Scott G Filler, M.D.


Work Titles and Affiliation
CTSI Co-Leader, Center for Translational Technologies
Harbor UCLA Medical Center Attending Physician, Harbor UCLA Medical Center
LABioMed Attending Physician, INFECTIOUS DISEASES Principal Investigator, LABioMed
UCLA Professor in Residence, Medicine
Education:
Degrees:
M.D., UCLA School of Medicine, Los Angeles, 1979 - 1983
A.B., Dartmouth College, 1975 - 1979
Fellowship:
1989 - 1992 Harbor-UCLA Medical Center, Torrance, CA
Internship:
1983 - 1986 Harbor-UCLA Medical Center, Torrance, CA
Residency:
1983 - 1986 Harbor-UCLA Medical Center, Torrance, CA

Contact Information:

Email Address:

sfiller@ucla.edu


Website:

Home Page
Home Page

Fax Number:

(310) 782-2016

Work Phone Number:

310 222-6426

Mailing Address:

Harbor-UCLA Medl Cntr-Inf Dis
1124 West Carson Street
Torrance, CA 90509

Work Address:

Laboratory
RB-2
Los Angeles, CA 90095

Publications:

Jung Sook-In, Finkel Jonathan S, Solis Norma V, Chaili Siyang, Mitchell Aaron P, Yeaman Michael R, Filler Scott G   Bcr1 functions downstream of Ssd1 to mediate antimicrobial peptide resistance in Candida albicans Eukaryotic cell, 2013; 12(3): 411-9.
Luo Guanpingsheng, Gebremariam Teclegiorgis, Lee Hongkyu, French Samuel W, Wiederhold Nathan P, Patterson Thomas F, Filler Scott G, Ibrahim Ashraf S   Efficacy of Liposomal Amphotericin B and Posaconazole in Intratracheal Models of Murine Mucormycosis Antimicrobial agents and chemotherapy, 2013; .
Chooi Yit-Heng, Fang Jinxu, Liu Hong, Filler Scott G, Wang Pin, Tang Yi   Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi Organic letters, 2013; 15(4): 780-3.
Fu Yue, Phan Quynh T, Luo Guanpingsheng, Solis Norma V, Liu Yaoping, Cormack Brendan P, Edwards John E, Ibrahim Ashraf S, Filler Scott G   Investigation of the Function of Candida albicans Als3 by Heterologous Expression in Candida glabrata Infection and immunity, 2013; .
Desai Jigar V, Bruno Vincent M, Ganguly Shantanu, Stamper Ronald J, Mitchell Kaitlin F, Solis Norma, Hill Elizabeth M, Xu Wenjie, Filler Scott G, Andes David R, Fanning Saranna, Lanni Frederick, Mitchell Aaron P   Regulatory Role of Glycerol in Candida albicans Biofilm Formation mBio, 2013; 4(2): .
Ariyachet Chaiyaboot, Solis Norma V, Liu Yaoping, Prasadarao Nemani V, Filler Scott G, McBride Anne E   SR-like RNA-binding protein Slr1 affects Candida albicans filamentation and virulence Infection and immunity, 2013; 81(4): 1267-76.
Seidl Kati, Solis Norma V, Bayer Arnold S, Hady Wessam Abdel, Ellison Steven, Klashman Meredith C, Xiong Yan Q, Filler Scott G   Divergent responses of different endothelial cell types to infection with Candida albicans and Staphylococcus aureus PloS one, 2012; 7(6): e39633.
Fanning Saranna, Xu Wenjie, Solis Norma, Woolford Carol A, Filler Scott G, Mitchell Aaron P   Divergent targets of Candida albicans biofilm regulator Bcr1 in vitro and in vivo Eukaryotic cell, 2012; .
Zhu Weidong, Phan Quynh T, Boontheung Pinmanee, Solis Norma V, Loo Joseph A, Filler Scott G   EGFR and HER2 receptor kinase signaling mediate epithelial cell invasion by Candida albicans during oropharyngeal infection Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(35): 14194-9.
Filler Scott G   Insights from human studies into the host defense against candidiasis Cytokine, 2012; 58(1): 129-32.
Solis Norma V, Filler Scott G   Mouse model of oropharyngeal candidiasis Nature protocols, 2012; 7(4): 637-42.
Schmidt Clint S, White C Jo, Ibrahim Ashraf S, Filler Scott G, Fu Yue, Yeaman Michael R, Edwards John E, Hennessey John P   NDV-3, a recombinant alum-adjuvanted vaccine for Candida and Staphylococcus aureus, is safe and immunogenic in healthy adults Vaccine, 2012; 30(52): 7594-600.
Chen Ying-Lien, Brand Alexandra, Morrison Emma L, Silao Fitz Gerald S, Bigol Ursela G, Malbas Fedelino F, Nett Jeniel E, Andes David R, Solis Norma V, Filler Scott G, Averette Anna, Heitman Joseph   Calcineurin controls drug tolerance, hyphal growth, and virulence in Candida dubliniensis Eukaryotic cell, 2011; 10(6): 803-19.
Liu Yaoping, Filler Scott G   Candida albicans Als3, a multifunctional adhesin and invasin Eukaryotic cell, 2011; 10(2): 168-73.
Filler Scott G   Editorial overview Current opinion in microbiology, 2011; 14(4): 373-4.
Seidl Kati, Bayer Arnold S, McKinnell James A, Ellison Steven, Filler Scott G, Xiong Yan Q   In vitro endothelial cell damage is positively correlated with enhanced virulence and poor vancomycin responsiveness in experimental endocarditis due to methicillin-resistant Staphylococcus aureus Cellular microbiology, 2011; 13(10): 1530-41.
Liu Yaoping, Mittal Rahul, Solis Norma V, Prasadarao Nemani V, Filler Scott G   Mechanisms of Candida albicans trafficking to the brain PLoS pathogens, 2011; 7(10): e1002305.
Peltz Gary, Zaas Aimee K, Zheng Ming, Solis Norma V, Zhang Mason X, Liu Hong-Hsing, Hu Yajing, Boxx Gayle M, Phan Quynh T, Dill David, Filler Scott G   Next-generation computational genetic analysis: multiple complement alleles control survival after Candida albicans infection Infection and immunity, 2011; 79(11): 4472-9.
Liu Hong, Gravelat Fabrice N, Chiang Lisa Y, Chen Dan, Vanier Ghyslaine, Ejzykowicz Daniele E, Ibrahim Ashraf S, Nierman William C, Sheppard Donald C, Filler Scott G   Aspergillus fumigatus AcuM regulates both iron acquisition and gluconeogenesis Molecular microbiology, 2010; 78(4): 1038-54.
