Genhong Cheng, Ph.D.


Work Titles
UCLA Professor, Microbiology, Immunology & Molecular Genetics
Education:
Degrees:
Ph.D.

Contact Information:

Department Email Address:

genhongc@microbio.ucla.edu

Work Email Address:

gcheng@mednet.ucla.edu


Work Phone Number:

(310) 825-8896

Work Address:

Office
BSRB 210A
Los Angeles, CA 90095

BSRB 210A
CAMPUS - 736422
CA

Laboratory
Factor
Los Angeles, CA 90095


Detailed Biography:

Dr. Cheng is a Professor in Microbiology, Immunology and Molecular Genetics at UCLA. He had his PhD training in Molecular Biology with Dr. Arthur Skoultchi at Albert Einstein College of Medicine, and had his postdoctoral training in Molecular Immunology with Dr. David Baltimore at Rockefeller University and Massachusetts Institute of Technology (MIT). Dr. Cheng is an expert on immune responses in host defense against infections and cancers as well as their associations with inflammatory and metabolic diseases. He has authored close to 100 peer-reviewed articles, many of which are published in top journals like Nature and Science. He has been the principal investigator in many research grants from government and private sources. Dr. Cheng has received many awards, including Stop Cancer Award, Leukemia & Lymphoma Society Scholar Award, Leukemia & Lymphoma Society Stohlman Scholar Award and NIH Merit Award.

Publications:

