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Shaping the Future

Jean De Vellis, Ph.D.

Contact Information:

Lab Number:

(310) 825-0239

Office Phone Number:

310-825-9395

Work Address:

Laboratory
NPI
Los Angeles, CA 90095
UNITED STATES
Office
NRB 375D
Los Angeles, CA 90095
UNITED STATES

Email Address:

jdevellis@mednet.ucla.edu

Director, Center for Developmental Neurobiology (MRRC)

Distinguished Professor, Neurobiology

Professor, Psychiatry and Biobehavioral Sciences


Detailed Biography:

Research Interest: Regulation of Gene Expression in Brain Cells My laboratory is interested in the molecular mechanisms controlling neuronal and glial cells interaction during development. What are the environmental signals and the mechanisms that regulate the system events that fashion the progression of the multipotential neuroepithelial cells into the enormous cellular phenotypic diversity of the nervous sytems? We have developed rat brain culture system capable of recapitulating important developmental events of glial cells and neurons. These model systems have been used to identify growth factors and other agents that regulated proliferation, survival and differentiation in a cell specific manner. In this way, many environmental signals and numerous cell processes have been correlated with the appearance of different neural phenotypes. The expression of regulatory genes such as transcription factors particularly those who are lineage restricted, are regulated in a combinatorial manner by growth factors, hormones, neurotransmitters and cytokines. This research has helped define at the molecular level the plasticity of brain cells and their potential for regeneration. Regeneration in dysmyelinating rat mutants has been achieved by transplantation of glia progenitor cells. A main focus of the laboratory is on development of the oligodendrocytes, the myelin forming cells in the central nervous system and a key cell in brain iron homeostasis. The growth factors and other agents studied include neurotrophins, (NGF, BDNF, NT3) basis fibroblast growth factor, platelet-derived growth factor, transferrin, glucocorticoid hormones, retinoic acid and various cytokines known to be active in the immune system. Recent findings suggest that astrocytes microglia and neurons provide key signals for oligodendrocyte survival and differentiation. ----------------------------------------------

neurobiology neuroscience

Publications:

