Laszlo Boros, M.D.

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Work Titles
CTSI Member, CTSI
Harbor-UCLA Medical Center Assistant Adjunct Professor, Harbor-UCLA Medical Center
The Lundquist Institute for Biomedical Innovation Associate Professor, ENDOCRINOLOGY/METABOLISM
Education:
Degrees:
M.D.

Contact Information:

Work Email Address:

boros@lundquist.org


Website:

http://www.sidmap.com/ homee/ team/ laszlo-boros-md/

Fax Number:

(310) 222-3887

Work Phone Number:

(310) 222-1856

3102221883

Work Address:

1000 W Carson St, Box 446, Torrance CA 90509
Campus-176847
CA

1124 West Carson Street
Torrance, CA


Detailed Biography:

Areas of Research Focus: Cancer, Metabolism and Stable Isotopes

Publications:

A selected list of publications:

Huang Jingyu, Simcox Judith, Mitchell T Creighton, Jones Deborah, Cox James, Luo Bai, Cooksey Robert C, Boros Laszlo G, McClain Donald A   Iron regulates glucose homeostasis in liver and muscle via AMP-activated protein kinase in mice FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2013; .
Harris Diane M, Li Luyi, Chen Monica, Lagunero F Tracy, Go Vay Liang W, Boros Laszlo G   Diverse mechanisms of growth inhibition by luteolin, resveratrol, and quercetin in MIA PaCa-2 cells: a comparative glucose tracer study with the fatty acid synthase inhibitor C75 Metabolomics : Official journal of the Metabolomic Society, 2012; 8(2): 201-210.
Sonko Bakary J, Schmitt Thomas C, Guo Lei, Shi Qiang, Boros Laszlo G, Leakey Julian E A, Beger Richard D   Assessment of usnic acid toxicity in rat primary hepatocytes using ¹³C isotopomer distribution analysis of lactate, glutamate and glucose Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2011; 49(11): 2968-74.
Huang Danshan, Dhawan Tania, Young Stephen, Yong William H, Boros Laszlo G, Heaney Anthony P   Fructose impairs glucose-induced hepatic triglyceride synthesis Lipids in health and disease, 2011; 10(1): 20.
Gu Wei, Lloyd David J, Chinookswong Narumol, Komorowski Renée, Sivits Glenn, Graham Melissa, Winters Katherine A, Yan Hai, Boros Laszlo G, Lindberg Richard A, Véniant Murielle M   Pharmacological targeting of glucagon and glucagon-like peptide 1 receptors has different effects on energy state and glucose homeostasis in diet-induced obese mice The Journal of pharmacology and experimental therapeutics, 2011; 338(1): 70-81.
Espinoza Daniel O, Boros Laszlo G, Crunkhorn Sarah, Gami Hiral, Patti Mary-Elizabeth   Dual modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in cultured myotubes FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010; 24(4): 1003-14.
Liu Haibo, Huang Danshan, McArthur David L, Boros Laszlo G, Nissen Nicholas, Heaney Anthony P   Fructose induces transketolase flux to promote pancreatic cancer growth Cancer research, 2010; 70(15): 6368-76.
Kominsky Douglas J, Klawitter Jelena, Brown Jaimi L, Boros Laszlo G, Melo Junia V, Eckhardt S Gail, Serkova Natalie J   Abnormalities in glucose uptake and metabolism in imatinib-resistant human BCR-ABL-positive cells Clinical cancer research : an official journal of the American Association for Cancer Research, 2009; 15(10): 3442-50.
Hui Hongxiang, Huang Danshan, McArthur David, Nissen Nicholas, Boros Laszlo G, Heaney Anthony P   Direct spectrophotometric determination of serum fructose in pancreatic cancer patients Pancreas, 2009; 38(6): 706-12.
