Kenneth Bradley, Ph.D.

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Work Titles
California NanoSystems Institute Director, Molecular Screening Shared Resource (MSSR)
UCLA Associate Professor, Microbiology, Immunology & Molecular Genetics Member, Molecular Pharmacology GPB Home Area
Education:
Degrees:
Ph.D., Harvard University, 2002
B.A., UC Santa Cruz, 1993
Professional Societies:
American Society of Microbiology

Contact Information:

Email Address:

kbradley@microbio.ucla.edu


Fax Number:

(310) 206-5231

Work Phone Number:

310-206-7465

310-206-7465

310-206-7517

310-206-7517

Laboratory Address:

Laboratory
MSB 2817


Mailing Address:

Mail Code: 148906
Los Angeles, CA 90095


Work Address:

Office
MSB 2825

Laboratory
Molecular Sciences Building
Los Angeles, CA 90095

Office
Molecular Sciences Building
Los Angeles, CA 90095


Detailed Biography:

Dr. Bradley received a B.A. in Biochemistry and Molecular Biology from U.C. Santa Cruz and a Ph.D. in Microbiology and Molecular Genetics from Harvard Medical School. He has been a member of the UCLA faculty since 2002 and is currently an Associate Professor in the Department of Microbiology, Immunology & Molecular Genetics. In addition, Dr. Bradley serves as Director for the Molecular Screening Shared Resource, a high-throughput screening facility that provides robotics for multiple applications including chemical genomics.

Publications:

A selected list of publications:

Jung, Michael E; Chamberlain, Brian T; Ho, Chi-Lee C; Gillespie, Eugene J; Bradley, Kenneth A   Structure-Activity Relationship of Semicarbazone EGA Furnishes Photoaffinity Inhibitors of Anthrax Toxin Cellular Entry, ACS Medicinal Chemistry Letters, 2014; .
Gillespie, E. J.; Ho, C. L.; Balaji, K.; Clemens, D. L.; Deng, G.; Wang, Y. E.; Elsaesser, H. J.; Tamilselvam, B.; Gargi, A.; Dixon, S. D.; France, B.; Chamberlain, B. T.; Blanke, S. R.; Cheng, G.; de la Torre, J. C.; Brooks, D. G.; Jung, M. E.; Colicelli, J.; Damoiseaux, R.; Bradley, K. A.   Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses Proceedings of the National Academy of Sciences of the United States of America, 2013; 110(50): E4904-12.
Gargi, A.; Tamilselvam, B.; Powers, B.; Prouty, M. G.; Lincecum, T.; Eshraghi, A.; Maldonado-Arocho, F. J.; Wilson, B. A.; Bradley, K. A.; Blanke, S. R.   Cellular interactions of the cytolethal distending toxins from Escherichia coli and Haemophilus ducreyi The Journal of biological chemistry, 2013; 288(11): 7492-505.
Ivask, A.; Suarez, E.; Patel, T.; Boren, D.; Ji, Z.; Holden, P.; Telesca, D.; Damoiseaux, R.; Bradley, K. A.; Godwin, H.   Genome-wide bacterial toxicity screening uncovers the mechanisms of toxicity of a cationic polystyrene nanomaterial Environmental science & technology, 2012; 46(4): 2398-405.
Visnyei, K.; Onodera, H.; Damoiseaux, R.; Saigusa, K.; Petrosyan, S.; De Vries, D.; Ferrari, D.; Saxe, J.; Panosyan, E. H.; Masterman-Smith, M.; Mottahedeh, J.; Bradley, K. A.; Huang, J.; Sabatti, C.; Nakano, I.; Kornblum, H. I.   A molecular screening approach to identify and characterize inhibitors of glioblastoma stem cells Molecular cancer therapeutics, 2011; 10(10): 1818-28.
Terra, J. K.; France, B.; Cote, C. K.; Jenkins, A.; Bozue, J. A.; Welkos, S. L.; Bhargava, R.; Ho, C. L.; Mehrabian, M.; Pan, C.; Lusis, A. J.; Davis, R. C.; LeVine, S. M.; Bradley, K. A.   Allelic variation on murine chromosome 11 modifies host inflammatory responses and resistance to Bacillus anthracis PLoS pathogens, 2011; 7(12): e1002469.
Larabee, J. L.; Maldonado-Arocho, F. J.; Pacheco, S.; France, B.; DeGiusti, K.; Shakir, S. M.; Bradley, K. A.; Ballard, J. D.   Glycogen synthase kinase 3 activation is important for anthrax edema toxin-induced dendritic cell maturation and anthrax toxin receptor 2 expression in macrophages Infection and immunity, 2011; 79(8): 3302-8.
Kim, K.; Damoiseaux, R.; Norris, A. J.; Rivina, L.; Bradley, K.; Jung, M. E.; Gatti, R. A.; Schiestl, R. H.; McBride, W. H.   High throughput screening of small molecule libraries for modifiers of radiation responses Int J Radiat Biol, 2011; .
Zhang, H.; Xia, T.; Meng, H.; Xue, M.; George, S.; Ji, Z.; Wang, X.; Liu, R.; Wang, M.; France, B.; Rallo, R.; Damoiseaux, R.; Cohen, Y.; Bradley, K. A.; Zink, J. I.; Nel, A. E.   Differential Expression of Syndecan-1 Mediates Cationic Nanoparticle Toxicity in Undifferentiated versus Differentiated Normal Human Bronchial Epithelial Cells ACS Nano, 2011; .
George, S.; Xia, T.; Rallo, R.; Zhao, Y.; Ji, Z.; Lin, S.; Wang, X.; Zhang, H.; France, B.; Schoenfeld, D.; Damoiseaux, R.; Liu, R.; Bradley, K. A.; Cohen, Y.; Nel, A. E.   Use of a High-Throughput Screening Approach Coupled with In Vivo Zebrafish Embryo Screening To Develop Hazard Ranking for Engineered Nanomaterials ACS Nano, 2011; .
Rallo, R.; France, B.; Liu, R.; Nair, S.; George, S.; Damoiseaux, R.; Giralt, F.; Nel, A.; Bradley, K.; Cohen, Y.   Self-Organizing Map Analysis of Toxicity-Related Cell Signaling Pathways for Metal and Metal Oxide Nanoparticles Environ Sci Technol, 2011; .
Bradley, K. A.; LeVine, S. M.   Anthrax toxin delivers a one-two punch Cell Host Microbe, 2010; 8(5): 394-5.
Ramey, J. D.; Villareal, V. A.; Ng, C.; Ward, S. C.; Xiong, J. P.; Clubb, R. T.; Bradley, K. A.   Anthrax toxin receptor 1/tumor endothelial marker 8: mutation of conserved inserted domain residues overrides cytosolic control of protective antigen binding Biochemistry, 2010; 49(34): 7403-10.
Eshraghi, A.; Maldonado-Arocho, F. J.; Gargi, A.; Cardwell, M. M.; Prouty, M. G.; Blanke, S. R.; Bradley, K. A.   Cytolethal distending toxin family members are differentially affected by alterations in host glycans and membrane cholesterol J Biol Chem, 2010; 285(24): 18199-207.
George, S.; Pokhrel, S.; Xia, T.; Gilbert, B.; Ji, Z.; Schowalter, M.; Rosenauer, A.; Damoiseaux, R.; Bradley, K. A.; Madler, L.; Nel, A. E.   Use of a rapid cytotoxicity screening approach to engineer a safer zinc oxide nanoparticle through iron doping ACS Nano, 2010; 4(1): 15-29.
Terra, J. K.; Cote, C. K.; France, B.; Jenkins, A. L.; Bozue, J. A.; Welkos, S. L.; LeVine, S. M.; Bradley, K. A.   Cutting edge: resistance to Bacillus anthracis infection mediated by a lethal toxin sensitive allele of Nalp1b/Nlrp1b J Immunol, 2010; 184(1): 17-20.