He F, Ge W, Martinowich K, Becker-Catania S, Coskun V, Zhu W, Wu H, Castro D, Guillemot F, Fan G, de Vellis J, Sun YE.   A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis, Nat Neurosci, ; 8(5): 616.
de Vellis Jean, Cole Ruth   Preparation of mixed glial cultures from postnatal rat brain Methods in molecular biology (Clifton, N.J.), 2012; 814: 49-59.
Ghiani Cristina A, Mattan Natalia S, Nobuta Hiroko, Malvar Jemily S, Boles Julie, Ross Michael G, Waschek James A, Carpenter Ellen M, Fisher Robin S, de Vellis Jean   Early effects of lipopolysaccharide-induced inflammation on foetal brain development in rat ASN neuro, 2011; 3(4): .
Mattan Natalia S, Ghiani Cristina A, Lloyd Marcia, Matalon Reuben, Bok Dean, Casaccia Patrizia, de Vellis Jean   Aspartoacylase deficiency affects early postnatal development of oligodendrocytes and myelination Neurobiology of disease, 2010; 40(2): 432-43.
Zaghi Justin, Goldenson Ben, Inayathullah Mohammed, Lossinsky Albert S, Masoumi Ava, Avagyan Hripsime, Mahanian Michelle, Bernas Michael, Weinand Martin, Rosenthal Mark J, Espinosa-Jeffrey Araceli, de Vellis Jean, Teplow David B, Fiala Milan   Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy Acta neuropathologica, 2009; 117(2): 111-24.
Espinosa-Jeffrey Araceli, Wakeman Dustin R, Kim Seung U, Snyder Evan Y, de Vellis Jean   Culture system for rodent and human oligodendrocyte specification, lineage progression, and maturation Current protocols in stem cell biology, 2009; Chapter 2(15): Unit 2D.4.
Rasband Matt, Bansal Rashmi, Macklin Wendy, de Vellis Jean   Editorial Journal of neuroscience research, 2009; 87(15): 3239-40.
Kumar Shalini, Biancotti Juan Carlos, Matalon Reuben, de Vellis Jean   Lack of aspartoacylase activity disrupts survival and differentiation of neural progenitors and oligodendrocytes in a mouse model of Canavan disease Journal of neuroscience research, 2009; 87(15): 3415-27.
Kim Seung U, de Vellis Jean   Stem cell-based cell therapy in neurological diseases: a review Journal of neuroscience research, 2009; 87(10): 2183-200.
Biancotti JC, Kumar S, de Vellis J.   Activation of Inflammatory Response by a Combination of Growth Factors in Cuprizone-Induced Demyelinated Brain Leads to Myelin Repair, Neurochem Res, 2008; .
Biancotti Juan Carlos, Kumar Shalini, de Vellis Jean   Activation of inflammatory response by a combination of growth factors in cuprizone-induced demyelinated brain leads to myelin repair Neurochemical research, 2008; 33(12): 2615-28.
Coskun V, Wu H, Blanchi B, Tsao S, Kim K, Zhao J, Biancotti JC, Hutnick L, Krueger RC Jr, Fan G, de Vellis J, Sun YE.   CD133+ neural stem cells in the ependyma of mammalian postnatal forebrain, Proc Natl Acad Sci U S A, 2008; 105(3): 1026-31.
Coskun Volkan, Wu Hao, Blanchi Bruno, Tsao Sean, Kim Kevin, Zhao Jing, Biancotti Juan Carlos, Hutnick Leah, Krueger Richard C, Fan Guoping, de Vellis Jean, Sun Yi E   CD133+ neural stem cells in the ependyma of mammalian postnatal forebrain Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(3): 1026-31.
Chattopadhyay N, Espinosa-Jeffrey A, Tfelt-Hansen J, Yano S, Bandyopadhyay S, Brown EM, de Vellis J.   Calcium receptor expression and function in oligodendrocyte commitment and lineage progression: potential impact on reduced myelin basic protein in CaR-null mice, J Neurosci Res, 2008; 86(10): 2159-67.
Chattopadhyay Naibedya, Espinosa-Jeffrey Araceli, Tfelt-Hansen Jacob, Yano Shozo, Bandyopadhyay Sanghamitra, Brown Edward M, de Vellis Jean   Calcium receptor expression and function in oligodendrocyte commitment and lineage progression: potential impact on reduced myelin basic protein in CaR-null mice Journal of neuroscience research, 2008; 86(10): 2159-67.
WU Zheng-zhi, Huang Andrew C J, de Vellis Jean, LI Ying-hong   Effect of Tiantai No.1 on beta-amyloid-induced neurotoxicity and NF-kappa B and cAMP responsive element-binding protein Chinese journal of integrative medicine, 2008; 14(4): 286-92.