Boros Laszlo G, Deng Qinggao, Pandol Stephen J, Tsukamoto Hidekazu, Go Vay Liang W, Lee Wai-Nang Paul   Ethanol diversely alters palmitate, stearate, and oleate metabolism in the liver and pancreas of rats using the deuterium oxide single tracer Pancreas, 2009; 38(2): e47-52.
Beger Richard D, Hansen Deborah K, Schnackenberg Laura K, Cross Brandie M, Fatollahi Javad J, Lagunero F Tracy, Sarnyai Zoltan, Boros Laszlo G   Single valproic acid treatment inhibits glycogen and RNA ribose turnover while disrupting glucose-derived cholesterol synthesis in liver as revealed by the [U-C(6)]-d-glucose tracer in mice Metabolomics : Official journal of the Metabolomic Society, 2009; 5(3): 336-345.
Rehan Virender K, Wang Ying, Sugano Sharon, Santos Jamie, Patel Sanjay, Sakurai Reiko, Boros Laszlo G, Boros Laszlo W, Lee W-P, Torday John S   In utero nicotine exposure alters fetal rat lung alveolar type II cell proliferation, differentiation, and metabolism American journal of physiology. Lung cellular and molecular physiology, 2007; 292(1): L323-33.
Huang Jingyu, Gabrielsen J Scott, Cooksey Robert C, Luo Bai, Boros László G, Jones Deborah L, Jouihan Hani A, Soesanto Yudi, Knecht Lauren, Hazel Mark W, Kushner James P, McClain Donald A   Increased glucose disposal and AMP-dependent kinase signaling in a mouse model of hemochromatosis The Journal of biological chemistry, 2007; 282(52): 37501-7.
Maguire Greg, Lee Paul, Manheim David, Boros Laszlo   SiDMAP: a metabolomics approach to assess the effects of drug candidates on the dynamic properties of biochemical pathways Expert opinion on drug discovery, 2006; 1(4): 351-9.
Serkova Natalie, Boros László G   Detection of resistance to imatinib by metabolic profiling: clinical and drug development implications American journal of pharmacogenomics : genomics-related research in drug development and clinical practice, 2005; 5(5): 293-302.
Boros Laszlo G, Nichelatti Michele, Shoenfeld Yehuda   Fermented wheat germ extract (Avemar) in the treatment of cancer and autoimmune diseases Annals of the New York Academy of Sciences, 2005; 1051(13): 529-42.
Eibl Guido, Takata Yasunori, Boros Laszlo G, Liu Joey, Okada Yuji, Reber Howard A, Hines Oscar J   Growth stimulation of COX-2-negative pancreatic cancer by a selective COX-2 inhibitor Cancer research, 2005; 65(3): 982-90.
Vizan Pedro, Boros Laszlo G, Figueras Agnes, Capella Gabriel, Mangues Ramon, Bassilian Sara, Lim Shu, Lee Wai-Nang P, Cascante Marta   K-ras codon-specific mutations produce distinctive metabolic phenotypes in NIH3T3 mice [corrected] fibroblasts Cancer research, 2005; 65(13): 5512-5.
Balog Attila, Gyulai Zsolt, Boros Laszlo G, Farkas Gyula, Takács Tamas, Lonovics Janos, Mándi Yvette   Polymorphism of the TNF-alpha, HSP70-2, and CD14 genes increases susceptibility to severe acute pancreatitis Pancreas, 2005; 30(2): e46-50.
Boros László G, Lerner Megan R, Morgan Daniel L, Taylor Stephanie L, Smith Brenda J, Postier Russell G, Brackett Daniel J   [1,2-13C2]-D-glucose profiles of the serum, liver, pancreas, and DMBA-induced pancreatic tumors of rats Pancreas, 2005; 31(4): 337-43.
Marin Silvia, Lee W-N Paul, Bassilian Sara, Lim Shu, Boros Laszlo G, Centelles Josep J, FernAndez-Novell Josep Maria, Guinovart Joan J, Cascante Marta   Dynamic profiling of the glucose metabolic network in fasted rat hepatocytes using [1,2-13C2]glucose The Biochemical journal, 2004; 381(Pt 1): 287-94.
