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Shaping the Future

Brennan Spiegel, M.D.

Contact Information:

Work Phone Number:

(310) 478-3711 X44516

Mailing Address:

11301 Wilshire Blvd
Building 115, Room 215
Los Angeles, CA 90073
UNITED STATES

Work Email Address:

bspiegel@mednet.ucla.edu

Director, Center for Outcomes Research and Education (CORE)

Professor, Digestive Diseases/Gastroenterology


Awards and Honors:

Appointed as a Fellow of the American Gastroenterological Association (AGA).
Director the 2013 Annual AGA Postgraduate Course
American Gastroenterological Association Distinguished Presidential Plenary Abstract
VA Health Services Research and Development (HSR&D) National Meeting Plenary Abstract
One of 8 “Key Leaders” in Gastroenterology to receive the American College of Gastroenterology Leadership Training Award.
Appointed as Council Member of the American Neurogastroenterology and Motility Society (ANMS).
“Breath of Fresh Air Award” from the UCLA GI Fellowship Program for enthusiasm and novelty in teaching
Appointed to United Stated Food and Drug Administration (FDA) Gastroenterology Field Advisory Board
Appointed as a Fellow of the American College of Gastroenterology (FACG)
American Gastroenterological Association Clinical Plenary Abstract
International Foundation for Functional Gastrointestinal Disorders (IFFGD) Distinguished Clinical Investigator Award
American Gastroenterological Association Distinguished Plenary Abstract
UCLA Department of Medicine Research Day – Plenary Abstract Speaker
AstraZeneca Emerging Leader in Gastroenterology Award
UCLA Department of Medicine Research Day – First Place Award
American Gastroenterological Association Outcomes Research Award
NIH CURE Center Named New Investigator Award
Janssen Research Excellence in Gastroenterology and Liver (REGAL) Award
Rubenstein Award for excellence in research, Cedars-Sinai Medical Center
Solomon's Scholar's Research Award
Leo G. Rigler Award for academic achievement, Cedars-Sinai Medical Center
Alpha Omega Alpha Honors Medical Society

Detailed Biography:

Dr. Spiegel is Associate Professor of Medicine in the Division of Digestive Diseases, UCLA School of Medicine, and in the Division of Gastroenterology, VA Greater Los Angeles Health Care System. Dr. Spiegel is the Section Chief for Outcomes Research at the UCLA Divisions of Digestive Diseases, adjunct faculty in the Department of Health Services, UCLA School of Public Health, and a member of the CURE Digestive Diseases Research Center. Dr. Spiegel attended Tufts University where he majored in Philosophy and Community Health, and received his M.D. with Alpha Omega Alpha honors from New York Medical College. He received training in internal medicine at Cedars-Sinai Medical Center in Los Angeles, completed a fellowship in Gastroenterology at UCLA, and completed advanced studies in Health Services Research at the UCLA School of Public Health, where he received a Master’s Degree in Health Services. He received a Research Career Development Award through the Veteran Administration during which time he was trained in health services methodology.

Dr. Spiegel's research focuses on acid-peptic disorders, colon cancer screening, gastrointestinal hemorrhage, diverticular diseases, and functional bowel disorders such as irritable bowel syndrome (IBS). His overall research is defining strategies that improve the quality and cost-effectiveness of care for patients with digestive diseases. To achieve this goal, Dr. Spiegel conductscost-effectiveness analyses, patient reported outcome (PRO) research, health related quality of life studies, meta-analyses, epidemiological studies, provider surveys, quality indicator developmental studies, and other "outcomes" research.

Dr. Spiegel’s group is also developing new technological innovations to expand care outside of the provider visit, including use of patient-provider electronic portals to support clinical decision making in electronic health records, use of social media as a clinical tool, and a range of wearable biosensors to track physiology remotely and in real time. In addition, as Chair of the Rome Foundation Outcomes and Endpoints Committee and a member of the U.S. Food and Drug Administration Gastroenterology Field Advisory Committee, Dr. Spiegel is focused on developing valid and reliable endpoints for GI clinical trials.