Kumar Shalini, Biancotti Juan Carlos, Yamaguchi Masahiro, de Vellis Jean   Combination of growth factors enhances remyelination in a cuprizone-induced demyelination mouse model Neurochemical research, 2007; 32(4-5): 783-97.
Ghiani CA, Ying Z, de Vellis J, Gomez-Pinilla F.   Exercise decreases myelin-associated glycoprotein expression in the spinal cord and positively modulates neuronal growth, Glia, 2007; 55(9): 966-75.
Ghiani Cristina A, Ying Zhe, de Vellis Jean, Gomez-Pinilla Fernando   Exercise decreases myelin-associated glycoprotein expression in the spinal cord and positively modulates neuronal growth Glia, 2007; 55(9): 966-75.
Ghiani Cristina A, Beltran-Parrazal Luis, Sforza Daniel M, Malvar Jemily S, Seksenyan Akop, Cole Ruth, Smith Desmond J, Charles Andrew, Ferchmin Pedro A, de Vellis Jean   Genetic program of neuronal differentiation and growth induced by specific activation of NMDA receptors Neurochemical research, 2007; 32(2): 363-76.
Espinosa-Jeffrey A, Zhao P, Awosika W, Wu N, Macias F, Cepeda C, Levine M, de Vellis J.   Activation, proliferation and commitment of endogenous stem/progenitor cells to the oligodendrocyte lineage by TS1 in a rat model of dysmyelination, Dev Neurosci, 2006; 28(6): 488-98.
Espinosa-Jeffrey Araceli, Zhao Paul, Awosika Wole, Wu Nanping, Macias Fernando, Cepeda Carlos, Levine Michael, de Vellis Jean   Activation, proliferation and commitment of endogenous stem/progenitor cells to the oligodendrocyte lineage by TS1 in a rat model of dysmyelination Developmental neuroscience, 2006; 28(6): 488-98.
Kumar S, Mattan NS, de Vellis J.   Canavan disease: a white matter disorder, Ment Retard Dev Disabil Res Rev, 2006; 12(2): 157-65.
Kumar Shalini, Mattan Natalia S, de Vellis Jean   Canavan disease: a white matter disorder Mental retardation and developmental disabilities research reviews, 2006; 12(2): 157-65.
Kumar S, Biancotti JC, Yamaguchi M, de Vellis J.   Combination of growth factors enhances remyelination in a cuprizone-induced demyelination mouse model, Neurochem Res, 2006; 32(4-5): 783-97.
Kumar S, Sowmyalakshmi R, Daniels SL, Chang R, Surendran S, Matalon R, de Vellis J.   Does ASPA gene mutation in Canavan disease alter oligodendrocyte development? A tissue culture study of ASPA KO mice brain, Adv Exp Med Biol, 2006; 576: 175-82.
Kumar Shalini, Sowmyalakshmi Rasika, Daniels Sarah L, Chang Ruth, Surendran Sankar, Matalon Reuben, de Vellis Jean   Does ASPA gene mutation in Canavan disease alter oligodendrocyte development? A tissue culture study of ASPA KO mice brain Advances in experimental medicine and biology, 2006; 576(4): 175-82; discussion 361-3.
Ghiani CA, Lelievre V, Beltran-Parrazal L, Sforza DM, Malvar J, Smith DJ, Charles AC, Ferchmin PA, de Vellis J.   Gene expression is differentially regulated by neurotransmitters in embryonic neuronal cortical culture, J Neurochem, 2006; .
Ghiani CA, Lelievre V, Beltran-Parrazal L, Sforza DM, Malvar J, Smith DJ, Charles AC, Ferchmin PA, de Vellis J.   Gene expression is differentially regulated by neurotransmitters in embryonic neuronal cortical culture, J Neurochem, 2006; 97(Suppl 1): 35-43.
Ghiani Cristina A, Lelievre Vincent, Beltran-Parrazal Luis, Sforza Daniel M, Malvar Jemily, Smith Desmond J, Charles Andrew C, Ferchmin Pedro A, de Vellis Jean   Gene expression is differentially regulated by neurotransmitters in embryonic neuronal cortical culture Journal of neurochemistry, 2006; 97 Suppl 1(4): 35-43.
Ghiani CA, Beltran-Parrazal L, Sforza DM, Malvar JS, Seksenyan A, Cole R, Smith DJ, Charles A, Ferchmin PA, de Vellis J.   Genetic program of neuronal differentiation and growth induced by specific activation of NMDA receptors, Neurochem Res, 2006; 32(2): 363-76.
Lelievre V, Ghiani CA, Seksenyan A, Gressens P, de Vellis J, Waschek JA.   Growth factor-dependent actions of PACAP on oligodendrocyte progenitor proliferation, Regul Pept, 2006; 137(1-2): 58-66.