Gravelat Fabrice N, Ejzykowicz Daniele E, Chiang Lisa Y, Chabot Josée C, Urb Mirjam, Macdonald K Denyese, al-Bader Nadia, Filler Scott G, Sheppard Donald C   Aspergillus fumigatus MedA governs adherence, host cell interactions and virulence Cellular microbiology, 2010; 12(4): 473-88.
Reedy Jennifer L, Filler Scott G, Heitman Joseph   Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence Fungal genetics and biology : FG & B, 2010; 47(2): 107-16.
Sun Jianing N, Solis Norma V, Phan Quynh T, Bajwa Jashanjot S, Kashleva Helena, Thompson Angela, Liu Yaoping, Dongari-Bagtzoglou Anna, Edgerton Mira, Filler Scott G   Host cell invasion and virulence mediated by Candida albicans Ssa1 PLoS pathogens, 2010; 6(11): e1001181.
Niemann James T, Youngquist Scott, Rosborough John P, Shah Atman P, Phan Quynh T, Filler Scott G   Infliximab attenuates early myocardial dysfunction after resuscitation in a swine cardiac arrest model Critical care medicine, 2010; 38(4): 1162-7.
Zhu Weidong, Filler Scott G   Interactions of Candida albicans with epithelial cells Cellular microbiology, 2010; 12(3): 273-82.
Ejzykowicz Daniele E, Solis Norma V, Gravelat Fabrice N, Chabot Josee, Li Xuexian, Sheppard Donald C, Filler Scott G   Role of Aspergillus fumigatus DvrA in host cell interactions and virulence Eukaryotic cell, 2010; 9(10): 1432-40.
Al-Bader Nadia, Vanier Ghyslaine, Liu Hong, Gravelat Fabrice N, Urb Mirjam, Hoareau Christopher M-Q, Campoli Paolo, Chabot Joseé, Filler Scott G, Sheppard Donald C   Role of trehalose biosynthesis in Aspergillus fumigatus development, stress response, and virulence Infection and immunity, 2010; 78(7): 3007-18.
Liu Mingfu, Spellberg Brad, Phan Quynh T, Fu Yue, Fu Yong, Lee Amy S, Edwards John E, Filler Scott G, Ibrahim Ashraf S   The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice The Journal of clinical investigation, 2010; 120(6): 1914-24.
Pappas Peter G, Chetchotisakd Ploenchan, Larsen Robert A, Manosuthi Weerawat, Morris Michele I, Anekthananon Thomansak, Sungkanuparph Somnuek, Supparatpinyo Khauncahi, Nolen Tracy L, Zimmer Louise O, Kendrick Amy S, Johnson Phillip, Sobel Jack D, Filler Scott G   A phase II randomized trial of amphotericin B alone or combined with fluconazole in the treatment of HIV-associated cryptococcal meningitis Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2009; 48(12): 1775-83.
Elson Sarah L, Noble Suzanne M, Solis Norma V, Filler Scott G, Johnson Alexander D   An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth PLoS genetics, 2009; 5(9): e1000664.
Moreno-Ruiz Emilia, Galán-Díez Marta, Zhu Weidong, Fernández-Ruiz Elena, d'Enfert Christophe, Filler Scott G, Cossart Pascale, Veiga Esteban   Candida albicans internalization by host cells is mediated by a clathrin-dependent mechanism Cellular microbiology, 2009; 11(8): 1179-89.
Niemann James T, Rosborough John P, Youngquist Scott, Shah Atman P, Lewis Roger J, Phan Quynh T, Filler Scott G   Cardiac function and the proinflammatory cytokine response after recovery from cardiac arrest in swine Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2009; 29(11): 749-58.
Pappas Peter G, Kauffman Carol A, Andes David, Benjamin Daniel K, Calandra Thierry F, Edwards John E, Filler Scott G, Fisher John F, Kullberg Bart-Jan, Ostrosky-Zeichner Luis, Reboli Annette C, Rex John H, Walsh Thomas J, Sobel Jack D, Sobel Jack D   Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2009; 48(5): 503-35.
Sungkanuparph Somnuek, Filler Scott G, Chetchotisakd Ploenchan, Pappas Peter G, Nolen Tracy L, Manosuthi Weerawat, Anekthananon Thanomsak, Morris Michele I, Supparatpinyo Khuanchai, Kopetskie Heather, Kendrick Amy S, Johnson Philip C, Sobel Jack D, Larsen Robert A   Cryptococcal immune reconstitution inflammatory syndrome after antiretroviral therapy in AIDS patients with cryptococcal meningitis: a prospective multicenter study Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2009; 49(6): 931-4.
Manosuthi Weerawat, Sungkanuparph Somnuek, Anekthananon Thanomsak, Supparatpinyo Khuanchai, Nolen Tracy L, Zimmer Louise O, Pappas Peter G, Larsen Robert A, Filler Scott G, Chetchotisakd Ploenchan, Chetchotisakd Ploenchan   Effect of high-dose fluconazole on QT interval in patients with human immunodeficiency virus (HIV)-associated cryptococcal meningitis International journal of antimicrobial agents, 2009; 34(5): 494-6.
Phan Quynh T, Filler Scott G   Endothelial cell stimulation by Candida albicans Methods in molecular biology (Clifton, N.J.), 2009; 470(1): 313-26.
Kamai Yasuki, Lossinsky Albert S, Liu Hong, Sheppard Donald C, Filler Scott G   Polarized response of endothelial cells to invasion by Aspergillus fumigatus Cellular microbiology, 2009; 11(1): 170-82.
Conti Heather R, Shen Fang, Nayyar Namrata, Stocum Eileen, Sun Jianing N, Lindemann Matthew J, Ho Allen W, Hai Justine Hoda, Yu Jeffrey J, Jung Ji Won, Filler Scott G, Masso-Welch Patricia, Edgerton Mira, Gaffen Sarah L   Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis The Journal of experimental medicine, 2009; 206(2): 299-311.
Ejzykowicz Daniele E, Cunha Marcel M, Rozental Sonia, Solis Norma V, Gravelat Fabrice N, Sheppard Donald C, Filler Scott G   The Aspergillus fumigatus transcription factor Ace2 governs pigment production, conidiation and virulence Molecular microbiology, 2009; 72(1): 155-69.