Mirjam Schenk, Stephan R Krutzik, Peter A Sieling, Delphine J Lee, Rosane M B Teles, Maria Teresa Ochoa, Evangelia Komisopoulou, Euzenir N Sarno, Thomas H Rea, Thomas G Graeber, Soohyun Kim, Genhong Cheng & Robert L Modlin   NOD2 triggers an interleukin-32–dependent human dendritic cell program in leprosy Nature Medicine, 2012; 18(4): 555-563.
Zheng C, Kabaleeswaran V, Wang Y, Cheng G, Wu H   Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation Mol Cell. , 2010; 38(1): 101-13.
Cho JS, Pietras EM, Garcia NC, Ramos RI, Farzam DM, Monroe HR, Magorien JE, Blauvelt A, Kolls JK, Cheung AL, Cheng G, Modlin RL, Miller LS   IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice J Clin Invest, 2010; 120(5): 1762-3.
Razani B, Zarnegar B, Ytterberg AJ, Shiba T, Dempsey PW, Ware CF, Loo JA, Cheng G   Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation Sci Signal, 2010; 3(123): ra41.
Liu PT, Schenk M, Walker VP, Dempsey PW, Kanchanapoomi M, Wheelwright M, Vazirnia A, Zhang X, Steinmeyer A, Zügel U, Hollis BW, Cheng G, Modlin RL.   Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses PLoS One, 2009; 4(6): e5810.
Montoya D, Cruz D, Teles RM, Lee DJ, Ochoa MT, Krutzik SR, Chun R, Schenk M, Zhang X, Ferguson BG, Burdick AE, Sarno EN, Rea TH, Hewison M, Adams JS, Cheng G, Modlin RL.   Divergence of macrophage phagocytic and antimicrobial programs in leprosy Cell Host Microbe, 2009; 6(4): 343-53.
Shahangian A, Chow EK, Tian X, Kang JR, Ghaffari A, Liu SY, Belperio JA, Cheng G, Deng JC.   Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice J Clin Invest. , 2009; 119(7): 1910-20.
Hwang S, Kim KS, Flano E, Wu TT, Tong LM, Park AN, Song MJ, Sanchez DJ, O'Connell RM, Cheng G, Sun R   Conserved herpesviral kinase promotes viral persistence by inhibiting the IRF-3-mediated type I interferon response Cell Host Microbe, 2009; 5(2): 166-78.
Miyahira, AK, Shahangian, A., Hwang, S., Sun, R. Cheng G   TANK-binding kinase-1 plays an important role during in vitro and in vivo type I interferon responses to DNA virus infections J Immunol, 2009; 182(4): 2248-57.
Cheng LS., Hwang S., Huang TH, Sheu TC, Sun R., Morrison SL, Cheng G, and Shahangian A   Antibody-fused interferons as an effective approach to enhance target specificity and antiviral efficacy of type I interferons Cell Res. advance online publication, 2008; .
Zarnegar BJ, Wang Y.,, Mahoney DJ, Dempsey PD, Cheung HH, He J, Shiba T, Yang X., Yeh WC, Mak TW, Korneluk RG, and Cheng G   Noncanonical NF-κB Activation Requires the Coordinated Assembly of the cIAP1/2-NIK Regulatory Complex by TRAF2 and TRAF3 Nature Immunology, 2008; 9(12): 1371-8.
Pietras EM, Cheng G   A New TRADDition in intracellular antiviral signaling Science Signaling, 2008; 1(30): 36.
Wong PK., Yu, F., Shahangian, A., Cheng, G., Sun, R., and Ho, CM   Closed-loop Control of Cellular Functions By using a Stochastic Search Algorithm PNAS, 2008; 105: 5105-5110.
Chow, EKH., Pierstorff, E., Cheng, G., and Ho, D   Copolymeric Nanofilm Platform for Controlled and Localized Therapeutic Delivery ACS Nano, 2008; 2(1): 33-40.
Zhai Y, Qiao B, Shen XD, Gao F, Busuttil RW, Cheng G, Platt JL, Volk HD, Kupiec-Weglinski JW   Evidence for the Pivotal Role of Endogenous Toll-Like Receptor 4 Ligands in Liver Ischemia and Reperfusion Injury Transplantation, 2008; 85(7): 1016-1022.
Miller, L. S. Pietras, E. M. Garcia, N. Cheung, A. L. Blauvelt, A. Cheng, G. Modlin, R. L.   IL-1R activation is required for IL-17-dependent neutrophil recruitment against Staphylococcus aureus skin infections, Journal of Investigative Dermatology, 2008; 128: S190-S190.
Pietras EM, Cheng G.   New tricks for old NODs Genome Biol, 2008; 9(4): 217.
