Susan L. Smalley


Work Titles and Affiliation
UCLA Director, ADHD Professor, Psychiatry and Biobehavioral Sciences Faculty, Center for Neurobehavioral Genetics

Contact Information:

Email Address:

ssmalley@mednet.ucla.edu


Work Phone Number:

310-206-7528

Detailed Biography:

Research Interest:

Smalley's research centers on the identification of genetic factors influencing complex behavioral traits, particularly psychiatric disorders with onset in childhood or adolescence. Her laboratory is currently conducting a genome scan to identify genes underlying attention deficit hyperactivity disorder (ADHD) and is collaborating on a genome scan in autism with the International Molecular Genetic Study of Autism Consortium (IMGSAC). Her research on ADHD includes studies of treatment by gene interactions, neuropsychological deficits in ADHD, and gene by environment interactions. In addition to the identification of susceptibility genes underlying complex behavior traits, Smalley?s laboratory focuses on the development and application of statistical methods to uncover genes and gene by environment interactions that may underlie common, complex traits, such as human behavior. Her group developed a multivariate statistical approach to carry out genome scans using extremely large numbers of molecular markers or novel methods such as genomic mismatch scanning. Smalley?s laboratory recently evaluated several putative candidate genes underlying ADHD that are involved in dopamine regulation. They found evidence that the dopamine D4 receptor gene contributes a minor risk to ADHD but that in their sample of largely multiplex families, the dopamine transporter gene does not. The IMGSAC team recently identified a potential region on chromosome 7q that may harbor a susceptibility gene for autism.

MeSH Terms:

What is MeSH?

Medical Subject Headings

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  • an acronym for Medical Subject Headings.
  • the U.S. National Library of Medicine's controlled vocabulary (thesaurus).
  • a vocabulary that gives uniformity and consistency to the indexing and cataloging of biomedical literature.
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MeSH Vocabulary includes four types of terms:

  • Headings
  • Subheadings
  • Supplementary Concept Records
  • Publication Characteristics (or Types)

Over 26,000 MeSH headings (also called "main headings" or "descriptors" represents concepts found in the biomedical literature

Subheadings - (also called qualifiers) are attached to MeSH headings to describe a specific aspect of a concept.

Supplementary Concept Records are over 200,000 terms in a separate thesaurus from the Medical Subject Headings. These are primarily substance terms, but also include some protocols and rare desease terms. These terms are updated weekly.

Publication Characteristics or (Publication Types) describe the type of publication being indexed; i.e., what the item is, not what the article is about.

Information from U.S. National Library of Medicine.

Attention Deficit Disorder with Hyperactivity Gene Expression Genetic Markers Genotype Intelligence Tests Interview, Psychological Interviews as Topic Motivational Interviewing Neuropsychological Tests Pathologic Processes Polymerase Chain Reaction Psychological Tests Questionnaires Sex Chromosomes

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