Park Hyunsook, Liu Yaoping, Solis Norma, Spotkov Joshua, Hamaker Jessica, Blankenship Jill R, Yeaman Michael R, Mitchell Aaron P, Liu Haoping, Filler Scott G   Transcriptional responses of candida albicans to epithelial and endothelial cells Eukaryotic cell, 2009; 8(10): 1498-510.
Chiang Lisa Y, Sheppard Donald C, Gravelat Fabrice N, Patterson Thomas F, Filler Scott G   Aspergillus fumigatus stimulates leukocyte adhesion molecules and cytokine production by endothelial cells in vitro and during invasive pulmonary disease Infection and immunity, 2008; 76(8): 3429-38.
Nobile Clarissa J, Solis Norma, Myers Carter L, Fay Allison J, Deneault Jean-Sebastien, Nantel Andre, Mitchell Aaron P, Filler Scott G   Candida albicans transcription factor Rim101 mediates pathogenic interactions through cell wall functions Cellular microbiology, 2008; 10(11): 2180-96.
Reed Caitlin, Bryant Richard, Ibrahim Ashraf S, Edwards John, Filler Scott G, Goldberg Robert, Spellberg Brad   Combination polyene-caspofungin treatment of rhino-orbital-cerebral mucormycosis Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2008; 47(3): 364-71.
Nobile Clarissa J, Schneider Heather A, Nett Jeniel E, Sheppard Donald C, Filler Scott G, Andes David R, Mitchell Aaron P   Complementary adhesin function in C. albicans biofilm formation Current biology : CB, 2008; 18(14): 1017-24.
Spikes Sara, Xu Ran, Nguyen C Kim, Chamilos Georgios, Kontoyiannis Dimitrios P, Jacobson Raymond H, Ejzykowicz Daniele E, Chiang Lisa Y, Filler Scott G, May Gregory S   Gliotoxin production in Aspergillus fumigatus contributes to host-specific differences in virulence The Journal of infectious diseases, 2008; 197(3): 479-86.
Gravelat Fabrice N, Doedt Thomas, Chiang Lisa Y, Liu Hong, Filler Scott G, Patterson Thomas F, Sheppard Donald C   In vivo analysis of Aspergillus fumigatus developmental gene expression determined by real-time reverse transcription-PCR Infection and immunity, 2008; 76(8): 3632-9.
Gank Kimberly D, Yeaman Michael R, Kojima Satoshi, Yount Nannette Y, Park Hyunsook, Edwards John E, Filler Scott G, Fu Yue   SSD1 is integral to host defense peptide resistance in Candida albicans Eukaryotic cell, 2008; 7(8): 1318-27.
Goyard Sophie, Knechtle Philipp, Chauvel Murielle, Mallet Adeline, Prévost Marie-Christine, Proux Caroline, Coppée Jean-Yves, Schwartz Patrick, Dromer Françoise, Park Hyunsook, Filler Scott G, Janbon Guilhem, d'Enfert Christophe   The Yak1 kinase is involved in the initiation and maintenance of hyphal growth in Candida albicans Molecular biology of the cell, 2008; 19(5): 2251-66.
Spellberg Brad, Ibrahim Ashraf S, Yeaman Michael R, Lin Lin, Fu Yue, Avanesian Valentina, Bayer Arnold S, Filler Scott G, Lipke Peter, Otoo Henry, Edwards John E   The antifungal vaccine derived from the recombinant N terminus of Als3p protects mice against the bacterium Staphylococcus aureus Infection and immunity, 2008; 76(10): 4574-80.
Barker Katherine S, Park Hyunsook, Phan Quynh T, Xu Lijing, Homayouni Ramin, Rogers P David, Filler Scott G   Transcriptome profile of the vascular endothelial cell response to Candida albicans The Journal of infectious diseases, 2008; 198(2): 193-202.
Almeida Ricardo S, Brunke Sascha, Albrecht Antje, Thewes Sascha, Laue Michael, Edwards John E, Filler Scott G, Hube Bernhard   the hyphal-associated adhesin and invasin Als3 of Candida albicans mediates iron acquisition from host ferritin PLoS pathogens, 2008; 4(11): e1000217.
Phan Quynh T, Myers Carter L, Fu Yue, Sheppard Donald C, Yeaman Michael R, Welch William H, Ibrahim Ashraf S, Edwards John E, Filler Scott G   Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells PLoS biology, 2007; 5(3): e64.
Chiang Lisa Y, Sheppard Donald C, Bruno Vincent M, Mitchell Aaron P, Edwards John E, Filler Scott G   Candida albicans protein kinase CK2 governs virulence during oropharyngeal candidiasis Cellular microbiology, 2007; 9(1): 233-45.
Thewes Sascha, Kretschmar Marianne, Park Hyunsook, Schaller Martin, Filler Scott G, Hube Bernhard   In vivo and ex vivo comparative transcriptional profiling of invasive and non-invasive Candida albicans isolates identifies genes associated with tissue invasion Molecular microbiology, 2007; 63(6): 1606-28.
Filler Scott G, Solis Norma V, Guo Jane, Doellgast George, Ruiz-Garcia Ana, Pan Wei-Jian   Pharmacokinetics of murine p75-Fc fusion protein and MP6-XT22 anti-murine TNF-alpha mAb in mice The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research, 2007; 12(1): 52-6.
Norice Carmelle T, Smith Frank J, Solis Norma, Filler Scott G, Mitchell Aaron P   Requirement for Candida albicans Sun41 in biofilm formation and virulence Eukaryotic cell, 2007; 6(11): 2046-55.
Martinez-Lopez Raquel, Park Hyunsook, Myers Carter L, Gil Concha, Filler Scott G   Candida albicans Ecm33p is important for normal cell wall architecture and interactions with host cells Eukaryotic cell, 2006; 5(1): 140-7.
Filler Scott G   Candida-host cell receptor-ligand interactions Current opinion in microbiology, 2006; 9(4): 333-9.
Nobile Clarissa J, Andes David R, Nett Jeniel E, Smith Frank J, Yue Fu, Phan Quynh-Trang, Edwards John E, Filler Scott G, Mitchell Aaron P   Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo PLoS pathogens, 2006; 2(7): e63.