Zheng D., Chen G., Guo B., Cheng G, and Tang H   PLP2, a potent deubiquitinase from murine hepatitis virus, can strongly inhibit cellular type I interferon production Cell Res. , 2008; 11: 1105-13.
Velázquez, P, Wei, B, McPherso,n M, Mendoza, LM, Nguyen, SL, Turovskaya, O, Kronenberg, M, Huang, TT, Schrage, M, Lobato, LN, Fujiwara, D, Brewer, S, Arditi, M, Cheng, G, Sartor, RB, Newberry, RD, Braun, J.   Villous B cells of the small intestine are specialized for invariant NK T cell dependence J Immunol, 2008; 180(7): 4629-38.
Tricker, E. Cheng, G.   With a little help from my friends: modulation of phagocytosis through TLR activation Cell Research, 2008; 18(7): 711-712.
Zanegar, B., Yamazak S. He JQ, Cheng G   Control of Canonical NF-κB Activation through the NIK-IKK-Complex Pathway PNAS, 2008; 105(9): 3503-3508.
Oganesyan, G. Saha, S. K. Pietras, E. M. Guo, B. Miyahira, A. K. Zarnegar, B. Cheng, G.   IRF3-dependent type I interferon response in B cells regulates CpG-mediated antibody production Journal of Biological Chemistry, 2008; 283(2): 802-808.
Sanchez DJ, Miranda D Jr, Arumugaswami V, Hwang S, Singer AE, Senaati A, Shahangian A, Song MJ, Sun R, Cheng G.   A Repetitive Region of Gamma-herpesvirus Genomic DNA Is a Ligand for Induction of Type I Interferon J Virol, 2007; 82(5): 2208-17.
Kayagaki, N., Phung, Q., Chan, S., Chaudhari R, Quan, C., O'Rourke, KM., Eby, M., Pietras, E, Cheng, G., Bazan, JF., Zhang, Z., Arnott, D., Dixit, VM..   DUBA: A Deubiquitinase That Regulates Type I Interferon Production Science, 2007; 318(5856): 1628-32.
Miller, LS., Pietras, EM., Uricchio, LH., Hirano, K.,Rao, S., Lin, H., O'Connell, RM., Iwakura,, Y., Ambrose L. Cheung, AL., Cheng G., Modlin, RL   Inflammasome-mediated production of IL-1β is required for neutrophil recruitment against Staphylococcus aureus in vivo J. Immunol, 2007; 179(10): 6933-42.
Chow, EKH., Chu, B., Cheng G., Tai, YC., Pierstorff, P., and Ho., D   Copolymer-mediated Fabrication of Versatile Electro-Active and Inflammation Attenuating Substrates for Biological Interrogation NANO: Brief Reports and Reviews, 2007; 2(6): 351-359.
Miller, L. S. Pietras, E. M. Uricchio, L. O'Connell, R. M. Hirano, K. A. Rao, S. Cheung, A. L. Cheng, G. Modlin, R. L.   IL-1 beta and the inflammasome but not IL-1 alpha mediate IL-1R-dependent neutrophil recruitment against Staphylococcus aureus skin infection, Journal of Investigative Dermatology, 2007; 127: S130-S130.
Lee DJ, Sieling PA, Ochoa MT, Krutzik SR, Guo B, Hernandez M, Rea TH, Cheng G, Colonna M, Modlin RL.   LILRA2 Activation Inhibits Dendritic Cell Differentiation and Antigen Presentation to T Cells J Immunol, 2007; 179(12): 8128-36.
O'connell RM, Taganov KD, Boldin MP, Cheng G, Baltimore D   MicroRNA-155 is induced during the macrophage inflammatory response PNAS, 2007; 104(5): 1604-9.
He, J. Q. Oganesyan, G. Saha, S. K. Zarnegar, B. Cheng, G.   TRAF3 and its biological function Tnf Receptor Associated Factors (Trafs), 2007; 597: 48-59.
Guo B, Cheng G.   Modulation of the interferon antiviral response by the TBK1/IKKI adaptor protein tank J Biol Chem, 2007; 282(16): 11817-26.
Chow EK, Razani B, Cheng G.   Innate immune system regulation of nuclear hormone receptors in metabolic diseases J Leukoc Biol, 2007; 82(2): 187-95.
Chow EK, Castrillo A, Shahangian A, Pei L, O'Connell RM, Modlin RL, Tontonoz P, Cheng G.   A role for IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections J Exp Med. , 2006; 203: 2589-602.
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Oganesyan, G., Saha, SK, Guo, B., He, J., Shahangian, A., Zarnegar B., Perry, AK., Cheng, G.   Critical role of TRAF3 in the Toll-like receptor-dependent and independent antiviral response. Nature, 2006; 439: 208-211.