Lelievre Vincent, Ghiani Cristina A, Seksenyan Akop, Gressens Pierre, de Vellis Jean, Waschek James A   Growth factor-dependent actions of PACAP on oligodendrocyte progenitor proliferation Regulatory peptides, 2006; 137(1-2): 58-66.
Becker-Catania SG, Gregory TL, Yang Y, Gau CL, de Vellis J, Cederbaum SD, Iyer RK.   Loss of arginase I results in increased proliferation of neural stem cells, J Neurosci Res, 2006; 84(4): 735-46.
Becker-Catania Sara G, Gregory Teresa L, Yang Yawei, Gau Chia-Ling, de Vellis Jean, Cederbaum Stephen D, Iyer Ramaswamy K   Loss of arginase I results in increased proliferation of neural stem cells Journal of neuroscience research, 2006; 84(4): 735-46.
Beltran-Parrazal L, Lopez-Valdes HE, Brennan KC, Diaz-Munoz M, de Vellis J, Charles AC.   Mitochondrial transport in processes of cortical neurons is independent of intracellular calcium, Am J Physiol Cell Physiol, 2006; 291(6): C1193-7.
Beltran-Parrazal Luis, López-Valdés Héctor E, Brennan K C, Díaz-Muñoz Mauricio, de Vellis Jean, Charles Andrew C   Mitochondrial transport in processes of cortical neurons is independent of intracellular calcium American journal of physiology. Cell physiology, 2006; 291(6): C1193-7.
Givogri MI, de Planell M, Galbiati F, Superchi D, Gritti A, Vescovi A, de Vellis J, Bongarzone ER.   Notch signaling in astroctyes and neuroblasts of the adult subventricular zone in health and after cortical injury, Dev Neurosci, 2006; 28(1-2): 81-91.
Givogri Maria I, de Planell Maria, Galbiati Francesca, Superchi Daniela, Gritti Angela, Vescovi Angelo, de Vellis Jean, Bongarzone Ernesto R   Notch signaling in astrocytes and neuroblasts of the adult subventricular zone in health and after cortical injury Developmental neuroscience, 2006; 28(1-2): 81-91.
Gallo V, de Vellis J.   Preface: white matter disorders, Ment Retard Dev Disabil Res Rev, 2006; 12(2): 83-4.
Gallo Vittorio, de Vellis Jean   Preface: white matter disorders Mental retardation and developmental disabilities research reviews, 2006; 12(2): 83-4.
He Fei, Ge Weihong, Martinowich Keri, Becker-Catania Sara, Coskun Volkan, Zhu Wenyu, Wu Hao, Castro Diogo, Guillemot Francois, Fan Guoping, de Vellis Jean, Sun Yi E   A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis Nature neuroscience, 2005; 8(5): 616-25.
Woerly S, Awosika O, Zhao P, Agbo C, Gomez-Pinilla F, de Vellis J, Espinosa-Jeffrey A.   Expression of heat shock protein (HSP)-25 and HSP-32 in the rat spinal cord reconstructed with Neurogel, Neurochem Res, 2005; 30(6-7): 721-35.
Woerly Stéphane, Awosika Oluwole, Zhao Paul, Agbo Chioma, Gomez-Pinilla Fernando, de Vellis Jean, Espinosa-Jeffrey Araceli   Expression of heat shock protein (HSP)-25 and HSP-32 in the rat spinal cord reconstructed with Neurogel Neurochemical research, 2005; 30(6-7): 721-35.
Kim SU, de Vellis J.   Microglia in health and disease, J Neurosci Res, 2005; 81(3): 302-13.
Kim Seung U, de Vellis Jean   Microglia in health and disease Journal of neuroscience research, 2005; 81(3): 302-13.
Ferchmin PA, Hao J, Perez D, Penzo M, Maldonado HM, Gonzalez MT, Rodriguez AD, de Vellis J.   Tobacco cembranoids protect the function of acute hippocampal slices against NMDA by a mechanism mediated by alpha4beta2 nicotinic receptors, J Neurosci Res, 2005; 82(5): 631-41.
Ferchmin P A, Hao Jiukuan, Perez Dinely, Penzo Mario, Maldonado Hector M, Gonzalez Maria T, Rodriguez Abimael D, de Vellis Jean   Tobacco cembranoids protect the function of acute hippocampal slices against NMDA by a mechanism mediated by alpha4beta2 nicotinic receptors Journal of neuroscience research, 2005; 82(5): 631-41.
Liu JC, DeFazio RA, Espinosa-Jeffrey A, Cepeda C, de Vellis J, Levine MS.   Calcium modulates dopamine potentiation of N-methyl-D-aspartate responses: electrophysiological and imaging evidence, J Neurosci Res, 2004; 76(3): 315-22.