Spellberg Brad J, Filler Scott G, Edwards John E   Current treatment strategies for disseminated candidiasis Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2006; 42(2): 244-51.
Fowler Vance G, Boucher Helen W, Corey G Ralph, Abrutyn Elias, Karchmer Adolf W, Rupp Mark E, Levine Donald P, Chambers Henry F, Tally Francis P, Vigliani Gloria A, Cabell Christopher H, Link Arthur Stanley, DeMeyer Ignace, Filler Scott G, Zervos Marcus, Cook Paul, Parsonnet Jeffrey, Bernstein Jack M, Price Connie Savor, Forrest Graeme N, Fätkenheuer Gerd, Gareca Marcelo, Rehm Susan J, Brodt Hans Reinhardt, Tice Alan, Cosgrove Sara E, Cosgrove Sara E   Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureus The New England journal of medicine, 2006; 355(7): 653-65.
Chiang Lisa Y, Ejzykowicz Daniele E, Tian Zong-Qiang, Katz Leonard, Filler Scott G   Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis Antimicrobial agents and chemotherapy, 2006; 50(10): 3464-6.
Spellberg Brad J, Ibrahim Ashraf S, Avanesian Valentina, Fu Yue, Myers Carter, Phan Quynh T, Filler Scott G, Yeaman Michael R, Edwards John E   Efficacy of the anti-Candida rAls3p-N or rAls1p-N vaccines against disseminated and mucosal candidiasis The Journal of infectious diseases, 2006; 194(2): 256-60.
Filler Scott G, Sheppard Donald C   Fungal invasion of normally non-phagocytic host cells PLoS pathogens, 2006; 2(12): e129.
Kamai Y, Chiang L Y, Lopes Bezerra L M, Doedt T, Lossinsky A S, Sheppard D C, Filler S G   Interactions of Aspergillus fumigatus with vascular endothelial cells Medical mycology : official publication of the International Society for Human and Animal Mycology, 2006; 44 Suppl 1(4): S115-7.
Sheppard Donald C, Graybill John R, Najvar Laura K, Chiang Lisa Y, Doedt Thomas, Kirkpatrick William R, Bocanegra Rosie, Vallor Ana C, Patterson Thomas F, Filler Scott G   Standardization of an experimental murine model of invasive pulmonary aspergillosis Antimicrobial agents and chemotherapy, 2006; 50(10): 3501-3.
Goldman Mitchell, Cloud Gretchen A, Wade Karen D, Reboli Annette C, Fichtenbaum Carl J, Hafner Richard, Sobel Jack D, Powderly William G, Patterson Thomas F, Wheat Lawrence J, Stein David K, Dismukes William E, Filler Scott G, Filler Scott G, Filler Scott G   A randomized study of the use of fluconazole in continuous versus episodic therapy in patients with advanced HIV infection and a history of oropharyngeal candidiasis: AIDS Clinical Trials Group Study 323/Mycoses Study Group Study 40 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2005; 41(10): 1473-80.
Spellberg Brad, Ibrahim Ashraf S, Edwards John E, Filler Scott G   Mice with disseminated candidiasis die of progressive sepsis The Journal of infectious diseases, 2005; 192(2): 336-43.
Phan Quynh T, Fratti Rutillio A, Prasadarao Nemani V, Edwards John E, Filler Scott G   N-cadherin mediates endocytosis of Candida albicans by endothelial cells The Journal of biological chemistry, 2005; 280(11): 10455-61.
Park Hyunsook, Myers Carter L, Sheppard Donald C, Phan Quynh T, Sanchez Angela A, E Edwards John, Filler Scott G   Role of the fungal Ras-protein kinase A pathway in governing epithelial cell interactions during oropharyngeal candidiasis Cellular microbiology, 2005; 7(4): 499-510.
Sheppard Donald C, Doedt Thomas, Chiang Lisa Y, Kim H Stanley, Chen Dan, Nierman William C, Filler Scott G   The Aspergillus fumigatus StuA protein governs the up-regulation of a discrete transcriptional program during the acquisition of developmental competence Molecular biology of the cell, 2005; 16(12): 5866-79.
Spellberg Brad J, Ibrahim Ashraf S, Avenissian Valentina, Filler Scott G, Myers Carter L, Fu Yue, Edwards John E   The anti-Candida albicans vaccine composed of the recombinant N terminus of Als1p reduces fungal burden and improves survival in both immunocompetent and immunocompromised mice Infection and immunity, 2005; 73(9): 6191-3.
Filler Scott G, Yeaman Michael R, Sheppard Donald C   Tumor necrosis factor inhibition and invasive fungal infections Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2005; 41 Suppl 3(9): S208-12.
Ibrahim Ashraf S, Spellberg Brad J, Avenissian Valentina, Fu Yue, Filler Scott G, Edwards John E   Vaccination with recombinant N-terminal domain of Als1p improves survival during murine disseminated candidiasis by enhancing cell-mediated, not humoral, immunity Infection and immunity, 2005; 73(2): 999-1005.
Dilmaghanian Shahrzad, Gerber John G, Filler Scott G, Sanchez Angela, Gal Joseph   Enantioselectivity of inhibition of cytochrome P450 3A4 (CYP3A4) by ketoconazole: Testosterone and methadone as substrates Chirality, 2004; 16(2): 79-85.
Loza Lucio, Fu Yue, Ibrahim Ashraf S, Sheppard Donald C, Filler Scott G, Edwards John E   Functional analysis of the Candida albicans ALS1 gene product Yeast (Chichester, England), 2004; 21(6): 473-82.
Sheppard Donald C, Yeaman Michael R, Welch William H, Phan Quynh T, Fu Yue, Ibrahim Ashraf S, Filler Scott G, Zhang Mason, Waring Alan J, Edwards John E   Functional and structural diversity in the Als protein family of Candida albicans The Journal of biological chemistry, 2004; 279(29): 30480-9.
Pappas Peter G, Rex John H, Sobel Jack D, Filler Scott G, Dismukes William E, Walsh Thomas J, Edwards John E, Edwards John E   Guidelines for treatment of candidiasis Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2004; 38(2): 161-89.
