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Shaping the Future

Bob Lehrer, M.D.

Contact Information:

Work Phone Number:

(310) 825-8467
310-825-5340

Work Address:

Office
CHS
Los Angeles, CA 90095
UNITED STATES
37-062 CHS
CAMPUS - 169017
CA
UNITED STATES
Laboratory
CHS
Los Angeles, CA 90095
UNITED STATES

Professor, Department of Medicine

Infectious Diseases

Member, Basic/Translational Research, Jonsson Comprehensive Cancer Center

Molecular Biology


Detailed Biography:

Research Interest: Function of antimicrobial peptides Leukocytes, epithelial cells and glands produce endogenous antimicrobial peptides that serve as natural antibiotics. Our laboratory examines these antimicrobial peptides at many levels, from their initial discovery (by "grind and find" biochemistry), to characterizing their structure (by sequencing and cloning) , and then trying to figure out how they work (by any methods that we can). During the past decade, we have discovered antibiotic peptides produced by humans, rabbits, rodents, horses, pigs and birds. Possibly that is why itís so hard to keep our lab clean. We have been occupied for the past few years examining a family of antibiotic peptides called protegrins, and have just started to look for antimicrobial factors in human tears. We are also purifying various antimicrobial peptides from the hemocytes of tunicates (sea-squirts), simple marine protochordate ancestors of the vertebrates.

Publications:

Kokryakov VN, Harwig SS, Panyutich EA, Shevchenko AA, Aleshina GM, Shamova OV, Korneva HA, Lehrer RI   Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins FEBS letters. , 1993; 327(2): 231-6.
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