Godwin, H. A.; Chopra, K.; Bradley, K. A.; Cohen, Y.; Harthorn, B. H.; Hoek, E. M.; Holden, P.; Keller, A. A.; Lenihan, H. S.; Nisbet, R. M.; Nel, A. E.   The University of California Center for the Environmental Implications of Nanotechnology Environ Sci Technol, 2009; 43(17): 6453-7.
Maldonado-Arocho, F. J.; Bradley, K. A.   Anthrax edema toxin induces maturation of dendritic cells and enhances chemotaxis towards macrophage inflammatory protein 3beta Infect Immun, 2009; 77(5): 2036-42.
Averette, K. M.; Pratt, M. R.; Yang, Y.; Bassilian, S.; Whitelegge, J. P.; Loo, J. A.; Muir, T. W.; Bradley, K. A.   Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent PLoS ONE, 2009; 4(11): e7913.
Liong, Monty; France, Bryan; Bradley, Kenneth A.; Zink, Jeffrey I.   Antimicrobial Activity of Silver Nanocrystals Encapsulated in Mesoporous Silica Nanoparticles Advanced Materials, 2009; 21(17): 1684-1689.
Lehrer, R. I.; Jung, G.; Ruchala, P.; Wang, W.; Micewicz, E. D.; Waring, A. J.; Gillespie, E. J.; Bradley, K. A.; Ratner, A. J.; Rest, R. F.; Lu, W.   Human alpha-defensins inhibit hemolysis mediated by cholesterol-dependent cytolysins Infect Immun, 2009; 77(9): 4028-40.
Poulos, J. L.; Jeon, T. J.; Damoiseaux, R.; Gillespie, E. J.; Bradley, K. A.; Schmidt, J. J.   Ion channel and toxin measurement using a high throughput lipid membrane platform Biosens Bioelectron, 2009; 24(6): 1806-10.
Lee, S.; Deng, H.; Yu, F.; Melega, W. P.; Damoiseaux, R.; Bradley, K. A.; Sun, R.   Regulation of Kaposi's sarcoma-associated herpesvirus reactivation by dopamine receptor-mediated signaling pathways J Acquir Immune Defic Syndr, 2008; 48(5): 531-40.
Cote, C. K.; DiMezzo, T. L.; Banks, D. J.; France, B.; Bradley, K. A.; Welkos, S. L.   Early interactions between fully virulent Bacillus anthracis and macrophages that influence the balance between spore clearance and development of a lethal infection Microbes Infect, 2008; 10(6): 613-9.
Sanchez, A. M.; Thomas, D.; Gillespie, E. J.; Damoiseaux, R.; Rogers, J.; Saxe, J. P.; Huang, J.; Manchester, M.; Bradley, K. A.   Amiodarone and bepridil inhibit anthrax toxin entry into host cells Antimicrob Agents Chemother, 2007; 51(7): 2403-11.
Nassanian, H.; Sanchez, A. M.; Lo, A.; Bradley, K. A.; Lee, B.   Efficient construction of an inverted minimal H1 promoter driven siRNA expression cassette: facilitation of promoter and siRNA sequence exchange PLoS ONE, 2007; 2(1): e767.
Banks, D. J.; Bradley, K. A.   SILENCE: a new forward genetic technology Nat Methods, 2007; 4(1): 51-3.
Christman, K. L.; Requa, M. V.; Enriquez-Rios, V. D.; Ward, S. C.; Bradley, K. A.; Turner, K. L.; Maynard, H. D.   Submicron streptavidin patterns for protein assembly Langmuir, 2006; 22(17): 7444-50.
Wang, W.; Mulakala, C.; Ward, S. C.; Jung, G.; Luong, H.; Pham, D.; Waring, A. J.; Kaznessis, Y.; Lu, W.; Bradley, K. A.; Lehrer, R. I.   Retrocyclins kill bacilli and germinating spores of Bacillus anthracis and inactivate anthrax lethal toxin J Biol Chem, 2006; .
Maldonado-Arocho, F. J.; Fulcher, J. A.; Lee, B.; Bradley, K. A.   Anthrax oedema toxin induces anthrax toxin receptor expression in monocyte-derived cells Mol Microbiol, 2006; 61(2): 324-37.
Salles,, II; Voth, D. E.; Ward, S. C.; Averette, K. M.; Tweten, R. K.; Bradley, K. A.; Ballard, J. D.   Cytotoxic activity of Bacillus anthracis protective antigen observed in a macrophage cell line overexpressing ANTXR1 Cell Microbiol, 2006; 8(8): 1272-81.
Ding, Z.; Bradley, K. A.; Amin Arnaout, M.; Xiong, J. P.   Expression and purification of functional human anthrax toxin receptor (ATR/TEM8) binding domain from Escherichia coli Protein Expr Purif, 2006; 49(1): 121-8.
Banks, D. J.; Ward, S. C.; Bradley, K. A.   New insights into the functions of anthrax toxin Expert Rev Mol Med, 2006; 8(7): 1-18.
Banks, D. J.; Barnajian, M.; Maldonado-Arocho, F. J.; Sanchez, A. M.; Bradley, K. A.   Anthrax toxin receptor 2 mediates Bacillus anthracis killing of macrophages following spore challenge Cell Microbiol, 2005; 7(8): 1173-85.
Bruce, J. W.; Bradley, K. A.; Ahlquist, P.; Young, J. A.   Isolation of cell lines that show novel, murine leukemia virus-specific blocks to early steps of retroviral replication J Virol, 2005; 79(20): 12969-78.
Sanchez, A. M.; Bradley, K. A.   Anthrax toxin: can a little be a good thing? Trends Microbiol, 2004; 12(4): 143-5.
Bradley, K. A.; Mogridge, J.; Jonah, G.; Rainey, A.; Batty, S.; Young, J. A.   Binding of anthrax toxin to its receptor is similar to alpha integrin-ligand interactions J Biol Chem, 2003; 278(49): 49342-7.
Scobie, H. M.; Rainey, G. J.; Bradley, K. A.; Young, J. A.   Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor Proc Natl Acad Sci U S A, 2003; 100(9): 5170-4.
Bradley, K. A.; Young, J. A.   Anthrax toxin receptor proteins Biochem Pharmacol, 2003; 65(3): 309-14.
Bradley, K. A.; Mogridge, J.; Mourez, M.; Collier, R. J.; Young, J. A.   Identification of the cellular receptor for anthrax toxin Nature, 2001; 414(6860): 225-9.

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