Dr. Spiegel is a peer-reviewer for numerous medical journals, and is on the editorial boards for the Alimentary Pharmacology and Therapeutics and Clinical Gastroenterology and Hepatology. He is currently an Associate Editor of the American Journal of Gastroenterology. He receives active funding from the NIH, VA, and industry sources.

Publications:

Wang Hank S, Pisegna Joseph, Modi Rusha, Liang Li-Jung, Atia Mary, Nguyen Minh, Cohen Hartley, Ohning Gordon, van Oijen Martijn, Spiegel Brennan M R   Adenoma detection rate is necessary but insufficient for distinguishing high versus low endoscopist performance Gastrointestinal endoscopy, 2013; 77(1): 71-8.
Spiegel Brennan M R   Burden of illness in irritable bowel syndrome: looking beyond the patient Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2013; 11(2): 156-7.
Cohen Erica, Fuller Garth, Bolus Roger, Modi Rusha, Vu Michelle, Shahedi Kamyar, Shah Rena, Atia Mary, Kurzbard Nicole, Sheen Victoria, Agarwal Nikhil, Kaneshiro Marc, Yen Linnette, Hodgkins Paul, Erder M Haim, Spiegel Brennan   Increased Risk for Irritable Bowel Syndrome Following Acute Diverticulitis Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2013; 19(2): .
SimrĂ©n Magnus, Barbara Giovanni, Flint Harry J, Spiegel Brennan M R, Spiller Robin C, Vanner Stephen, Verdu Elena F, Whorwell Peter J, Zoetendal Erwin G, Zoetendal Erwin G   Intestinal microbiota in functional bowel disorders: a Rome foundation report Gut, 2013; 62(1): 159-76.
Spiegel Brennan M R   Patient-reported outcomes in gastroenterology: clinical and research applications Journal of neurogastroenterology and motility, 2013; 19(2): 137-48.
Melmed Gil Y, Siegel Corey Allan, Spiegel Brennan M, Allen John I, Cima Robert, Colombel Jean-Frederic, Dassopoulos Themistocles, Denson Lee A, Dudley-Brown Sharon, Garb Andrew, Hanauer Stephen B, Kappelman Michael D, Lewis James D, Lynch Isabelle, Moynihan Amy, Rubin David T, Sartor R Balfour, Schwartz Ronald M, Wolf Douglas C, Ullman Thomas A   Quality indicators for inflammatory bowel disease: development of process and outcome measures Inflammatory bowel diseases, 2013; 19(3): 662-8.
Surti Bijal, Spiegel Brennan, Ippoliti Andrew, Vasiliauskas Eric A, Simpson Peter, Shih David Q, Targan Stephan R, McGovern Dermot P B, Melmed Gil Y   Assessing Health Status in Inflammatory Bowel Disease Using a Novel Single-Item Numeric Rating Scale Digestive diseases and sciences, 2012; 62(1): .
Strate Lisa L, Modi Rusha, Cohen Erica, Spiegel Brennan M R   Diverticular disease as a chronic illness: evolving epidemiologic and clinical insights The American journal of gastroenterology, 2012; 107(10): 1486-93.
Khanna Dinesh, Maranian Paul, Rothrock Nan, Cella David, Gershon Richard, Khanna Puja P, Spiegel Brennan, Furst Daniel E, Clements Phil J, Bechtel Amber, Hays Ron D   Feasibility and construct validity of PROMIS and "legacy" instruments in an academic scleroderma clinic Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 2012; 15(1): 128-34.
Spiegel Brennan   H. pylori: should we still be looking for it? What should we be doing about it? A case-based approach Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 2012; 24(3): 208.
Spiegel Brennan M R   Treatment center characteristics associated with better outcomes: a role for the medical director? Seminars in dialysis, 2012; 25(3): 296-8.
Au Karen, Singh Manjit K, Bodukam Vijay, Bae Sangmee, Maranian Paul, Ogawa Rikke, Spiegel Brennan, McMahon Maureen, Hahn Bevra, Khanna Dinesh   Atherosclerosis in systemic sclerosis- A systematic review and meta analysis Arthritis and rheumatism, 2011; 106(5): .