Sheppard Donald C, Rieg Gunter, Chiang Lisa Y, Filler Scott G, Edwards John E, Ibrahim Ashraf S   Novel inhalational murine model of invasive pulmonary aspergillosis Antimicrobial agents and chemotherapy, 2004; 48(5): 1908-11.
Sanchez Angela A, Johnston Douglas A, Myers Carter, Edwards John E, Mitchell Aaron P, Filler Scott G   Relationship between Candida albicans virulence during experimental hematogenously disseminated infection and endothelial cell damage in vitro Infection and immunity, 2004; 72(1): 598-601.
Blankenship Jill R, Wormley Floyd L, Boyce Molly K, Schell Wiley A, Filler Scott G, Perfect John R, Heitman Joseph   Calcineurin is essential for Candida albicans survival in serum and virulence Eukaryotic cell, 2003; 2(3): 422-30.
Fukuoka Takashi, Johnston Douglas A, Winslow Carol A, de Groot Marcel J, Burt Catherine, Hitchcock Christopher A, Filler Scott G   Genetic basis for differential activities of fluconazole and voriconazole against Candida krusei Antimicrobial agents and chemotherapy, 2003; 47(4): 1213-9.
Spellberg Brad, Johnston Douglas, Phan Quynh Trang, Edwards John E, French Samuel W, Ibrahim Ashraf S, Filler Scott G   Parenchymal organ, and not splenic, immunity correlates with host survival during disseminated candidiasis Infection and immunity, 2003; 71(10): 5756-64.
Bensen Eric S, Filler Scott G, Berman Judith   A forkhead transcription factor is important for true hyphal as well as yeast morphogenesis in Candida albicans Eukaryotic cell, 2002; 1(5): 787-98.
Fu Yue, Ibrahim Ashraf S, Sheppard Donald C, Chen Yee-Chun, French Samuel W, Cutler Jim E, Filler Scott G, Edwards John E   Candida albicans Als1p: an adhesin that is a downstream effector of the EFG1 filamentation pathway Molecular microbiology, 2002; 44(1): 61-72.
Davis Dana A, Bruno Vincent M, Loza Lucio, Filler Scott G, Mitchell Aaron P   Candida albicans Mds3p, a conserved regulator of pH responses and virulence identified through insertional mutagenesis Genetics, 2002; 162(4): 1573-81.
Cannom Rebecca R M, French Samuel W, Johnston Douglas, Edwards Jr John E, Filler Scott G   Candida albicans stimulates local expression of leukocyte adhesion molecules and cytokines in vivo The Journal of infectious diseases, 2002; 186(3): 389-96.
Kamai Yasuki, Kubota Mikie, Kamai Yoko, Hosokawa Tsunemichi, Fukuoka Takashi, Filler Scott G   Contribution of Candida albicans ALS1 to the pathogenesis of experimental oropharyngeal candidiasis Infection and immunity, 2002; 70(9): 5256-8.
Belanger Paul H, Johnston Douglas A, Fratti Rutilio A, Zhang Mason, Filler Scott G   Endocytosis of Candida albicans by vascular endothelial cells is associated with tyrosine phosphorylation of specific host cell proteins Cellular microbiology, 2002; 4(12): 805-12.
Swindells Susan, Evans Scott, Zackin Robert, Goldman Mitchell, Haubrich Richard, Filler Scott G, Balfour Henry H, Balfour Henry H   Predictive value of HIV-1 viral load on risk for opportunistic infection Journal of acquired immune deficiency syndromes (1999), 2002; 30(2): 154-8.
Oh C K, Filler S G, Cho S H   Eukaryotic translation initiation factor-6 enhances histamine and IL-2 production in mast cells Journal of immunology (Baltimore, Md. : 1950), 2001; 166(5): 3606-11.
Rex J H, Walsh T J, Sobel J D, Filler S G, Pappas P G, Dismukes W E, Edwards J E   Reply to Dr. Chandrasekar (Clin Infect Dis 2001; 32:320-1) and Drs. Marr and Boeckh (Clin Infect Dis 2001; 32:321) Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2001; 32(3): 518-9.
Orozco A S, Zhou X, Filler S G   Mechanisms of the proinflammatory response of endothelial cells to Candida albicans infection Infection and immunity, 2000; 68(3): 1134-41.
Tsuchimori N, Sharkey L L, Fonzi W A, French S W, Edwards J E, Filler S G   Reduced virulence of HWP1-deficient mutants of Candida albicans and their interactions with host cells Infection and immunity, 2000; 68(4): 1997-2002.
Phan Q T, Belanger P H, Filler S G   Role of hyphal formation in interactions of Candida albicans with endothelial cells Infection and immunity, 2000; 68(6): 3485-90.
Rieg G, Fu Y, Ibrahim A S, Zhou X, Filler S G, Edwards J E   Unanticipated heterogeneity in growth rate and virulence among Candida albicans AAF1 null mutants Infection and immunity, 1999; 67(7): 3193-8.
Fu Y, Filler S G, Spellberg B J, Fonzi W, Ibrahim A S, Kanbe T, Ghannoum M A, Edwards J E   Cloning and characterization of CAD1/AAF1, a gene from Candida albicans that induces adherence to endothelial cells after expression in Saccharomyces cerevisiae Infection and immunity, 1998; 66(5): 2078-84.
Fu Y, Rieg G, Fonzi W A, Belanger P H, Edwards J E, Filler S G   Expression of the Candida albicans gene ALS1 in Saccharomyces cerevisiae induces adherence to endothelial and epithelial cells Infection and immunity, 1998; 66(4): 1783-6.
Orozco A S, Higginbotham L M, Hitchcock C A, Parkinson T, Falconer D, Ibrahim A S, Ghannoum M A, Filler S G   Mechanism of fluconazole resistance in Candida krusei Antimicrobial agents and chemotherapy, 1998; 42(10): 2645-9.
Ibrahim A S, Filler S G, Sanglard D, Edwards J E, Hube B   Secreted aspartyl proteinases and interactions of Candida albicans with human endothelial cells Infection and immunity, 1998; 66(6): 3003-5.