Woerly S, Doan VD, Sosa N, de Vellis J, Espinosa-Jeffrey A.   Prevention of gliotic scar formation by NeuroGel allows partial endogenous repair of transected cat spinal cord, J Neurosci Res, 2004; 75(2): 262-72.
Woerly Stéphane, Doan Van Diep, Sosa Norma, de Vellis Jean, Espinosa-Jeffrey Araceli   Prevention of gliotic scar formation by NeuroGel allows partial endogenous repair of transected cat spinal cord Journal of neuroscience research, 2004; 75(2): 262-72.
Lopez IA, Zhao PM, Yamaguchi M, de Vellis J, Espinosa-Jeffrey A.   Stem/progenitor cells in the postnatal inner ear of the GFP-nestin transgenic mouse, Int J Dev Neurosci, 2004; 22(4): 205-13.
Lopez Ivan A, Zhao Paul M, Yamaguchi Masahiro, de Vellis Jean, Espinosa-Jeffrey Araceli   Stem/progenitor cells in the postnatal inner ear of the GFP-nestin transgenic mouse International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2004; 22(4): 205-13.
Saleh MC, Espinosa de los Monteros A, de Arriba Zerpa GA, Fontaine I, Piaud O, Djordjijevic D, Baroukh N, Garcia Otin AL, Ortiz E, Lewis S, Fiette L, Santambrogio P, Belzung , Connor JR, de Vellis J, Pasquini JM, Zakin MM, Baron B, Guillou F.   Myelination and motor coordination are increased in transferrin transgenic mice, J Neurosci Res, 2003; 72(5): 587-94.
Saleh Maria-Carla, Espinosa de los Monteros Araceli, de Arriba Zerpa Gonzalo A, Fontaine Isabelle, Piaud Oriane, Djordjijevic Dragan, Baroukh Nadine, Garcia Otin Angel Luis, Ortiz Esteban, Lewis Sandra, Fiette Laurence, Santambrogio Paolo, Belzung Catherine, Connor James R, de Vellis Jean, Pasquini Juana M, Zakin Mario M, Baron Bruno, Guillou Florian   Myelination and motor coordination are increased in transferrin transgenic mice Journal of neuroscience research, 2003; 72(5): 587-94.
Ferchmin PA, Perez D, Eterovic VA, de Vellis J.   Nicotinic receptors differentially regulate N-methyl-D-aspartate damage in acute hippocampal slices, J Pharmacol Exp Ther, 2003; 305(3): 1071-8.
Ferchmin P A, Perez Dinely, Eterovic Vesna A, de Vellis Jean   Nicotinic receptors differentially regulate N-methyl-D-aspartate damage in acute hippocampal slices The Journal of pharmacology and experimental therapeutics, 2003; 305(3): 1071-8.
Ferchmin, PA Perez, D Eterovic, VA de Vellis, J   Nicotinic receptors differentially regulate N-methyl-D-aspartate damage in acute hippocampal slices The Journal of pharmacology and experimental therapeutics. , 2003; 305(3): 1071-8.
Givogri MI, Schonmann V, Cole R, de Vellis J, Bongarzone ER.   Notch1 and Numb genes are inversely expressed as oligodendrocytes differentiate, Dev Neurosci, 2003; 25(1): 50-64.
Givogri Maria I, Schonmann Vilma, Cole Ruth, De Vellis Jean, Bongarzone Ernesto R   Notch1 and Numb genes are inversely expressed as oligodendrocytes differentiate Developmental neuroscience, 2003; 25(1): 50-64.
Dopp JM, Sarafian TA, Spinella FM, Kahn MA, Shau H, de Vellis J.   Expression of the p75 TNF receptor is linked to TNF-induced NFkappaB translocation and oxyradical neutralization in glial cells, Neurochem Res, 2002; 27(11): 1535-42.
Dopp Joel M, Sarafian Theodore A, Spinella Francesca M, Kahn Michelle A, Shau Hungyi, de Vellis Jean   Expression of the p75 TNF receptor is linked to TNF-induced NFkappaB translocation and oxyradical neutralization in glial cells Neurochemical research, 2002; 27(11): 1535-42.
Dopp, JM Sarafian, TA Spinella, FM Kahn, MA Shau, H de Vellis, J   Expression of the p75 TNF receptor is linked to TNF-induced NFkappaB translocation and oxyradical neutralization in glial cells Neurochemical research. , 2002; 27(11): 1535-42.
Cristobal, R Popper, P Lopez, I Micevych, P De Vellis, J Honrubia, V   In vivo and in vitro localization of brain-derived neurotrophic factor, fibroblast growth factor-2 and their receptors in the bullfrog vestibular end organs Brain research. Molecular brain research. , 2002; 102(1-2): 83-99.