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Miller, LS., O'Connell, RM., Gutierrez, MA., Pietras, EM., Shahangian, A., Gross, CE., Thirumala, A., Cheung, AL., Cheng , G., Modlin, RL.   MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus Immunity, 2006; 24: 79-91.
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Saha, SK., Pietras, EM., He, JQ., Kang, JR., Liu, SY., Oganesyan, G., Shahangian, A., Zarnegar, B., Shiba TL., and Cheng, G.   Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. EMBO J. , 2006; 25: 3257-3263.
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He, JQ., Zarnegar, B., Yamazaki, S., Oganesyan, G., Saha, SK., Doyle, S., Dempsey, P., and Cheng, G.   Rescue of TRAF3 null mice by p100 NF-kB deficiency. J Exp Med, 2006; 203: 2413-2418.
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Deng, JC., Cheng, G. Newstead, MW., Zeng, X., Kobayashi, K., Flavell, R., Standiford, TJ.   Sepsis-Induced Suppression of Lung Innate Immunity is mediated by IRAK-M. Journal of clinical investigation (JCI), 2006; 116: 2532-2542.
He JQ, Saha SK, Kang JR, Zarnegar B, Cheng G.   Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway J Biol Chem, 2006; 282(6): 3688-94.
Renn, CN, Sanchez, DJ, Ochoa, MT, Legaspi, AJ, Oh, CK, Liu, PT, Krutzik, SR, Sieling, PA, Cheng, G, Modlin, RL.   TLR activation of Langerhans cell-like dendritic cells triggers an antiviral immune response J Immunol, 2006; 177: 298-305.
Saha, SK and Cheng, G.   TRAF3: A New Regulator of Type I Interferons Cell Cycle, 2006; 5: 804-807.
Pietras, EM., Saha, SK. and Cheng, G.   The Interferon Response to bacterial and viral infections. Journal of Endotoxin Research, 2006; 12: 246-50.
O'Connell, RM, Saha, SK and Cheng, G.   Combating bacterial pathogens through host defense gene programs. Current Immunology Reviews, 2005; 1: 43-54.
Miller, L. S. O'Connell, R. M. Gutierrez, M. A. Kim, J. Thirumala, A. Cheung, A. L. Cheng, G. Modlin, R. L.   Critical role of lL-1R in controlling Staphylococcus aureus skin infections: comparison to TNF-alpha RI, Journal of Investigative Dermatology, 2005; 124(4): A115-A115.
Damalas, A. Weis, L. Nordgard, S. H. Kristensen, V. N. Gardner, K. Cheng, G. Gelinas, C. Levrero, M. Strano, S. Borresen-Dale, A. L. Rotter, V. Oren, M. Blandino, G.   Mutant p53 exerts its gain of function through activation of the NF-kappa B pathway Breast Cancer Research, 2005; 7: S53-S53.
Chin,AI., Dempsey, PW. And Cheng, G   Rip2: a key molecule that regulates both innate and acquired immunity Current Medicinal Chemistry, 2005; 4: 35-42.
Jazirehi, AR., Huerta-Yepez, S., Cheng, G. and Bonavida, B   Rituximab (chimeric anti-CD20 mAb) inhibits the constitute NIK/IKK/IkB/NF-kB signaling pathway in non-Hodgkin’s lymphoma (NHL) B-cell lines: role in sensitization to chemotherapeutic drug-induced apoptosis, Cancer Research, 2005; 65: 264-276.
Chow, EK., O'Connell, RM, Schilling, S., , Wang, XF., Fu, XY., and Cheng , G.   TLR Agonists Regulate PDGF-B Production and Cell Proliferation through TGF-beta/Type I IFN Crosstalk EMBO J. , 2005; 24: 4071-4081.
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Perry, AK., Chen, G., Zheng, DH., Tang, H., Cheng, G.   The host type I interferon response to viral and bacterial infections Cell Res. , 2005; 15: 407-422.
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Shen, DX., Ke, B., Zhai, Y., Gao, F., Busuttil, RW., Cheng, G., Kupiec-Weglinski, JW   Toll-Like Receptor and Heme Oxygenase-1 Signaling in Hepatic Ischemia/Reperfusion Injury Am J Transplant, 2005; 5(8): 1793-1800.
