrick Donald L, Fredericksen Rob, Shulman Lisa M, Cella David, Crane Paul K   The role of technical advances in the adoption and integration of patient-reported outcomes in clinical care Medical care, 2015; 53(2): 153-9.
Almario Christopher V, Chey William D, Khanna Dinesh, Mosadeghi Sasan, Ahmed Shahzad, Afghani Elham, Whitman Cynthia, Fuller Garth, Reid Mark, Bolus Roger, Dennis Buddy, Encarnacion Rey, Martinez Bibiana, Soares Jennifer, Modi Rushaba, Agarwal Nikhil, Lee Aaron, Kubomoto Scott, Sharma Gobind, Bolus Sally, Spiegel Brennan M R   Impact of National Institutes of Health Gastrointestinal PROMIS Measures in Clinical Practice: Results of a Multicenter Controlled Trial The American journal of gastroenterology, 2016; 31(3): .
Bromley Erica G, May Folasade P, Federer Lisa, Spiegel Brennan M R, van Oijen Martijn G H   Explaining persistent under-use of colonoscopic cancer screening in African Americans: a systematic review Preventive medicine, 2015; 71(2): 40-8.
Chiang Austin L, Vartabedian Bryan, Spiegel Brennan   Harnessing the Hashtag: A Standard Approach to GI Dialogue on Social Media The American journal of gastroenterology, 2016; 111(8): 1082-4.
Almario Christopher V, Chey William, Kaung Aung, Whitman Cynthia, Fuller Garth, Reid Mark, Nguyen Ken, Bolus Roger, Dennis Buddy, Encarnacion Rey, Martinez Bibiana, Talley Jennifer, Modi Rushaba, Agarwal Nikhil, Lee Aaron, Kubomoto Scott, Sharma Gobind, Bolus Sally, Chang Lin, Spiegel Brennan M R   Computer-generated vs. physician-documented history of present illness (HPI): results of a blinded comparison The American journal of gastroenterology, 2015; 110(1): 170-9.
Mosadeghi Sasan, Reid Mark William, Martinez Bibiana, Rosen Bradley Todd, Spiegel Brennan Mason Ross   Feasibility of an Immersive Virtual Reality Intervention for Hospitalized Patients: An Observational Cohort Study JMIR mental health, 2016; 3(2): e28.
Cohen Erica, Spiegel Brennan   Reply: To PMID 23524129 Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2014; 12(7): 1200.
Dominitz Jason A, Spiegel Brennan   Editorial: On the Quality of Quality Metrics: Rethinking What Defines a Good Colonoscopy The American journal of gastroenterology, 2016; 111(5): 730-2.
Spiegel Brennan   2015 American Journal of Gastroenterology Lecture: How Digital Health Will Transform Gastroenterology The American journal of gastroenterology, 2016; 111(5): 624-30.
Irvine E Jan, Tack Jan, Crowell Michael D, Gwee Kok Ann, Ke Meiyun, Schmulson Max J, Whitehead William E, Spiegel Brennan   Design of Treatment Trials for Functional Gastrointestinal Disorders Gastroenterology, 2016; 150(6): 1469-1480.e1.
Spiegel Brennan, Irvine Jan E, Tack Jan, Crowell Michael D, Gwee Kok Ann, Ke Meiyun, Schmulson W Max J   Rome IV Design of Treatment Trials for FGIDs Gastroenterology, 2016; 150(6): .
Palsson Olafur S, Whitehead William E, van Tilburg Miranda A L, Chang Lin, Chey William, Crowell Michael D, Keefer Laurie, Lembo Anthony J, Parkman Henry P, Rao Satish Sc, Sperber Ami, Spiegel Brennan, Tack Jan, Vanner Stephen, Walker Lynn S, Whorwell Peter, Yang Yunsheng   Rome IV Diagnostic Questionnaires and Tables for Investigators and Clinicians Gastroenterology, 2016; 150(6): .
Lacy Brian E, Spiegel Brennan   The American Journal of Gastroenterology in 2016: Where Have We Been? Where Are We Going? The American journal of gastroenterology, 2016; 111(1): 1-3.
Kaneshiro Marc, Kaiser William, Pourmorady Jonathan, Fleshner Phillip, Russell Marcia, Zaghiyan Karen, Lin Anne, Martinez Bibiana, Patel Anish, Nguyen Amy, Singh Digvijay, Zegarski Vincent, Reid Mark, Dailey Francis, Xu Jason, Robbins Karen, Spiegel Brennan   Postoperative Gastrointestinal Telemetry with an Acoustic Biosensor Predicts Ileus vs. Uneventful GI Recovery Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2016; 20(1): 132-9; discussion 139.
Almario Christopher V, May Folasade P, Shaheen Nicholas J, Murthy Rekha, Gupta Kapil, Jamil Laith H, Lo Simon K, Spiegel Brennan M R   Cost Utility of Competing Strategies to Prevent Endoscopic Transmission of Carbapenem-Resistant Enterobacteriaceae The American journal of gastroenterology, 2015; 110(12): 1666-74.

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