Spiegel Brennan M R, Talley Jennifer, Shekelle Paul, Agarwal Nikhil, Snyder Bradley, Bolus Roger, Kurzbard Nicole, Chan Michael, Ho Andrew, Kaneshiro Marc, Cordasco Kristina, Cohen Hartley   Development and validation of a novel patient educational booklet to enhance colonoscopy preparation The American journal of gastroenterology, 2011; 106(5): 875-83.
Spiegel Brennan M R   Does time of day affect polyp detection rates from colonoscopy? Gastrointestinal endoscopy, 2011; 73(3): 476-9.
Huang Edward S, Karsan Sundip, Kanwal Fasiha, Singh Inder, Makhani Marc, Spiegel Brennan M   Impact of nasogastric lavage on outcomes in acute GI bleeding Gastrointestinal endoscopy, 2011; 74(5): 971-80.
Khanna Dinesh, Krishnan Eswar, Dewitt Esi Morgan, Khanna Puja P, Spiegel Brennan, Hays Ron D   Patient-Reported Outcomes Measurement Information System (PROMIS®) -- The future of measuring patient reported outcomes in rheumatology Arthritis care & research, 2011; 63(S11): S486-S490.
Spiegel Brennan M R   Questioning the Bacterial Overgrowth Hypothesis of Irritable Bowel Syndrome: An Epidemiologic and Evolutionary Perspective Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2011; 9(6): 461-469.
Foster Temitope, Hon Huiming, Kanwal Fasiha, Han Steven, Spiegel Brennan   Screening high risk individuals for hepatitis B: physician knowledge, attitudes, and beliefs Digestive diseases and sciences, 2011; 56(12): 3471-87.
Agarwal Nikhil, Spiegel Brennan M R   The effect of irritable bowel syndrome on health-related quality of life and health care expenditures Gastroenterology clinics of North America, 2011; 40(1): 11-9.
Khanna Dinesh, Krishnan Eswar, Dewitt Esi Morgan, Khanna Puja P, Spiegel Brennan, Hays Ron D   The future of measuring patient-reported outcomes in rheumatology: Patient-Reported Outcomes Measurement Information System (PROMIS) Arthritis care & research, 2011; 63 Suppl 11(12): S486-90.
Spiegel Brennan M R, Khanna Dinesh, Bolus Roger, Agarwal Nikhil, Khanna Puja, Chang Lin   Understanding gastrointestinal distress: a framework for clinical practice The American journal of gastroenterology, 2011; 106(3): 380-5.
Chang Lin, Lacy Brian E, Spiegel Brennan M R   An Evidence-based Approach to Therapy in IBS-D: A Case Study Compendium Gastroenterology & hepatology, 2010; 6(9 Suppl 15): 1-12.
Kanwal Fasiha, Kramer Jennifer, Asch Steven M, El-Serag Hashem, Spiegel Brennan M R, Edmundowicz Steven, Sanyal Arun J, Dominitz Jason A, McQuaid Kenneth R, Martin Paul, Keeffe Emmet B, Friedman Lawrence S, Ho Samuel B, Durazo Francisco, Bacon Bruce R   An explicit quality indicator set for measurement of quality of care in patients with cirrhosis Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2010; 8(8): 709-17.
Weinberg Benjamin M, Spiegel Brennan M R, Tomlinson James S, Farrell James J   Asymptomatic pancreatic cystic neoplasms: maximizing survival and quality of life using Markov-based clinical nomograms Gastroenterology, 2010; 138(2): 531-40.
Kaneshiro Marc, Ho Andrew, Chan Michael, Cohen Hartley, Spiegel Brennan M R   Colonoscopy yields fewer polyps as the day progresses despite using social influence theory to reverse the trend Gastrointestinal endoscopy, 2010; 72(6): 1233-40.
Spiegel Brennan, Bolus Roger, Desai Amar A, Zagar Philip, Parker Tom, Moran John, Solomon Matthew D, Khawar Osman, Gitlin Matthew, Talley Jennifer, Nissenson Allen   Dialysis practices that distinguish facilities with below- versus above-expected mortality Clinical journal of the American Society of Nephrology : CJASN, 2010; 5(11): 2024-33.