MeSH Terms:

What is MeSH?

Medical Subject Headings

We have integrated Faculty Profiles with the U.S. National Library of Medicine's MeSH terms. For every publication added to a profile, we pull its MeSH terms and display it here. This enhancement allows you to search for research themes of our faculty members.

Click on any of the terms below to see additional researchers with similar keywords.

MeSH is:

  • an acronym for Medical Subject Headings.
  • the U.S. National Library of Medicine's controlled vocabulary (thesaurus).
  • a vocabulary that gives uniformity and consistency to the indexing and cataloging of biomedical literature.
  • a distinctive feature of MEDLINE.
  • arranged in a hierarchical manner called the MeSH Tree Structures.
  • updated annually.

MeSH Vocabulary includes four types of terms:

  • Headings
  • Subheadings
  • Supplementary Concept Records
  • Publication Characteristics (or Types)

Over 26,000 MeSH headings (also called "main headings" or "descriptors" represents concepts found in the biomedical literature

Subheadings - (also called qualifiers) are attached to MeSH headings to describe a specific aspect of a concept.

Supplementary Concept Records are over 200,000 terms in a separate thesaurus from the Medical Subject Headings. These are primarily substance terms, but also include some protocols and rare desease terms. These terms are updated weekly.

Publication Characteristics or (Publication Types) describe the type of publication being indexed; i.e., what the item is, not what the article is about.

Information from U.S. National Library of Medicine.