Boros László G, Steinkamp Mara P, Fleming Judith C, Lee Wai-Nang Paul, Cascante Marta, Neufeld Ellis J   Defective RNA ribose synthesis in fibroblasts from patients with thiamine-responsive megaloblastic anemia (TRMA) Blood, 2003; 102(10): 3556-61.
Bulotta Angela, Perfetti Riccardo, Hui Hongxiang, Boros László G   GLP-1 stimulates glucose-derived de novo fatty acid synthesis and chain elongation during cell differentiation and insulin release Journal of lipid research, 2003; 44(8): 1559-65.
Boros László G, Brackett Daniel J, Harrigan George G   Metabolic biomarker and kinase drug target discovery in cancer using stable isotope-based dynamic metabolic profiling (SIDMAP) Current cancer drug targets, 2003; 3(6): 445-53.
Marin Silvia, Chiang Kelly, Bassilian Sara, Lee Wai-Nang Paul, Boros Laszlo G, Fernández-Novell Josep Maria, Centelles Josep Joan, Medrano Antonio, Rodriguez-Gil Joan Enric, Cascante Marta   Metabolic strategy of boar spermatozoa revealed by a metabolomic characterization FEBS letters, 2003; 554(3): 342-6.
Guo Taylor B, Boros Laszlo G, Chan Kam C, Hikim Amiya P Sinha, Hudson Alan P, Swerdloff Ronald S, Mitchell Aaron P, Salameh Wael A   Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors Journal of andrology, 2003; 24(2): 204-14.
Boren Joan, Lee Wai-Nang Paul, Bassilian Sara, Centelles Josep Joan, Lim Shu, Ahmed Sayed, Boros László G, Cascante Marta   The stable isotope-based dynamic metabolic profile of butyrate-induced HT29 cell differentiation The Journal of biological chemistry, 2003; 278(31): 28395-402.
Boros Laszlo G, Lee Wai-Nang Paul, Go Vay Liang W   A metabolic hypothesis of cell growth and death in pancreatic cancer Pancreas, 2002; 24(1): 26-33.
Comin-Anduix Begona, Boros Laszlo G, Marin Silvia, Boren Joan, Callol-Massot Carles, Centelles Josep J, Torres Josep L, Agell Neus, Bassilian Sara, Cascante Marta   Fermented wheat germ extract inhibits glycolysis/pentose cycle enzymes and induces apoptosis through poly(ADP-ribose) polymerase activation in Jurkat T-cell leukemia tumor cells The Journal of biological chemistry, 2002; 277(48): 46408-14.
Boros Laszlo G, Lee Wai-Nang Paul, Cascante Marta   Imatinib and chronic-phase leukemias The New England journal of medicine, 2002; 347(1): 67-8.
Bassilian Sara, Ahmed Syed, Lim Shu K, Boros Laszlo G, Mao Catherine S, Lee W-N Paul   Loss of regulation of lipogenesis in the Zucker diabetic rat. II. Changes in stearate and oleate synthesis American journal of physiology. Endocrinology and metabolism, 2002; 282(3): E507-13.
Cascante Marta, Boros Laszlo G, Comin-Anduix Begoña, de Atauri Pedro, Centelles Josep J, Lee Paul W-N   Metabolic control analysis in drug discovery and disease Nature biotechnology, 2002; 20(3): 243-9.
Boros László G, Cascante Marta, Lee Wai Nang Paul   Metabolic profiling of cell growth and death in cancer: applications in drug discovery Drug discovery today, 2002; 7(6): 364-72.
Boros László G, Torday John S, Paul Lee Wai-Nang, Rehan Virender K   Oxygen-induced metabolic changes and transdifferentiation in immature fetal rat lung lipofibroblasts Molecular genetics and metabolism, 2002; 77(3): 230-6.

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