Spiegel Brennan M R, Bolus Roger, Desai Amar A, Zager Philip, Parker Tom, Moran John, Bolus Sally, Solomon Matthew D, Khawar Osman, Gitlin Matthew, Sul Hack, Talley Jennifer, Nissenson Allen   Dialysis practices that distinguish top- versus bottom-performing facilities by hemoglobin outcomes American journal of kidney diseases : the official journal of the National Kidney Foundation, 2010; 56(1): 86-94.
Spiegel Brennan M R   How and when to prepare for the GI board examination Gastrointestinal endoscopy, 2010; 72(6): 1250-2.
Spiegel Brennan M R, Farid Mary, Esrailian Eric, Talley Jennifer, Chang Lin   Is irritable bowel syndrome a diagnosis of exclusion?: a survey of primary care providers, gastroenterologists, and IBS experts The American journal of gastroenterology, 2010; 105(4): 848-58.
Kanwal Fasiha, Barkun Alan, Gralnek Ian M, Asch Steven M, Kuipers Ernst J, Bardou Marc, Sung Joseph, Enns Robert, Agreus Lars, Armstrong David, Spiegel Brennan M R   Measuring quality of care in patients with nonvariceal upper gastrointestinal hemorrhage: development of an explicit quality indicator set The American journal of gastroenterology, 2010; 105(8): 1710-8.
Laine Loren, Spiegel Brennan, Rostom Alaa, Moayyedi Paul, Kuipers Ernst J, Bardou Marc, Sung Joseph, Barkun Alan N   Methodology for randomized trials of patients with nonvariceal upper gastrointestinal bleeding: recommendations from an international consensus conference The American journal of gastroenterology, 2010; 105(3): 540-50.
Chey William D, Spiegel Brennan   Proton pump inhibitors, irritable bowel syndrome, and small intestinal bacterial overgrowth: coincidence or Newton's third law revisited? Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2010; 8(6): 480-2.
Melmed Gil Y, Spiegel Brennan M, Bressler Brian, Cheifetz Adam S, Devlin Shane M, Harrell Laura E, Irving Peter M, Jones Jennifer, Kaplan Gilaad G, Kozuch Patricia L, Velayos Fernando S, Baidoo Leonard, Sparrow Miles P, Siegel Corey A   The appropriateness of concomitant immunomodulators with anti-tumor necrosis factor agents for Crohn's disease: one size does not fit all Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2010; 8(8): 655-9.
Spiegel Brennan M R   Treatment strategies for acid reflux: EncomPASSing practical solutions for primary care The American journal of gastroenterology, 2010; 105(11): 2347-9.
Spiegel Brennan, Brandt Lawrence J, Chey William D, Foxx-Orenstein Amy E, Schiller Lawrence R, Schoenfeld Philip S, Spiegel Brennan M, Talley Nicholas J, Quigley Eamonn M M   An evidence-based position statement on the management of irritable bowel syndrome The American journal of gastroenterology, 2009; 104 Suppl 1(5): S1-35.
Spiegel Brennan M R, Ho Wayne, Esrailian Eric, Targan Stephan, Higgins Peter D R, Siegel Corey A, Dubinsky Marla, Melmed Gil Y   Controversies in ulcerative colitis: a survey comparing decision making of experts versus community gastroenterologists Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2009; 7(2): 168-74, 174.e1.
Greengold Barbara, Nyamathi Adeline, Kominski Gerald, Wiley Dorothy, Lewis Mary Ann, Hodge Felicia, Singer Mendel, Spiegel Brennan   Cost-effectiveness analysis of behavioral interventions to improve vaccination compliance in homeless adults Vaccine, 2009; 27(5): 718-25.
Spiegel Brennan, Harris Lucinda, Lucak Susan, Mayer Emeran, Naliboff Bruce, Bolus Roger, Esrailian Eric, Chey William D, Lembo Anthony, Karsan Hetal, Tillisch Kirsten, Dulai Gareth, Talley Jennifer, Chang Lin   Developing valid and reliable health utilities in irritable bowel syndrome: results from the IBS PROOF Cohort The American journal of gastroenterology, 2009; 104(8): 1984-91.