Liu B, Yang R, Wong KA, Getman C, Stein N, Teitell MA, Cheng G, Wu H, Shuai K   Negative regulation of NF-kappaB signaling by PIAS1 Molecular and cellular biology. , 2005; 25(3): 1113-23.
Zhai Y, Shen XD, O'Connell R, Gao F, Lassman C, Busuttil RW, Cheng G, Kupiec-Weglinski JW   Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway Journal of immunology (Baltimore, Md. : 1950) , 2004; 173(12): 7115-9.
Ni CZ, Oganesyan G, Welsh K, Zhu X, Reed JC, Satterthwait AC, Cheng G, Ely KR   Key molecular contacts promote recognition of the BAFF receptor by TNF receptor-associated factor 3: implications for intracellular signaling regulation Journal of immunology (Baltimore, Md. : 1950) , 2004; 173(12): 7394-400.
Modlin RL, Cheng G   From plankton to pathogen recognition Nature medicine. , 2004; 10(11): 1173-4.
Joseph SB, Bradley MN, Castrillo A, Bruhn KW, Mak PA, Pei L, Hogenesch J, O'connell RM, Cheng G, Saez E, Miller JF, Tontonoz P   LXR-dependent gene expression is important for macrophage survival and the innate immune response Cell, 2004; 119(2): 299-309.
O'Connell RM, Saha SK, Vaidya SA, Bruhn KW, Miranda GA, Zarnegar B, Perry AK, Nguyen BO, Lane TF, Taniguchi T, Miller JF, Cheng G   Type I interferon production enhances susceptibility to Listeria monocytogenes infection The Journal of experimental medicine. , 2004; 200(4): 437-45.
Huerta-Yepez S, Vega M, Jazirehi A, Garban H, Hongo F, Cheng G, Bonavida B   Nitric oxide sensitizes prostate carcinoma cell lines to TRAIL-mediated apoptosis via inactivation of NF-kappa B and inhibition of Bcl-xl expression Oncogene. , 2004; 23(29): 4993-5003.
Perry, A. K. Chow, E. K. Goodnough, J. B. Yeh, W. C. Cheng, G.   Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection Journal of Experimental Medicine, 2004; 199(12): 1651-1658.
Miller, L. S. O'Connell, R. M. Kim, J. Cheng, G. Modlin, R. L.   Contrasting roles of TLR2 and MyD88 in an in vivo model of skin infection with Staphylococcus aureus, Journal of Investigative Dermatology, 2004; 122(3): A120-A120.
Bo, Q. Zhai, Y. Gao, W. Gao, F. Busuttil, R. W. Cheng, G. Kupiec-Weglinski, J. W.   Type-1 interferon-dependent hepatocyte production of IP-10, American Journal of Transplantation, 2004; 4: 248-248.
Zarnegar B, He JQ, Oganesyan G, Hoffmann A, Baltimore D, Cheng G   Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways Proc Natl Acad Sci U S A, 2004; 101(21): 8108-13.
Doyle SE, O'Connell RM, Miranda GA, Vaidya SA, Chow EK, Liu PT, Suzuki S, Suzuki N, Modlin RL, Yeh WC, Lane TF, Cheng G   Toll-like receptors induce a phagocytic gene program through p38 The Journal of experimental medicine. , 2004; 199(1): 81-90.
Dempsey PW, Vaidya SA, Cheng G   The art of war: Innate and adaptive immune responses Cellular and molecular life sciences : CMLS. , 2003; 60(12): 2604-21.
Castrillo A, Joseph SB, Vaidya SA, Haberland M, Fogelman AM, Cheng G, Tontonoz P   Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism Molecular cell. , 2003; 12(4): 805-16.
Brown HJ, Song MJ, Deng H, Wu TT, Cheng G, Sun R   NF-kappaB inhibits gammaherpesvirus lytic replication Journal of virology. , 2003; 77(15): 8532-40.
Dadgostar H, Doyle SE, Shahangian A, Garcia DE, and Cheng G   T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK FEBS Letters, 2003; 553(3): 403-40.
Chen, MC, Hwang, MJ, Chou, YC, Chen, WH, Cheng, G, Nakano, H, Luh, TY, Mai, SC, Hsieh, SL   The role of ASK1 in Lymphotoxin-beta receptor-mediated cell death J Biol Chem, 2003; 278: 16073-81.
Dempsey PW, Doyle SE, He JQ, Cheng G   The signaling adaptors and pathways activated by TNF superfamily Cytokine & growth factor reviews. , 2003; 14(3-4): 193-209.
Vaidya SA, Cheng G   Toll-like receptors and innate antiviral responses Curr Opin Immunol, 2003; 15(4): 402-7.
