David Sultzer, M.D.

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Work Titles
UCLA Professor, Psychiatry and Biobehavioral Sciences
Education:
Degrees:
M.D., University of North Carolina
Fellowship:
UCLA, UCLA
Residency:
UCLA, UCLA

Contact Information:

Email Address:

dsultzer@ucla.edu

Work Email Address:

david.sultzer@med.va.gov


Work Phone Number:

310 268-3708

Work Address:

Office
Psychiatry, 3 South, Room 3424, 116AF
11301 Wilshire Blvd
Los Angeles, CA 90073


Detailed Biography:

Dr. Sultzer is Professor in the Department of Psychiatry and Biobehavioral Sciences at the UCLA School of Medicine. He directs the UCLA Geriatric Psychiatry Fellowship Training Program and the Gero/Neuropsychiatry Division at VA Greater Los Angeles Healthcare System. He is recognized widely for his research activities to better understand the phenomenology, pathophysiology, and treatment of Alzheimer’s disease. He has received independent project research support from the NIMH and other funding sources to study psychiatric symptoms in patients with Alzheimer’s disease. His work using fluorodeoxyglucose positron emission tomography (PET) has demonstrated that specific clinical symptoms, including psychosis, are associated with regional metabolic dysfunction in patients with Alzheimer’s disease. These results indicate that psychiatric symptoms are fundamental expressions of the degenerative process. Recently, he has used PET imaging to better understand the neurobiological mechanisms involved in medication treatment response in Alzheimer’s disease. He has also completed clinical trials to compare the efficacy and adverse effects of medications for the treatment of psychosis and agitated behaviors in patients with dementia, and is one of the few researchers to have examined the differential response of specific clinical symptoms to pharmacologic interventions. Other areas of research interest include MRI imaging in Alzheimer’s disease, psychosis in older persons without cognitive disorders, and mood symptoms in patients with neuropsychiatric conditions. Dr. Sultzer received his medical degree from the University of North Carolina, and completed his residency training in psychiatry and fellowship training in neurobehavior at UCLA. He is prominently involved in graduate medical education at UCLA and the West Los Angeles VA Medical Center. He lectures widely and has published numerous articles in the medical literature. He has also received several awards for his research work, and is recognized nationally for his academic activities related to geriatric psychiatry and Alzheimer’s disease.

Publications:

A selected list of publications:

Feil Denise G, Zhu Carolyn W, Sultzer David L   The relationship between cognitive impairment and diabetes self-management in a population-based community sample of older adults with Type 2 diabetes Journal of behavioral medicine, 2012; 35(2): 190-9.
Mohamed Somaia, Rosenheck Robert, Lyketsos Constantine G, Kaczynski Richard, Sultzer David L, Schneider Lon S   Effect of second-generation antipsychotics on caregiver burden in Alzheimer's disease The Journal of clinical psychiatry, 2012; 73(1): 121-8.
Melrose Rebecca J, Ettenhofer Mark L, Harwood Dylan, Achamallah Natalie, Campa Olivia, Mandelkern Mark, Sultzer David L   Cerebral metabolism, cognition, and functional abilities in Alzheimer disease Journal of geriatric psychiatry and neurology, 2011; 24(3): 127-34.
Maher Alicia Ruelaz, Maglione Margaret, Bagley Steven, Suttorp Marika, Hu Jian-Hui, Ewing Brett, Wang Zhen, Timmer Martha, Sultzer David, Shekelle Paul G   Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis JAMA : the journal of the American Medical Association, 2011; 306(12): 1359-69.
Vigen Cheryl L P, Mack Wendy J, Keefe Richard S E, Sano Mary, Sultzer David L, Stroup T Scott, Dagerman Karen S, Hsiao John K, Lebowitz Barry D, Lyketsos Constantine G, Tariot Pierre N, Zheng Ling, Schneider Lon S   Cognitive effects of atypical antipsychotic medications in patients with Alzheimer's disease: outcomes from CATIE-AD The American journal of psychiatry, 2011; 168(8): 831-9.
Samadi Hossein, Sultzer David   Solanezumab for Alzheimer's disease Expert opinion on biological therapy, 2011; 11(6): 787-98.
Woo Benjamin K P, Harwood Dylan G, Melrose Rebecca J, Mandelkern Mark A, Campa Olivia M, Walston Amy, Sultzer David L   Executive deficits and regional brain metabolism in Alzheimer's disease International journal of geriatric psychiatry, 2010; 25(11): 1150-8.
Woo Benjamin K P, Sultzer David L   A key step for quality care in psychiatric emergency settings General hospital psychiatry, 2010; 31(6): 503-4.
Sultzer David L, Melrose Rebecca J, Harwood Dylan G, Campa Olivia, Mandelkern Mark A   Effect of memantine treatment on regional cortical metabolism in Alzheimer's disease The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2010; 18(7): 606-14.
Melrose Rebecca J, Campa Olivia M, Harwood Dylan G, Osato Sheryl, Mandelkern Mark A, Sultzer David L   The neural correlates of naming and fluency deficits in Alzheimer's disease: an FDG-PET study International journal of geriatric psychiatry, 2009; 24(8): 885-93.
Zheng Ling, Mack Wendy J, Dagerman Karen S, Hsiao John K, Lebowitz Barry D, Lyketsos Constantine G, Stroup T Scott, Sultzer David L, Tariot Pierre N, Vigen Cheryl, Schneider Lon S   Metabolic changes associated with second-generation antipsychotic use in Alzheimer's disease patients: the CATIE-AD study The American journal of psychiatry, 2009; 166(5): 583-90.
Sultzer David L, Davis Sonia M, Tariot Pierre N, Dagerman Karen S, Lebowitz Barry D, Lyketsos Constantine G, Rosenheck Robert A, Hsiao John K, Lieberman Jeffrey A, Schneider Lon S, Schneider Lon S   Clinical symptom responses to atypical antipsychotic medications in Alzheimer's disease: phase 1 outcomes from the CATIE-AD effectiveness trial The American journal of psychiatry, 2008; 165(7): 844-54.
McMurtray Aaron M, Sultzer David L, Monserratt Lorena, Yeo Tuty, Mendez Mario F   Content-specific delusions from right caudate lacunar stroke: association with prefrontal hypometabolism The Journal of neuropsychiatry and clinical neurosciences, 2008; 20(1): 62-7.
Feil Denise G, MacLean Catherine, Sultzer David   Quality indicators for the care of dementia in vulnerable elders Journal of the American Geriatrics Society, 2007; 55 Suppl 2(1): S293-301.
Chodosh Joshua, Sultzer David L, Lee Martin L, Hahn Theodore J, Reuben David B, Yano Elizabeth M, Mittman Brian S, Rubenstein Laurence Z   Memory impairment among primary care veterans Aging & mental health, 2007; 11(4): 444-50.
Marshall Gad A, Monserratt Lorena, Harwood Dylan, Mandelkern Mark, Cummings Jeffrey L, Sultzer David L   Positron emission tomography metabolic correlates of apathy in Alzheimer disease Archives of neurology, 2007; 64(7): 1015-20.
Hashimoto Hiroshi, Monserratt Lorena, Nguyen Peter, Feil Denise, Harwood Dylan, Mandelkern Mark A, Sultzer David L   Anxiety and regional cortical glucose metabolism in patients with Alzheimer's disease The Journal of neuropsychiatry and clinical neurosciences, 2006; 18(4): 521-8.