Spiegel Brennan M R   Endoscopy for acute upper GI tract hemorrhage: sooner is better Gastrointestinal endoscopy, 2009; 70(2): 236-9.
Chan Michael Y, Cohen Hartley, Spiegel Brennan M R   Fewer polyps detected by colonoscopy as the day progresses at a Veteran's Administration teaching hospital Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2009; 7(11): 1217-23; quiz 1143.
Kanwal Fasiha, Gralnek Ian M, Hays Ron D, Zeringue Angelique, Durazo Francisco, Han Steven B, Saab Sammy, Bolus Roger, Spiegel Brennan M R   Health-related quality of life predicts mortality in patients with advanced chronic liver disease Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2009; 7(7): 793-9.
Desai Amar A, Bolus Roger, Nissenson Allen, Chertow Glenn M, Bolus Sally, Solomon Matthew D, Khawar Osman S, Talley Jennifer, Spiegel Brennan M R   Is there "cherry picking" in the ESRD Program? Perceptions from a Dialysis Provider Survey Clinical journal of the American Society of Nephrology : CJASN, 2009; 4(4): 772-7.
Spiegel Brennan, Camilleri Michael, Bolus Roger, Andresen Viola, Chey William D, Fehnel Sheri, Mangel Allen, Talley Nicholas J, Whitehead William E   Psychometric evaluation of patient-reported outcomes in irritable bowel syndrome randomized controlled trials: a Rome Foundation report Gastroenterology, 2009; 137(6): 1944-53.e1-3.
Ford Alexander C, Spiegel Brennan M R, Talley Nicholas J, Moayyedi Paul   Small intestinal bacterial overgrowth in irritable bowel syndrome: systematic review and meta-analysis Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2009; 7(12): 1279-86.
Spiegel Brennan M R   The burden of IBS: looking at metrics Current gastroenterology reports, 2009; 11(4): 265-9.
Desai Amar A, Nissenson Allen, Chertow Glenn M, Farid Mary, Singh Inder, Van Oijen Martijn G H, Esrailian Eric, Solomon Matthew D, Spiegel Brennan M R   The relationship between laboratory-based outcome measures and mortality in end-stage renal disease: a systematic review Hemodialysis international. International Symposium on Home Hemodialysis, 2009; 13(3): 347-59.
Ford Alexander C, Chey William D, Talley Nicholas J, Malhotra Ashish, Spiegel Brennan M R, Moayyedi Paul   Yield of diagnostic tests for celiac disease in individuals with symptoms suggestive of irritable bowel syndrome: systematic review and meta-analysis Archives of internal medicine, 2009; 169(7): 651-8.
Spiegel Brennan M R, Chey William D, Chang Lin   Bacterial overgrowth and irritable bowel syndrome: unifying hypothesis or a spurious consequence of proton pump inhibitors? The American journal of gastroenterology, 2008; 103(12): 2972-6.
Spiegel Brennan M R, Melmed Gil, Robbins Sean, Esrailian Eric   Biomarkers and health-related quality of life in end-stage renal disease: a systematic review Clinical journal of the American Society of Nephrology : CJASN, 2008; 3(6): 1759-68.
Slavenburg Serena, van Oijen Martijn G H, Spiegel Brennan M R   Comparison of health-related quality of life between populations Liver international : official journal of the International Association for the Study of the Liver, 2008; 28(2): 285-6; author reply 286-7.
Ford Alexander C, Talley Nicholas J, Spiegel Brennan M R, Foxx-Orenstein Amy E, Schiller Lawrence, Quigley Eamonn M M, Moayyedi Paul   Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis BMJ (Clinical research ed.), 2008; 337(12): a2313.
Desai Amar A, Bolus Roger, Nissenson Allen, Bolus Sally, Solomon Matthew D, Khawar Osman, Gitlin Matthew, Talley Jennifer, Spiegel Brennan M R   Identifying best practices in dialysis care: results of cognitive interviews and a national survey of dialysis providers Clinical journal of the American Society of Nephrology : CJASN, 2008; 3(4): 1066-76.