AIDS-Related Opportunistic Infections Accounting Acquired Immunodeficiency Syndrome Acridine Orange Actin Cytoskeleton Actinomycosis Actinomycosis, Cervicofacial Adenovirus Infections, Human Adenoviruses, Human Adhesiveness Adolescent, Institutionalized Adrenal Cortex Hormones Adult Affect Aged Aged, 80 and over Alleles Alveolar Process Amino Acid Sequence Amphotericin B Animals Anti-Bacterial Agents Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Antibodies, Antineutrophil Cytoplasmic Antibodies, Monoclonal Antibodies, Monoclonal, Humanized Antifungal Agents Antigens, Human Platelet Antiretroviral Therapy, Highly Active Apoptosis Aspergillosis Aspergillus Aspergillus fumigatus Astronomical Processes Automatic Data Processing Autotrophic Processes Azoles Bacteremia Bacterial Adhesion Bacterial Processes Basal Ganglia Cerebrovascular Disease Base Sequence Beginning of Human Life Biochemical Processes Bioelectric Energy Sources Biofilms Biological Assay Biological Processes Biophysical Processes Bites, Human Blastomycosis Blood Blood Circulation Blood Physiological Processes Blood Vessels Bonding, Human-Pet Brain Breeding CHO Cells Cadherins Calcineurin Candida Candida albicans Candidemia Candidiasis Candidiasis, Oral Carbohydrates Cardiovascular Abnormalities Cardiovascular Agents Cardiovascular Deconditioning Cardiovascular Diseases Cardiovascular Infections Cardiovascular Physiological Phenomena Cardiovascular Physiological Processes Cardiovascular Surgical Procedures Cardiovascular System Casein Kinase II Catheters Cell Adhesion Cell Adhesion Molecules Cell Communication Cell Growth Processes Cell Line Cell Line, Tumor Cell Physiological Processes Cell Wall Cells Cells, Cultured Central Nervous System Vascular Malformations Cerebral Phaeohyphomycosis Cerebral Revascularization Cerebrovascular Circulation Cerebrovascular Disorders Cerebrovascular Trauma Chemical Processes Child, Institutionalized Chitinase Chorionic Gonadotropin, beta Subunit, Human Choroidal Neovascularization Chromoblastomycosis Chromosome Mapping Chromosomes, Artificial, Human Chromosomes, Human Chromosomes, Human, 1-3 Chromosomes, Human, 13-15 Chromosomes, Human, 16-18 Chromosomes, Human, 19-20 Chromosomes, Human, 21-22 and Y Chromosomes, Human, 4-5 Chromosomes, Human, 6-12 and X Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 10 Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 12 Chromosomes, Human, Pair 13 Chromosomes, Human, Pair 14 Chromosomes, Human, Pair 15 Chromosomes, Human, Pair 16 Chromosomes, Human, Pair 17 Chromosomes, Human, Pair 18 Chromosomes, Human, Pair 19 Chromosomes, Human, Pair 2 Chromosomes, Human, Pair 20 Chromosomes, Human, Pair 21 Chromosomes, Human, Pair 22 Chromosomes, Human, Pair 3 Chromosomes, Human, Pair 4 Chromosomes, Human, Pair 5 Chromosomes, Human, Pair 6 Chromosomes, Human, Pair 7 Chromosomes, Human, Pair 8 Chromosomes, Human, Pair 9 Chromosomes, Human, X Chromosomes, Human, Y Climatic Processes Cloning, Molecular Coccidioidomycosis Colony Count, Microbial Community-Institutional Relations Computing Methodologies Consensus Consensus Development Conferences, NIH as Topic Conservation of Energy Resources Conservation of Natural Resources Copying Processes Corneal Neovascularization Coronavirus 229E, Human Coronavirus NL63, Human Coronavirus OC43, Human Cortisone Cricetinae Cyclic AMP-Dependent Protein Kinases Cytochrome P-450 Enzyme System Cytokine Receptor Common beta Subunit Cytokine Receptor gp130 Cytokine-Induced Killer Cells Cytokines Cytokinesis DNA DNA Primers DNA-Binding Proteins Dehumanization Deinstitutionalization Dementia, Vascular Dental Physiological Processes Diabetes Mellitus Diagnosis Diagnostic Techniques, Cardiovascular Digestive System Processes Disease Disease Models, Animal Disease Progression Disease Susceptibility Disseminated Intravascular Coagulation Drug Resistance, Fungal E-Selectin Echinocandins Echovirus 6, Human Ecological and Environmental Processes Electrophysiological Processes Emigrants and Immigrants Endocarditis, Bacterial Endocytosis Endothelial Cells Endothelium Endothelium, Vascular Endovascular Procedures Energy-Generating Resources Enterovirus A, Human Enterovirus B, Human Enterovirus C, Human Enterovirus D, Human Enzyme Inhibitors Epistasis, Genetic Epithelial Cells Ethics, Institutional Extraction and Processing Industry Extravascular Lung Water Eye Movement Desensitization Reprocessing Flow Cytometry Fluconazole Follicle Stimulating Hormone, Human Food-Processing Industry Forefoot, Human Foundations Fungal Proteins Fungal Vaccines Fungi Galectin 3 Gastric Antral Vascular Ectasia Gene Deletion Gene Expression Gene Expression Profiling Gene Expression Regulation, Fungal Gene Rearrangement Gene Rearrangement, B-Lymphocyte Gene Rearrangement, B-Lymphocyte, Heavy Chain Gene Rearrangement, B-Lymphocyte, Light Chain Gene Rearrangement, T-Lymphocyte Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor Gene Rearrangement, beta-Chain T-Cell Antigen Receptor Gene Rearrangement, delta-Chain T-Cell Antigen Receptor Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor Gene Targeting Genes Genes, Fungal Genetic Complementation Test Genetic Diseases, X-Linked Genetic Diseases, Y-Linked Genetic Linkage Genetic Predisposition to Disease Genetic Processes Genetic Variation Genetic Vectors Genetics Genome Genome, Human Genomics Genotype Geological Processes Germination Glaucoma, Neovascular Glucans Goals Graft Occlusion, Vascular Group Processes Growth HIV HIV Infections Haplotypes HeLa Cells Health Health Resources Hemodynamics Hepatitis A Virus, Human Hepatitis, Viral, Human Herpesvirus 1, Human Herpesvirus 2, Human Herpesvirus 3, Human Herpesvirus 4, Human Herpesvirus 6, Human Herpesvirus 7, Human Herpesvirus 8, Human Heterotrophic Processes Homozygote Host-Pathogen Interactions Human Activities Human Body Human Characteristics Human Coprophagia Human Development Human Engineering Human Experimentation Human Genome Project Human Growth Hormone Human Immunodeficiency Virus Proteins Human Migration Human Papillomavirus DNA Tests Human Rights Human Rights Abuses Human T-lymphotropic virus 1 Human T-lymphotropic virus 2 Human T-lymphotropic virus 3 Human Umbilical Vein Endothelial Cells Human bocavirus Human papillomavirus 11 Human papillomavirus 16 Human papillomavirus 18 Human papillomavirus 31 Human papillomavirus 6 Humanism Humanities Humans Hyalohyphomycosis Hydrangea Hydrangeaceae Hydrogen Peroxide Hypertension, Renovascular Hyphae Image Processing, Computer-Assisted Immune System Immune System Processes