Scott Kitchen, Ph.D.

A Short Biography:

Dr. Scott Kitchen's research interests are focused on investigating the effects of viral infection, as well as other cellular abnormalities, on human hematopoiesis and on exploring ways to correct defects that exist in immunity to viral and cellular antigens. The human immune system is normally fastidious in controlling the environmental assaults that the body receives every day. However, there are many instances where the immune response is ineffective in clearing infection or cancerous cells. Kitchen's laboratory is interested in understanding the mechanisms that limit the immune systems' ability to clear infection or cancer and in developing ways that augment these responses. Specifically, they are investigating the role of the CD4 molecule in multilineage hematopoiesis and in cellular responses, particularly in the context of HIV infection. They are also interested in developing gene therapy-based approaches to engineer human hematopoietic stem cells to reconstitute and/or enhance immune responses following their development into mature cells that specifically target HIV infection as well as other viral and cellular antigens. In addition, his laboratory is interested in the development of mouse/human chimeric models that allow the characterization of human hematopoiesis and engineered immunity in a surrogate in vivo host.

Work Titles
UCLA Director, UCLA CFAR/JCCC Humanized Mouse Core Laboratory Associate Professor, Medicine
Education:
Degrees:
Ph.D., University of California, Los Angeles

Contact Information:

Email Address:

skitchen@ucla.edu


Work Phone Number:

310-983-1251

Mailing Address:

UCLA AIDS Institute
615 Charles E. Young Dr. S.
Los Angeles, CA 90095


Publications:

Zhen Anjie, Kamata Masakazu, Rezek Valerie, Rick Jonathan, Levin Bernard, Kasparian Saro, Chen Irvin Sy, Yang Otto O, Zack Jerome A, Kitchen Scott G   HIV-specific Immunity Derived From Chimeric Antigen Receptor-engineered Stem Cells Molecular therapy : the journal of the American Society of Gene Therapy, 2015; 23(8): 1358-67.
Zhen Anjie, Krutzik Stephan R, Levin Bernard R, Kasparian Saro, Zack Jerome A, Kitchen Scott G   CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection Journal of virology, 2014; 88(17): 9934-46.
Zhen Anjie, Kitchen Scott   Stem-cell-based gene therapy for HIV infection Viruses, 2014; 6(1): 1-12.
Kitchen Scott G, Levin Bernard R, Bristol Gregory, Rezek Valerie, Kim Sohn, Aguilera-Sandoval Christian, Balamurugan Arumugam, Yang Otto O, Zack Jerome A   In vivo suppression of HIV by antigen specific T cells derived from engineered hematopoietic stem cells PLoS pathogens, 2012; 8(4): e1002649.
Vatakis Dimitrios N, Bristol Gregory C, Kim Sohn G, Levin Bernard, Liu Wei, Radu Caius G, Kitchen Scott G, Zack Jerome A   Using the BLT humanized mouse as a stem cell based gene therapy tumor model Journal of visualized experiments : JoVE, 2012; (70): e4181.
Kitchen Scott G, Shimizu Saki, An Dong Sung   Stem cell-based anti-HIV gene therapy Virology, 2011; 411(2): 260-72.
Kitchen Scott G, Zack Jerome A   Stem cell-based approaches to treating HIV infection Current opinion in HIV and AIDS, 2011; 6(1): 68-73.
Epeldegui Marta, Thapa Dharma R, De la Cruz Justin, Kitchen Scott, Zack Jerome A, Martínez-Maza Otoniel   CD40 ligand (CD154) incorporated into HIV virions induces activation-induced cytidine deaminase (AID) expression in human B lymphocytes PloS one, 2010; 5(7): e11448.
Kitchen Christina M R, Krogstad Paul, Kitchen Scott G   In Vivo validation of a bioinformatics based tool to identify reduced replication capacity in HIV-1 The open medical informatics journal, 2010; 4(7): 225-32.
Kitchen Scott G, Bennett Michael, Galić Zoran, Kim Joanne, Xu Qing, Young Alan, Lieberman Alexis, Joseph Aviva, Goldstein Harris, Ng Hwee, Yang Otto, Zack Jerome A   Engineering antigen-specific T cells from genetically modified human hematopoietic stem cells in immunodeficient mice PloS one, 2009; 4(12): e8208.
Galić Zoran, Kitchen Scott G, Subramanian Aparna, Bristol Greg, Marsden Matthew D, Balamurugan Arumugam, Kacena Amelia, Yang Otto, Zack Jerome A   Generation of T lineage cells from human embryonic stem cells in a feeder free system Stem cells (Dayton, Ohio), 2009; 27(1): 100-7.
Subramanian Aparna, Guo Beichu, Marsden Matthew D, Galic Zoran, Kitchen Scott, Kacena Amelia, Brown Helen J, Cheng Genhong, Zack Jerome A   Macrophage differentiation from embryoid bodies derived from human embryonic stem cells Journal of stem cells, 2009; 4(1): 29-45.
Kitchen Christina Mr, Nuño Miriam, Kitchen Scott G, Krogstad Paul   Enfuvirtide antiretroviral therapy in HIV-1 infection Therapeutics and clinical risk management, 2008; 4(2): 433-9.
Galic Zoran, Kitchen Scott G, Kacena Amelia, Subramanian Aparna, Burke Bryan, Cortado Ruth, Zack Jerome A   T lineage differentiation from human embryonic stem cells Proceedings of the National Academy of Sciences of the United States of America, 2006; 103(31): 11742-7.
Kitchen Scott G, Whitmire Jason K, Jones Nicole R, Galic Zoran, Kitchen Christina M R, Ahmed Rafi, Zack Jerome A   The CD4 molecule on CD8+ T lymphocytes directly enhances the immune response to viral and cellular antigens Proceedings of the National Academy of Sciences of the United States of America, 2005; 102(10): 3794-9.
Kitchen Scott G, Jones Nicole R, LaForge Stuart, Whitmire Jason K, Vu Bien-Aimee, Galic Zoran, Brooks David G, Brown Stephen J, Kitchen Christina M R, Zack Jerome A   CD4 on CD8(+) T cells directly enhances effector function and is a target for HIV infection Proceedings of the National Academy of Sciences of the United States of America, 2004; 101(23): 8727-32.

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