Spiegel Brennan, Strickland Amy, Naliboff Bruce D, Mayer Emeran A, Chang Lin   Predictors of patient-assessed illness severity in irritable bowel syndrome The American journal of gastroenterology, 2008; 103(10): 2536-43.
Ho Wayne, Spiegel Brennan M R   The relationship between obesity and functional gastrointestinal disorders: causation, association, or neither? Gastroenterology & hepatology, 2008; 4(8): 572-8.
Spiegel Brennan M R, Esrailian Eric, Laine Loren, Chamberlain Marc C   Clinical impact of adjuvant chemotherapy in glioblastoma multiforme : a meta-analysis CNS drugs, 2007; 21(9): 775-87.
Spiegel Brennan M R, Bolus Roger, Han Steven, Tong Myron, Esrailian Eric, Talley Jennifer, Tran Tram, Smith Jason, Karsan Hetal A, Durazo Francisco, Bacon Bruce, Martin Paul, Younossi Zobair, Hwa-Ong Siew, Kanwal Fasiha   Development and validation of a disease-targeted quality of life instrument in chronic hepatitis B: the hepatitis B quality of life instrument, version 1.0 Hepatology (Baltimore, Md.), 2007; 46(1): 113-21.
Spiegel Brennan M R   Do physicians follow evidence-based guidelines in the diagnostic work-up of IBS? Nature clinical practice. Gastroenterology & hepatology, 2007; 4(6): 296-7.
Kanwal Fasiha, Hoang Tuyen, Spiegel Brennan M R, Eisen Seth, Dominitz Jason A, Gifford Allen, Goetz Mathew, Asch Steven M   Predictors of treatment in patients with chronic hepatitis C infection - role of patient versus nonpatient factors Hepatology (Baltimore, Md.), 2007; 46(6): 1741-9.
Spiegel Brennan M R, Esrailian Eric, Eisen Glenn   The budget impact of endoscopic screening for esophageal varices in cirrhosis Gastrointestinal endoscopy, 2007; 66(4): 679-92.
Spiegel Brennan M R, Farid Mary, Dulai Gareth S, Gralnek Ian M, Kanwal Fasiha   Comparing rates of dyspepsia with Coxibs vs NSAID+PPI: a meta-analysis The American journal of medicine, 2006; 119(5): 448.e27-36.
Gralnek Ian M, Dulai Gareth S, Fennerty M Brian, Spiegel Brennan M R   Esomeprazole versus other proton pump inhibitors in erosive esophagitis: a meta-analysis of randomized clinical trials Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2006; 4(12): 1452-8.
Spiegel Brennan M R, Dulai Gareth S, Lim Brian S, Mann Neel, Kanwal Fasiha, Gralnek Ian M   The cost-effectiveness and budget impact of intravenous versus oral proton pump inhibitors in peptic ulcer hemorrhage Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2006; 4(8): 988-997.
Singh Harminder, Latosinsky Steven, Spiegel Brennan M R, Targownik Laura E   The cost-effectiveness of colonic stenting as a bridge to curative surgery in patients with acute left-sided malignant colonic obstruction: a Canadian perspective Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2006; 20(12): 779-85.
Kanwal Fasiha, Farid Mary, Martin Paul, Chen Gary, Gralnek Ian M, Dulai Gareth S, Spiegel Brennan M R   Treatment alternatives for hepatitis B cirrhosis: a cost-effectiveness analysis The American journal of gastroenterology, 2006; 101(9): 2076-89.
Bloom Michael A, Barghout Victoria, Kahler Kristijan H, Bentkover Judith, Kurth Hannah, Gralnek Ian M, Spiegel Brennan M R   Budget impact of tegaserod on a managed care organization formulary The American journal of managed care, 2005; 11(1 Suppl): S27-34.
Karsan Hetal A, Morton Sally C, Shekelle Paul G, Spiegel Brennan M R, Suttorp Marika J, Edelstein Marc A, Gralnek Ian M   Combination endoscopic band ligation and sclerotherapy compared with endoscopic band ligation alone for the secondary prophylaxis of esophageal variceal hemorrhage: a meta-analysis Digestive diseases and sciences, 2005; 50(2): 399-406.