Immunity Immunity, Cellular Immunity, Innate Immunocompromised Host Immunogenetic Processes Immunosuppressive Agents Incidence Infection Influenza, Human Institutional Management Teams Institutional Practice Institutionalization Insulin, Regular, Human Integrins Interinstitutional Relations Interleukin-4 Interleukin-8 Invasive Pulmonary Aspergillosis Iron Kaplan-Meier Estimate Kidney Laboratories Lectins, C-Type Lepidoptera Leukemia, Neutrophilic, Chronic Leukocytes Libraries Life Ligands Light-Harvesting Protein Complexes Liver Lobomycosis Lung Lung Diseases, Fungal Macrophages Mammary Glands, Human Manihot Masks Mechanical Processes Meiosis Membrane Glycoproteins Membrane Proteins Meningitis, Cryptococcal Mental Processes Mesenteric Vascular Occlusion Methods Mice Mice, Inbred BALB C Mice, Inbred ICR Mice, Inbred Strains Mice, Knockout Mice, Mutant Strains Mice, Neurologic Mutants Microarray Analysis Microbial Sensitivity Tests Microbiological Processes Microscopy, Confocal Microscopy, Electron, Transmission Microvascular Angina Microvascular Decompression Surgery Middle Aged Milk, Human Models, Cardiovascular Models, Molecular Molecular Chaperones Molecular Sequence Data Morbidity Morphogenesis Mortality Mothers Moths Mouth Mucosa Mucormycosis Multi-Institutional Systems Muscle, Smooth, Vascular Musculoskeletal Physiological Processes Mutagenesis, Insertional Mutant Chimeric Proteins Mutant Proteins Mutation Mycoses Mycosis Fungoides Myocardial Revascularization NIH 3T3 Cells National Human Genome Research Institute (U.S.) National Institute of Child Health and Human Development (U.S.) National Institutes of Health (U.S.) Natural Language Processing Nature Neoplasms, Vascular Tissue Neoplastic Processes Neovascularization, Pathologic Neovascularization, Physiologic Nervous System Physiological Processes Neutropenia Neutrophil Activation Neutrophil Infiltration Neutrophils Nontherapeutic Human Experimentation Nursing Process Nutrition Processes Ocular Physiological Processes Odontoid Process Olecranon Process Oligonucleotide Array Sequence Analysis Onychomycosis Open Reading Frames Opportunistic Infections Optical Processes Organ Transplantation Organic Chemistry Processes Organisms, Genetically Modified Oropharynx Otomycosis Outcome and Process Assessment (Health Care) Outsourced Services Oxidative Stress Oxidoreductases Paracoccidioidomycosis Parainfluenza Virus 1, Human Parainfluenza Virus 2, Human Parainfluenza Virus 3, Human Parainfluenza Virus 4, Human Parents Parvovirus B19, Human Pathologic Processes Patients Peptide Fragments Peripheral Vascular Diseases Perivascular Epithelioid Cell Neoplasms Phaeohyphomycosis Phagocytes Pharmacological Processes Phenotype Pheromones, Human Phosphorylation Phosphotransferases Photochemical Processes Phototrophic Processes Physical Processes Physicochemical Processes Physiological Processes Plant Physiological Processes Plant Vascular Bundle Plasmids Plasminogen Plastics Polymerase Chain Reaction Population Pregnancy Complications, Cardiovascular Probability Process Assessment (Health Care) Protein Binding Protein Processing, Post-Translational Protein Structure, Secondary Protein Structure, Tertiary Protein Transport Protein-Serine-Threonine Kinases Proteins Psychological Phenomena and Processes Psychotherapeutic Processes Pulmonary Alveoli Pyrimidines Quantitative Trait Loci RNA RNA 3' End Processing RNA Processing, Post-Transcriptional RNA, Fungal RNA, Messenger RNA, Small Interfering Range of Motion, Articular Rats Rats, Mutant Strains Rats, Sprague-Dawley Receptor Protein-Tyrosine Kinases Receptors, Cytokine Receptors, Vascular Endothelial Growth Factor Recombinant Fusion Proteins Recombinant Proteins Repressor Proteins Reproducibility of Results Reproductive Physiological Processes Research Research Personnel Resource Allocation Respiratory Physiological Processes Respiratory Syncytial Virus, Human Retinal Neovascularization Reverse Genetics Reverse Transcriptase Polymerase Chain Reaction Ribonuclease H, Human Immunodeficiency Virus Risk Risk Factors Role Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Selectins Sepsis Sequence Homology, Amino Acid Sex Determination Processes Signal Processing, Computer-Assisted Signal Transduction Sjogren's Syndrome Skin Diseases, Vascular Skin Physiological Processes Species Specificity Specific Pathogen-Free Organisms Spinal Cord Vascular Diseases Spleen Spores, Fungal Staphylococcal Infections Staphylococcus aureus Steroids Sterol 14-Demethylase Stochastic Processes Stria Vascularis Suppressor of Cytokine Signaling Proteins Survival Analysis Synteny Syphilis, Cardiovascular Th1 Cells Therapeutic Human Experimentation Thoracic Surgical Procedures Thromboplastin Time Time Factors Tissue Culture Techniques Tissue and Organ Harvesting Tissues Transcription Factors Transcription, Genetic Transfection Transformation, Genetic Transients and Migrants Transmyocardial Laser Revascularization Treatment Outcome Trypanosoma rangeli Tuberculosis, Cardiovascular Tumor Necrosis Factor-alpha Tyrosine Umbilical Cord Umbilical Veins United States Dept. of Health and Human Services United States Health Resources and Services Administration Up-Regulation Urinary Tract Physiological Processes Vaccines, Synthetic Vaginal Birth after Cesarean Vancomycin Vascular Access Devices Vascular Calcification Vascular Capacitance Vascular Cell Adhesion Molecule-1 Vascular Diseases Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor B Vascular Endothelial Growth Factor C Vascular Endothelial Growth Factor D Vascular Endothelial Growth Factor Receptor-1 Vascular Endothelial Growth Factor Receptor-2 Vascular Endothelial Growth Factor Receptor-3 Vascular Endothelial Growth Factor, Endocrine-Gland-Derived Vascular Endothelial Growth Factors Vascular Fistula Vascular Grafting Vascular Headaches Vascular Malformations Vascular Neoplasms Vascular Patency Vascular Resistance Vascular Stiffness Vascular Surgical Procedures Vascular System Injuries Veins Virulence Virulence Factors Virus Physiological Processes Visible Human Projects Water Resources Word Processing Work Yeasts Zygomycosis env Gene Products, Human Immunodeficiency Virus gag Gene Products, Human Immunodeficiency Virus nef Gene Products, Human Immunodeficiency Virus pol Gene Products, Human Immunodeficiency Virus rev Gene Products, Human Immunodeficiency Virus tat Gene Products, Human Immunodeficiency Virus vif Gene Products, Human Immunodeficiency Virus vpr Gene Products, Human Immunodeficiency Virus

Does this profile need updating? Contact Us