Schneider Lon S, Tariot Pierre N, Dagerman Karen S, Davis Sonia M, Hsiao John K, Ismail M Saleem, Lebowitz Barry D, Lyketsos Constantine G, Ryan J Michael, Stroup T Scott, Sultzer David L, Weintraub Daniel, Lieberman Jeffrey A, Lieberman Jeffrey A   Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease The New England journal of medicine, 2006; 355(15): 1525-38.
Harwood Dylan G, Sultzer David L, Feil Denise, Monserratt Lorena, Freedman Evan, Mandelkern Mark A   Frontal lobe hypometabolism and impaired insight in Alzheimer disease The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2005; 13(11): 934-41.
Sultzer DL, Lavretsky H   Antipsychotic medication in the elderly, : Kaplan HI, Sadock BJ (eds), Comprehensive Textbook of Psychiatry, 8th Edition, 2005; .
Bartzokis George, Sultzer David, Lu Po H, Nuechterlein Keith H, Mintz Jim, Cummings Jeffrey L   Heterogeneous age-related breakdown of white matter structural integrity: implications for cortical "disconnection" in aging and Alzheimer's disease Neurobiology of aging, 2004; 25(7): 843-51.
Sultzer David L   Psychosis and antipsychotic medications in Alzheimer's disease: clinical management and research perspectives Dementia and geriatric cognitive disorders, 2004; 17(1-2): 78-90.
Sultzer, DL   Psychosis and antipsychotic medications in Alzheimer's disease: clinical management and research perspectives Dementia and geriatric cognitive disorders. , 2004; 17(1-2): 78-90.
Schneider, LS Ismail, MS Dagerman, K Davis, S Olin, J McManus, D Pfeiffer, E Ryan, JM Sultzer, DL Tariot, PN   Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE): Alzheimer's disease trial Schizophrenia bulletin. , 2003; 29(1): 57-72.
Bartzokis George, Cummings Jeffrey L, Sultzer David, Henderson Victor W, Nuechterlein Keith H, Mintz Jim   White matter structural integrity in healthy aging adults and patients with Alzheimer disease: a magnetic resonance imaging study Archives of neurology, 2003; 60(3): 393-8.
Bartzokis, G Cummings, JL Sultzer, D Henderson, VW Nuechterlein, KH Mintz, J   White matter structural integrity in healthy aging adults and patients with Alzheimer disease: a magnetic resonance imaging study Archives of neurology. , 2003; 60(3): 393-8.
Schneider Lon S, Ismail M Saleem, Dagerman Karen, Davis Sonia, Olin Jason, McManus Dennis, Pfeiffer Eric, Ryan J Michael, Sultzer David L, Tariot Pierre N   Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE): Alzheimer's disease trial Schizophrenia bulletin, 2003; 29(1): 57-72.
Sultzer David L, Brown Charles V, Mandelkern Mark A, Mahler Michael E, Mendez Mario F, Chen Stephen T, Cummings Jeffrey L   Delusional thoughts and regional frontal/temporal cortex metabolism in Alzheimer's disease The American journal of psychiatry, 2003; 160(2): 341-9.
Sultzer, DL Brown, CV Mandelkern, MA Mahler, ME Mendez, MF Chen, ST Cummings, JL   Delusional thoughts and regional frontal/temporal cortex metabolism in Alzheimer's disease The American journal of psychiatry. , 2003; 160(2): 341-9.
Feil Denise, Chuang Kenneth, Sultzer David L   Valproate-induced hyperammonemia as a cause of altered mental status The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2003; 10(4): 476-8.
Sultzer, DL Chen, ST Brown, CV Mahler, ME Cummings, JL Hinkin, CH Mandelkern, MA   Subcortical hyperintensities in Alzheimer's disease: associated clinical and metabolic findings The Journal of neuropsychiatry and clinical neurosciences. , 2002; 14(3): 262-9.
Feil D, Chuang K, Sultzer DL   Valproate-induced hyperammonemia as a cause of altered mental status, Am J Geriatr Psychiatry, 2002; 10: 476-478.
Harwood DG, Sultzer DL   “Life is not worth living”: hopelessness in Alzheimer’s disease, J Geriatr Psychiatry Neurol, 2002; 15: 38-43.
Harwood Dylan G, Sultzer David L   "Life is not worth living": hopelessness in Alzheimer's disease Journal of geriatric psychiatry and neurology, 2002; 15(1): 38-43.
Sultzer David L, Chen Stephen T, Brown Charles V, Mahler Michael E, Cummings Jeffrey L, Hinkin Charles H, Mandelkern Mark A   Subcortical hyperintensities in Alzheimer's disease: associated clinical and metabolic findings The Journal of neuropsychiatry and clinical neurosciences, 2002; 14(3): 262-9.
Sultzer DL, Gray KF, Gunay I, Wheatley MV, Mahler ME   Does behavioral improvement with haloperidol or trazodone treatment depend on psychosis or mood symptoms in patients with dementia?, J Am Geriatr Soc, 2001; 49: 1294-1300.

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