Cristobal Ricardo, Popper Paul, Lopez Ivan, Micevych Paul, De Vellis Jean, Honrubia Vicente   In vivo and in vitro localization of brain-derived neurotrophic factor, fibroblast growth factor-2 and their receptors in the bullfrog vestibular end organs Brain research. Molecular brain research, 2002; 102(1-2): 83-99.
Cristobal R, Popper P, Lopez I, Micevych P, de Vellis J, Honrubia V.   In vivo and in vitro localization of brain-dervied neurotrophic factor, fibroblast growth factor-2 and their receptors in the bullfrog vestibular end organs, Brain Res Mol Brain Res, 2002; 102(1-2): 83-99.
Chen WC, McBride WH, Iwamoto KS, Barber CL, Wang CC, Oh YT, Liao YP, Hong JH, de Vellis J, Shau H.   Induction of radioprotective peroxiredoxin-I by ionizing irradiation, J Neurosci Res, 2002; 70(6): 794-8.
Chen Wen-Cheng, McBride William H, Iwamoto Keisuke S, Barber Chad L, Wang Chun-Chieh, Oh Young-Taek, Liao Yu-Pei, Hong Ji-Hong, de Vellis Jean, Shau Hungyi   Induction of radioprotective peroxiredoxin-I by ionizing irradiation Journal of neuroscience research, 2002; 70(6): 794-8.
Espinosa-Jeffrey A, Becker-Catania SG, Zhao PM, Cole R, Edmond J, de Vellis J.   Selective specification of CNS stem cells into oligodendroglial or neuronal cell lineage: cell culture and transplant studies, J Neurosci Res, 2002; 69(6): 810-25.
Espinosa-Jeffrey, A Becker-Catania, SG Zhao, PM Cole, R Edmond, J de Vellis, J   Selective specification of CNS stem cells into oligodendroglial or neuronal cell lineage: cell culture and transplant studies Journal of neuroscience research. , 2002; 69(6): 810-25.
Espinosa-Jeffrey Araceli, Becker-Catania Sara G, Zhao Paul M, Cole Ruth, Edmond John, de Vellis Jean   Selective specification of CNS stem cells into oligodendroglial or neuronal cell lineage: cell culture and transplant studies Journal of neuroscience research, 2002; 69(6): 810-25.
de Vellis J.   The MRRC at the University of California (UCLA), Los Angeles, CA, Int J Dev Neurosci, 2002; 20(3-5): 287-8.
Espinosa-Jeffrey A, Kumar S, Zhao PM, Awosika O, Agbo C, Huang A, Chang R, de Vellis J.   Transferrin regulates transcription of the MBP gene and its action synergizes with IGF-1 to enhance myelinogenesis in the md rat Developmental neuroscience. , 2002; 24(2-3): 227-41.
Espinosa-Jeffrey A, Kumar S, Zhao PM, Awosika O, Agbo C, Huang A, Chang R, de Vellis J.   Transferrin regulates transcription of the MBP gene and its action synergizes with IGF-1 to enhance myelinogenesis in the md rat, Dev Neurosci, 2002; 24(2-3): 227-41.
Huang CJ, Nazarian R, Lee J, Zhao PM, Espinosa-Jeffrey A, de Vellis J.   Tumor necrosis factor modulates transcription of myelin basic protein gene through nuclear factor kappa B in a human oligodendroglioma cell line, Int J Dev Neurosci, 2002; 20(3-5): 289-96.
Huang, CJ Nazarian, R Lee, J Zhao, PM Espinosa-Jeffrey, A de Vellis, J   Tumor necrosis factor modulates transcription of myelin basic protein gene through nuclear factor kappa B in a human oligodendroglioma cell line International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. , 2002; 20(3-5): 289-96.
Huang Chang J, Nazarian Ramin, Lee Justin, Zhao Paul M, Espinosa-Jeffrey Araceli, de Vellis Jean   Tumor necrosis factor modulates transcription of myelin basic protein gene through nuclear factor kappa B in a human oligodendroglioma cell line International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2002; 20(3-5): 289-96.
Liva SM, de Vellis J.   IL-5 induced proliferation and activation of microglia via an unknown receptor, Neurochem Res, 2001; 26(6): 629-37.
Liva, SM de Vellis, J   IL-5 induces proliferation and activation of microglia via an unknown receptor Neurochemical research. , 2001; 26(6): 629-37.
De Los Monteros, AE Zhao, PM De Vellis, J   In vitro injury model for oligodendrocytes: development, injury, and recovery Microscopy research and technique. , 2001; 52(6): 719-30.