Dulai Gareth S, Shekelle Paul G, Jensen Dennis M, Spiegel Brennan M R, Chen Jaime, Oh David, Kahn Katherine L   Dysplasia and risk of further neoplastic progression in a regional Veterans Administration Barrett's cohort The American journal of gastroenterology, 2005; 100(4): 775-83.
Spiegel Brennan M R, Chen Kristina, Chiou Chiun-Fang, Robbins Sean, Younossi Zobair M   Erythropoietic growth factors for treatment-induced anemia in hepatitis C: a cost-effectiveness analysis Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2005; 3(10): 1034-42.
Kanwal Fasiha, Gralnek Ian M, Hays Ron D, Dulai Gareth S, Spiegel Brennan M R, Bozzette Samuel, Asch Steve   Impact of chronic viral hepatitis on health-related quality of life in HIV: results from a nationally representative sample The American journal of gastroenterology, 2005; 100(9): 1984-94.
Spiegel Brennan M R, Younossi Zobair M, Hays Ron D, Revicki Dennis, Robbins Sean, Kanwal Fasiha   Impact of hepatitis C on health related quality of life: a systematic review and quantitative assessment Hepatology (Baltimore, Md.), 2005; 41(4): 790-800.
Spiegel Brennan M R, Gralnek Ian M, Bolus Roger, Chang Lin, Dulai Gareth S, Naliboff Bruce, Mayer Emeran A   Is a negative colonoscopy associated with reassurance or improved health-related quality of life in irritable bowel syndrome? Gastrointestinal endoscopy, 2005; 62(6): 892-9.
Spiegel Brennan M R, Chiou Chiun-Fang, Ofman Joshua J   Minimizing complications from nonsteroidal antiinflammatory drugs: cost-effectiveness of competing strategies in varying risk groups Arthritis and rheumatism, 2005; 53(2): 185-97.
Spiegel Brennan M R, Kanwal Fasiha, Naliboff Bruce, Mayer Emeran   The impact of somatization on the use of gastrointestinal health-care resources in patients with irritable bowel syndrome The American journal of gastroenterology, 2005; 100(10): 2262-73.
Kanwal Fasiha, Gralnek Ian M, Martin Paul, Dulai Gareth S, Farid Mary, Spiegel Brennan M R   Treatment alternatives for chronic hepatitis B virus infection: a cost-effectiveness analysis Annals of internal medicine, 2005; 142(10): 821-31.
Spiegel Brennan M R, Gralnek Ian M, Bolus Roger, Chang Lin, Dulai Gareth S, Mayer Emeran A, Naliboff Bruce   Clinical determinants of health-related quality of life in patients with irritable bowel syndrome Archives of internal medicine, 2004; 164(16): 1773-80.
Spiegel, BM Gralnek, IM Bolus, R Chang, L Dulai, GS Mayer, EA Naliboff, B   Clinical determinants of health-related quality of life in patients with irritable bowel syndrome Archives of internal medicine. , 2004; 164(16): 1773-80.
Targownik Laura E, Spiegel Brennan M, Sack Jonathan, Hines Oscar J, Dulai Gareth S, Gralnek Ian M, Farrell James J   Colonic stent vs. emergency surgery for management of acute left-sided malignant colonic obstruction: a decision analysis Gastrointestinal endoscopy, 2004; 60(6): 865-74.
Spiegel BMR, DeRosa VP, Gralnek IM, Wang V, Dulai GS   Testing for celiac sprue in diarrhea-predominant irritable bowel syndrome: a cost-effectiveness analysis, Gastroenterology, 2004; .
Spiegel Brennan M R, DeRosa Vincent P, Gralnek Ian M, Wang Victor, Dulai Gareth S   Testing for celiac sprue in irritable bowel syndrome with predominant diarrhea: a cost-effectiveness analysis Gastroenterology, 2004; 126(7): 1721-32.
Targownik Laura E, Spiegel Brennan M R, Dulai Gareth S, Karsan Hetal A, Gralnek Ian M   The cost-effectiveness of hepatic venous pressure gradient monitoring in the prevention of recurrent variceal hemorrhage The American journal of gastroenterology, 2004; 99(7): 1306-15.