Ronni T, Agarwal V, Haykinson M, Haberland ME, Cheng G, Smale ST   Common interaction surfaces of the toll-like receptor 4 cytoplasmic domain stimulate multiple nuclear targets Molecular and cellular biology. , 2003; 23(7): 2543-55.
Doyle SE, O'Connell R, Vaidya SA, Chow EK, Yee K, Cheng G   Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4 Journal of immunology (Baltimore, Md. : 1950) , 2003; 170(7): 3565-71.
Cheng G, Schoenberger SP   CD40 Signaling and Autoimmunity Current Directions in Autoimmunity, 2002; 5: 51-61.
Dadgostar H, Zarnegar B, Hoffmann A, Qin XF, Truong U, Rao G, Baltimore D, Cheng G   Cooperation of Multiple Signaling Pathways in CD40-Regulated Gene Expression in B Lymphocytes Proceedings of the National Academy of Sciences of the USA, 2002; 99(3): 1497-1502.
Doyle, S. E. Vaidya, S. A. O'Connell, R. Dadgostar, H. Dempsey, P. W. Wu, T. T. Rao, G. Sun, R. Haberland, M. E. Modlin, R. L. Cheng, G.   IRF3 mediates a TLR3/TLR4-specific antiviral gene program Immunity, 2002; 17(3): 251-263.
Chin AI, Dempsey PW, Bruhn K, Miller JF, Xu Y, Cheng G   Involvement of receptor-interacting protein 2 in innate and adaptive immune responses Nature, 2002; 416(6877): 190-4.
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Li C, Ni CZ, Havert ML, Cabezas E, He J, Kaiser D, Reed JC, Satterthwait AC, Cheng G, Ely KR   Downstream regulator TANK binds to the CD40 recognition site on TRAF3 Structure (Cambridge, Mass. : 2001) , 2002; 10(3): 403-11.
Wang Y, Kelly CG, Karttunen JT, Whittall T, Lehner PJ, Duncan L, MacAry P, Younson JS, Singh M, Oehlmann W, Cheng G, Bergmeier L, Lehner T   CD40 is a cellular receptor mediating mycobacterial heat shock protein 70 stimulation of CC-chemokines Immunity, 2001; 15(6): 971-83.
Kwan G, Burnside J, Kurosahi T, Cheng G   MEKK1 is required for JNK activation and apoptosis in response to microtubule disruption Molecular and Cellular Biology, 2001; 21(21): 7183-7190.
Fischbein MP, Ardehali A, Yun J, Schoenberger S, Laks H, Irie Y, Dempsey P, Cheng G, Fishbein MC, Bonavida B   CD40 signaling replaces CD4+ lymphocytes and its blocking prevents chronic rejection of heart transplants Journal of Immunology, 2000; 165(12): 7316-22.
Cheng Q, Lee HH, Ying Li, Parks T, Cheng G   Upregulation of Bcl-x and Bfl-1 as a potential mechanism of chemoresistance, which can be overcome by NF-kB inhibition Oncogene, 2000; 19(42): 4936-4940.
Dadgostar H, Cheng G   Membrane localization of TRAF 3 enables JNK activation The Journal of Biological Chemistry, 2000; 275(4): 2539-44.
Lee HH, Dempsey PW, Parks TP, Zhu X, Baltimore D, Cheng G   Specificities of CD40 signaling: involvement of TRAF2 in CD40-induced NF-kappaB activation and intercellular adhesion molecule-1 up-regulation Proceedings of the National Academy of Sciences of the United States of America. , 1999; 96(4): 1421-6.
Brodeur SR, Cheng G, Baltimore D, Thorley-Lawson DA   Localization of the major NF-kB activation site and the sole TRAF3 binding site of LMP-1 defines two distinct signalling motifs The Journal of Biological Chemistry, 1997; 272(32): 19777-19784.
Cheng G, Baltimore D   TANK, a co-inducer with TRAF2 of TNF- and CD40L-mediated NF-kB activation Genes & Development, 1996; 10: 963-973.
Cheng G, Cleary AM, Ye ZS, Hong DI, Lederman S, Baltimore D   Involvement of CRAF1, a relative of TRAF, in CD40 signaling Science, 1995; 267(5203): 1494-8.
Cheng G, Ye ZS, Baltimore D   Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction Proceedings of the National Academy of Sciences of the United States of America, 1994; 91(17): 8152-5.

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