Dell'Albani P, Santangelo R, Torrisi L, Nicoletti VG, de Vellis J, Giuffrida Stella AM.   JAK/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures, J Neurosci Res, 2001; 65(5): 417-24.
Lee, M Lelievre, V Zhao, P Torres, M Rodriguez, W Byun, JY Doshi, S Ioffe, Y Gupta, G de los Monteros, AE de Vellis, J Waschek, J   Pituitary adenylyl cyclase-activating polypeptide stimulates DNA synthesis but delays maturation of oligodendrocyte progenitors The Journal of neuroscience : the official journal of the Society for Neuroscience. , 2001; 21(11): 3849-59.
Espinosa de los Monteros, A Baba, H Zhao, PM Pan, T Chang, R de Vellis, J Ikenaka, K   Remyelination of the adult demyelinated mouse brain by grafted oligodendrocyte progenitors and the effect of B-104 cografts Neurochemical research. , 2001; 26(6): 673-82.
Tzeng SF, Bresnahan JC, Beattie MS, de Vellis J.   Upregulation of the HLH Id gene family in neural progenitors and glial cells of the rat spinal cord following contusion injury, J Neurosci Res, 2001; 66(6): 1161-72.
Tzeng, SF Bresnahan, JC Beattie, MS de Vellis, J   Upregulation of the HLH Id gene family in neural progenitors and glial cells of the rat spinal cord following contusion injury Journal of neuroscience research. , 2001; 66(6): 1161-72.
de los Monteros AE, Korsak RA, Tran T, Vu D, de Vellis J, Edmond J   Dietary iron and the integrity of the developing rat brain: a study with the artifically-reared rat pup, Cell Mol Biol (Noisy-le-grand), 2000; 46(3): 501-15.
Cheng, JD de Vellis, J   Oligodendrocytes as glucocorticoids target cells: functional analysis of the glycerol phosphate dehydrogenase gene Journal of neuroscience research. , 2000; 59(3): 436-45.
Huang CJ, Spinella F, Nazarian R, Lee MM, Dopp JM, de Vellis J   Expression of green fluorescent protein in oligodendrocytes in a time- and level-controllable fashion with a tetracycline-regulated system, Mol Med, 1999; 5(2): 129-37.
Kahn, MA Kumar, S Liebl, D Chang, R Parada, LF De Vellis, J   Mice lacking NT-3, and its receptor TrkC, exhibit profound deficiencies in CNS glial cells Glia. , 1999; 26(2): 153-65.
Liva, SM Kahn, MA Dopp, JM de Vellis, J   Signal transduction pathways induced by GM-CSF in microglia: significance in the control of proliferation Glia. , 1999; 26(4): 344-52.
Kahn, MA Dopp, JM Liva, S MacKenzie-Graham, AJ Chang, R Huang, A Nazarian, R Dell'Albani, P Condorelli, D Voskuhl, RR de Vellis, J   Temporal kinetics and cellular phenotype of TNF p55/p75 receptors in experimental allergic encephalomyelitis Journal of neuroimmunology. , 1999; 95(1-2): 19-34.
Espinosa de los Monteros, A Kumar, S Zhao, P Huang, CJ Nazarian, R Pan, T Scully, S Chang, R de Vellis, J   Transferrin is an essential factor for myelination Neurochemical research. , 1999; 24(2): 235-48.
S.H. Tzeng, and J. de Vellis   Id1, Id2, and Id3 Gene Expression In Neural Cell Development, Glia, 1998; 20: 37-39.
M.A. Kahn, C.J. Huang, A. Caruso, V. Barresi, R. Nazarian, D.F. Condorelli, and J. de Vellis   Ciliary Neurotrophic Factor Activates JAK/Stat Signal transduction Cascade and Induces Transcriptional Expression of Glial Fi, J. of Neurochemistry, 1997; 68: 1413-1423.
Espinosa de los Monteros, A Zhao, P Huang, C Pan, T Chang, R Nazarian, R Espejo, D de Vellis, J   Transplantation of CG4 oligodendrocyte progenitor cells in the myelin-deficient rat brain results in myelination of axons and enhanced oligodendroglial markers Journal of neuroscience research. , 1997; 50(5): 872-87.
Kumar, S. and de Vellis, J.   J. Neurotrophin activates signal transduction in oligodendroglial cells: Expression of functional TrkC receptor isoforms, J. Neurosci. Res, 1996; 44: 490-498.
Kahn, MA Ellison, JA Speight, GJ de Vellis, J   CNTF regulation of astrogliosis and the activation of microglia in the developing rat central nervous system Brain research. , 1995; 685(1-2): 55-67.
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