Spiegel, BM Targownik, LE Kanwal, F Derosa, V Dulai, GS Gralnek, IM Chiou, CF   The quality of published health economic analyses in digestive diseases: a systematic review and quantitative appraisal Gastroenterology. , 2004; 127(2): 403-11.
Spiegel Brennan M R, Targownik Laura E, Kanwal Fasiha, Derosa Vincent, Dulai Gareth S, Gralnek Ian M, Chiou Chiun-Fang   The quality of published health economic analyses in digestive diseases: a systematic review and quantitative appraisal Gastroenterology, 2004; 127(2): 403-11.
Spiegel, BM Targownik, L Dulai, GS Karsan, HA Gralnek, IM   Endoscopic screening for esophageal varices in cirrhosis: Is it ever cost effective? Hepatology (Baltimore, Md.) , 2003; 37(2): 366-77.
Spiegel Brennan M r, Targownik Laura, Dulai Gareth S, Karsan Hetal A, Gralnek Ian M   Endoscopic screening for esophageal varices in cirrhosis: Is it ever cost effective? Hepatology (Baltimore, Md.), 2003; 37(2): 366-77.
Targownik Laura E, Gralnek Ian M, Dulai Gareth S, Spiegel Brennan M R, Oei Tommy, Bernstein Charles N   Management of acute nonvariceal upper gastrointestinal hemorrhage: comparison of an American and a Canadian medical centre Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2003; 17(8): 489-95.
Spiegel Brennan M R, Ofman Joshua J, Woods Karen, Vakil Nimish B   Minimizing recurrent peptic ulcer hemorrhage after endoscopic hemostasis: the cost-effectiveness of competing strategies The American journal of gastroenterology, 2003; 98(1): 86-97.
Spiegel, BM Ofman, JJ Woods, K Vakil, NB   Minimizing recurrent peptic ulcer hemorrhage after endoscopic hemostasis: the cost-effectiveness of competing strategies The American journal of gastroenterology. , 2003; 98(1): 86-97.
Spiegel Brennan M R, Targownik Laura, Dulai Gareth S, Gralnek Ian M   The cost-effectiveness of cyclooxygenase-2 selective inhibitors in the management of chronic arthritis Annals of internal medicine, 2003; 138(10): 795-806.
Spiegel BMR, Targownik LE, Dulai GS, Gralnek IM   The cost-effectiveness of cyclooxygenase-2 selective inhibitors in the management of chronic arthritis, Annals of Internal Medicine, 2003; .
Spiegel, BM Vakil, NB Ofman, JJ   Dyspepsia management in primary care: a decision analysis of competing strategies Gastroenterology. , 2002; 122(5): 1270-85.
Spiegel Brennan M R, Vakil Nimish B, Ofman Joshua J   Dyspepsia management in primary care: a decision analysis of competing strategies Gastroenterology, 2002; 122(5): 1270-85.
Spiegel BMR, Vakil NB, Ofman JJ   Endoscopy for acute non-variceal upper gastrointestinal tract hemorrhage: is sooner better? A systematic review, Archives of Internal Medicine, 2001; .
Spiegel Brennan   Diagnostic testing in extraesophageal GERD: another case of "furor medicus"? The American journal of gastroenterology, 2013; 108(6): 912-4.
Shahedi Kamyar, Fuller Garth, Bolus Roger, Cohen Erica, Vu Michelle, Shah Rena, Agarwal Nikhil, Kaneshiro Marc, Atia Mary, Sheen Victoria, Kurzbard Nicole, van Oijen Martijn G H, Yen Linnette, Hodgkins Paul, Erder M Haim, Spiegel Brennan   Long-term Risk of Acute Diverticulitis Among Patients With Incidental Diverticulosis Found During Colonoscopy Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2013; 11(12): 1609-13.
Cohen Erica, Spiegel Brennan   Reply Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2013; 11(11): 1521-2.
Whitman Cynthia B, Shreay Sanatan, Gitlin Matthew, van Oijen Martijn G H, Spiegel Brennan M R   Clinical factors and the decision to transfuse chronic dialysis patients Clinical journal of the American Society of Nephrology : CJASN, 2013; 8(11): 1942-51.
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